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Protein

Guanine nucleotide-binding protein subunit beta-2-like 1

Gene

rack-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • chromosome separation Source: WormBase
  • defense response to fungus Source: WormBase
  • embryo development ending in birth or egg hatching Source: WormBase
  • mitotic cytokinesis Source: WormBase
  • motor neuron axon guidance Source: WormBase
  • polar body extrusion after meiotic divisions Source: WormBase
  • protein localization to organelle Source: WormBase
  • regulation of cell migration Source: WormBase
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ21215.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein subunit beta-2-like 1
Gene namesi
Name:rack-1
ORF Names:K04D7.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiK04D7.1; CE06090; WBGene00010556; rack-1.

Subcellular locationi

GO - Cellular componenti

  • axon Source: WormBase
  • cell body Source: WormBase
  • centrosome Source: WormBase
  • cytoplasm Source: WormBase
  • growth cone Source: WormBase
  • kinetochore Source: WormBase
  • nuclear envelope Source: WormBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 325324Guanine nucleotide-binding protein subunit beta-2-like 1PRO_0000127739Add
BLAST

Proteomic databases

EPDiQ21215.
PaxDbiQ21215.
PRIDEiQ21215.

2D gel databases

World-2DPAGE0020:Q21215.

PTM databases

iPTMnetiQ21215.

Expressioni

Gene expression databases

BgeeiWBGene00010556.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
sipa-1G5EBY52EBI-315497,EBI-314833
unc-115Q95QM52EBI-315497,EBI-4405677

Protein-protein interaction databases

BioGridi42997. 9 interactions.
DIPiDIP-26516N.
IntActiQ21215. 6 interactions.
MINTiMINT-1071040.
STRINGi6239.K04D7.1.4.

Structurei

3D structure databases

ProteinModelPortaliQ21215.
SMRiQ21215. Positions 4-321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati5 – 4844WD 1Add
BLAST
Repeati58 – 9942WD 2Add
BLAST
Repeati100 – 14142WD 3Add
BLAST
Repeati143 – 18644WD 4Add
BLAST
Repeati187 – 22741WD 5Add
BLAST
Repeati228 – 26841WD 6Add
BLAST
Repeati269 – 32052WD 7Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat G protein beta family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0279. Eukaryota.
ENOG410XQGZ. LUCA.
GeneTreeiENSGT00840000129847.
HOGENOMiHOG000091643.
InParanoidiQ21215.
KOiK14753.
OMAiRQFISHT.
OrthoDBiEOG091G0KZQ.
PhylomeDBiQ21215.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 5 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q21215-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQEQMKLTG TLEGHTGWVT QIATYTRNDK TTVLSSSRDK TILVWDVDSV
60 70 80 90 100
APVDEGPIGR PVRSLTGHNH FVSDVVISSD GQFALSGSWD KTLRLWDLNQ
110 120 130 140 150
GVSTRQFISH TKDVLSVAFS ADNRQIVSGS RDKSIKLWNT LAQCKYTITD
160 170 180 190 200
DCHTDWVSTV RFSPSNRDPV IVSAGWDKVV KVWNLGNCRL KTNHIGHTGY
210 220 230 240 250
VNTVTVSPDG SLCASGGKDG QAMLWDLNEG KHLYTLPGND VINAMSFSPN
260 270 280 290 300
RYWLCAAVGS SIKIWDLEDK KEIEELKPEI ASSGSSRGSS PQCISLAWSQ
310 320
DGQTLFAGYT DNIIRVYQVS IRASN
Length:325
Mass (Da):35,830
Last modified:January 23, 2007 - v3
Checksum:iC50669418DBCD0A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z69664 Genomic DNA. Translation: CAA93514.1.
PIRiT23309.
RefSeqiNP_501859.1. NM_069458.4.
UniGeneiCel.4889.

Genome annotation databases

EnsemblMetazoaiK04D7.1.1; K04D7.1.1; WBGene00010556.
K04D7.1.2; K04D7.1.2; WBGene00010556.
K04D7.1.3; K04D7.1.3; WBGene00010556.
GeneIDi177895.
KEGGicel:CELE_K04D7.1.
UCSCiK04D7.1.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z69664 Genomic DNA. Translation: CAA93514.1.
PIRiT23309.
RefSeqiNP_501859.1. NM_069458.4.
UniGeneiCel.4889.

3D structure databases

ProteinModelPortaliQ21215.
SMRiQ21215. Positions 4-321.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi42997. 9 interactions.
DIPiDIP-26516N.
IntActiQ21215. 6 interactions.
MINTiMINT-1071040.
STRINGi6239.K04D7.1.4.

PTM databases

iPTMnetiQ21215.

2D gel databases

World-2DPAGE0020:Q21215.

Proteomic databases

EPDiQ21215.
PaxDbiQ21215.
PRIDEiQ21215.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK04D7.1.1; K04D7.1.1; WBGene00010556.
K04D7.1.2; K04D7.1.2; WBGene00010556.
K04D7.1.3; K04D7.1.3; WBGene00010556.
GeneIDi177895.
KEGGicel:CELE_K04D7.1.
UCSCiK04D7.1.1. c. elegans.

Organism-specific databases

CTDi177895.
WormBaseiK04D7.1; CE06090; WBGene00010556; rack-1.

Phylogenomic databases

eggNOGiKOG0279. Eukaryota.
ENOG410XQGZ. LUCA.
GeneTreeiENSGT00840000129847.
HOGENOMiHOG000091643.
InParanoidiQ21215.
KOiK14753.
OMAiRQFISHT.
OrthoDBiEOG091G0KZQ.
PhylomeDBiQ21215.

Enzyme and pathway databases

SignaLinkiQ21215.

Miscellaneous databases

PROiQ21215.

Gene expression databases

BgeeiWBGene00010556.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 5 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGBLP_CAEEL
AccessioniPrimary (citable) accession number: Q21215
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.