Reviewed, UniProtKB/Swiss-Prot Q20CR4 (DUSTY_MACMU)

Names and origin

Protein names

Recommended name:
    Dual serine/threonine and tyrosine protein kinase
    EC=2.7.12.1
Alternative name(s):
    Dusty protein kinase
      Short name=Dusty PK
    Receptor-interacting serine/threonine-protein kinase 5

Gene names

Name:	DSTYK
Synonyms:	RIPK5

Organism

Macaca mulatta (Rhesus macaque)

Taxonomic identifier

9544 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	907 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May induce both caspase-dependent apoptosis and caspase-independent cell death By similarity. UniProtKB Q6XUX3
Catalytic activity	ATP + a protein = ADP + a phosphoprotein. UniProtKB P16879
Subcellular location	Cytoplasm By similarity UniProtKB Q6XUX3.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Coiled coil
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase Tyrosine-protein kinase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW protein tyrosine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 907	907	Dual serine/threonine and tyrosine protein kinase		PRO_0000374056
Regions
	Domain	630 – 884	255	Protein kinase
	Nucleotide binding	636 – 644	9	ATP By similarity
	Coiled coil	373 – 409	37	Potential
Sites
	Active site	755	1	Proton acceptor By similarity
	Binding site	659	1	ATP By similarity
Amino acid modifications
	Modified residue	906	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q20CR4-1 [UniParc]. Last modified April 18, 2006. Version 1. Checksum: F77E50BF58972BF1	FASTA	907	103,206
	10 20 30 40 50 60 MIRELCRGFG RYRRYLGRLR QNLRETQKFF RDIKCSHNHT CPSSPTSGGG AERGPAGDVA 70 80 90 100 110 120 ETGLQAGQLS CISFPPKEEK YLQQIVDCLP CILILGQDCN VKCQLLNLLL GVQVLPTTKL 130 140 150 160 170 180 GSEESCKLRR LRFTYGTQTR VSLALPGQYE LVHTLVAHQG NWETIPEEDL EVQENNEDAA 190 200 210 220 230 240 HVLAELEVTM HHALLQEVDV VVAPCQGLRP TVDVLGDLVN DFLPVITYAL HKDELSERDE 250 260 270 280 290 300 QELQEIRKYF SFPVFFFKVP KLGSEITDSS TRRTESERSL LYRQLIDLGY LSSSHWNCGT 310 320 330 340 350 360 PGQDTKAQSV LVEQSEKLRH LSTFSHQVLQ TRLVDAAKAL NLVHCHCLDI FINQAFDMQR 370 380 390 400 410 420 DLQITPKRLE YTRKKENELY ESLMNIANRK QEEMKDMIVE TLNTMKEELL DDAANMEFKD 430 440 450 460 470 480 VIVPENGEPV GTREIKCCIR QIQELIISRL NQAVANKLIS SVDYLRESFV GTLERCLQSL 490 500 510 520 530 540 EKSQDVSVHI TSNYLKQILN AAYHVEVTFH SGSSVTRMLW EQIKQIIQRI TWVSPPAITL 550 560 570 580 590 600 EWKRKVAQEA IESLSASKLA KSICSQFRTR LNSSHEAFAA SLRQLEAGHS GRLEKTEDLW 610 620 630 640 650 660 LKVRKDHAPR LARLSLESRS LQDVLLHRKP KLGQELGRGQ YGVVYLCDNW GGHFPCALKS 670 680 690 700 710 720 VVPPDEKHWN DLALEFHYMR SLPKHERLVD LHGSVIDYNY GGGSSIAVLL IMERLHRDLY 730 740 750 760 770 780 TGLKAGLTLE TRLQIALDVV EGIRFLHSQG LVHRDIKLKN VLLDKQNRAK ITDLGFCKPE 790 800 810 820 830 840 AMMSGSIVGT PIHMAPELFT GKYDNSVDVY AFGILFWYIC SGSVKLPEAF ERCASKDHLW 850 860 870 880 890 900 NNVRRGARPE RLPVFDEECW QLMEACWDGD PLKRPLLGIV QPMLQGIMDR LCKSNSEQPN RGLDDST

References

[1]

"Dusty protein kinases: primary structure, gene evolution, tissue specific expression and unique features of the catalytic domain." Peng J., Dong W., Chen Y., Mo R., Cheng J.-F., Hui C.-C., Mohandas N., Huang C.-H. Biochim. Biophys. Acta 1759:562-572(2006) [PubMed: 17123648] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ341264 mRNA. Translation: ABD72471.1.
RefSeq	NP_001035038.1.
UniGene	Mmu.9551
3D structure databases
SMR	Q20CR4. Positions 629-887.
ModBase	Search...
Genome annotation databases
Ensembl	ENSMMUT00000014659; ENSMMUP00000013732; ENSMMUG00000010478; Macaca mulatta. [Genome view]
GeneID	664732.
KEGG	mcc:664732.
Organism-specific databases
CTD	664732.
Phylogenomic databases
eggNOG	prNOG16330.
HOVERGEN	Q20CR4.
InParanoid	Q20CR4.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_prot_kinase-like_dom. IPR008271. Ser/Thr_prot_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DUSTY_MACMU

Accession

Primary (citable) accession number: Q20CR4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 5, 2009
Last sequence update:	April 18, 2006
Last modified:	February 9, 2010
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)