Reviewed,
UniProtKB/Swiss-Prot Q21166 (SUR5_CAEEL)
Last modified
June 16, 2009.
Version 53.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Acetoacetyl-CoA synthetase EC=6.2.1.16 Alternative name(s): Suppressor of activated let-60 Ras protein 5 | ||||
| Gene names |
| ||||
| Organism | Caenorhabditis elegans [Complete proteome] | ||||
| Taxonomic identifier | 6239 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Protein attributes
| Sequence length | 700 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Activates acetoacetate to acetoacetyl-CoA By similarity. Negatively regulates let-60 Ras activity during vulval induction. |
| Catalytic activity | ATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoA. |
| Subcellular location | |
| Tissue specificity | Present in most cells of the organism. Ref.1 |
| Sequence similarities | Belongs to the ATP-dependent AMP-binding enzyme family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Fatty acid metabolism Lipid metabolism |
| Cellular component | Cytoplasm Nucleus |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | fatty acid metabolic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleusInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetoacetate-CoA ligase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 700 | 700 | Acetoacetyl-CoA synthetase | PRO_0000315791 | |||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Caenorhabditis elegans SUR-5, a novel but conserved protein, negatively regulates LET-60 Ras activity during vulval induction." Gu T., Orita S., Han M. Mol. Cell. Biol. 18:4556-4564(1998) [PubMed: 9671465] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. |
| [2] | "Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2. |
Cross-references
Sequence databases | |
|---|---|
| AY091467 mRNA. Translation: AAM44123.1. U41625 Genomic DNA. Translation: AAA83327.1. | |
| PIR | T34321. |
| RefSeq | NP_509229.1. |
| UniGene | Cel.22610 |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | K03A1.5. Caenorhabditis elegans. [Contig view] |
| GeneID | 180992. |
| KEGG | cel:K03A1.5. |
Organism-specific databases | |
| WormBase | WBGene00006351. sur-5. |
| WormPep | K03A1.5. CE04713. [WorfDB] |
Phylogenomic databases | |
| OMA | Q21166. WAHGDYA. |
Enzyme and pathway databases | |
| BRENDA | 6.2.1.16. 672. |
Gene expression databases | |
| ArrayExpress | Q21166. |
Family and domain databases | |
| InterPro | IPR005914. Acac_CoA_synth. IPR000873. AMP-dep_Synth/Lig. [Graphical view] |
| Pfam | PF00501. AMP-binding. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01217. ac_ac_CoA_syn. 1 hit. |
| PROSITE | PS00455. AMP_BINDING. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 911894. |
Entry information
| Entry name | SUR5_CAEEL | ||||||||
| Accession | Primary (citable) accession number: Q21166 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Caenorhabditis annotation project | ||||||||
Relevant documents
| Caenorhabditis elegans Caenorhabditis elegans: entries, gene names and cross-references to WormPep |
| SIMILARITY comments Index of protein domains and families |

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