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Protein

Probable calcium-binding mitochondrial carrier K02F3.2

Gene

K02F3.2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Calcium-dependent mitochondrial solute carrier.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi106 – 117121Add
BLAST
Calcium bindingi140 – 151122Add
BLAST
Calcium bindingi211 – 222123Add
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-CEL-70263. Gluconeogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable calcium-binding mitochondrial carrier K02F3.2
Gene namesi
ORF Names:K02F3.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiK02F3.2a; CE48021; WBGene00019326.
K02F3.2b; CE48184; WBGene00019326.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei118 – 13821Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei262 – 28221Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei382 – 40221Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei431 – 45121Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei475 – 49521Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei574 – 59421Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 716716Probable calcium-binding mitochondrial carrier K02F3.2PRO_0000090603Add
BLAST

Proteomic databases

EPDiQ21153.
PaxDbiQ21153.
PRIDEiQ21153.

Interactioni

Protein-protein interaction databases

STRINGi6239.K02F3.2.

Structurei

3D structure databases

ProteinModelPortaliQ21153.
SMRiQ21153. Positions 58-345, 382-709.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini93 – 12634EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini127 – 16236EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini165 – 19531EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini198 – 23336EF-hand 4PROSITE-ProRule annotationAdd
BLAST
Repeati376 – 46893Solcar 1Add
BLAST
Repeati475 – 56086Solcar 2Add
BLAST
Repeati568 – 65689Solcar 3Add
BLAST

Sequence similaritiesi

Contains 4 EF-hand domains.PROSITE-ProRule annotation
Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0751. Eukaryota.
ENOG410XNRM. LUCA.
GeneTreeiENSGT00530000062944.
HOGENOMiHOG000180633.
InParanoidiQ21153.
KOiK15105.
OMAiCDEFEAV.
OrthoDBiEOG70GMF1.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
1.50.40.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF13405. EF-hand_6. 1 hit.
PF13833. EF-hand_8. 1 hit.
PF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
SSF47473. SSF47473. 3 hits.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
PS50920. SOLCAR. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform b (identifier: Q21153-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFDHLLTSS KRRELLQNLG IGHGSDVFST GLFRKAECNA ETAISQRSIP
60 70 80 90 100
RANPDHLRPI FDRFATKEIK GKKLMTPEDF IRGYLGLYTE ENYNKETVRL
110 120 130 140 150
LASAADTTKD GDISFEEFCA FEALLCSPDA LYLTAFELFD RNASDTISCD
160 170 180 190 200
EFEAVIRHTQ PLHDQDFDFS SEFIKRYFGA DKQRNVNYHS FCQLLHDFYE
210 220 230 240 250
EQGIQAFKRY DKNGNGTISS LDFQQIMTTV KGHLLTDFVR HNLIAVSGGG
260 270 280 290 300
ASGHKFSDTR GGFVTFPYYA AFNSLLAKME LIKRVYVSTT RGNLDIEMTK
310 320 330 340 350
EEFLHAIQSY TQVTPYEVEI LFHLSELNHP GRKTLCLKDI QAIDPERLKR
360 370 380 390 400
VSQMDRLINI KAVHHKDDRG VGTAFLESAY RFLLGSVAGA CGATAVYPID
410 420 430 440 450
LVKTRMQNQR TSGSFVGEVM YKNSLDCFKK VVKFEGLLGL YRGLLPQIVG
460 470 480 490 500
VAPEKAIKLT MNDYMRDKFT KDGKIPLYGE IIAGGTGGMC QVVFTNPLEI
510 520 530 540 550
VKIRLQTAGE VQQAGKKIGV FTVLKELGFL GLYKGSRACF LRDIPFSAIY
560 570 580 590 600
FPAYAHAKLA SADEDGMNSP GTLFASAFIA GVPAAGLVTP ADVIKTRLQV
610 620 630 640 650
AARAGQTTYN GVIDCARKLI KEEGPMSLWK GTAARVCRSS PQFAVTLLTY
660 670 680 690 700
EVLQRLFYVD FAGSRPTGSE LATTKTIQDE SSTNPDHVGG YKLAAATFSG
710
IEHKFGLFLP KFETSK
Note: No experimental confirmation available.
Length:716
Mass (Da):79,595
Last modified:October 16, 2013 - v3
Checksum:iFD9C7DC32D50ADAD
GO
Isoform a (identifier: Q21153-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     256-263: Missing.

Note: No experimental confirmation available.
Show »
Length:708
Mass (Da):78,727
Checksum:i08EF7F94A4B0B1B1
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei256 – 2638Missing in isoform a. CuratedVSP_053225

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080195 Genomic DNA. Translation: CCD61871.2.
FO080195 Genomic DNA. Translation: CCQ25712.1.
PIRiT16533.
RefSeqiNP_001263698.1. NM_001276769.1. [Q21153-1]
NP_497274.3. NM_064873.5. [Q21153-2]

Genome annotation databases

EnsemblMetazoaiK02F3.2b; K02F3.2b; WBGene00019326. [Q21153-1]
GeneIDi175242.
KEGGicel:CELE_K02F3.2.
UCSCiK02F3.2. c. elegans. [Q21153-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080195 Genomic DNA. Translation: CCD61871.2.
FO080195 Genomic DNA. Translation: CCQ25712.1.
PIRiT16533.
RefSeqiNP_001263698.1. NM_001276769.1. [Q21153-1]
NP_497274.3. NM_064873.5. [Q21153-2]

3D structure databases

ProteinModelPortaliQ21153.
SMRiQ21153. Positions 58-345, 382-709.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.K02F3.2.

Proteomic databases

EPDiQ21153.
PaxDbiQ21153.
PRIDEiQ21153.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK02F3.2b; K02F3.2b; WBGene00019326. [Q21153-1]
GeneIDi175242.
KEGGicel:CELE_K02F3.2.
UCSCiK02F3.2. c. elegans. [Q21153-1]

Organism-specific databases

CTDi175242.
WormBaseiK02F3.2a; CE48021; WBGene00019326.
K02F3.2b; CE48184; WBGene00019326.

Phylogenomic databases

eggNOGiKOG0751. Eukaryota.
ENOG410XNRM. LUCA.
GeneTreeiENSGT00530000062944.
HOGENOMiHOG000180633.
InParanoidiQ21153.
KOiK15105.
OMAiCDEFEAV.
OrthoDBiEOG70GMF1.

Enzyme and pathway databases

ReactomeiR-CEL-70263. Gluconeogenesis.

Miscellaneous databases

PROiQ21153.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
1.50.40.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF13405. EF-hand_6. 1 hit.
PF13833. EF-hand_8. 1 hit.
PF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
SSF47473. SSF47473. 3 hits.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
PS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiCMC1_CAEEL
AccessioniPrimary (citable) accession number: Q21153
Secondary accession number(s): L8E976
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 16, 2013
Last modified: July 6, 2016
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.