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Q211R2

- PANC_RHOPB

UniProt

Q211R2 - PANC_RHOPB

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Protein

Pantothenate synthetase

Gene

panC

Organism
Rhodopseudomonas palustris (strain BisB18)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei41 – 411Proton donorUniRule annotation
Binding sitei65 – 651Beta-alanineUniRule annotation
Binding sitei65 – 651PantoateUniRule annotation
Binding sitei158 – 1581PantoateUniRule annotation
Binding sitei181 – 1811ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi34 – 418ATPUniRule annotation
Nucleotide bindingi152 – 1554ATPUniRule annotation
Nucleotide bindingi189 – 1924ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRPAL316056:GH3E-3374-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
Ordered Locus Names:RPC_3332
OrganismiRhodopseudomonas palustris (strain BisB18)
Taxonomic identifieri316056 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
ProteomesiUP000001948: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 283283Pantothenate synthetasePRO_0000305534Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi316056.RPC_3332.

Structurei

3D structure databases

ProteinModelPortaliQ211R2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
KOiK01918.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q211R2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRSPVIVRT LPALRRALDT LRARNASLAL VPTMGALHDG HVSLVRLAKR
60 70 80 90 100
RASKVAVSIF INPAQFAPNE DFAAYPRTWK ADLARLTAEK VDLIWNPDAK
110 120 130 140 150
TMYPAGFASK ILTEGPALAG LEDRFRPQFF GGVTTVVGKL FAQVRPDLAL
160 170 180 190 200
FGEKDFQQLR VVARMARDLD LGVKVVGAQI VRERDGLAMS SRNRYLSPEH
210 220 230 240 250
RESATALCRG LKEAAKRIRA GEAIEAALAG SAALITAAGF KIDYLEARHA
260 270 280
ETLAPVASRK DGPIRLLVAA TIGTTRLIDN VAV
Length:283
Mass (Da):30,673
Last modified:October 2, 2007 - v2
Checksum:i58A71EB5E1FB446E
GO

Sequence cautioni

The sequence ABD88874.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000301 Genomic DNA. Translation: ABD88874.1. Different initiation.
RefSeqiYP_533193.1. NC_007925.1.

Genome annotation databases

EnsemblBacteriaiABD88874; ABD88874; RPC_3332.
GeneIDi3973442.
KEGGirpc:RPC_3332.
PATRICi23271470. VBIRhoPal29154_3419.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000301 Genomic DNA. Translation: ABD88874.1 . Different initiation.
RefSeqi YP_533193.1. NC_007925.1.

3D structure databases

ProteinModelPortali Q211R2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316056.RPC_3332.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD88874 ; ABD88874 ; RPC_3332 .
GeneIDi 3973442.
KEGGi rpc:RPC_3332.
PATRICi 23271470. VBIRhoPal29154_3419.

Phylogenomic databases

eggNOGi COG0414.
HOGENOMi HOG000175516.
KOi K01918.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci RPAL316056:GH3E-3374-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BisB18.

Entry informationi

Entry nameiPANC_RHOPB
AccessioniPrimary (citable) accession number: Q211R2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: October 29, 2014
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3