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Protein

Profilin-3

Gene

pfn-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Also binds to poly(L-proline) and phosphatidylinositol 4,5-bisphosphate micelles.1 Publication

GO - Molecular functioni

GO - Biological processi

  • muscle thin filament assembly Source: WormBase
  • sequestering of actin monomers Source: GO_Central

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Profilin-3
Gene namesi
Name:pfn-3
ORF Names:K03E6.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiK03E6.6 ; CE07332 ; WBGene00003991 ; pfn-3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001995921 – 126Profilin-3Add BLAST126

Proteomic databases

EPDiQ21193
PaxDbiQ21193
PeptideAtlasiQ21193
PRIDEiQ21193

PTM databases

iPTMnetiQ21193

Expressioni

Tissue specificityi

In embryos, expression is specifically detected in body wall muscle cells. In adults, expression is localized to a striking dot-like fashion in body wall muscle.1 Publication

Gene expression databases

BgeeiWBGene00003991

Interactioni

Subunit structurei

Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi6239.K03E6.6

Structurei

3D structure databases

ProteinModelPortaliQ21193
SMRiQ21193
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the profilin family.Curated

Phylogenomic databases

eggNOGiKOG1755 Eukaryota
ENOG41126PD LUCA
GeneTreeiENSGT00730000112841
HOGENOMiHOG000171591
InParanoidiQ21193
KOiK05759
OMAiAGQKFFT
OrthoDBiEOG091G104O
PhylomeDBiQ21193

Family and domain databases

CDDicd00148 PROF, 1 hit
InterProiView protein in InterPro
IPR005455 PFN
IPR036140 PFN_sf
PANTHERiPTHR11604 PTHR11604, 1 hit
PfamiView protein in Pfam
PF00235 Profilin, 1 hit
PRINTSiPR00392 PROFILIN
PR01640 PROFILINPLNT
SMARTiView protein in SMART
SM00392 PROF, 1 hit
SUPFAMiSSF55770 SSF55770, 1 hit

Sequencei

Sequence statusi: Complete.

Q21193-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWSDIINNN LIGSGNVSKA AILGFDGAVW AKSDNFNISV EEAVAAGKAF
60 70 80 90 100
TSLDALLGTG LRLEGQKFLV LNADNDRIIG KQGGSGFFIY KTIQAVIISI
110 120
YEKGLQPEMC SKTTGALADY FRSIKY
Length:126
Mass (Da):13,531
Last modified:November 1, 1996 - v1
Checksum:i9E8437D38314F6BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY530910 mRNA Translation: AAT01435.1
FO080324 Genomic DNA Translation: CCD62864.1
PIRiT34327
RefSeqiNP_508205.1, NM_075804.3
UniGeneiCel.739

Genome annotation databases

EnsemblMetazoaiK03E6.6; K03E6.6; WBGene00003991
GeneIDi180460
KEGGicel:CELE_K03E6.6
UCSCiK03E6.6 c. elegans

Similar proteinsi

Entry informationi

Entry nameiPROF3_CAEEL
AccessioniPrimary (citable) accession number: Q21193
Secondary accession number(s): Q5GHR0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health