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Q20XN0

- MDH2_RHOPB

UniProt

Q20XN0 - MDH2_RHOPB

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Protein

Malate dehydrogenase 2

Gene
mdh2, RPC_4584
Organism
Rhodopseudomonas palustris (strain BisB18)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341NAD By similarity
Binding sitei83 – 831Substrate By similarity
Binding sitei89 – 891Substrate By similarity
Binding sitei96 – 961NAD By similarity
Binding sitei121 – 1211Substrate By similarity
Binding sitei152 – 1521Substrate By similarity
Active sitei176 – 1761Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 156NAD By similarity
Nucleotide bindingi119 – 1213NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciRPAL316056:GH3E-4654-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase 2 (EC:1.1.1.37)
Gene namesi
Name:mdh2
Ordered Locus Names:RPC_4584
OrganismiRhodopseudomonas palustris (strain BisB18)
Taxonomic identifieri316056 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
ProteomesiUP000001948: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320Malate dehydrogenase 2UniRule annotationPRO_0000241963Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi316056.RPC_4584.

Structurei

3D structure databases

ProteinModelPortaliQ20XN0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213794.
KOiK00024.
OMAiFPTISAN.
OrthoDBiEOG6091FG.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q20XN0-1 [UniParc]FASTAAdd to Basket

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MSRKKIVLAG AGQIGGTLAH LAMLHRLGDV TLLDVNANPP KGKALDLSHA    50
AAVEGCDAVL TGTADQADIA GADVVIVTAG VPRRPGVDRD ALLAINLPVM 100
ESIGTAIGRY CPDAFVICIT NPLDAMVWAL RRFSGLPPAR VVGMGGVLDS 150
ARLRSFLAEA LGVSVTEVQA MTLGGHGDDM VPLVRQATVG GVPLPALVKM 200
GWITQQAIDD IVQRTRTGGA EVVNLLWTSS AYYAPASAAI AMATSYLGDQ 250
KRVFAASAAL SGQYGVDGLH VGVPVMIGAG GIEKIIELEF DDEEQRQFTR 300
SVAAVAALVE DCKRLHRGLA 320
Length:320
Mass (Da):33,295
Last modified:April 18, 2006 - v1
Checksum:iFB66148031961E30
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000301 Genomic DNA. Translation: ABD90106.1.
RefSeqiYP_534425.1. NC_007925.1.

Genome annotation databases

EnsemblBacteriaiABD90106; ABD90106; RPC_4584.
GeneIDi3971883.
KEGGirpc:RPC_4584.
PATRICi23274052. VBIRhoPal29154_4690.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000301 Genomic DNA. Translation: ABD90106.1 .
RefSeqi YP_534425.1. NC_007925.1.

3D structure databases

ProteinModelPortali Q20XN0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316056.RPC_4584.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD90106 ; ABD90106 ; RPC_4584 .
GeneIDi 3971883.
KEGGi rpc:RPC_4584.
PATRICi 23274052. VBIRhoPal29154_4690.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000213794.
KOi K00024.
OMAi FPTISAN.
OrthoDBi EOG6091FG.

Enzyme and pathway databases

BioCyci RPAL316056:GH3E-4654-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BisB18.

Entry informationi

Entry nameiMDH2_RHOPB
AccessioniPrimary (citable) accession number: Q20XN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: April 18, 2006
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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