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Protein

Zinc metalloproteinase nas-17

Gene

nas-17

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Metalloprotease.By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi152Zinc; catalyticPROSITE-ProRule annotation1
Active sitei153PROSITE-ProRule annotation1
Metal bindingi156Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi162Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM12.A31

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc metalloproteinase nas-17 (EC:3.4.24.-By similarity)
Alternative name(s):
Nematode astacin 17
Gene namesi
Name:nas-17
ORF Names:K03B8.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiK03B8.2 ; CE06076 ; WBGene00003536 ; nas-17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000028921? – 429Zinc metalloproteinase nas-17
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000044266422 – ?Curated

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi54N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi250 ↔ 258By similarity
Disulfide bondi252 ↔ 272By similarity
Disulfide bondi274 ↔ 283By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ21178
PeptideAtlasiQ21178

Expressioni

Gene expression databases

BgeeiWBGene00003536

Interactioni

Protein-protein interaction databases

STRINGi6239.K03B8.2

Structurei

3D structure databases

ProteinModelPortaliQ21178
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini245 – 284EGF-likeAdd BLAST40

Sequence similaritiesi

Belongs to the peptidase M12A family.Curated

Keywords - Domaini

EGF-like domain, Signal

Phylogenomic databases

eggNOGiKOG3714 Eukaryota
ENOG410ZPX7 LUCA
HOGENOMiHOG000022534
InParanoidiQ21178
KOiK08076
OrthoDBiEOG091G0A41
PhylomeDBiQ21178

Family and domain databases

CDDicd04280 ZnMc_astacin_like, 1 hit
Gene3Di3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR034035 Astacin-like_dom
IPR024079 MetalloPept_cat_dom_sf
IPR017050 Metallopeptidase_nem
IPR001506 Peptidase_M12A
IPR006026 Peptidase_Metallo
PfamiView protein in Pfam
PF01400 Astacin, 1 hit
PIRSFiPIRSF036365 Astacin_nematoda, 1 hit
PRINTSiPR00480 ASTACIN
SMARTiView protein in SMART
SM00235 ZnMc, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS00142 ZINC_PROTEASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q21178-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLRPSTLLL TLFLALVAGS AIRKDVDEFD SNKGKDGIVD GDIMLTEAQL
60 70 80 90 100
RILNGTAKRS KRQITKIWKK WPDAKVFYYY ENEFTSLKRE LMSYAMAHIS
110 120 130 140 150
SNTCVKFQES NSATNRIRFT NTGGCASYIG MNGGEQTLWF GDGCLIFGTA
160 170 180 190 200
VHEIMHSLGL FHTHSRFDRD NFLSVSYKDV PENMVGNLEK ETEQTTYNAV
210 220 230 240 250
PFEYGSTMLY RYNTFGEGTL VSKNEDYQKT MGLRRVSFYD LVNINVRYSC
260 270 280 290 300
GCAKSLTCEN GGYTNPSNCA TCVCPTGFAG TLCNEAPSNT IKLTAESYWK
310 320 330 340 350
GYWVNFGYST SIQTTNYYLA YLWITAPADK TIEVKIMDLS GFTCSYGCNY
360 370 380 390 400
NGVEVKYMGD PRITNPLRCC AQDTEYLNQV ISSKQNPTPI VMQQRYGSSK
410 420
LTIHYRYVDT PLSSNKKSTN GYDNYQYYV
Length:429
Mass (Da):48,563
Last modified:January 4, 2005 - v2
Checksum:iD3C603863FD4C9BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74039 Genomic DNA Translation: CAA98501.1
PIRiT23263
RefSeqiNP_505892.1, NM_073491.1
UniGeneiCel.32978

Genome annotation databases

GeneIDi186923
KEGGicel:CELE_K03B8.2
UCSCiK03B8.2 c. elegans

Similar proteinsi

Entry informationi

Entry nameiNAS17_CAEEL
AccessioniPrimary (citable) accession number: Q21178
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 4, 2005
Last modified: April 25, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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