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Q20IJ2 (Q20IJ2_9FLAV) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
OrganismDengue virus 2 EMBL ABA61178.1
Taxonomic identifier11060 [NCBI]
Taxonomic lineageVirusesssRNA positive-strand viruses, no DNA stageFlaviviridaeFlavivirusDengue virus group

Protein attributes

Sequence length3391 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). SAAS SAAS007094

Sequence similarities

Contains RdRp catalytic domain. SAAS SAAS007094

Contains helicase ATP-binding domain. SAAS SAAS007094

Contains helicase C-terminal domain. SAAS SAAS007094

Ontologies

Keywords
   Biological processFusion of virus membrane with host endosomal membrane SAAS SAAS000336
Fusion of virus membrane with host membrane
Host-virus interaction
Viral attachment to host cell SAAS SAAS011998
Viral penetration into host cytoplasm
Viral RNA replication SAAS SAAS007094
Virus entry into host cell
   Cellular componentCapsid protein SAAS SAAS011998
Host membrane SAAS SAAS011998
Membrane
Virion
   DomainTransmembrane
Transmembrane helix SAAS SAAS011998
   LigandATP-binding
Nucleotide-binding
RNA-binding SAAS SAAS007094
   Molecular functionHelicase SAAS SAAS007094
Hydrolase
Nucleotidyltransferase
Protease
RNA-directed RNA polymerase SAAS SAAS007094
Serine protease SAAS SAAS000336
Transferase
   PTMDisulfide bond SAAS SAAS000336
   Technical term3D-structure PDB 2P3Q
Gene Ontology (GO)
   Biological_processclathrin-mediated endocytosis of virus by host cell

Inferred from electronic annotation. Source: UniProtKB-KW

fusion of virus membrane with host endosome membrane

Inferred from electronic annotation. Source: UniProtKB-KW

viral RNA genome replication

Inferred from electronic annotation. Source: InterPro

virion attachment to host cell

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componenthost cell endoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

viral capsid

Inferred from electronic annotation. Source: UniProtKB-KW

viral envelope

Inferred from electronic annotation. Source: UniProtKB-KW

virion membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATP-dependent helicase activity

Inferred from electronic annotation. Source: InterPro

RNA helicase activity

Inferred from electronic annotation. Source: InterPro

RNA-directed RNA polymerase activity

Inferred from electronic annotation. Source: UniProtKB-KW

double-stranded RNA binding

Inferred from electronic annotation. Source: InterPro

mRNA (guanine-N7-)-methyltransferase activity

Inferred from electronic annotation. Source: InterPro

mRNA (nucleoside-2'-O-)-methyltransferase activity

Inferred from electronic annotation. Source: InterPro

serine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

serine-type exopeptidase activity

Inferred from electronic annotation. Source: InterPro

structural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region2601 – 26022Sulfate 4 binding PDB 2P3Q

Sites

Binding site25291Sulfate 1 PDB 2P3Q
Binding site25401Sulfate 2 PDB 2P3Q
Binding site25471S-adenosyl-L-homocysteine PDB 2P3Q
Binding site25481Sulfate 1 PDB 2P3Q
Binding site25751Sulfate 1 PDB 2P3Q
Binding site25781S-adenosyl-L-homocysteine PDB 2P3Q
Binding site25961S-adenosyl-L-homocysteine; via amide nitrogen PDB 2P3Q
Binding site26231S-adenosyl-L-homocysteine; via amide nitrogen PDB 2P3Q
Binding site26421Sulfate 5 PDB 2P3Q
Binding site26511Sulfate 5 PDB 2P3Q

Sequences

Sequence LengthMass (Da)Tools
Q20IJ2 [UniParc].

Last modified April 18, 2006. Version 1.
Checksum: E78A50ADF58D2EA5

FASTA3,391379,453
        10         20         30         40         50         60 
MNNQRKKAKN APFNMLKRER NRVSTVQQLT KRFSLGMLQG RGPLKLFMAL VAFLRFLTIP 

        70         80         90        100        110        120 
PTAGILKRWG TIKKSKAINV LRGFRKEIGR MLNILNRRRR SAGMIIMLIP TVMAFHLTTR 

       130        140        150        160        170        180 
NGEPHMIVSM QEKGKSLLFK TEDGVNMCTL MAMDLGELCE DTITYKCPLL RQNEPEDIDC 

       190        200        210        220        230        240 
WCNSTSTWVT YGTCTTTGEH RREKRSVALV PHVGMGLETR TETWMSSEGA WKHAQRIETW 

       250        260        270        280        290        300 
ILRHPGFTIM AAILAYTIGT THFQRALIFI LLTAVAPSMT MRCIGISNRD FVEGVSGGSW 

       310        320        330        340        350        360 
VDIVLEHGSC VTTMAKNKPT LDFELIKTEA KQPATLRKYC IEAKLTNTTT ESRCPTQGEP 

       370        380        390        400        410        420 
SLKEEQDKRF VCKHSMVDRG WGNGCGLFGK GGIVTCAMFT CKKNMEGKIV QPENLEYTIV 

       430        440        450        460        470        480 
VTPHSGEEHA VGNDTGKHGK EIKVTPQSSI TEAELTGYGT VTMECSPRTG LDFNEMVLLQ 

       490        500        510        520        530        540 
MENKAWLVHR QWFLDLPLPW LPGADTQGSN WIQKETLVTF KNPHAKKQDV VVLGSQEGAM 

       550        560        570        580        590        600 
HTALTGATEI QMSSGNLLFT GHLKCRLRMD KLQLKGMSYS MCTGKFKVVK EIAETQHGTI 

       610        620        630        640        650        660 
VIRVQYEGDG SPCKIPFEIM DLEKRYVLGR LITVNPIVTE KDSPVNIEAE PPFGDSYIII 

       670        680        690        700        710        720 
GVEPGQLKLN WFKKGSSIGQ MFETTMRGAK RMAILGDTAW DFGSLGGVFT SIGKALHQVF 

       730        740        750        760        770        780 
GAIYGAAFSG VSWTMKILIG VIITWIGMNS RSTSLSVSLV LVGIVTLYLG VMVQADSGCV 

       790        800        810        820        830        840 
VSWKNKELKC GSGIFITDNV HTWTEQYKFQ PESPSKLASA IQKAQEEGIC GIRSVTRLEN 

       850        860        870        880        890        900 
LMWKQITPEL NHILAENEVK LTIMTGDIKG IMQAGKRSLR PQPTELKYSW KTWGKAKMLS 

       910        920        930        940        950        960 
TESHNQTFLI DGPETAECPN TNRAWNSLEV EDYGFGVFTT NIWLKLKEKQ DAFCDSKLMS 

       970        980        990       1000       1010       1020 
AAIKDNRAVH ADMGYWIESA LNDTWKIEKA SFIEVKNCHW PKSHTLWSNG VLESEMIIPK 

      1030       1040       1050       1060       1070       1080 
NLAGPVSQHN YRPGYHTQIA GPWHLGKLEM DFDFCDGTTV VVTEDCGNRG PSLRTTTASG 

      1090       1100       1110       1120       1130       1140 
KLITEWCCRS CTLPPLRYRG EDGCWYGMEI RPLKEKEENL VNSLVTAGHG QVDNFSLGVL 

      1150       1160       1170       1180       1190       1200 
GMALFLEEML RTRVGTKHAI LLVAVSFVTL ITGNMSFKDL GRVVVMVGAT MTDDIGMGVT 

      1210       1220       1230       1240       1250       1260 
YLALLAAFKV RPTFAAGLLL RKLTSKELMM TTIGIVLLSQ STIPETILEL TDALALGMMV 

      1270       1280       1290       1300       1310       1320 
LKIVRKMEKY QLAVTIMAIL CVPNAVILQN AWKVSCTILA AVSVSPLLLT SSQQKTDWIP 

      1330       1340       1350       1360       1370       1380 
LALTIKGLNP TAIFLTTLSR TNKKRSWPLN EAIMAVGMVS ILASSLLKND IPMTGPLVAG 

      1390       1400       1410       1420       1430       1440 
GLLTVCYVLT GRSADLELER ATDVKWEDQA EISGSSPILS ITISEDGSMS IKNEEEEQTL 

      1450       1460       1470       1480       1490       1500 
TILIRTGLLV ISGLFPVSIP ITAAAWYLWE VKKQRAGVLW DVPSPPPMGK AELEDGAYRI 

      1510       1520       1530       1540       1550       1560 
KQKGILGYSQ IGAGVYKEGT FHTMWHVTRG AVLMHKGKRI EPSWADVKKD LISYGGGWKL 

      1570       1580       1590       1600       1610       1620 
EGEWKEGEEV QVLALEPGKN PRAVQTKPGL FKTNTGTIGA VSLDFSPGTS GSPIIDKKGK 

      1630       1640       1650       1660       1670       1680 
VVGLYGNGVV TRSGAYVSAI AQTEKSIEDN PEIEDDIFRK RRLTIMDLHP GAGKTKRYLP 

      1690       1700       1710       1720       1730       1740 
AIVREAIKRG LRTLILAPTR VVAAEMEEAL RGLPIRYQTP AIRAEHTGRE IVDLMCHATF 

      1750       1760       1770       1780       1790       1800 
TMRLLSPVRV PNYNLIIMDE AHFTDPASIA ARGYISTRVE MGEAAGIFMT ATPPGSRDPF 

      1810       1820       1830       1840       1850       1860 
PQSNAPIIDE EREIPERSWN SGHEWVTDFK GKTVWFVPSI KAGNDIAACL RKNGKKVIQL 

      1870       1880       1890       1900       1910       1920 
SRKTFDSEYV KTRTNDWDFV VTTDISEMGA NFKAERVIDP RRCMKPVILT DGEERVILAG 

      1930       1940       1950       1960       1970       1980 
PMPVTHSSAA QRRGRIGRNP KNENDQYIYM GEPLENDEDC AHWKEAKMLL DNINTPEGII 

      1990       2000       2010       2020       2030       2040 
PSMFEPEREK VDAIDGEYRL RGEARKTFVD LMRRGDLPVW LAYKVAAEGI NYADRRWCFD 

      2050       2060       2070       2080       2090       2100 
GIKNNQILEE NVEVEIWTKE GERKKLKPRW LDARIYSDPL ALKEFKEFAA GRKSLALNLI 

      2110       2120       2130       2140       2150       2160 
TEMGRLPTFM TQKTRDALDN LAVLHTAEAG GRAYNHALSE LPETLETLLL LTLLATVTGG 

      2170       2180       2190       2200       2210       2220 
IFLFLMSGRG IGKMTLGMCC IITASILLWY AQIQPHWIAA SIILEFFLIV LLIPEPEKQR 

      2230       2240       2250       2260       2270       2280 
TPQDNQLTYV VIAILTVVAA TMANEMGFLE KTKKDLGLGS IATHQPESNI LDIDLRPASA 

      2290       2300       2310       2320       2330       2340 
WTLYAVATTF VTPMLRHSIE NSSVNVSLTA IANQATVLMG LGKGWPLSKM DIGVPLLAIG 

      2350       2360       2370       2380       2390       2400 
CYSQVNPITL TAALLLLVAH YAIIGPGLQA KATREAQKRA AAGIMKNPTV DGITVIDLDP 

      2410       2420       2430       2440       2450       2460 
IPYDPKFEKQ LGQVMLLVLC VTQVLMMRTT WALCEALTLA TGPISTLWEG NPGRFWNTTI 

      2470       2480       2490       2500       2510       2520 
AVSMANIFRG SYLAGAGLLF SIMKNTTNTR RGTGNIGETL GEKWKSRLNA LGKSEFQIYK 

      2530       2540       2550       2560       2570       2580 
KSGIQEVDRT LAKEGIKRGE TDHHAVSRGS AKLRWFVERN MVTPEGKVVD LGCGRGGWSY 

      2590       2600       2610       2620       2630       2640 
YCGGLKNVRE VKGLTKGGPG HEEPIPMSTY GWNLVRLQSG VDVFFIPPEK CDTLLCDIGE 

      2650       2660       2670       2680       2690       2700 
SSPNPTVEAG RTLRVLNLVE NWLNNNTQFC IKVLNPYMPS VIEKMEALQR KYGGALVRNP 

      2710       2720       2730       2740       2750       2760 
LSRNSTHEMY WVSNASGNIV SSVNMISRML INRFTMRHKK ATYEPDVDLG SGTRNIGIES 

      2770       2780       2790       2800       2810       2820 
EIPNLDIIGK RIEKIKQEHE TSWHYDQDHP YKTWAYHGSY ETKQTGSASS MVNGVVRLLT 

      2830       2840       2850       2860       2870       2880 
KPWDVLPTVT QMAMTDTTPF GQQRVFKEKV DTRTQEPKEG TKKLMKITAE WLWKELGKKK 

      2890       2900       2910       2920       2930       2940 
TPRMCTREEF TRKVRSNAAL GAIFTDENKW KSAREAVEDS RFWELVDKER NLHLEGKCET 

      2950       2960       2970       2980       2990       3000 
CVYNMMGKRE KKLGEFGKAK GSRAIWYMWL GARFLEFEAL GFLNEDHWFS RENSLSGVEG 

      3010       3020       3030       3040       3050       3060 
EGLHKLGYIL RDVSKKEGGA MYADDTAGWD TRITLEDLKN EEMVTNHMEG EHKKLAEAIF 

      3070       3080       3090       3100       3110       3120 
RLTYQNKVVR VQRPTPRGTV MDIISRRDQR GSGQVGTYGL NTFTNMEAQL IRQMEGEGVF 

      3130       3140       3150       3160       3170       3180 
KNIQHLTVTE EIAVQNWLAR VGRERLSRMA ISGDDCVVKP LDDRFASALT ALNDMGKIRK 

      3190       3200       3210       3220       3230       3240 
DIQQWEPSRG WNDWTQVPFC SHHFHELIMK DGRVLVVPCR NQDELIGRAR ISQGAGWSLR 

      3250       3260       3270       3280       3290       3300 
ETACLGKSYA QMWSLMYFHR RDLRLAANAI CSAVPSHWVP TSRTTWSIHA KHEWMTTEDM 

      3310       3320       3330       3340       3350       3360 
LTVWNRVWIQ ENPWMEDKTP VESWEEIPYL GKREDQWCGS LIGLTSRATW AKNIQAAINQ 

      3370       3380       3390 
VRSLIGNEEY TDYMPSMKRF RREEEEAGVL W 

« Hide

References

[1]"Structure and age of genetic diversity of dengue virus type 2 in Thailand."
Zhang C., Mammen M.P. Jr., Chinnawirotpisan P., Klungthong C., Rodpradit P., Nisalak A., Vaughn D.W., Nimmannitya S., Kalayanarooj S., Holmes E.C.
J. Gen. Virol. 87:873-883(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: ThD2_0017_98 EMBL ABA61178.1.
[2]"Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5."
Egloff M.P., Decroly E., Malet H., Selisko B., Benarroch D., Ferron F., Canard B.
J. Mol. Biol. 372:723-736(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 2495-2787 IN COMPLEX WITH S-ADENOSYL-L-HOMOCYSTEINE AND SULFATE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ181799 Genomic RNA. Translation: ABA61178.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2P3QX-ray2.75A2495-2787[»]
ProteinModelPortalQ20IJ2.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.60.40.350. 1 hit.
2.60.98.10. 2 hits.
3.30.387.10. 1 hit.
3.40.50.150. 1 hit.
3.40.50.300. 2 hits.
InterProIPR011492. DEAD_Flavivir.
IPR000069. Env_glycoprot_M_flavivir.
IPR013755. Flav_gly_cen_dom_subdom1.
IPR001122. Flavi_capsidC.
IPR026470. Flavi_E_Stem/Anchor_dom.
IPR001157. Flavi_NS1.
IPR000752. Flavi_NS2A.
IPR000487. Flavi_NS2B.
IPR000404. Flavi_NS4A.
IPR001528. Flavi_NS4B.
IPR002535. Flavi_propep.
IPR000336. Flavivir/Alphavir_Ig-like.
IPR001850. Flavivirus_NS3_S7.
IPR027287. Flavovir_Ig-like.
IPR014412. Gen_Poly_FLV.
IPR011998. Glycoprot_cen/dimer.
IPR013754. GlyE_dim.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR014756. Ig_E-set.
IPR026490. mRNA_cap_0/1_MeTrfase.
IPR027417. P-loop_NTPase.
IPR000208. RNA-dir_pol_flavivirus.
IPR007094. RNA-dir_pol_PSvirus.
IPR002877. rRNA_MeTrfase_FtsJ_dom.
IPR029063. SAM-dependent_MTases-like.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF01003. Flavi_capsid. 1 hit.
PF07652. Flavi_DEAD. 1 hit.
PF02832. Flavi_glycop_C. 1 hit.
PF00869. Flavi_glycoprot. 1 hit.
PF01004. Flavi_M. 1 hit.
PF00948. Flavi_NS1. 1 hit.
PF01005. Flavi_NS2A. 1 hit.
PF01002. Flavi_NS2B. 1 hit.
PF01350. Flavi_NS4A. 1 hit.
PF01349. Flavi_NS4B. 1 hit.
PF00972. Flavi_NS5. 1 hit.
PF01570. Flavi_propep. 1 hit.
PF01728. FtsJ. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00949. Peptidase_S7. 1 hit.
[Graphical view]
PIRSFPIRSF003817. Gen_Poly_FLV. 1 hit.
SMARTSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF53335. SSF53335. 1 hit.
SSF56983. SSF56983. 1 hit.
SSF81296. SSF81296. 1 hit.
TIGRFAMsTIGR04240. flavi_E_stem. 1 hit.
PROSITEPS51527. FLAVIVIRUS_NS2B. 1 hit.
PS51528. FLAVIVIRUS_NS3PRO. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50507. RDRP_SSRNA_POS. 1 hit.
PS51591. RNA_CAP01_NS5_MT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ20IJ2.

Entry information

Entry nameQ20IJ2_9FLAV
AccessionPrimary (citable) accession number: Q20IJ2
Entry history
Integrated into UniProtKB/TrEMBL: April 18, 2006
Last sequence update: April 18, 2006
Last modified: July 9, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)