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Protein
Submitted name:

TWiK family of potassium channels

Gene

twk-14

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionIon channelUniRule annotationSAAS annotationImported
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-1299287 Tandem pore domain halothane-inhibited K+ channel (THIK)
R-CEL-5576886 Phase 4 - resting membrane potential

Names & Taxonomyi

Protein namesi
Submitted name:
TWiK family of potassium channelsImported
Gene namesi
Name:twk-14Imported
ORF Names:CELE_K01D12.4Imported, K01D12.4Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiK01D12.4a ; CE42133 ; WBGene00006669 ; twk-14

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei51 – 72HelicalSequence analysisAdd BLAST22
Transmembranei158 – 179HelicalSequence analysisAdd BLAST22
Transmembranei240 – 259HelicalSequence analysisAdd BLAST20
Transmembranei271 – 288HelicalSequence analysisAdd BLAST18
Transmembranei300 – 327HelicalSequence analysisAdd BLAST28

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiWBGene00006669
ExpressionAtlasiQ21094 baseline and differential

Interactioni

Protein-protein interaction databases

DIPiDIP-26443N
IntActiQ21094, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliQ21094
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini125 – 182Ion_trans_2InterPro annotationAdd BLAST58
Domaini247 – 328Ion_trans_2InterPro annotationAdd BLAST82

Sequence similaritiesi

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG4404 Eukaryota
ENOG410XRZJ LUCA
GeneTreeiENSGT00860000133807
HOGENOMiHOG000013227
PhylomeDBiQ21094

Family and domain databases

InterProiView protein in InterPro
IPR003280 2pore_dom_K_chnl
IPR005410 2pore_dom_K_chnl_THIK
IPR013099 K_chnl_dom
PfamiView protein in Pfam
PF07885 Ion_trans_2, 2 hits
PRINTSiPR01333 2POREKCHANEL
PR01588 THIKCHANNEL

Sequencei

Sequence statusi: Complete.

Q21094-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAITQTVMHK LQFARGIGQR EMLRANTLPS ITRAKVGCFA RLRIYEENAR
60 70 80 90 100
FVLICIILIV YLAFGAILFH WLEWENEVDE RIAIDNRMAD YQKVYCKHKP
110 120 130 140 150
LNECDFEEMV RFISDGATSG LLNSRSRFDH LGSLFFSATV ISTIGFGTST
160 170 180 190 200
PRTHLGRFIT IVYGVVGCTC CVLFFNLFLE RLVTGMSYIL RSLRERKIRY
210 220 230 240 250
RLKESGNKPV TLLLNNEDFN ESSSSCGGHM DNWRPSVYKV FFILFSMCLV
260 270 280 290 300
LITASAGIYS VVENWNYIDS LYFCFISFAT IGFGDYVSNQ QDVTRMSPDL
310 320 330 340 350
YRFVNFCLLT LGACFFYCLS NVSSIVVRQL LNWMIKKMDV KVEDRSFLCF
360 370 380 390 400
KKKRRYMGLG LRPPKGYDMT SERSSVDYAD GLLSLKEFLM NNQSSMIMLQ
410 420 430
KQLIKSAMKN VVENEEQKIS ATRVGPMGIL DEAFGDEP
Length:438
Mass (Da):50,260
Last modified:March 18, 2008 - v2
Checksum:i1B9B42DA28F2DAFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CAA99871.2
RefSeqiNP_001256415.1, NM_001269486.1
UniGeneiCel.2069

Genome annotation databases

EnsemblMetazoaiK01D12.4a; K01D12.4a; WBGene00006669
GeneIDi179699
UCSCiK01D12.4 c. elegans

Similar proteinsi

Entry informationi

Entry nameiQ21094_CAEEL
AccessioniPrimary (citable) accession number: Q21094
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: March 18, 2008
Last modified: May 23, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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