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Protein

Chemotaxis response regulator protein-glutamate methylesterase 2

Gene

cheB2

Organism
Rhodopseudomonas palustris (strain BisB18)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.UniRule annotation

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei181UniRule annotation1
Active sitei208UniRule annotation1
Active sitei305UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesterase 2UniRule annotation (EC:3.1.1.61UniRule annotation)
Gene namesi
Name:cheB2UniRule annotation
Ordered Locus Names:RPC_4611
OrganismiRhodopseudomonas palustris (strain BisB18)
Taxonomic identifieri316056 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
Proteomesi
  • UP000001948 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002643071 – 366Chemotaxis response regulator protein-glutamate methylesterase 2Add BLAST366

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei534-aspartylphosphateUniRule annotation1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi316056.RPC_4611.

Structurei

3D structure databases

ProteinModelPortaliQ20XK3.
SMRiQ20XK3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 119Response regulatoryPROSITE-ProRule annotationAdd BLAST117
Domaini171 – 363CheB-type methylesteraseUniRule annotationAdd BLAST193

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CMP. Bacteria.
COG2201. LUCA.
HOGENOMiHOG000151423.
KOiK03412.
OMAiHPSVDVL.
OrthoDBiPOG091H045J.

Family and domain databases

CDDicd16432. CheB_Rec. 1 hit.
cd00156. REC. 1 hit.
Gene3Di3.40.50.180. 1 hit.
HAMAPiMF_00099. CheB_methylest. 1 hit.
InterProiView protein in InterPro
IPR035909. CheB_C.
IPR011006. CheY-like_superfamily.
IPR008248. Sig_transdc_resp-reg_CheB.
IPR000673. Sig_transdc_resp-reg_Me-estase.
IPR001789. Sig_transdc_resp-reg_receiver.
PfamiView protein in Pfam
PF01339. CheB_methylest. 1 hit.
PF00072. Response_reg. 1 hit.
PIRSFiPIRSF000876. RR_chemtxs_CheB. 1 hit.
SMARTiView protein in SMART
SM00448. REC. 1 hit.
SUPFAMiSSF52172. SSF52172. 1 hit.
SSF52738. SSF52738. 1 hit.
PROSITEiView protein in PROSITE
PS50122. CHEB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

Q20XK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRLLIADDS ALVRKLLEGV FLEEGDFEIR TARTGLEALD MVRAFDPHVV
60 70 80 90 100
TLDVQMPGMD GLTCLGRIML EAPRPVVMIS SLTEQNADAT LSAMALGAVD
110 120 130 140 150
VIAKPGGTFS LELDRLRPLL VATIRSAAQA KIRPTHRLAD RIRHQFRDAA
160 170 180 190 200
SSPRAKAARR GAARQRAKAE PAPGLVLIGT STGGPAALNI LLPQLPADFP
210 220 230 240 250
WPVLIAQHLP ATFTGAFAKR LDRECALNVV EVDVPRQLEP GTVYIGRGDA
260 270 280 290 300
DVIVAPRPSG LIALSVPARR DYPWHPSVER MVDSALEHYD GKRLLGVLMT
310 320 330 340 350
GMGDDGATAM TRLQALGGRT IAEAESTAVV WGMPGELVRQ GGATLVLPVE
360
EIAAAVIEWG NADAAD
Length:366
Mass (Da):39,092
Last modified:April 18, 2006 - v1
Checksum:iD9ED3D8C0F8F458E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000301 Genomic DNA. Translation: ABD90133.1.
RefSeqiWP_011475011.1. NC_007925.1.

Genome annotation databases

EnsemblBacteriaiABD90133; ABD90133; RPC_4611.
KEGGirpc:RPC_4611.

Similar proteinsi

Entry informationi

Entry nameiCHEB2_RHOPB
AccessioniPrimary (citable) accession number: Q20XK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: April 18, 2006
Last modified: November 22, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome