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Q20MH0

- PB1F2_I33A0

UniProt

Q20MH0 - PB1F2_I33A0

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Protein

Protein PB1-F2

Gene

PB1

Organism
Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain A/WS/1933 H1N1))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Plays an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection. Promotes alteration of mitochondrial morphology, dissipation of mitochondrial membrane potential, and cell death. Alternatively, inhibits the production of interferon in the infected cell at the level of host mitochondrial antiviral signaling MAVS. Its level of expression differs greatly depending on which cell type is infected, in a manner that is independent of the levels of expression of other viral proteins. Monocytic cells are more affected than epithelial cells. Seems to disable virus-infected monocytes or other host innate immune cells. May also act in trans: extracellular PB1-F2 released by infected cells could potentially inactivate hosts cell recruitment to the site of infection. During early stage of infection, may predispose the mitochondria to permeability transition through interaction with human SLC25A6/ANT3 and VDAC1. These proteins participate in the formation of the permeability transition pore complex (PTPC) responsible of the release of mitochondrial products that triggers apoptosis (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei66 – 661Important for pathogenicity, S is highly pathogenic whereas N is low pathogenic

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. modulation by virus of host apoptotic process Source: UniProtKB-KW
  3. suppression by virus of host MAVS activity Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host MAVS by virus, Inhibition of host RLR pathway by virus, Modulation of host cell apoptosis by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Protein PB1-F2
Gene namesi
Name:PB1
OrganismiInfluenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain A/WS/1933 H1N1))
Taxonomic identifieri381518 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A
Virus hostiAves [TaxID: 8782]
Homo sapiens (Human) [TaxID: 9606]
Sus scrofa (Pig) [TaxID: 9823]
ProteomesiUP000000834: Genome

Subcellular locationi

Host mitochondrion inner membrane By similarity. Host nucleus By similarity. Host cytoplasmhost cytosol By similarity
Note: Inner mitochondrial membrane in most cells types. Otherwise is detected in the nucleus and cytosol (By similarity).By similarity

GO - Cellular componenti

  1. host cell mitochondrial inner membrane Source: UniProtKB-KW
  2. host cell nucleus Source: UniProtKB-KW
  3. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Host membrane, Host mitochondrion, Host mitochondrion inner membrane, Host nucleus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9090Protein PB1-F2PRO_0000278728Add
BLAST

Interactioni

Subunit structurei

Oligomer. Interacts with human SLC25A6/ANT3 and VDAC1 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ20MH0.
SMRiQ20MH0. Positions 50-87.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni65 – 8723Mitochondrial targeting sequenceBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the influenza viruses PB1-F2 family.Curated

Family and domain databases

InterProiIPR021045. Flu_proapoptotic_PB1-F2.
[Graphical view]
PfamiPF11986. PB1-F2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q20MH0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGQEQDTPWI LSTGHISTQK GEDGQQTPKL EHRNSTRLMG HCQKTMNQVV
60 70 80 90
MPKQIVYWKQ WPSLRNPILV SLKTRVLKRW RLFSKHEWTS
Length:90
Mass (Da):10,683
Last modified:April 18, 2006 - v1
Checksum:iB70703482BCE448E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti73 – 742KT → RP in strain: A/WSN/1933 TS61.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CY009610 Genomic RNA. Translation: ABD77805.1.
CY010794 Genomic RNA. Translation: ABF47964.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CY009610 Genomic RNA. Translation: ABD77805.1 .
CY010794 Genomic RNA. Translation: ABF47964.1 .

3D structure databases

ProteinModelPortali Q20MH0.
SMRi Q20MH0. Positions 50-87.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR021045. Flu_proapoptotic_PB1-F2.
[Graphical view ]
Pfami PF11986. PB1-F2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: A/WSN/1933 and A/WSN/1933 TS61.

Entry informationi

Entry nameiPB1F2_I33A0
AccessioniPrimary (citable) accession number: Q20MH0
Secondary accession number(s): Q1I2B0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: April 18, 2006
Last modified: October 29, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

Is not encoded in all strains, and seems to be dispensable for replication.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3