Reviewed, UniProtKB/Swiss-Prot Q21122 (F26_CAEEL)

Names and origin

Protein names

Recommended name:
    Putative 6PF-2-K/Fru-2,6-P2ASE
Including the following 2 domains:
    1- Recommended name:
            6-phosphofructo-2-kinase
              EC=2.7.1.105
    2- Recommended name:
            Fructose-2,6-bisphosphatase
              EC=3.1.3.46

Gene names

ORF Names:

K02B2.1

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	457 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Synthesis and degradation of fructose 2,6-bisphosphate By similarity.
Catalytic activity	Beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate.
Sequence similarities	In the C-terminal section; belongs to the phosphoglycerate mutase family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase Kinase Transferase
Technical term	Complete proteome Multifunctional enzyme
Gene Ontology (GO)
Biological process	fructose 2,6-bisphosphate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	6-phosphofructo-2-kinase activity Inferred from electronic annotation. Source: EC ATP binding Inferred from electronic annotation. Source: UniProtKB-KW fructose-2,6-bisphosphate 2-phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 457	457	Putative 6PF-2-K/Fru-2,6-P2ASE		PRO_0000179974
Regions
	Nucleotide binding	36 – 43	8	ATP Potential
	Region	1 – 244	244	6-phosphofructo-2-kinase
	Region	245 – 457	213	Fructose-2,6-bisphosphatase
Sites
	Active site	124	1	Potential
	Active site	154	1	Potential
	Active site	253	1	Tele-phosphohistidine intermediate By similarity
	Active site	324	1	Potential
	Active site	389	1	Proton donor By similarity
	Binding site	98	1	Fructose-6-phosphate By similarity
	Binding site	190	1	Fructose-6-phosphate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q21122-1 [UniParc]. Last modified June 6, 2002. Version 2. Checksum: E04A9A892378E413	FASTA	457	52,091
	10 20 30 40 50 60 MEIPPGLETT KRKVAHSDEH GFSDQVRVPN VIVMVGLPAR GKTYISKKLC RYLKWTGFTT 70 80 90 100 110 120 KVFNVGEYRR SDANAADAIH GANASFFSPN NADALKVRAE SARRAMEDMA DYLNSGTGGV 130 140 150 160 170 180 AIFDATNTTK DRRRIIIDFC KKQRLRCFFI ESVCDDPAII DCNVTDVKVN SPDYKGLMTA 190 200 210 220 230 240 EQAKEDFMNR IENYKKQYEP LDESEDESLS FIKVINAGRS FKVHQVRGHV QSRVVYFLMN 250 260 270 280 290 300 IHLLPRSIYL TRHGQSEYNA MGRLGGDSPL TEDGQKYASA LADFFEEEEV PGLRVWCSQK 310 320 330 340 350 360 VRAAQTAQHL KPDFHTEYWK ALDELDAGIC EGLTYEDILQ RYPKQADDRA TDKYHYRYPS 370 380 390 400 410 420 GESYEDVVSR LEPVIMELER QANVLVVSHQ AVLRCVLAYF YDRPLSELPY IDIPLHSLVK 430 440 450 LTPRAYHCDS TIYALDLESG EWTETSDQLP LCDSPRD

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U41558 Genomic DNA. Translation: AAK39245.2.
RefSeq	NP_500893.2.
UniGene	Cel.7619
3D structure databases
HSSP	HSSP built from PDB template 1C80 based on UniProtKB P07953.
ModBase	Search...
Genome annotation databases
Ensembl	K02B2.1. Caenorhabditis elegans. [Contig view]
GeneID	177363.
KEGG	cel:K02B2.1.
NMPDR	fig|6239.3.peg.13532.
Organism-specific databases
WormBase	WBGene00019295. K02B2.1.
WormPep	K02B2.1. CE30082. [WorfDB]
Phylogenomic databases
OMA	Q21122. FNNGELR.
Enzyme and pathway databases
BRENDA	2.7.1.105. 672. 3.1.3.46. 672.
Gene expression databases
ArrayExpress	Q21122.
Family and domain databases
InterPro	IPR003094. 6Pfruct_kin. IPR013079. 6Phosfructo_kin. IPR016260. Bifunct_6PFK/fruc_bisP_Ptase. IPR001345. PG/BPGM_mutase. IPR013078. PG_mutase. [Graphical view]
PANTHER	PTHR10606. 6Pfruct_kin. 1 hit.
Pfam	PF01591. 6PF2K. 1 hit. PF00300. PGAM. 1 hit. [Graphical view]
PIRSF	PIRSF000709. 6PFK_2-Ptase. 1 hit.
PRINTS	PR00991. 6PFRUCTKNASE.
PROSITE	PS00175. PG_MUTASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	896460.

Entry information

Entry name

F26_CAEEL

Accession

Primary (citable) accession number: Q21122

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	June 6, 2002
Last modified:	June 16, 2009
This is version 67 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project