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Q21217

- GABT_CAEEL

UniProt

Q21217 - GABT_CAEEL

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Protein

Probable 4-aminobutyrate aminotransferase, mitochondrial

Gene

gta-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.
(S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate.

Cofactori

Pyridoxal phosphate.By similarity

GO - Molecular functioni

  1. (S)-3-amino-2-methylpropionate transaminase activity Source: UniProtKB-EC
  2. 4-aminobutyrate transaminase activity Source: UniProtKB-EC
  3. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. gamma-aminobutyric acid metabolic process Source: InterPro
  2. neurotransmitter catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Biological processi

Neurotransmitter degradation

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

ReactomeiREACT_183180. Degradation of GABA.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 4-aminobutyrate aminotransferase, mitochondrial (EC:2.6.1.19)
Alternative name(s):
(S)-3-amino-2-methylpropionate transaminase (EC:2.6.1.22)
GABA aminotransferase
Short name:
GABA-AT
Gamma-amino-N-butyrate transaminase
Short name:
GABA transaminase
L-AIBAT
Gene namesi
Name:gta-1
ORF Names:K04D7.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome IV

Organism-specific databases

WormBaseiK04D7.3a; CE06092; WBGene00001794; gta-1.

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrion Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 483Probable 4-aminobutyrate aminotransferase, mitochondrialPRO_0000001254
Transit peptidei1 – ?MitochondrionBy similarity

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei341 – 3411N6-(pyridoxal phosphate)lysineSequence Analysis

Proteomic databases

PaxDbiQ21217.

2D gel databases

World-2DPAGE0020:Q21217.

Expressioni

Gene expression databases

ExpressionAtlasiQ21217. baseline.

Interactioni

Protein-protein interaction databases

STRINGi6239.K04D7.3.

Structurei

3D structure databases

ProteinModelPortaliQ21217.
SMRiQ21217. Positions 27-483.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0160.
GeneTreeiENSGT00550000074885.
HOGENOMiHOG000020208.
InParanoidiQ21217.
KOiK13524.
OMAiKDRATFI.
PhylomeDBiQ21217.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiIPR004631. 4NH2But_aminotransferase_euk.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PTHR11986:SF6. PTHR11986:SF6. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00699. GABAtrns_euk. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q21217-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLPRLAKSSL IQQVRGVSAI ANAEPSGPSI STSIPGPKSK ALKQEMDKVH
60 70 80 90 100
QTTSVRFHVD YEKSFGNYVV DADGNALLDV YTQISSLPLG YNHPDLVKVA
110 120 130 140 150
SQPHLITSLV SRPALGSFPR TDFADGISHA LTSIAPKGLK AVQTMLCGTS
160 170 180 190 200
ANENAIKTAF IWYQAQRRGG LGPDALHLES CMNQQKPGTP NLSVMGFEGA
210 220 230 240 250
FHGRSLCMLS VTRSKPIHKV DIPAFDWPIA KFPRYKYPLD QNVAYNKKQD
260 270 280 290 300
QECLADVEAK ISEWKRRDND VAAIIVEPIQ AEGGDHYGSP AFFQGLRDIT
310 320 330 340 350
SKHGIVFIVD EVQTGGGATG DIWAHDHWNL SSPPDMVTFS KKLLTGGYFY
360 370 380 390 400
GEHLRVKEAY RIYNTWMGDP TKLLLLEKAV EVIKRDGLIE QSREVGAEFQ
410 420 430 440 450
KRLGELQASS GGKLDQARGR GTFAAVDFPS GSLRDKFVDL AISNGLHCGG
460 470 480
CGDRSLRFRP SLVYTKKHLD LTFDLLDKTL KGL
Length:483
Mass (Da):53,055
Last modified:November 1, 1996 - v1
Checksum:i669965D22A0C4FB0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z69664 Genomic DNA. Translation: CAA93517.1.
PIRiT23312.
RefSeqiNP_501862.1. NM_069461.3.
UniGeneiCel.5440.

Genome annotation databases

EnsemblMetazoaiK04D7.3a; K04D7.3a; WBGene00001794.
GeneIDi177897.
KEGGicel:CELE_K04D7.3.
UCSCiK04D7.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z69664 Genomic DNA. Translation: CAA93517.1 .
PIRi T23312.
RefSeqi NP_501862.1. NM_069461.3.
UniGenei Cel.5440.

3D structure databases

ProteinModelPortali Q21217.
SMRi Q21217. Positions 27-483.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.K04D7.3.

2D gel databases

World-2DPAGE 0020:Q21217.

Proteomic databases

PaxDbi Q21217.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai K04D7.3a ; K04D7.3a ; WBGene00001794 .
GeneIDi 177897.
KEGGi cel:CELE_K04D7.3.
UCSCi K04D7.3. c. elegans.

Organism-specific databases

CTDi 177897.
WormBasei K04D7.3a ; CE06092 ; WBGene00001794 ; gta-1.

Phylogenomic databases

eggNOGi COG0160.
GeneTreei ENSGT00550000074885.
HOGENOMi HOG000020208.
InParanoidi Q21217.
KOi K13524.
OMAi KDRATFI.
PhylomeDBi Q21217.

Enzyme and pathway databases

Reactomei REACT_183180. Degradation of GABA.

Miscellaneous databases

NextBioi 898846.
PROi Q21217.

Gene expression databases

ExpressionAtlasi Q21217. baseline.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProi IPR004631. 4NH2But_aminotransferase_euk.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
PTHR11986:SF6. PTHR11986:SF6. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00699. GABAtrns_euk. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGABT_CAEEL
AccessioniPrimary (citable) accession number: Q21217
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3