Q20YZ3 (AROE_RHOPB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	RPC_4117

Organism

Rhodopseudomonas palustris (strain BisB18) [Complete proteome] [HAMAP]

Taxonomic identifier

316056 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Rhodopseudomonas

Protein attributes

Sequence length	277 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 277	277	Shikimate dehydrogenase HAMAP MF_00222		PRO_0000325156
Regions
	Nucleotide binding	128 – 132	5	NADP By similarity
Sites
	Active site	68	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q20YZ3 [UniParc]. Last modified April 18, 2006. Version 1. Checksum: 7A97F6193C7D7DB7	FASTA	277	29,589
	10 20 30 40 50 60 MTRIKAACLI GWPAAHSRSP MIHHYWLRTL GIEGGYAIES VPPEGFGEFV LHLSTHGYLG 70 80 90 100 110 120 ANVTIPHKER ALLLTEPDAR ARAVGAANTL WYDGETLRST NTDIEGFLNN LDACAPGWDG 130 140 150 160 170 180 IDEALVLGAG GSSRAVVFGL IERGIKRIHL ANRTLDRAQA VADQFNADVV PTAWQDLAAV 190 200 210 220 230 240 LPRAKLLVNT TSLGMKGQPA LEVDIGLLPT DAAVADLVYV PLETPLLAAA RARGLATADG 250 260 270 LGMLLHQAVR GFELWFGTRP SVTPELRALI EADLAPA

References

[1]

"Complete sequence of Rhodopseudomonas palustris BisB18." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Pelletier D.A., Kyrpides N., Anderson I., Oda Y., Harwood C.S., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BisB18.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000301 Genomic DNA. Translation: ABD89643.1.
RefSeq	YP_533962.1. NC_007925.1.
3D structure databases
ProteinModelPortal	Q20YZ3.
ModBase	Search...
Protein-protein interaction databases
STRING	Q20YZ3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3973167.
GenomeReviews	Gene locus RPC_4117 in contig CP000301_GR.
KEGG	rpc:RPC_4117.
PATRIC	23273054. VBIRhoPal29154_4202.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0169.
HOGENOM	HBG553408.
OMA	FERWFGI.
PhylomeDB	Q20YZ3.
ProtClustDB	CLSK820486.
Enzyme and pathway databases
BioCyc	RPAL316056:RPC_4117-MONOMER.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_RHOPB

Accession

Primary (citable) accession number: Q20YZ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	April 18, 2006
Last modified:	January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program