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Protein

Zinc metalloproteinase nas-17

Gene

nas-17

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Probable metalloprotease.By similarity

Catalytic activityi

Hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi152Zinc; catalyticPROSITE-ProRule annotation1
Active sitei153PROSITE-ProRule annotation1
Metal bindingi156Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi162Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM12.A31.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc metalloproteinase nas-17 (EC:3.4.24.21)
Alternative name(s):
Nematode astacin 17
Gene namesi
Name:nas-17
ORF Names:K03B8.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiK03B8.2; CE06076; WBGene00003536; nas-17.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002892122 – 429Zinc metalloproteinase nas-17Add BLAST408

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi54N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi250 ↔ 258By similarity
Disulfide bondi252 ↔ 272By similarity
Disulfide bondi274 ↔ 283By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ21178.
PeptideAtlasiQ21178.

Expressioni

Gene expression databases

BgeeiWBGene00003536.

Structurei

3D structure databases

ProteinModelPortaliQ21178.
SMRiQ21178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini245 – 284EGF-likeAdd BLAST40

Sequence similaritiesi

Belongs to the peptidase M12A family.Curated
Contains 1 EGF-like domain.Curated

Keywords - Domaini

EGF-like domain, Signal

Phylogenomic databases

eggNOGiKOG3714. Eukaryota.
ENOG410ZPX7. LUCA.
HOGENOMiHOG000022534.
InParanoidiQ21178.
KOiK08076.
OrthoDBiEOG091G0A41.
PhylomeDBiQ21178.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR017050. Metallopeptidase_nem.
IPR001506. Peptidase_M12A.
IPR006026. Peptidase_Metallo.
[Graphical view]
PfamiPF01400. Astacin. 1 hit.
[Graphical view]
PIRSFiPIRSF036365. Astacin_nematoda. 1 hit.
PRINTSiPR00480. ASTACIN.
SMARTiSM00235. ZnMc. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q21178-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLRPSTLLL TLFLALVAGS AIRKDVDEFD SNKGKDGIVD GDIMLTEAQL
60 70 80 90 100
RILNGTAKRS KRQITKIWKK WPDAKVFYYY ENEFTSLKRE LMSYAMAHIS
110 120 130 140 150
SNTCVKFQES NSATNRIRFT NTGGCASYIG MNGGEQTLWF GDGCLIFGTA
160 170 180 190 200
VHEIMHSLGL FHTHSRFDRD NFLSVSYKDV PENMVGNLEK ETEQTTYNAV
210 220 230 240 250
PFEYGSTMLY RYNTFGEGTL VSKNEDYQKT MGLRRVSFYD LVNINVRYSC
260 270 280 290 300
GCAKSLTCEN GGYTNPSNCA TCVCPTGFAG TLCNEAPSNT IKLTAESYWK
310 320 330 340 350
GYWVNFGYST SIQTTNYYLA YLWITAPADK TIEVKIMDLS GFTCSYGCNY
360 370 380 390 400
NGVEVKYMGD PRITNPLRCC AQDTEYLNQV ISSKQNPTPI VMQQRYGSSK
410 420
LTIHYRYVDT PLSSNKKSTN GYDNYQYYV
Length:429
Mass (Da):48,563
Last modified:January 4, 2005 - v2
Checksum:iD3C603863FD4C9BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74039 Genomic DNA. Translation: CAA98501.1.
PIRiT23263.
RefSeqiNP_505892.1. NM_073491.1.
UniGeneiCel.32978.

Genome annotation databases

GeneIDi186923.
KEGGicel:CELE_K03B8.2.
UCSCiK03B8.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74039 Genomic DNA. Translation: CAA98501.1.
PIRiT23263.
RefSeqiNP_505892.1. NM_073491.1.
UniGeneiCel.32978.

3D structure databases

ProteinModelPortaliQ21178.
SMRiQ21178.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiM12.A31.

Proteomic databases

PaxDbiQ21178.
PeptideAtlasiQ21178.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi186923.
KEGGicel:CELE_K03B8.2.
UCSCiK03B8.2. c. elegans.

Organism-specific databases

CTDi186923.
WormBaseiK03B8.2; CE06076; WBGene00003536; nas-17.

Phylogenomic databases

eggNOGiKOG3714. Eukaryota.
ENOG410ZPX7. LUCA.
HOGENOMiHOG000022534.
InParanoidiQ21178.
KOiK08076.
OrthoDBiEOG091G0A41.
PhylomeDBiQ21178.

Miscellaneous databases

PROiQ21178.

Gene expression databases

BgeeiWBGene00003536.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR017050. Metallopeptidase_nem.
IPR001506. Peptidase_M12A.
IPR006026. Peptidase_Metallo.
[Graphical view]
PfamiPF01400. Astacin. 1 hit.
[Graphical view]
PIRSFiPIRSF036365. Astacin_nematoda. 1 hit.
PRINTSiPR00480. ASTACIN.
SMARTiSM00235. ZnMc. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNAS17_CAEEL
AccessioniPrimary (citable) accession number: Q21178
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 4, 2005
Last modified: November 2, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.