Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc metalloproteinase nas-18

Gene

nas-18

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Metalloprotease.By similarity

Catalytic activityi

Hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'.By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi168Zinc; catalyticPROSITE-ProRule annotation1
Active sitei169PROSITE-ProRule annotation1
Metal bindingi172Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi178Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM12.A32

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc metalloproteinase nas-18 (EC:3.4.24.21By similarity)
Alternative name(s):
Nematode astacin 18
Gene namesi
Name:nas-18
ORF Names:K03B8.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiK03B8.3 ; CE51528 ; WBGene00003537 ; nas-18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000028922? – 410Zinc metalloproteinase nas-18
PropeptideiPRO_00004426651 – ?Curated

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi126N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi157N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi195N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi208N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi227N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi261 ↔ 269By similarity
Disulfide bondi263 ↔ 283By similarity
Disulfide bondi285 ↔ 294By similarity
Glycosylationi397N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ21179
PRIDEiQ21179

Expressioni

Gene expression databases

BgeeiWBGene00003537

Interactioni

Protein-protein interaction databases

STRINGi6239.K03B8.3

Structurei

3D structure databases

ProteinModelPortaliQ21179
SMRiQ21179
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini256 – 295EGF-likeAdd BLAST40

Sequence similaritiesi

Belongs to the peptidase M12A family.Curated

Keywords - Domaini

EGF-like domain

Phylogenomic databases

eggNOGiKOG3714 Eukaryota
ENOG410ZPX7 LUCA
HOGENOMiHOG000022534
InParanoidiQ21179
KOiK08076
PhylomeDBiQ21179

Family and domain databases

Gene3Di3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR024079 MetalloPept_cat_dom_sf
IPR017050 Metallopeptidase_nem
IPR001506 Peptidase_M12A
IPR006026 Peptidase_Metallo
PfamiView protein in Pfam
PF01400 Astacin, 1 hit
PIRSFiPIRSF036365 Astacin_nematoda, 1 hit
PRINTSiPR00480 ASTACIN
SMARTiView protein in SMART
SM00235 ZnMc, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS00142 ZINC_PROTEASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q21179-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCASCLHNAN AASFLMETFS RHRLNFICIG KMNIFYNVTS LDNKYSFHNP
60 70 80 90 100
SAPVPHSSHA LSSRQAHFTS FRAPVAPPSR PRRSQLPSSA KLLYCFDSSF
110 120 130 140 150
STEKRELMLF SMNFISSQTC VTFEENCSIP NRVQLVNGKG CSSYIGMNNI
160 170 180 190 200
VQHLTFNDTC IDFGTAVHEL MHALGVIHTH SRLDRDNFLN INLTNVSKEM
210 220 230 240 250
MHNYAIFNQS TNVVPYEYGS TMHYYANIST MFPKKSEYSA TLGIGRVTFY
260 270 280 290 300
DMVILNTAYN CKCPNELLCG NGGYTNPSKC SECICPLGYG GVLCDRPSLI
310 320 330 340 350
GKDTGLPLEV KDKIIEVKVV GIDNFFSYPT CLINGLEIKY MGDPRITNPI
360 370 380 390 400
YCSADLINGK SFRSKLNPLL MNIHTLFGKN KVTFHYRYVT ERLSGYNKTT
410
NGYDNYEYYD
Length:410
Mass (Da):46,271
Last modified:November 1, 1996 - v1
Checksum:i0101D9E1D151EA6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74039 Genomic DNA Translation: CAA98502.1
PIRiT23264
RefSeqiNP_001309451.1, NM_001322588.1

Genome annotation databases

GeneIDi186924
KEGGicel:CELE_K03B8.3
UCSCiK03B8.3 c. elegans

Entry informationi

Entry nameiNAS18_CAEEL
AccessioniPrimary (citable) accession number: Q21179
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health