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Protein

Liprin-alpha

Gene

syd-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in regulating the structure of the neuronal region, called the active zone, from which synaptic vesicles send neurotransmitter signals across the synapse.1 Publication

GO - Molecular functioni

  • kinesin binding Source: WormBase
  • protein homodimerization activity Source: WormBase
  • receptor signaling complex scaffold activity Source: WormBase

GO - Biological processi

  • axo-dendritic transport Source: WormBase
  • locomotion Source: WormBase
  • locomotory behavior Source: WormBase
  • neuromuscular synaptic transmission Source: WormBase
  • oviposition Source: WormBase
  • positive regulation of anterograde synaptic vesicle transport Source: WormBase
  • positive regulation of ATP-dependent microtubule motor activity, plus-end-directed Source: WormBase
  • protein localization Source: WormBase
  • receptor clustering Source: WormBase
  • regulation of synapse structure or activity Source: WormBase
  • synapse organization Source: WormBase
  • synaptic vesicle transport Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Liprin-alpha
Alternative name(s):
LAR-interacting protein alpha
Synapse defective protein 2
Gene namesi
Name:syd-2
ORF Names:F59F5.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF59F5.6; CE03447; WBGene00006364; syd-2.

Subcellular locationi

  • Cell junctionsynapse 1 Publication

  • Note: Presynaptic region.

GO - Cellular componenti

  • axon Source: WormBase
  • cell junction Source: UniProtKB-KW
  • cytoplasm Source: WormBase
  • presynaptic active zone Source: WormBase
  • presynaptic active zone dense projection Source: WormBase
  • synapse Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11391139Liprin-alphaPRO_0000191038Add
BLAST

Proteomic databases

EPDiQ21049.
PaxDbiQ21049.
PRIDEiQ21049.

PTM databases

iPTMnetiQ21049.

Expressioni

Tissue specificityi

Detected in vulval muscle and other cells near the vulva; in neurons located in the lateral ganglion, posterior ganglion, ventral cord and lateral body; and in pharyngeal and body wall muscle cells.1 Publication

Interactioni

GO - Molecular functioni

  • kinesin binding Source: WormBase
  • protein homodimerization activity Source: WormBase
  • receptor signaling complex scaffold activity Source: WormBase

Protein-protein interaction databases

BioGridi46167. 3 interactions.
DIPiDIP-26340N.
IntActiQ21049. 1 interaction.
MINTiMINT-1064488.
STRINGi6239.F59F5.6.

Structurei

3D structure databases

ProteinModelPortaliQ21049.
SMRiQ21049. Positions 840-1107.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini867 – 93367SAM 1PROSITE-ProRule annotationAdd
BLAST
Domaini952 – 101665SAM 2PROSITE-ProRule annotationAdd
BLAST
Domaini1040 – 110970SAM 3PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili30 – 144115Sequence analysisAdd
BLAST
Coiled coili172 – 298127Sequence analysisAdd
BLAST
Coiled coili329 – 517189Sequence analysisAdd
BLAST
Coiled coili655 – 70147Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the liprin family. Liprin-alpha subfamily.Curated
Contains 3 SAM (sterile alpha motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0249. Eukaryota.
ENOG410XP8Z. LUCA.
GeneTreeiENSGT00760000119138.
HOGENOMiHOG000017513.
InParanoidiQ21049.
OMAiINCDIMP.
OrthoDBiEOG7T7GS7.
PhylomeDBiQ21049.

Family and domain databases

Gene3Di1.10.150.50. 2 hits.
InterProiIPR029515. Liprin.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR030442. Syd-2.
[Graphical view]
PANTHERiPTHR12587. PTHR12587. 1 hit.
PTHR12587:SF20. PTHR12587:SF20. 1 hit.
PfamiPF00536. SAM_1. 2 hits.
PF07647. SAM_2. 1 hit.
[Graphical view]
SMARTiSM00454. SAM. 3 hits.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 2 hits.
PROSITEiPS50105. SAM_DOMAIN. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q21049-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYSNGNINC DIMPTISEDG VDNGGPIDEP SDRDNIEQLM MNMLEDRDKL
60 70 80 90 100
QEQLENYKVQ LENAGLRTKE VEKERDMMKR QFEVHTQNLP QELQTMTREL
110 120 130 140 150
CLLKEQLLEK DEEIVELKAE RNNTRLLLEH LECLVSRHER SLRMTVMKRQ
160 170 180 190 200
AQNHAGVSSE VEVLKALKSL FEHHKALDEK VRERLRVAME RVATLEEELS
210 220 230 240 250
TKGDENSSLK ARIATYAAEA EEAMASNAPI NGSISSESAN RLIEMQEALE
260 270 280 290 300
RMKTELANSL KQSTEITTRN AELEDQLTED AREKHAAQES IVRLKNQICE
310 320 330 340 350
LDAQRTDQET RITTFESRFL TAQRESTCIR DLNDKLEHQL ANKDAAVRLN
360 370 380 390 400
EEKVHSLQER LELAEKQLAQ SLKKAESLPS VEAELQQRME ALTAAEQKSV
410 420 430 440 450
SAEERIQRLD RNIQELSAEL ERAVQRERMN EEHSQRLSST VDKLLSESND
460 470 480 490 500
RLQLHLKERM QALDDKNRLT QQLDGTKKIY DQAERIKDRL QRDNESLRQE
510 520 530 540 550
IEALRQQLYN ARTAQFQSRM HAIPFTHAQN IVQQQPQASI AQQSAYQMYK
560 570 580 590 600
QQPAQQYQTV GMRRPNKGRI SALQDDPNKV QTLNEQEWDR LQQAHVLANV
610 620 630 640 650
QQAFSSSPSL ADVGQSTLPR PNTAVQHQQD DMMNSGMGMP SGMQGGMQGG
660 670 680 690 700
MGGGQDAQML ASMLQDRLDA INTEIRLIQQ EKHHAERVAE QLERSSREFY
710 720 730 740 750
DDQGISTRSS PRASPQLDNM RQHKYNTLPA NVSGDRRYDI YGNPQFVDDR
760 770 780 790 800
MVRDLDYEPR RGYNQFDEMQ YERDRMSPAS SVASSTDGVL GGKKKRSNSS
810 820 830 840 850
SGLKTLGRFF NKKKNSSSDL FKRNGDYSDG EQSGTEGNQK ADYDRRKKKK
860 870 880 890 900
HELLEEAMKA RTPFALWNGP TVVAWLELWV GMPAWYVAAC RANVKSGAIM
910 920 930 940 950
SALSDQEIQK EIGISNPLHR LKLRLAIQEM VSLTSPSAPR TARLTLAFGD
960 970 980 990 1000
MNHEYIGNDW LPCLGLAQYR SAFMECLLDA RMLEHLSKRD LRTHLRMVDT
1010 1020 1030 1040 1050
FHRTSLQYGI MCLKKVNYDK KVLADRRKAC DNINTDLLVW SNERVQRWVE
1060 1070 1080 1090 1100
EIGLGVFSRN LVDSGIHGAL IALDETFDAS AFAYALQIGS QDVPNRQLLE
1110 1120 1130
KKFIGLVNDH RQQSDPHPRS GSSRKNDSIA KSYEFHLYT
Length:1,139
Mass (Da):130,334
Last modified:November 1, 1996 - v1
Checksum:i31A34BE5FB5AB99D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50794 Genomic DNA. Translation: CAA90660.1.
AF170122 mRNA. Translation: AAD47840.1.
PIRiT23018.
RefSeqiNP_509768.1. NM_077367.6.
UniGeneiCel.19549.

Genome annotation databases

EnsemblMetazoaiF59F5.6; F59F5.6; WBGene00006364.
GeneIDi181255.
KEGGicel:CELE_F59F5.6.
UCSCiF59F5.6. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50794 Genomic DNA. Translation: CAA90660.1.
AF170122 mRNA. Translation: AAD47840.1.
PIRiT23018.
RefSeqiNP_509768.1. NM_077367.6.
UniGeneiCel.19549.

3D structure databases

ProteinModelPortaliQ21049.
SMRiQ21049. Positions 840-1107.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi46167. 3 interactions.
DIPiDIP-26340N.
IntActiQ21049. 1 interaction.
MINTiMINT-1064488.
STRINGi6239.F59F5.6.

PTM databases

iPTMnetiQ21049.

Proteomic databases

EPDiQ21049.
PaxDbiQ21049.
PRIDEiQ21049.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF59F5.6; F59F5.6; WBGene00006364.
GeneIDi181255.
KEGGicel:CELE_F59F5.6.
UCSCiF59F5.6. c. elegans.

Organism-specific databases

CTDi181255.
WormBaseiF59F5.6; CE03447; WBGene00006364; syd-2.

Phylogenomic databases

eggNOGiKOG0249. Eukaryota.
ENOG410XP8Z. LUCA.
GeneTreeiENSGT00760000119138.
HOGENOMiHOG000017513.
InParanoidiQ21049.
OMAiINCDIMP.
OrthoDBiEOG7T7GS7.
PhylomeDBiQ21049.

Miscellaneous databases

NextBioi913122.
PROiQ21049.

Family and domain databases

Gene3Di1.10.150.50. 2 hits.
InterProiIPR029515. Liprin.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR030442. Syd-2.
[Graphical view]
PANTHERiPTHR12587. PTHR12587. 1 hit.
PTHR12587:SF20. PTHR12587:SF20. 1 hit.
PfamiPF00536. SAM_1. 2 hits.
PF07647. SAM_2. 1 hit.
[Graphical view]
SMARTiSM00454. SAM. 3 hits.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 2 hits.
PROSITEiPS50105. SAM_DOMAIN. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The liprin protein SYD-2 regulates the differentiation of presynaptic termini in C. elegans."
    Zhen M., Jin Y.
    Nature 401:371-375(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, FUNCTION.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  3. "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins."
    Serra-Pages C., Medley Q.G., Tang M., Hart A., Streuli M.
    J. Biol. Chem. 273:15611-15620(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiLIPA_CAEEL
AccessioniPrimary (citable) accession number: Q21049
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.