Reviewed, UniProtKB/Swiss-Prot Q21217 (GABT_CAEEL)

Names and origin

Protein names

Recommended name:
    Probable 4-aminobutyrate aminotransferase, mitochondrial
    EC=2.6.1.19
Alternative name(s):
    Gamma-amino-N-butyrate transaminase
      Short name=GABA transaminase
    GABA aminotransferase
      Short name=GABA-AT
    L-AIBAT
    (S)-3-amino-2-methylpropionate transaminase
    EC=2.6.1.22

Gene names

Name:	gta-1
ORF Names:	K04D7.3

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	483 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate. (S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate.
Cofactor	Pyridoxal phosphate By similarity.
Subcellular location	Mitochondrion matrix By similarity.
Sequence similarities	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

Ontologies

Keywords
Biological process	Neurotransmitter degradation
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gamma-aminobutyric acid metabolic process Inferred from electronic annotation. Source: InterPro neurotransmitter catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	(S)-3-amino-2-methylpropionate transaminase activity Inferred from electronic annotation. Source: EC 4-aminobutyrate transaminase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion By similarity
	Chain	? – 483		Probable 4-aminobutyrate aminotransferase, mitochondrial		PRO_0000001254
Amino acid modifications
	Modified residue	341	1	N6-(pyridoxal phosphate)lysine Potential

Sequences

	Sequence		Length	Mass (Da)
	Q21217-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 669965D22A0C4FB0	FASTA	483	53,055
	10 20 30 40 50 60 MLPRLAKSSL IQQVRGVSAI ANAEPSGPSI STSIPGPKSK ALKQEMDKVH QTTSVRFHVD 70 80 90 100 110 120 YEKSFGNYVV DADGNALLDV YTQISSLPLG YNHPDLVKVA SQPHLITSLV SRPALGSFPR 130 140 150 160 170 180 TDFADGISHA LTSIAPKGLK AVQTMLCGTS ANENAIKTAF IWYQAQRRGG LGPDALHLES 190 200 210 220 230 240 CMNQQKPGTP NLSVMGFEGA FHGRSLCMLS VTRSKPIHKV DIPAFDWPIA KFPRYKYPLD 250 260 270 280 290 300 QNVAYNKKQD QECLADVEAK ISEWKRRDND VAAIIVEPIQ AEGGDHYGSP AFFQGLRDIT 310 320 330 340 350 360 SKHGIVFIVD EVQTGGGATG DIWAHDHWNL SSPPDMVTFS KKLLTGGYFY GEHLRVKEAY 370 380 390 400 410 420 RIYNTWMGDP TKLLLLEKAV EVIKRDGLIE QSREVGAEFQ KRLGELQASS GGKLDQARGR 430 440 450 460 470 480 GTFAAVDFPS GSLRDKFVDL AISNGLHCGG CGDRSLRFRP SLVYTKKHLD LTFDLLDKTL KGL

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z69664 Genomic DNA. Translation: CAA93517.1.
PIR	T23312.
RefSeq	NP_501862.1.
UniGene	Cel.5440
3D structure databases
SMR	Q21217. Positions 25-482.
ModBase	Search...
Protein-protein interaction databases
STRING	Q21217.
Genome annotation databases
Ensembl	K04D7.3; K04D7.3; K04D7.3; Caenorhabditis elegans. [Genome view]
GeneID	177897.
KEGG	cel:K04D7.3.
NMPDR	fig|6239.3.peg.14826.
UCSC	K04D7.3. c. elegans.
Organism-specific databases
CTD	177897.
WormBase	WBGene00001794. gta-1.
WormPep	K04D7.3. CE06092. [WorfDB]
Phylogenomic databases
eggNOG	meNOG04947.
HOGENOM	HBG483813.
InParanoid	Q21217.
OMA	INIIKRE.
PhylomeDB	Q21217.
Enzyme and pathway databases
BRENDA	2.6.1.19. 672. 2.6.1.22. 672.
Gene expression databases
ArrayExpress	Q21217.
Family and domain databases
InterPro	IPR004631. 4NH2But_aminotransferase_euk. IPR005814. Aminotrans_3. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11986. Aminotrans_3. 1 hit. PTHR11986:SF6. GABAtrns_euk. 1 hit.
Pfam	PF00202. Aminotran_3. 1 hit. [Graphical view]
TIGRFAMs	TIGR00699. GABAtrns_euk. 1 hit.
PROSITE	PS00600. AA_TRANSFER_CLASS_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	898846.

Entry information

Entry name

GABT_CAEEL

Accession

Primary (citable) accession number: Q21217

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	November 1, 1996
Last modified:	February 9, 2010
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project