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Protein

Peptide transporter family 1

Gene

pept-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Low-affinity peptide transporter that is necessary for proton-dependent uptake of di- or tripeptides, and to a minor extent tetrapeptides, in the intestine. Transport is independent of sodium and chloride ions. Controls the uptake of dietary fatty acids, plays a role in fatty acid synthesis and is responsible for dipeptide-induced acidification of the intestine. Regulates cellular pH differences together with the antiporter protein, nhx-2. Amino acid uptake and absorption levels influence the insulin signaling/daf-2 and let-363/TOR pathways, subsequently affecting the stress response and longevity of the organism.7 Publications

GO - Molecular functioni

  • dipeptide transmembrane transporter activity Source: WormBase

GO - Biological processi

  • amino acid homeostasis Source: WormBase
  • determination of adult lifespan Source: WormBase
  • dipeptide transport Source: WormBase
  • lipid storage Source: WormBase
  • negative regulation of fatty acid transport Source: WormBase
  • nematode larval development Source: WormBase
  • positive regulation of growth rate Source: WormBase
  • positive regulation of multicellular organism growth Source: WormBase
  • protein transport Source: UniProtKB-KW
  • regulation of endoplasmic reticulum unfolded protein response Source: WormBase
  • regulation of pH Source: WormBase
  • regulation of TOR signaling Source: WormBase
  • reproduction Source: WormBase
  • response to heat Source: WormBase
  • response to oxidative stress Source: WormBase

Keywordsi

Biological processPeptide transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-427975 Proton/oligopeptide cotransporters

Protein family/group databases

TCDBi2.A.17.4.11 the proton-dependent oligopeptide transporter (pot/ptr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide transporter family 1
Alternative name(s):
Di-/tri-peptide transporter CPTB
Oligopeptide transporter 1
Gene namesi
Name:pept-1
Synonyms:cptb, opt-2, pep-2
ORF Names:K04E7.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi

Organism-specific databases

WormBaseiK04E7.2 ; CE25039 ; WBGene00003877 ; pept-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Transmembranei325 – 345HelicalSequence analysisAdd BLAST21
Transmembranei368 – 388HelicalSequence analysisAdd BLAST21
Transmembranei401 – 421HelicalSequence analysisAdd BLAST21
Transmembranei697 – 717HelicalSequence analysisAdd BLAST21
Transmembranei738 – 758HelicalSequence analysisAdd BLAST21
Transmembranei765 – 785HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mutant worms have decreased body size, high fat stores, increased uptake of fatty acids, reduced brood size, retarded postembryonic growth, extended reproductive life span and increased resistance to stress. RNAi-mediated knockdown of the protein results in impaired synthesis of long-chain and polyunsaturated fatty acids. Pharyngeal pumping rate is similar to wild type but simultaneous knockdown with nhx-2 results in reduced rate of pharyngeal pumping and slightly higher acidic intestinal pH.6 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000643141 – 835Peptide transporter family 1Add BLAST835

Proteomic databases

EPDiQ21219
PaxDbiQ21219
PeptideAtlasiQ21219
PRIDEiQ21219

PTM databases

iPTMnetiQ21219

Expressioni

Tissue specificityi

Expressed specifically in the intestine.1 Publication

Developmental stagei

Biphasic expression pattern observed. Gradual increase in expression during development from embryo through to adult with a decrease during larva stages 1 and 2.1 Publication

Gene expression databases

BgeeiWBGene00003877

Interactioni

Protein-protein interaction databases

STRINGi6239.K04E7.2.1

Structurei

3D structure databases

ProteinModelPortaliQ21219
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1237 Eukaryota
COG3104 LUCA
GeneTreeiENSGT00530000062961
HOGENOMiHOG000285186
InParanoidiQ21219
KOiK14206
OMAiIFAIMTR
OrthoDBiEOG091G0M1S
PhylomeDBiQ21219

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004768 Oligopep_transport
IPR000109 POT_fam
IPR018456 PTR2_symporter_CS
PANTHERiPTHR11654 PTHR11654, 1 hit
PfamiView protein in Pfam
PF00854 PTR2, 2 hits
SUPFAMiSSF103473 SSF103473, 2 hits
TIGRFAMsiTIGR00926 2A1704, 1 hit
PROSITEiView protein in PROSITE
PS01022 PTR2_1, 1 hit
PS01023 PTR2_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q21219-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGYSESRSES VSSKGKTSYG HELETVPLPE KKIYTTWPDM IRHWPKTTLC
60 70 80 90 100
IVSNEFCERF SYYGMRTVLT FYLLNVLKFT DSQSTIFFNG FTVLCYTTPL
110 120 130 140 150
LGSIVADGYI GKFWTIFSVS ILYAIGQVVL ALASTKNFQS SVHPWMDLSG
160 170 180 190 200
LLIIAFGTGG IKPCVSAFGG DQFELGQERM LSLFFSMFYF SINAGSMIST
210 220 230 240 250
FISPIFRSQP CLGQDSCYPM AFGIPAILMI VATLVFMGGS FWYKKNPPKD
260 270 280 290 300
NVFGEVSRLM FRAVGNKMKS GSTPKEHWLL HYLTTHDCAL DAKCLELQAE
310 320 330 340 350
KRNKNLCQKK KFIDDVRSLL RVLVMFLPVP MFWALYDQQG SVWLIQAIQM
360 370 380 390 400
DCRLSDTLLL LPDQMQTLNA VLILLFIPLF QVIIYPVAAK CVRLTPLRKM
410 420 430 440 450
VTGGLLASLA FLITGFVQLQ VNTTLPTLPE EGEASISFWN QFETDCTITV
460 470 480 490 500
MSGIHKRVLP HDKYLHEDKK NKSGIYNLFT TKSPAKGNGD WTLTYDLSYD
510 520 530 540 550
GACGDTSKLE KTVKVTAKSK KIIYVGVGSF GYYQNTANTD KPTDGTGEFS
560 570 580 590 600
MGIVTVFNSS YGGNFAMCRQ NTSDFDVNHP CNPRHPADFY FWETDYNSHT
610 620 630 640 650
DDRDQNATIT GSLSSQPAVT YKQKSVKPGY WQLYYLLNTP KDVDRQTYNK
660 670 680 690 700
TATLVAPTNY GFHRVKQGGV FIYALTGTYE NPKIHELQIV QSNSVSILWQ
710 720 730 740 750
IPQIVVITAA EILFSITGYE FAYSQSAPSM KALVQALWLL TTAAGDSIIV
760 770 780 790 800
VITILNLFEN MAVEFFVYAA AMFVVIAIFA LLSIFYYTYN YYTTDEEDGE
810 820 830
IGVDDEEEIE DHNPRYSIDN KGFHPDEKDT FDMHF
Length:835
Mass (Da):94,109
Last modified:October 25, 2004 - v2
Checksum:i5CC84A90800ED617
GO

Sequence cautioni

The sequence AAC39119 differs from that shown. Reason: Frameshift at position 11.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000418 mRNA Translation: AAC39119.1 Frameshift.
FO080549 Genomic DNA Translation: CCD64583.1
PIRiE89551
T37330
RefSeqiNP_509087.1, NM_076686.5
UniGeneiCel.19638

Genome annotation databases

EnsemblMetazoaiK04E7.2; K04E7.2; WBGene00003877
GeneIDi180919
KEGGicel:CELE_K04E7.2
UCSCiK04E7.2.2 c. elegans

Similar proteinsi

Entry informationi

Entry nameiPEPT1_CAEEL
AccessioniPrimary (citable) accession number: Q21219
Secondary accession number(s): O76186
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 25, 2004
Last modified: May 23, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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