Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Liprin-alpha

Gene

syd-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in regulating the structure of the neuronal region, called the active zone, from which synaptic vesicles send neurotransmitter signals across the synapse.1 Publication

GO - Molecular functioni

  • kinesin binding Source: WormBase
  • protein homodimerization activity Source: WormBase
  • receptor signaling complex scaffold activity Source: WormBase

GO - Biological processi

  • axo-dendritic transport Source: WormBase
  • locomotion Source: WormBase
  • locomotory behavior Source: WormBase
  • neuromuscular synaptic transmission Source: WormBase
  • oviposition Source: WormBase
  • positive regulation of anterograde synaptic vesicle transport Source: WormBase
  • positive regulation of ATP-dependent microtubule motor activity, plus-end-directed Source: WormBase
  • positive regulation of presynapse assembly Source: UniProtKB
  • protein localization Source: WormBase
  • receptor clustering Source: WormBase
  • regulation of synapse organization Source: UniProtKB
  • regulation of synapse structure or activity Source: WormBase
  • synapse organization Source: WormBase
  • synaptic vesicle transport Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-CEL-388844 Receptor-type tyrosine-protein phosphatases

Names & Taxonomyi

Protein namesi
Recommended name:
Liprin-alpha
Alternative name(s):
LAR-interacting protein alpha
Synapse defective protein 2
Gene namesi
Name:syd-2
ORF Names:F59F5.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF59F5.6 ; CE03447 ; WBGene00006364 ; syd-2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910381 – 1139Liprin-alphaAdd BLAST1139

Proteomic databases

EPDiQ21049
PaxDbiQ21049
PeptideAtlasiQ21049
PRIDEiQ21049

PTM databases

iPTMnetiQ21049

Expressioni

Tissue specificityi

Detected in vulval muscle and other cells near the vulva; in neurons located in the lateral ganglion, posterior ganglion, ventral cord and lateral body; and in pharyngeal and body wall muscle cells.1 Publication

Gene expression databases

BgeeiWBGene00006364

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
unc-104P23678-19EBI-327903,EBI-15812209

GO - Molecular functioni

  • kinesin binding Source: WormBase
  • protein homodimerization activity Source: WormBase
  • receptor signaling complex scaffold activity Source: WormBase

Protein-protein interaction databases

BioGridi46167, 3 interactors
DIPiDIP-26340N
IntActiQ21049, 2 interactors
STRINGi6239.F59F5.6

Structurei

3D structure databases

ProteinModelPortaliQ21049
SMRiQ21049
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini867 – 933SAM 1PROSITE-ProRule annotationAdd BLAST67
Domaini952 – 1016SAM 2PROSITE-ProRule annotationAdd BLAST65
Domaini1040 – 1109SAM 3PROSITE-ProRule annotationAdd BLAST70

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili30 – 144Sequence analysisAdd BLAST115
Coiled coili172 – 298Sequence analysisAdd BLAST127
Coiled coili329 – 517Sequence analysisAdd BLAST189
Coiled coili655 – 701Sequence analysisAdd BLAST47

Sequence similaritiesi

Belongs to the liprin family. Liprin-alpha subfamily.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0249 Eukaryota
ENOG410XP8Z LUCA
GeneTreeiENSGT00760000119138
HOGENOMiHOG000017513
InParanoidiQ21049
OMAiSWAQCPV
OrthoDBiEOG091G14UK
PhylomeDBiQ21049

Family and domain databases

CDDicd09562 SAM_liprin-alpha1_2_3_4_repeat, 1 hit
cd09565 SAM_liprin-alpha1_2_3_4_repeat, 1 hit
cd09568 SAM_liprin-alpha1_2_3_4_repeat, 1 hit
InterProiView protein in InterPro
IPR029515 Liprin
IPR037620 Liprin-alpha_SAM_rpt_1
IPR037621 Liprin-alpha_SAM_rpt_2
IPR037622 Liprin-alpha_SAM_rpt_3
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR030442 Syd-2
PANTHERiPTHR12587 PTHR12587, 1 hit
PTHR12587:SF20 PTHR12587:SF20, 1 hit
PfamiView protein in Pfam
PF00536 SAM_1, 2 hits
PF07647 SAM_2, 1 hit
SMARTiView protein in SMART
SM00454 SAM, 3 hits
SUPFAMiSSF47769 SSF47769, 2 hits
PROSITEiView protein in PROSITE
PS50105 SAM_DOMAIN, 3 hits

Sequencei

Sequence statusi: Complete.

Q21049-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYSNGNINC DIMPTISEDG VDNGGPIDEP SDRDNIEQLM MNMLEDRDKL
60 70 80 90 100
QEQLENYKVQ LENAGLRTKE VEKERDMMKR QFEVHTQNLP QELQTMTREL
110 120 130 140 150
CLLKEQLLEK DEEIVELKAE RNNTRLLLEH LECLVSRHER SLRMTVMKRQ
160 170 180 190 200
AQNHAGVSSE VEVLKALKSL FEHHKALDEK VRERLRVAME RVATLEEELS
210 220 230 240 250
TKGDENSSLK ARIATYAAEA EEAMASNAPI NGSISSESAN RLIEMQEALE
260 270 280 290 300
RMKTELANSL KQSTEITTRN AELEDQLTED AREKHAAQES IVRLKNQICE
310 320 330 340 350
LDAQRTDQET RITTFESRFL TAQRESTCIR DLNDKLEHQL ANKDAAVRLN
360 370 380 390 400
EEKVHSLQER LELAEKQLAQ SLKKAESLPS VEAELQQRME ALTAAEQKSV
410 420 430 440 450
SAEERIQRLD RNIQELSAEL ERAVQRERMN EEHSQRLSST VDKLLSESND
460 470 480 490 500
RLQLHLKERM QALDDKNRLT QQLDGTKKIY DQAERIKDRL QRDNESLRQE
510 520 530 540 550
IEALRQQLYN ARTAQFQSRM HAIPFTHAQN IVQQQPQASI AQQSAYQMYK
560 570 580 590 600
QQPAQQYQTV GMRRPNKGRI SALQDDPNKV QTLNEQEWDR LQQAHVLANV
610 620 630 640 650
QQAFSSSPSL ADVGQSTLPR PNTAVQHQQD DMMNSGMGMP SGMQGGMQGG
660 670 680 690 700
MGGGQDAQML ASMLQDRLDA INTEIRLIQQ EKHHAERVAE QLERSSREFY
710 720 730 740 750
DDQGISTRSS PRASPQLDNM RQHKYNTLPA NVSGDRRYDI YGNPQFVDDR
760 770 780 790 800
MVRDLDYEPR RGYNQFDEMQ YERDRMSPAS SVASSTDGVL GGKKKRSNSS
810 820 830 840 850
SGLKTLGRFF NKKKNSSSDL FKRNGDYSDG EQSGTEGNQK ADYDRRKKKK
860 870 880 890 900
HELLEEAMKA RTPFALWNGP TVVAWLELWV GMPAWYVAAC RANVKSGAIM
910 920 930 940 950
SALSDQEIQK EIGISNPLHR LKLRLAIQEM VSLTSPSAPR TARLTLAFGD
960 970 980 990 1000
MNHEYIGNDW LPCLGLAQYR SAFMECLLDA RMLEHLSKRD LRTHLRMVDT
1010 1020 1030 1040 1050
FHRTSLQYGI MCLKKVNYDK KVLADRRKAC DNINTDLLVW SNERVQRWVE
1060 1070 1080 1090 1100
EIGLGVFSRN LVDSGIHGAL IALDETFDAS AFAYALQIGS QDVPNRQLLE
1110 1120 1130
KKFIGLVNDH RQQSDPHPRS GSSRKNDSIA KSYEFHLYT
Length:1,139
Mass (Da):130,334
Last modified:November 1, 1996 - v1
Checksum:i31A34BE5FB5AB99D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50794 Genomic DNA Translation: CAA90660.1
AF170122 mRNA Translation: AAD47840.1
PIRiT23018
RefSeqiNP_509768.1, NM_077367.6
UniGeneiCel.19549

Genome annotation databases

EnsemblMetazoaiF59F5.6; F59F5.6; WBGene00006364
GeneIDi181255
KEGGicel:CELE_F59F5.6
UCSCiF59F5.6 c. elegans

Similar proteinsi

Entry informationi

Entry nameiLIPA_CAEEL
AccessioniPrimary (citable) accession number: Q21049
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health