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Protein

Probable 4-aminobutyrate aminotransferase, mitochondrial

Gene

gta-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.
(S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate.

Cofactori

pyridoxal 5'-phosphateBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei204SubstrateBy similarity1
Binding sitei365Pyridoxal phosphate; shared with dimeric partnerBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
Biological processNeurotransmitter degradation
LigandPyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-CEL-916853. Degradation of GABA.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 4-aminobutyrate aminotransferase, mitochondrial (EC:2.6.1.19)
Alternative name(s):
(S)-3-amino-2-methylpropionate transaminase (EC:2.6.1.22)
GABA aminotransferase
Short name:
GABA-AT
Gamma-amino-N-butyrate transaminase
Short name:
GABA transaminase
L-AIBAT
Gene namesi
Name:gta-1
ORF Names:K04D7.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiK04D7.3a; CE06092; WBGene00001794; gta-1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial matrix Source: UniProtKB-SubCell
  • mitochondrion Source: WormBase

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000001254? – 483Probable 4-aminobutyrate aminotransferase, mitochondrial
Transit peptidei1 – ?MitochondrionBy similarity

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei341N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

EPDiQ21217.
PaxDbiQ21217.
PeptideAtlasiQ21217.
PRIDEiQ21217.

2D gel databases

World-2DPAGEi0020:Q21217.

Expressioni

Gene expression databases

BgeeiWBGene00001794.
ExpressionAtlasiQ21217. baseline.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi6239.K04D7.3.2.

Structurei

3D structure databases

ProteinModelPortaliQ21217.
SMRiQ21217.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni148 – 149Pyridoxal phosphate bindingBy similarity2

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1405. Eukaryota.
COG0160. LUCA.
GeneTreeiENSGT00550000074885.
HOGENOMiHOG000020208.
InParanoidiQ21217.
KOiK13524.
OMAiALGMNHP.
OrthoDBiEOG091G08T5.
PhylomeDBiQ21217.

Family and domain databases

CDDicd00610. OAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiView protein in InterPro
IPR004631. 4NH2But_aminotransferase_euk.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_sub2.
PfamiView protein in Pfam
PF00202. Aminotran_3. 1 hit.
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00699. GABAtrns_euk. 1 hit.
PROSITEiView protein in PROSITE
PS00600. AA_TRANSFER_CLASS_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q21217-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPRLAKSSL IQQVRGVSAI ANAEPSGPSI STSIPGPKSK ALKQEMDKVH
60 70 80 90 100
QTTSVRFHVD YEKSFGNYVV DADGNALLDV YTQISSLPLG YNHPDLVKVA
110 120 130 140 150
SQPHLITSLV SRPALGSFPR TDFADGISHA LTSIAPKGLK AVQTMLCGTS
160 170 180 190 200
ANENAIKTAF IWYQAQRRGG LGPDALHLES CMNQQKPGTP NLSVMGFEGA
210 220 230 240 250
FHGRSLCMLS VTRSKPIHKV DIPAFDWPIA KFPRYKYPLD QNVAYNKKQD
260 270 280 290 300
QECLADVEAK ISEWKRRDND VAAIIVEPIQ AEGGDHYGSP AFFQGLRDIT
310 320 330 340 350
SKHGIVFIVD EVQTGGGATG DIWAHDHWNL SSPPDMVTFS KKLLTGGYFY
360 370 380 390 400
GEHLRVKEAY RIYNTWMGDP TKLLLLEKAV EVIKRDGLIE QSREVGAEFQ
410 420 430 440 450
KRLGELQASS GGKLDQARGR GTFAAVDFPS GSLRDKFVDL AISNGLHCGG
460 470 480
CGDRSLRFRP SLVYTKKHLD LTFDLLDKTL KGL
Length:483
Mass (Da):53,055
Last modified:November 1, 1996 - v1
Checksum:i669965D22A0C4FB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z69664 Genomic DNA. Translation: CAA93517.1.
PIRiT23312.
RefSeqiNP_501862.1. NM_069461.3.
UniGeneiCel.5440.

Genome annotation databases

EnsemblMetazoaiK04D7.3a; K04D7.3a; WBGene00001794.
GeneIDi177897.
KEGGicel:CELE_K04D7.3.
UCSCiK04D7.3. c. elegans.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGABT_CAEEL
AccessioniPrimary (citable) accession number: Q21217
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: June 7, 2017
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families