ID   F26_CAEEL               Reviewed;         457 AA.
AC   Q21122;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   06-JUN-2002, sequence version 2.
DT   16-JUN-2009, entry version 67.
DE   RecName: Full=Putative 6PF-2-K/Fru-2,6-P2ASE;
DE   Includes:
DE     RecName: Full=6-phosphofructo-2-kinase;
DE              EC=2.7.1.105;
DE   Includes:
DE     RecName: Full=Fructose-2,6-bisphosphatase;
DE              EC=3.1.3.46;
GN   ORFNames=K02B2.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea;
OC   Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   MEDLINE=99069613; PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Synthesis and degradation of fructose 2,6-bisphosphate
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: Beta-D-fructose 2,6-bisphosphate + H(2)O = D-
CC       fructose 6-phosphate + phosphate.
CC   -!- CATALYTIC ACTIVITY: ATP + D-fructose 6-phosphate = ADP + beta-D-
CC       fructose 2,6-bisphosphate.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the
CC       phosphoglycerate mutase family.
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DR   EMBL; U41558; AAK39245.2; -; Genomic_DNA.
DR   RefSeq; NP_500893.2; -.
DR   UniGene; Cel.7619; -.
DR   HSSP; P07953; 1C80.
DR   Ensembl; K02B2.1; Caenorhabditis elegans.
DR   GeneID; 177363; -.
DR   KEGG; cel:K02B2.1; -.
DR   NMPDR; fig|6239.3.peg.13532; -.
DR   WormBase; WBGene00019295; K02B2.1.
DR   WormPep; K02B2.1; CE30082.
DR   OMA; Q21122; FNNGELR.
DR   BRENDA; 2.7.1.105; 672.
DR   BRENDA; 3.1.3.46; 672.
DR   NextBio; 896460; -.
DR   ArrayExpress; Q21122; -.
DR   GO; GO:0003873; F:6-phosphofructo-2-kinase activity; IEA:EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase act...; IEA:EC.
DR   GO; GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.
DR   InterPro; IPR003094; 6Pfruct_kin.
DR   InterPro; IPR013079; 6Phosfructo_kin.
DR   InterPro; IPR016260; Bifunct_6PFK/fruc_bisP_Ptase.
DR   InterPro; IPR001345; PG/BPGM_mutase.
DR   InterPro; IPR013078; PG_mutase.
DR   PANTHER; PTHR10606; 6Pfruct_kin; 1.
DR   Pfam; PF01591; 6PF2K; 1.
DR   Pfam; PF00300; PGAM; 1.
DR   PIRSF; PIRSF000709; 6PFK_2-Ptase; 1.
DR   PRINTS; PR00991; 6PFRUCTKNASE.
DR   PROSITE; PS00175; PG_MUTASE; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Complete proteome; Hydrolase; Kinase;
KW   Multifunctional enzyme; Nucleotide-binding; Transferase.
FT   CHAIN         1    457       Putative 6PF-2-K/Fru-2,6-P2ASE.
FT                                /FTId=PRO_0000179974.
FT   NP_BIND      36     43       ATP (Potential).
FT   REGION        1    244       6-phosphofructo-2-kinase.
FT   REGION      245    457       Fructose-2,6-bisphosphatase.
FT   ACT_SITE    124    124       Potential.
FT   ACT_SITE    154    154       Potential.
FT   ACT_SITE    253    253       Tele-phosphohistidine intermediate (By
FT                                similarity).
FT   ACT_SITE    324    324       Potential.
FT   ACT_SITE    389    389       Proton donor (By similarity).
FT   BINDING      98     98       Fructose-6-phosphate (By similarity).
FT   BINDING     190    190       Fructose-6-phosphate (By similarity).
SQ   SEQUENCE   457 AA;  52091 MW;  E04A9A892378E413 CRC64;
     MEIPPGLETT KRKVAHSDEH GFSDQVRVPN VIVMVGLPAR GKTYISKKLC RYLKWTGFTT
     KVFNVGEYRR SDANAADAIH GANASFFSPN NADALKVRAE SARRAMEDMA DYLNSGTGGV
     AIFDATNTTK DRRRIIIDFC KKQRLRCFFI ESVCDDPAII DCNVTDVKVN SPDYKGLMTA
     EQAKEDFMNR IENYKKQYEP LDESEDESLS FIKVINAGRS FKVHQVRGHV QSRVVYFLMN
     IHLLPRSIYL TRHGQSEYNA MGRLGGDSPL TEDGQKYASA LADFFEEEEV PGLRVWCSQK
     VRAAQTAQHL KPDFHTEYWK ALDELDAGIC EGLTYEDILQ RYPKQADDRA TDKYHYRYPS
     GESYEDVVSR LEPVIMELER QANVLVVSHQ AVLRCVLAYF YDRPLSELPY IDIPLHSLVK
     LTPRAYHCDS TIYALDLESG EWTETSDQLP LCDSPRD
//