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Protein

Profilin-3

Gene

pfn-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Also binds to poly(L-proline) and phosphatidylinositol 4,5-bisphosphate micelles.1 Publication

GO - Molecular functioni

GO - Biological processi

  • muscle thin filament assembly Source: WormBase
  • sequestering of actin monomers Source: GO_Central
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Profilin-3
Gene namesi
Name:pfn-3
ORF Names:K03E6.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiK03E6.6; CE07332; WBGene00003991; pfn-3.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: GO_Central
  • cell cortex Source: GO_Central
  • striated muscle dense body Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001995921 – 126Profilin-3Add BLAST126

Proteomic databases

EPDiQ21193.
PaxDbiQ21193.
PeptideAtlasiQ21193.
PRIDEiQ21193.

PTM databases

iPTMnetiQ21193.

Expressioni

Tissue specificityi

In embryos, expression is specifically detected in body wall muscle cells. In adults, expression is localized to a striking dot-like fashion in body wall muscle.1 Publication

Gene expression databases

BgeeiWBGene00003991.

Interactioni

Subunit structurei

Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi6239.K03E6.6.

Structurei

3D structure databases

ProteinModelPortaliQ21193.
SMRiQ21193.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the profilin family.Curated

Phylogenomic databases

eggNOGiKOG1755. Eukaryota.
ENOG41126PD. LUCA.
GeneTreeiENSGT00730000112841.
HOGENOMiHOG000171591.
InParanoidiQ21193.
KOiK05759.
OMAiATFPQFK.
OrthoDBiEOG091G104O.
PhylomeDBiQ21193.

Family and domain databases

CDDicd00148. PROF. 1 hit.
InterProiIPR005455. PFN.
[Graphical view]
PANTHERiPTHR11604. PTHR11604. 1 hit.
PfamiPF00235. Profilin. 1 hit.
[Graphical view]
PRINTSiPR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTiSM00392. PROF. 1 hit.
[Graphical view]
SUPFAMiSSF55770. SSF55770. 1 hit.

Sequencei

Sequence statusi: Complete.

Q21193-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWSDIINNN LIGSGNVSKA AILGFDGAVW AKSDNFNISV EEAVAAGKAF
60 70 80 90 100
TSLDALLGTG LRLEGQKFLV LNADNDRIIG KQGGSGFFIY KTIQAVIISI
110 120
YEKGLQPEMC SKTTGALADY FRSIKY
Length:126
Mass (Da):13,531
Last modified:November 1, 1996 - v1
Checksum:i9E8437D38314F6BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY530910 mRNA. Translation: AAT01435.1.
FO080324 Genomic DNA. Translation: CCD62864.1.
PIRiT34327.
RefSeqiNP_508205.1. NM_075804.3.
UniGeneiCel.739.

Genome annotation databases

EnsemblMetazoaiK03E6.6; K03E6.6; WBGene00003991.
GeneIDi180460.
KEGGicel:CELE_K03E6.6.
UCSCiK03E6.6. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY530910 mRNA. Translation: AAT01435.1.
FO080324 Genomic DNA. Translation: CCD62864.1.
PIRiT34327.
RefSeqiNP_508205.1. NM_075804.3.
UniGeneiCel.739.

3D structure databases

ProteinModelPortaliQ21193.
SMRiQ21193.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.K03E6.6.

PTM databases

iPTMnetiQ21193.

Proteomic databases

EPDiQ21193.
PaxDbiQ21193.
PeptideAtlasiQ21193.
PRIDEiQ21193.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK03E6.6; K03E6.6; WBGene00003991.
GeneIDi180460.
KEGGicel:CELE_K03E6.6.
UCSCiK03E6.6. c. elegans.

Organism-specific databases

CTDi180460.
WormBaseiK03E6.6; CE07332; WBGene00003991; pfn-3.

Phylogenomic databases

eggNOGiKOG1755. Eukaryota.
ENOG41126PD. LUCA.
GeneTreeiENSGT00730000112841.
HOGENOMiHOG000171591.
InParanoidiQ21193.
KOiK05759.
OMAiATFPQFK.
OrthoDBiEOG091G104O.
PhylomeDBiQ21193.

Miscellaneous databases

PROiQ21193.

Gene expression databases

BgeeiWBGene00003991.

Family and domain databases

CDDicd00148. PROF. 1 hit.
InterProiIPR005455. PFN.
[Graphical view]
PANTHERiPTHR11604. PTHR11604. 1 hit.
PfamiPF00235. Profilin. 1 hit.
[Graphical view]
PRINTSiPR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTiSM00392. PROF. 1 hit.
[Graphical view]
SUPFAMiSSF55770. SSF55770. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPROF3_CAEEL
AccessioniPrimary (citable) accession number: Q21193
Secondary accession number(s): Q5GHR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.