Q20Z21 (TYPH_RHOPB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative thymidine phosphorylase
EC=2.4.2.4

Alternative name(s):
TdRPase

Gene names

Ordered Locus Names:

RPC_4089

Organism

Rhodopseudomonas palustris (strain BisB18) [Complete proteome] [HAMAP]

Taxonomic identifier

316056 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Rhodopseudomonas › Rhodopseudomonas palustris

Protein attributes

Sequence length	513 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_00703
Sequence similarities	Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pyrimidine nucleobase metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleoside metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	phosphorylase activity Inferred from electronic annotation. Source: InterPro thymidine phosphorylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 513	513	Putative thymidine phosphorylase HAMAP-Rule MF_00703		PRO_0000314715

Sequences

	Sequence		Length	Mass (Da)
	Q20Z21 [UniParc]. Last modified April 18, 2006. Version 1. Checksum: A97C3D79D65D8A8A	FASTA	513	54,925
	10 20 30 40 50 60 MTSADAPRPQ LKIRLIHLDT GRENVAVMSR RSKALRPEVF SGFSRVEIRR NAKSVLATLL 70 80 90 100 110 120 ITDDDALVGP DELGLAEPAF RRFGEPAGTF VTVSPATPPD SLDAVRGKIQ GRTLSAAEIT 130 140 150 160 170 180 AIVNDLTRYR YSDMEIAAFL IGAARFMTSD ELLALVSAMA SVGTQLRWDR PIVVDKHCIG 190 200 210 220 230 240 GIPGNRTSMI LVPIVAAHGL TIPKTSSRAI TSPAGTADTM EVLARVDVSV AEMKEIVAAC 250 260 270 280 290 300 NGCLIWGGHV NLSPADDILI SVERPLCLDT REQMVASIMS KKLAAGSTHL LVDLPVGPTA 310 320 330 340 350 360 KVASALDAMR LRKLFEFVGD HFGIAVETIT TDGRQPIGNG IGPVLEAQDV MAVLGNDPKA 370 380 390 400 410 420 PADLREKSLR LAAHLLEYDP HLRGGAGYAR ARELLESGAA LKQMQKIIDN QGPSTCHKDL 430 440 450 460 470 480 GTLTAEVTAE RDGVVSAIDC LQLNRLARTA GAPIDKGAGI RLFKKVGDRV EAGEPLYRIY 490 500 510 AFDPAERELA VAAAKLACGY TVDDAQTFRE QVM

References

[1]

"Complete sequence of Rhodopseudomonas palustris BisB18." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Pelletier D.A., Kyrpides N., Anderson I., Oda Y., Harwood C.S., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BisB18.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000301 Genomic DNA. Translation: ABD89615.1.
RefSeq	YP_533934.1. NC_007925.1.
3D structure databases
ProteinModelPortal	Q20Z21.
ModBase	Search...
Protein-protein interaction databases
STRING	316056.RPC_4089.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABD89615; ABD89615; RPC_4089.
GeneID	3973178.
KEGG	rpc:RPC_4089.
PATRIC	23272990. VBIRhoPal29154_4170.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0213.
HOGENOM	HOG000252767.
KO	K00758.
OMA	VGDHFGI.
ProtClustDB	PRK04350.
Enzyme and pathway databases
BioCyc	RPAL316056:GH3E-4162-MONOMER.
Family and domain databases
Gene3D	3.40.1030.10. 1 hit. 3.90.1170.30. 1 hit.
HAMAP	MF_00703. Thymid_phosp_2.
InterPro	IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N_dom. IPR013102. PYNP_C. IPR000053. Pyrmidine_PPase. IPR017872. Pyrmidine_PPase_CS. IPR013466. Thymidine_Pase_type2. [Graphical view]
PANTHER	PTHR10515. PTHR10515. 1 hit.
Pfam	PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. PF07831. PYNP_C. 1 hit. [Graphical view]
PIRSF	PIRSF000478. TP_PyNP. 1 hit.
SMART	SM00941. PYNP_C. 1 hit. [Graphical view]
SUPFAM	SSF47648. Glyco_trans_3. 1 hit. SSF52418. Glyco_trans_3. 1 hit. SSF54680. PYNP_C. 1 hit.
TIGRFAMs	TIGR02645. ARCH_P_rylase. 1 hit.
PROSITE	PS00647. THYMID_PHOSPHORYLASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYPH_RHOPB

Accession

Primary (citable) accession number: Q20Z21

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	April 18, 2006
Last modified:	May 1, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program