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Q21217

- GABT_CAEEL

UniProt

Q21217 - GABT_CAEEL

Protein

Probable 4-aminobutyrate aminotransferase, mitochondrial

Gene

gta-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.
    (S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate.

    Cofactori

    Pyridoxal phosphate.By similarity

    GO - Molecular functioni

    1. (S)-3-amino-2-methylpropionate transaminase activity Source: UniProtKB-EC
    2. 4-aminobutyrate transaminase activity Source: UniProtKB-EC
    3. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. gamma-aminobutyric acid metabolic process Source: InterPro
    2. neurotransmitter catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Keywords - Biological processi

    Neurotransmitter degradation

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    ReactomeiREACT_183180. Degradation of GABA.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable 4-aminobutyrate aminotransferase, mitochondrial (EC:2.6.1.19)
    Alternative name(s):
    (S)-3-amino-2-methylpropionate transaminase (EC:2.6.1.22)
    GABA aminotransferase
    Short name:
    GABA-AT
    Gamma-amino-N-butyrate transaminase
    Short name:
    GABA transaminase
    L-AIBAT
    Gene namesi
    Name:gta-1
    ORF Names:K04D7.3
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome IV

    Organism-specific databases

    WormBaseiK04D7.3a; CE06092; WBGene00001794; gta-1.

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell
    2. mitochondrion Source: WormBase

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 483Probable 4-aminobutyrate aminotransferase, mitochondrialPRO_0000001254
    Transit peptidei1 – ?MitochondrionBy similarity

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei341 – 3411N6-(pyridoxal phosphate)lysineSequence Analysis

    Proteomic databases

    PaxDbiQ21217.

    2D gel databases

    World-2DPAGE0020:Q21217.

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.K04D7.3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ21217.
    SMRiQ21217. Positions 27-483.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0160.
    GeneTreeiENSGT00550000074885.
    HOGENOMiHOG000020208.
    InParanoidiQ21217.
    KOiK13524.
    OMAiKDRATFI.
    PhylomeDBiQ21217.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    InterProiIPR004631. 4NH2But_aminotransferase_euk.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PTHR11986:SF6. PTHR11986:SF6. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00699. GABAtrns_euk. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q21217-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLPRLAKSSL IQQVRGVSAI ANAEPSGPSI STSIPGPKSK ALKQEMDKVH    50
    QTTSVRFHVD YEKSFGNYVV DADGNALLDV YTQISSLPLG YNHPDLVKVA 100
    SQPHLITSLV SRPALGSFPR TDFADGISHA LTSIAPKGLK AVQTMLCGTS 150
    ANENAIKTAF IWYQAQRRGG LGPDALHLES CMNQQKPGTP NLSVMGFEGA 200
    FHGRSLCMLS VTRSKPIHKV DIPAFDWPIA KFPRYKYPLD QNVAYNKKQD 250
    QECLADVEAK ISEWKRRDND VAAIIVEPIQ AEGGDHYGSP AFFQGLRDIT 300
    SKHGIVFIVD EVQTGGGATG DIWAHDHWNL SSPPDMVTFS KKLLTGGYFY 350
    GEHLRVKEAY RIYNTWMGDP TKLLLLEKAV EVIKRDGLIE QSREVGAEFQ 400
    KRLGELQASS GGKLDQARGR GTFAAVDFPS GSLRDKFVDL AISNGLHCGG 450
    CGDRSLRFRP SLVYTKKHLD LTFDLLDKTL KGL 483
    Length:483
    Mass (Da):53,055
    Last modified:November 1, 1996 - v1
    Checksum:i669965D22A0C4FB0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z69664 Genomic DNA. Translation: CAA93517.1.
    PIRiT23312.
    RefSeqiNP_501862.1. NM_069461.3.
    UniGeneiCel.5440.

    Genome annotation databases

    EnsemblMetazoaiK04D7.3a; K04D7.3a; WBGene00001794.
    GeneIDi177897.
    KEGGicel:CELE_K04D7.3.
    UCSCiK04D7.3. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z69664 Genomic DNA. Translation: CAA93517.1 .
    PIRi T23312.
    RefSeqi NP_501862.1. NM_069461.3.
    UniGenei Cel.5440.

    3D structure databases

    ProteinModelPortali Q21217.
    SMRi Q21217. Positions 27-483.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.K04D7.3.

    2D gel databases

    World-2DPAGE 0020:Q21217.

    Proteomic databases

    PaxDbi Q21217.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai K04D7.3a ; K04D7.3a ; WBGene00001794 .
    GeneIDi 177897.
    KEGGi cel:CELE_K04D7.3.
    UCSCi K04D7.3. c. elegans.

    Organism-specific databases

    CTDi 177897.
    WormBasei K04D7.3a ; CE06092 ; WBGene00001794 ; gta-1.

    Phylogenomic databases

    eggNOGi COG0160.
    GeneTreei ENSGT00550000074885.
    HOGENOMi HOG000020208.
    InParanoidi Q21217.
    KOi K13524.
    OMAi KDRATFI.
    PhylomeDBi Q21217.

    Enzyme and pathway databases

    Reactomei REACT_183180. Degradation of GABA.

    Miscellaneous databases

    NextBioi 898846.
    PROi Q21217.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    InterProi IPR004631. 4NH2But_aminotransferase_euk.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    PTHR11986:SF6. PTHR11986:SF6. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00699. GABAtrns_euk. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiGABT_CAEEL
    AccessioniPrimary (citable) accession number: Q21217
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3