Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable 4-aminobutyrate aminotransferase, mitochondrial

Gene

gta-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.
(S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate.

Cofactori

pyridoxal 5'-phosphateBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei204 – 2041SubstrateBy similarity
Binding sitei365 – 3651Pyridoxal phosphate; shared with dimeric partnerBy similarity

GO - Molecular functioni

  1. (S)-3-amino-2-methylpropionate transaminase activity Source: UniProtKB-EC
  2. 4-aminobutyrate transaminase activity Source: UniProtKB-EC
  3. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. gamma-aminobutyric acid metabolic process Source: InterPro
  2. neurotransmitter catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Biological processi

Neurotransmitter degradation

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

ReactomeiREACT_183180. Degradation of GABA.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 4-aminobutyrate aminotransferase, mitochondrial (EC:2.6.1.19)
Alternative name(s):
(S)-3-amino-2-methylpropionate transaminase (EC:2.6.1.22)
GABA aminotransferase
Short name:
GABA-AT
Gamma-amino-N-butyrate transaminase
Short name:
GABA transaminase
L-AIBAT
Gene namesi
Name:gta-1
ORF Names:K04D7.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome IV

Organism-specific databases

WormBaseiK04D7.3a; CE06092; WBGene00001794; gta-1.

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
  2. mitochondrion Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 483Probable 4-aminobutyrate aminotransferase, mitochondrialPRO_0000001254
Transit peptidei1 – ?MitochondrionBy similarity

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei341 – 3411N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

PaxDbiQ21217.

2D gel databases

World-2DPAGE0020:Q21217.

Expressioni

Gene expression databases

ExpressionAtlasiQ21217. baseline.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi6239.K04D7.3.

Structurei

3D structure databases

ProteinModelPortaliQ21217.
SMRiQ21217. Positions 27-483.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni148 – 1492Pyridoxal phosphate bindingBy similarity

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0160.
GeneTreeiENSGT00550000074885.
HOGENOMiHOG000020208.
InParanoidiQ21217.
KOiK13524.
OMAiTWCGDPA.
PhylomeDBiQ21217.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiIPR004631. 4NH2But_aminotransferase_euk.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PTHR11986:SF6. PTHR11986:SF6. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00699. GABAtrns_euk. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q21217-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPRLAKSSL IQQVRGVSAI ANAEPSGPSI STSIPGPKSK ALKQEMDKVH
60 70 80 90 100
QTTSVRFHVD YEKSFGNYVV DADGNALLDV YTQISSLPLG YNHPDLVKVA
110 120 130 140 150
SQPHLITSLV SRPALGSFPR TDFADGISHA LTSIAPKGLK AVQTMLCGTS
160 170 180 190 200
ANENAIKTAF IWYQAQRRGG LGPDALHLES CMNQQKPGTP NLSVMGFEGA
210 220 230 240 250
FHGRSLCMLS VTRSKPIHKV DIPAFDWPIA KFPRYKYPLD QNVAYNKKQD
260 270 280 290 300
QECLADVEAK ISEWKRRDND VAAIIVEPIQ AEGGDHYGSP AFFQGLRDIT
310 320 330 340 350
SKHGIVFIVD EVQTGGGATG DIWAHDHWNL SSPPDMVTFS KKLLTGGYFY
360 370 380 390 400
GEHLRVKEAY RIYNTWMGDP TKLLLLEKAV EVIKRDGLIE QSREVGAEFQ
410 420 430 440 450
KRLGELQASS GGKLDQARGR GTFAAVDFPS GSLRDKFVDL AISNGLHCGG
460 470 480
CGDRSLRFRP SLVYTKKHLD LTFDLLDKTL KGL
Length:483
Mass (Da):53,055
Last modified:November 1, 1996 - v1
Checksum:i669965D22A0C4FB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z69664 Genomic DNA. Translation: CAA93517.1.
PIRiT23312.
RefSeqiNP_501862.1. NM_069461.3.
UniGeneiCel.5440.

Genome annotation databases

EnsemblMetazoaiK04D7.3a; K04D7.3a; WBGene00001794.
GeneIDi177897.
KEGGicel:CELE_K04D7.3.
UCSCiK04D7.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z69664 Genomic DNA. Translation: CAA93517.1.
PIRiT23312.
RefSeqiNP_501862.1. NM_069461.3.
UniGeneiCel.5440.

3D structure databases

ProteinModelPortaliQ21217.
SMRiQ21217. Positions 27-483.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.K04D7.3.

2D gel databases

World-2DPAGE0020:Q21217.

Proteomic databases

PaxDbiQ21217.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK04D7.3a; K04D7.3a; WBGene00001794.
GeneIDi177897.
KEGGicel:CELE_K04D7.3.
UCSCiK04D7.3. c. elegans.

Organism-specific databases

CTDi177897.
WormBaseiK04D7.3a; CE06092; WBGene00001794; gta-1.

Phylogenomic databases

eggNOGiCOG0160.
GeneTreeiENSGT00550000074885.
HOGENOMiHOG000020208.
InParanoidiQ21217.
KOiK13524.
OMAiTWCGDPA.
PhylomeDBiQ21217.

Enzyme and pathway databases

ReactomeiREACT_183180. Degradation of GABA.

Miscellaneous databases

NextBioi898846.
PROiQ21217.

Gene expression databases

ExpressionAtlasiQ21217. baseline.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiIPR004631. 4NH2But_aminotransferase_euk.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PTHR11986:SF6. PTHR11986:SF6. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00699. GABAtrns_euk. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGABT_CAEEL
AccessioniPrimary (citable) accession number: Q21217
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: March 4, 2015
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.