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Protein

Isocitrate dehydrogenase [NADP]

Gene

idh-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg2+ or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei78SubstrateUniRule annotation1
Binding sitei83NADPUniRule annotation1
Binding sitei110SubstrateUniRule annotation1
Binding sitei133SubstrateUniRule annotation1
Sitei140Critical for catalysisUniRule annotation1
Sitei212Critical for catalysisUniRule annotation1
Metal bindingi251Magnesium or manganeseUniRule annotation1
Binding sitei259NADPUniRule annotation1
Metal bindingi274Magnesium or manganeseUniRule annotation1
Binding sitei327NADP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi76 – 78NADPUniRule annotation3
Nucleotide bindingi309 – 314NADPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processTricarboxylic acid cycleUniRule annotation
LigandMagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

ReactomeiR-CEL-389542. NADPH regeneration.
R-CEL-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:idh-1Imported
ORF Names:CELE_F59B8.2Imported, F59B8.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiF59B8.2a; CE03436; WBGene00010317; idh-1.

PTM / Processingi

Proteomic databases

EPDiQ21032.
PaxDbiQ21032.

Expressioni

Gene expression databases

BgeeiWBGene00010317.
ExpressionAtlasiQ21032. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi6239.F59B8.2.1.

Structurei

3D structure databases

ProteinModelPortaliQ21032.
SMRiQ21032.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 402Iso_dhInterPro annotationAdd BLAST393

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni95 – 101Substrate bindingUniRule annotation7

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1526. Eukaryota.
COG0538. LUCA.
GeneTreeiENSGT00390000012547.
HOGENOMiHOG000019858.
PhylomeDBiQ21032.

Family and domain databases

InterProiView protein in InterPro
IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiView protein in Pfam
PF00180. Iso_dh. 1 hit.
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
SMARTiView protein in SMART
SM01329. Iso_dh. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiView protein in PROSITE
PS00470. IDH_IMDH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q21032-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQKIQGGD IVEMQGDEMT RIIWDLIKEK LILPYVDLNV HFFDLGIEHR
60 70 80 90 100
DATDDQVTID AANATLKYNV AVKCATITPD EARVEEFKLK KMWKSPNGTI
110 120 130 140 150
RNILGGTVFR EPIIVKNVPR LVNTWSKPII IGRHAHADQY KATDFVVPGA
160 170 180 190 200
GKLEIKFVSA DGTQTIQETV FDFKGPGVSL SMYNTDDSIR DFAHASFKYA
210 220 230 240 250
LQRKFPLYLS TKNTILKKYD GRFKDIFAEI YPEYEAEFKA AGIWYEHRLI
260 270 280 290 300
DDMVAQAMKS DGGFVWACKN YDGDVQSDSV AQGYGSLGLM TSVLVCPDGK
310 320 330 340 350
TVEAEAAHGT VTRHYRMHQK GQETSTNPIA SIFAWSRGLA HRATLDKNSA
360 370 380 390 400
LETFANNLEA VCIETMEAGF LTKDLAICVK GGNASAVTRT DYLNTFEFLD
410
KLAENLAKKQ AH
Length:412
Mass (Da):45,959
Last modified:November 1, 1996 - v1
Checksum:i43418A8176D31152
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CAA92778.1.
PIRiT22983.
RefSeqiNP_001255393.1. NM_001268464.1.
UniGeneiCel.8903.

Genome annotation databases

EnsemblMetazoaiF59B8.2a.1; F59B8.2a.1; WBGene00010317.
F59B8.2a.2; F59B8.2a.2; WBGene00010317.
GeneIDi177775.
UCSCiF59B8.2.1. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiQ21032_CAEEL
AccessioniPrimary (citable) accession number: Q21032
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: October 25, 2017
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported