Q20952 (ADD2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adducin-related protein 2

Gene names

Name:	add-2
ORF Names:	F57F5.4

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	611 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network By similarity.
Subcellular location	Cytoplasm › cytoskeleton By similarity. Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity.
Sequence similarities	Belongs to the aldolase class II family. Adducin subfamily.

Ontologies

Keywords
Cellular component	Cell membrane Cytoplasm Cytoskeleton Membrane
Ligand	Actin-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	actin binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 611	611	Adducin-related protein 2		PRO_0000218541

Sequences

	Sequence		Length	Mass (Da)
	Q20952 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 9815707C45CD70D8	FASTA	611	68,561
	10 20 30 40 50 60 MSDGSDDDTN NDGNYCKNVS YNFLIQRLAE VSNRKCLLLP KKKNRVDYIS IMQTAEFYPE 70 80 90 100 110 120 LVNSSPPLEP GFTSCEVFVV DKKVDKDTLH LDNFSPYHIG ATRRTLERQH SYFYRVNESG 130 140 150 160 170 180 NFVPAIKTNG THILRILVSI LGSCPALNRK IYRMVKIESQ NKNCLPSLIV YTFEPGHEIP 190 200 210 220 230 240 KPNAPAILRR QTSDEIQKIL NIPGTSFSQA HSEAVLNRFY DDLPIRDEAS DQKRARYSIE 250 260 270 280 290 300 STSSTNNQLN EINSFVVPKF EGRQESEQLF RDVKVEQFEE SAEISINNRA LSPHIQPSKT 310 320 330 340 350 360 SVVNRPNQQN RKFQNYDMFS AGVISTATVP APMFHPHITP IADLKDDDGY DPEELTQRNK 370 380 390 400 410 420 LASLYRLVDL FRWSQGIYNH ITVRVSTDPD EILINAFGQL YSEVSASSLI KVDLDGTVID 430 440 450 460 470 480 GGSTNFGVNQ AGYVLHSAIH NGRPEVKCVV HLHHPSVVAV SAQKCGLLPI SQESMIVGDV 490 500 510 520 530 540 GYHEYRGILI DEAERALLVR DLGDRNVMIL RNHGFVVCGE SIEHALSLTY HLIIACETQI 550 560 570 580 590 600 RTVPGGNTDN VHFPAQSAIK QVYKVASQGG GGVNRQNGHV NSMQWKKGEL EWQAYMRQLD 610 AQGYVTGNVP N

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular and functional analysis of the spectrin based membrane skeleton in Caenorhabditis elegans." Moorthy S., Bennett V. Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF166171 mRNA. Translation: AAD49860.1. Z75953 Genomic DNA. Translation: CAB00100.1.
PIR	T22855.
RefSeq	NP_001041130.1. NM_001047665.2.
UniGene	Cel.18006.
3D structure databases
ProteinModelPortal	Q20952.
SMR	Q20952. Positions 347-605.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q20952. 1 interaction.
STRING	Q20952.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	F57F5.4a.1; F57F5.4a.1; F57F5.4. F57F5.4a.2; F57F5.4a.2; F57F5.4.
GeneID	179647.
KEGG	cel:F57F5.4.
UCSC	F57F5.4a.1. c. elegans.
Organism-specific databases
CTD	179647.
WormBase	F57F5.4a; CE06002; WBGene00000073; add-2.
Phylogenomic databases
GeneTree	EMGT00050000013962.
HOGENOM	HBG385495.
InParanoid	Q20952.
OMA	YHEYRGI.
PhylomeDB	Q20952.
Gene expression databases
ArrayExpress	Q20952.
Family and domain databases
InterPro	IPR001303. Aldolase_II/adducin_N. [Graphical view]
Gene3D	G3DSA:3.40.225.10. Aldolase_II/adducin_N. 1 hit.
Pfam	PF00596. Aldolase_II. 1 hit. [Graphical view]
SMART	SM01007. Aldolase_II. 1 hit. [Graphical view]
SUPFAM	SSF53639. Aldolase_II_N. 1 hit.
ProtoNet	Search...
Other
NextBio	906288.

Entry information

Entry name

ADD2_CAEEL

Accession

Primary (citable) accession number: Q20952

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project