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Protein

Zinc metalloproteinase nas-18

Gene

nas-18

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Probable metalloprotease.By similarity

Catalytic activityi

Hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi168Zinc; catalyticPROSITE-ProRule annotation1
Active sitei169PROSITE-ProRule annotation1
Metal bindingi172Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi178Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM12.A32.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc metalloproteinase nas-18 (EC:3.4.24.21)
Alternative name(s):
Nematode astacin 18
Gene namesi
Name:nas-18
ORF Names:K03B8.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiK03B8.3; CE51528; WBGene00003537; nas-18.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000028922? – 410Zinc metalloproteinase nas-18
Signal peptidei1 – ?Sequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37N-linked (GlcNAc...)Sequence analysis1
Glycosylationi126N-linked (GlcNAc...)Sequence analysis1
Glycosylationi157N-linked (GlcNAc...)Sequence analysis1
Glycosylationi192N-linked (GlcNAc...)Sequence analysis1
Glycosylationi195N-linked (GlcNAc...)Sequence analysis1
Glycosylationi208N-linked (GlcNAc...)Sequence analysis1
Glycosylationi227N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi261 ↔ 269By similarity
Disulfide bondi263 ↔ 283By similarity
Disulfide bondi285 ↔ 294By similarity
Glycosylationi397N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ21179.

Expressioni

Gene expression databases

BgeeiWBGene00003537.

Interactioni

Protein-protein interaction databases

STRINGi6239.K03B8.3.

Structurei

3D structure databases

ProteinModelPortaliQ21179.
SMRiQ21179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini256 – 295EGF-likeAdd BLAST40

Sequence similaritiesi

Belongs to the peptidase M12A family.Curated
Contains 1 EGF-like domain.Curated

Keywords - Domaini

EGF-like domain, Signal

Phylogenomic databases

eggNOGiKOG3714. Eukaryota.
ENOG410ZPX7. LUCA.
GeneTreeiENSGT00760000119227.
HOGENOMiHOG000022534.
InParanoidiQ21179.
KOiK08076.
PhylomeDBiQ21179.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR001506. Peptidase_M12A.
IPR006026. Peptidase_Metallo.
[Graphical view]
PfamiPF01400. Astacin. 1 hit.
[Graphical view]
PRINTSiPR00480. ASTACIN.
SMARTiSM00235. ZnMc. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q21179-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCASCLHNAN AASFLMETFS RHRLNFICIG KMNIFYNVTS LDNKYSFHNP
60 70 80 90 100
SAPVPHSSHA LSSRQAHFTS FRAPVAPPSR PRRSQLPSSA KLLYCFDSSF
110 120 130 140 150
STEKRELMLF SMNFISSQTC VTFEENCSIP NRVQLVNGKG CSSYIGMNNI
160 170 180 190 200
VQHLTFNDTC IDFGTAVHEL MHALGVIHTH SRLDRDNFLN INLTNVSKEM
210 220 230 240 250
MHNYAIFNQS TNVVPYEYGS TMHYYANIST MFPKKSEYSA TLGIGRVTFY
260 270 280 290 300
DMVILNTAYN CKCPNELLCG NGGYTNPSKC SECICPLGYG GVLCDRPSLI
310 320 330 340 350
GKDTGLPLEV KDKIIEVKVV GIDNFFSYPT CLINGLEIKY MGDPRITNPI
360 370 380 390 400
YCSADLINGK SFRSKLNPLL MNIHTLFGKN KVTFHYRYVT ERLSGYNKTT
410
NGYDNYEYYD
Length:410
Mass (Da):46,271
Last modified:November 1, 1996 - v1
Checksum:i0101D9E1D151EA6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74039 Genomic DNA. Translation: CAA98502.1.
PIRiT23264.
RefSeqiNP_001309451.1. NM_001322588.1.

Genome annotation databases

EnsemblMetazoaiK03B8.3; K03B8.3; WBGene00003537.
GeneIDi186924.
KEGGicel:CELE_K03B8.3.
UCSCiK03B8.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74039 Genomic DNA. Translation: CAA98502.1.
PIRiT23264.
RefSeqiNP_001309451.1. NM_001322588.1.

3D structure databases

ProteinModelPortaliQ21179.
SMRiQ21179.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.K03B8.3.

Protein family/group databases

MEROPSiM12.A32.

Proteomic databases

PaxDbiQ21179.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK03B8.3; K03B8.3; WBGene00003537.
GeneIDi186924.
KEGGicel:CELE_K03B8.3.
UCSCiK03B8.3. c. elegans.

Organism-specific databases

CTDi186924.
WormBaseiK03B8.3; CE51528; WBGene00003537; nas-18.

Phylogenomic databases

eggNOGiKOG3714. Eukaryota.
ENOG410ZPX7. LUCA.
GeneTreeiENSGT00760000119227.
HOGENOMiHOG000022534.
InParanoidiQ21179.
KOiK08076.
PhylomeDBiQ21179.

Miscellaneous databases

PROiQ21179.

Gene expression databases

BgeeiWBGene00003537.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR001506. Peptidase_M12A.
IPR006026. Peptidase_Metallo.
[Graphical view]
PfamiPF01400. Astacin. 1 hit.
[Graphical view]
PRINTSiPR00480. ASTACIN.
SMARTiSM00235. ZnMc. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNAS18_CAEEL
AccessioniPrimary (citable) accession number: Q21179
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.