Q21166 (SUR5_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetoacetyl-CoA synthetase
EC=6.2.1.16

Alternative name(s):
Suppressor of activated let-60 Ras protein 5

Gene names

Name:	sur-5
ORF Names:	K03A1.5

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	700 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Activates acetoacetate to acetoacetyl-CoA By similarity. Negatively regulates let-60 Ras activity during vulval induction. Ref.1
Catalytic activity	ATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoA.
Subcellular location	Cytoplasm. Nucleus Ref.1.
Tissue specificity	Present in most cells of the organism. Ref.1
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
Biological process	Fatty acid metabolism Lipid metabolism
Cellular component	Cytoplasm Nucleus
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	fatty acid metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetoacetate-CoA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 700	700	Acetoacetyl-CoA synthetase		PRO_0000315791

Sequences

	Sequence		Length	Mass (Da)
	Q21166 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 6821FD4A33275CF7	FASTA	700	78,339
	10 20 30 40 50 60 MTAVSANGKT TEKHENGAHT NGTTNGTTNG SMNGNEISHV QKLQPVYYKP PQNLETFELS 70 80 90 100 110 120 LRNHFEEKTN KKFADYREFH RFTCDNYGIF WEDLLKLSDV KLHQNYNQVI DHNLKINERP 130 140 150 160 170 180 RWFNGATLNY TENVIERGTA TDIAVLNASI EETVTEYTYD NLRKDVYRIA TSLRNYGIGP 190 200 210 220 230 240 GDTVCGFVPN TYDTLVAVFA TAAVGAAWCS ASVDFGPAGV LDRFRQVHPK VLFTVNHVTY 250 260 270 280 290 300 KKKLIDQTDK INEIVKELPT LEKIVVSDTF TSVKFDATKY NQSDKFSSLE EFKTPIADVV 310 320 330 340 350 360 LPFVYTPVPF SDPLFVMFSS GTTGIPKAMV HTVGGTLLKH IEEHLVQGDS KKHDRMFFYT 370 380 390 400 410 420 TCGWMMYNWM ISFLYSKGSV VLFDECPLAP DTHIIMKIAA KTQSTMIGMG AKLYDEYLRL 430 440 450 460 470 480 QIPFNTLYDL SKIHTVYSTG SPLKKECFAY INTYIAPGAL IASISGGTDI IGCFVGGIKS 490 500 510 520 530 540 LSITPGECQC LFLGMDIKSF NYMDEEIINS DEQGELVCVT PFPSMPSHFL NDTDGKKYRD 550 560 570 580 590 600 AYFARLEPFW AHGDFVRVNH STGGVEMLGR SDATLNRGGV RIGTAEIYSV VEKIPHIADC 610 620 630 640 650 660 IVAGRLVEEG MDEEVLLFVK MVPGQELTHS IQAAIVSKLR NDMSPRHVPN KIYAVDDIPY 670 680 690 700 TSSGKKVEVA VKQIVSGKAV QKASSIRNPE SLDHFVQYRL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Caenorhabditis elegans SUR-5, a novel but conserved protein, negatively regulates LET-60 Ras activity during vulval induction." Gu T., Orita S., Han M. Mol. Cell. Biol. 18:4556-4564(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY091467 mRNA. Translation: AAM44123.1. FO081579 Genomic DNA. Translation: CCD72541.1.
PIR	T34321.
RefSeq	NP_509229.1. NM_076828.5.
UniGene	Cel.22610.
3D structure databases
ProteinModelPortal	Q21166.
SMR	Q21166. Positions 122-680.
ModBase	Search...
Protein-protein interaction databases
STRING	6239.K03A1.5.
Proteomic databases
PaxDb	Q21166.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	K03A1.5; K03A1.5; K03A1.5.
GeneID	180992.
KEGG	cel:CELE_K03A1.5.
UCSC	K03A1.5. c. elegans.
Organism-specific databases
CTD	180992.
WormBase	K03A1.5; CE04713; WBGene00006351; sur-5.
Phylogenomic databases
eggNOG	COG0365.
GeneTree	ENSGT00700000104176.
HOGENOM	HOG000229992.
InParanoid	Q21166.
KO	K01907.
OMA	YHWYSST.
Family and domain databases
InterPro	IPR005914. Acac_CoA_synth. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
Pfam	PF00501. AMP-binding. 1 hit. [Graphical view]
TIGRFAMs	TIGR01217. ac_ac_CoA_syn. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	911894.

Entry information

Entry name

SUR5_CAEEL

Accession

Primary (citable) accession number: Q21166

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project