Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q21217 (GABT_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable 4-aminobutyrate aminotransferase, mitochondrial

EC=2.6.1.19
Alternative name(s):
(S)-3-amino-2-methylpropionate transaminase
EC=2.6.1.22
GABA aminotransferase
Short name=GABA-AT
Gamma-amino-N-butyrate transaminase
Short name=GABA transaminase
L-AIBAT
Gene names
Name:gta-1
ORF Names:K04D7.3
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length483 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.

(S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate.

Cofactor

Pyridoxal phosphate By similarity.

Subcellular location

Mitochondrion matrix By similarity.

Sequence similarities

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion By similarity
Chain? – 483Probable 4-aminobutyrate aminotransferase, mitochondrialPRO_0000001254

Amino acid modifications

Modified residue3411N6-(pyridoxal phosphate)lysine Potential

Sequences

Sequence LengthMass (Da)Tools
Q21217 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 669965D22A0C4FB0

FASTA48353,055
        10         20         30         40         50         60 
MLPRLAKSSL IQQVRGVSAI ANAEPSGPSI STSIPGPKSK ALKQEMDKVH QTTSVRFHVD 

        70         80         90        100        110        120 
YEKSFGNYVV DADGNALLDV YTQISSLPLG YNHPDLVKVA SQPHLITSLV SRPALGSFPR 

       130        140        150        160        170        180 
TDFADGISHA LTSIAPKGLK AVQTMLCGTS ANENAIKTAF IWYQAQRRGG LGPDALHLES 

       190        200        210        220        230        240 
CMNQQKPGTP NLSVMGFEGA FHGRSLCMLS VTRSKPIHKV DIPAFDWPIA KFPRYKYPLD 

       250        260        270        280        290        300 
QNVAYNKKQD QECLADVEAK ISEWKRRDND VAAIIVEPIQ AEGGDHYGSP AFFQGLRDIT 

       310        320        330        340        350        360 
SKHGIVFIVD EVQTGGGATG DIWAHDHWNL SSPPDMVTFS KKLLTGGYFY GEHLRVKEAY 

       370        380        390        400        410        420 
RIYNTWMGDP TKLLLLEKAV EVIKRDGLIE QSREVGAEFQ KRLGELQASS GGKLDQARGR 

       430        440        450        460        470        480 
GTFAAVDFPS GSLRDKFVDL AISNGLHCGG CGDRSLRFRP SLVYTKKHLD LTFDLLDKTL 


KGL 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z69664 Genomic DNA. Translation: CAA93517.1.
PIRT23312.
RefSeqNP_501862.1. NM_069461.3.
UniGeneCel.5440.

3D structure databases

ProteinModelPortalQ21217.
SMRQ21217. Positions 27-483.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6239.K04D7.3.

2D gel databases

World-2DPAGE0020:Q21217.

Proteomic databases

PaxDbQ21217.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaK04D7.3a; K04D7.3a; WBGene00001794.
GeneID177897.
KEGGcel:CELE_K04D7.3.
UCSCK04D7.3. c. elegans.

Organism-specific databases

CTD177897.
WormBaseK04D7.3a; CE06092; WBGene00001794; gta-1.

Phylogenomic databases

eggNOGCOG0160.
GeneTreeENSGT00550000074885.
HOGENOMHOG000020208.
InParanoidQ21217.
KOK13524.
OMAKDRATFI.
PhylomeDBQ21217.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProIPR004631. 4NH2But_aminotransferase_euk.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERPTHR11986. PTHR11986. 1 hit.
PTHR11986:SF6. PTHR11986:SF6. 1 hit.
PfamPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
TIGRFAMsTIGR00699. GABAtrns_euk. 1 hit.
PROSITEPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio898846.
PROQ21217.

Entry information

Entry nameGABT_CAEEL
AccessionPrimary (citable) accession number: Q21217
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase