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Protein
Submitted name:

TWiK family of potassium channels

Gene

twk-14

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotationSAAS annotationImported

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-1299287. Tandem pore domain halothane-inhibited K+ channel (THIK).

Names & Taxonomyi

Protein namesi
Submitted name:
TWiK family of potassium channelsImported
Gene namesi
Name:twk-14Imported
ORF Names:CELE_K01D12.4Imported, K01D12.4Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiK01D12.4a; CE42133; WBGene00006669; twk-14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei51 – 7222HelicalSequence analysisAdd
BLAST
Transmembranei158 – 17922HelicalSequence analysisAdd
BLAST
Transmembranei240 – 25920HelicalSequence analysisAdd
BLAST
Transmembranei271 – 28818HelicalSequence analysisAdd
BLAST
Transmembranei300 – 32728HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ21094.

Expressioni

Gene expression databases

ExpressionAtlasiQ21094. baseline and differential.

Interactioni

Protein-protein interaction databases

DIPiDIP-26443N.
IntActiQ21094. 2 interactions.
MINTiMINT-1054869.
STRINGi6239.K01D12.4b.

Structurei

3D structure databases

ProteinModelPortaliQ21094.
SMRiQ21094. Positions 54-312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini126 – 18257Ion_trans_2InterPro annotationAdd
BLAST
Domaini247 – 32882Ion_trans_2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG4404. Eukaryota.
ENOG410XRZJ. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000013227.
OrthoDBiEOG7DC24D.
PhylomeDBiQ21094.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR005410. 2pore_dom_K_chnl_THIK.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
PR01588. THIKCHANNEL.

Sequencei

Sequence statusi: Complete.

Q21094-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAITQTVMHK LQFARGIGQR EMLRANTLPS ITRAKVGCFA RLRIYEENAR
60 70 80 90 100
FVLICIILIV YLAFGAILFH WLEWENEVDE RIAIDNRMAD YQKVYCKHKP
110 120 130 140 150
LNECDFEEMV RFISDGATSG LLNSRSRFDH LGSLFFSATV ISTIGFGTST
160 170 180 190 200
PRTHLGRFIT IVYGVVGCTC CVLFFNLFLE RLVTGMSYIL RSLRERKIRY
210 220 230 240 250
RLKESGNKPV TLLLNNEDFN ESSSSCGGHM DNWRPSVYKV FFILFSMCLV
260 270 280 290 300
LITASAGIYS VVENWNYIDS LYFCFISFAT IGFGDYVSNQ QDVTRMSPDL
310 320 330 340 350
YRFVNFCLLT LGACFFYCLS NVSSIVVRQL LNWMIKKMDV KVEDRSFLCF
360 370 380 390 400
KKKRRYMGLG LRPPKGYDMT SERSSVDYAD GLLSLKEFLM NNQSSMIMLQ
410 420 430
KQLIKSAMKN VVENEEQKIS ATRVGPMGIL DEAFGDEP
Length:438
Mass (Da):50,260
Last modified:March 18, 2008 - v2
Checksum:i1B9B42DA28F2DAFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CAA99871.2.
RefSeqiNP_001256415.1. NM_001269486.1.
UniGeneiCel.2069.

Genome annotation databases

EnsemblMetazoaiK01D12.4a; K01D12.4a; WBGene00006669.
GeneIDi179699.
UCSCiK01D12.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CAA99871.2.
RefSeqiNP_001256415.1. NM_001269486.1.
UniGeneiCel.2069.

3D structure databases

ProteinModelPortaliQ21094.
SMRiQ21094. Positions 54-312.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-26443N.
IntActiQ21094. 2 interactions.
MINTiMINT-1054869.
STRINGi6239.K01D12.4b.

Proteomic databases

PaxDbiQ21094.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK01D12.4a; K01D12.4a; WBGene00006669.
GeneIDi179699.
UCSCiK01D12.4. c. elegans.

Organism-specific databases

CTDi179699.
WormBaseiK01D12.4a; CE42133; WBGene00006669; twk-14.

Phylogenomic databases

eggNOGiKOG4404. Eukaryota.
ENOG410XRZJ. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000013227.
OrthoDBiEOG7DC24D.
PhylomeDBiQ21094.

Enzyme and pathway databases

ReactomeiR-CEL-1299287. Tandem pore domain halothane-inhibited K+ channel (THIK).

Miscellaneous databases

NextBioi906502.

Gene expression databases

ExpressionAtlasiQ21094. baseline and differential.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR005410. 2pore_dom_K_chnl_THIK.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
PR01588. THIKCHANNEL.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ21094_CAEEL
AccessioniPrimary (citable) accession number: Q21094
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: March 18, 2008
Last modified: May 11, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.