Q20MH0 (PB1F2_I33A0) Reviewed, UniProtKB/Swiss-Prot
Last modified February 19, 2014. Version 33. History...
Names and origin
|Protein names||Recommended name:|
|Organism||Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain A/WS/1933 H1N1)) [Complete proteome]|
|Taxonomic identifier||381518 [NCBI]|
|Taxonomic lineage||Viruses › ssRNA negative-strand viruses › Orthomyxoviridae › Influenzavirus A ›|
|Virus host||Aves [TaxID: 8782]|
Homo sapiens (Human) [TaxID: 9606]
Sus scrofa (Pig) [TaxID: 9823]
|Sequence length||90 AA.|
|Protein existence||Inferred from homology|
General annotation (Comments)
Plays an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection. Promotes alteration of mitochondrial morphology, dissipation of mitochondrial membrane potential, and cell death. Alternatively, inhibits the production of interferon in the infected cell at the level of host mitochondrial antiviral signaling MAVS. Its level of expression differs greatly depending on which cell type is infected, in a manner that is independent of the levels of expression of other viral proteins. Monocytic cells are more affected than epithelial cells. Seems to disable virus-infected monocytes or other host innate immune cells. May also act in trans: extracellular PB1-F2 released by infected cells could potentially inactivate hosts cell recruitment to the site of infection. During early stage of infection, may predispose the mitochondria to permeability transition through interaction with human SLC25A6/ANT3 and VDAC1. These proteins participate in the formation of the permeability transition pore complex (PTPC) responsible of the release of mitochondrial products that triggers apoptosis By similarity.
Oligomer. Interacts with human SLC25A6/ANT3 and VDAC1 By similarity.
Host mitochondrion inner membrane By similarity. Host nucleus By similarity. Host cytoplasm › host cytosol By similarity. Note: Inner mitochondrial membrane in most cells types. Otherwise is detected in the nucleus and cytosol By similarity.
Is not encoded in all strains, and seems to be dispensable for replication.
Belongs to the influenza viruses PB1-F2 family.
Sequence annotation (Features)
|Feature key||Position(s)||Length||Description||Graphical view||Feature identifier|
|Chain||1 – 90||90||Protein PB1-F2||PRO_0000278728|
|Region||65 – 87||23||Mitochondrial targeting sequence By similarity|
|Site||66||1||Important for pathogenicity, S is highly pathogenic whereas N is low pathogenic|
|Natural variant||73 – 74||2||KT → RP in strain: A/WSN/1933 TS61. |
|||"The NIAID influenza genome sequencing project."|
Ghedin E., Spiro D., Miller N., Zaborsky J., Feldblyum T., Subbu V., Shumway M., Sparenborg J., Groveman L., Halpin R., Sitz J., Koo H., Salzberg S.L., Webster R.G., Hoffmann E., Krauss S., Naeve C., Bao Y. Tatusova T.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: A/WSN/1933 and A/WSN/1933 TS61.
|CY009610 Genomic RNA. Translation: ABD77805.1.|
CY010794 Genomic RNA. Translation: ABF47964.1.
3D structure databases
|SMR||Q20MH0. Positions 50-87. |
Protocols and materials databases
Family and domain databases
|InterPro||IPR021045. Flu_proapoptotic_PB1-F2. |
|Pfam||PF11986. PB1-F2. 1 hit. |
|Accession||Primary (citable) accession number: Q20MH0|
Secondary accession number(s): Q1I2B0
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Viral Protein Annotation Program|
Index of protein domains and families