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Reviewed, UniProtKB/Swiss-Prot Q20942 (NAS38_CAEEL)

Last modified June 16, 2009. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Zinc metalloproteinase nas-38
    EC=3.4.24.21
Alternative name(s):
    Nematode astacin 38
Gene names
Name: nas-38
ORF Names: F57C12.1
OrganismCaenorhabditis elegans [Complete proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

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Protein attributes

Sequence length745 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Probable metalloprotease By similarity.

Catalytic activity

Hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the peptidase M12A family.

Contains 1 CUB domain.

Contains 1 EGF-like domain.

Contains 1 TSP type-1 domain.

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Ontologies

Keywords
   Cellular componentSecreted
   DomainEGF-like domain
Signal
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
Metalloprotease
Protease
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processproteolysis

Inferred from electronic annotation. Source: InterPro

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionmetalloendopeptidase activity

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 745720Zinc metalloproteinase nas-38
PRO_0000028942

Regions

Domain306 – 34540EGF-like
Domain371 – 487117CUB
Domain628 – 67649TSP type-1
Compositional bias496 – 595100Thr-rich

Sites

Active site2081 By similarity
Metal binding2071Zinc; catalytic By similarity
Metal binding2111Zinc; catalytic By similarity
Metal binding2171Zinc; catalytic By similarity

Amino acid modifications

Glycosylation3301N-linked (GlcNAc...) Potential
Glycosylation6711N-linked (GlcNAc...) Potential
Glycosylation7321N-linked (GlcNAc...) Potential
Disulfide bond311 ↔ 320 By similarity
Disulfide bond315 ↔ 331 By similarity
Disulfide bond336 ↔ 345 By similarity
Disulfide bond371 ↔ 401 By similarity
Disulfide bond429 ↔ 450 By similarity
Disulfide bond641 ↔ 670 By similarity
Disulfide bond645 ↔ 675 By similarity
Disulfide bond657 ↔ 662 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q20942-1 [UniParc].

Last modified October 1, 2002. Version 2.
Checksum: B94630CE86366D95

FASTA74583,350
        10         20         30         40         50         60 
MPSPSYNRHI IIASCFCCLL IFSSAARVPK ASKKHLARVK QLLNDEAERH NTLIQSDSVT 

        70         80         90        100        110        120 
VFDDIQRNPN TGVHHDELAV NNADEYFQGD VDLSEQQVKI IEDQFTQGKR EKRKIGRNPL 

       130        140        150        160        170        180 
YKKWDTRGPI SFDYAESIPF QTRQKIRSAM LLWQQHTCLR FEEGGPNVDR LEFFDGGGCS 

       190        200        210        220        230        240 
SFVGRVGGTQ GISISTPGCD VVGIISHEIG HALGIFHEQA RPDQERHIAI NYNNIPLSRW 

       250        260        270        280        290        300 
NNFQAVGENH AETYNLPYDT GSVMHYGPYG FASDPYTPTI RTLERVQQST IGQRAGPSFL 

       310        320        330        340        350        360 
DYQAINMAYG CTESCADLPC LRNGYTHPNN CSMCACPEGL SGRYCEQVYP SNAQCARGKL 

       370        380        390        400        410        420 
TRERHINERE CYQSAIWTAT KEVKYITSPN YPDKFPIDTE CNWIIAAPIE GRVFMEFEGD 

       430        440        450        460        470        480 
FDFLCEDTCD KAYVEVKYHS DKRLTGARYC CSLLPKNRFI SFKNEMIIIM RGYRSSGAGF 

       490        500        510        520        530        540 
KAKFWSNLGE PEGVSTPLPP TTAPLPEISE TTQKPEPTTV QSTTTYTTAI PRRTAKKQFF 

       550        560        570        580        590        600 
TRKPITIPLT PLTSSSTTTE STTVSSTTQS TTWLPTEPSF ATGETEITTA SPTITLFPSL 

       610        620        630        640        650        660 
STILPPINSL AGVLPSTQAP DIINSVLECG CGAWSEWQGE CSQQCGGCGH RLRKRECKKE 

       670        680        690        700        710        720 
ACRKEEKRPC NFSACPDGTN FLINNAEFHI LWRGCCVGLF RSGDQCSALE TESNPFFKII 

       730        740 
NSLLNIQDAK NNDTLIAKRM MRGEH

« Hide

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References

« Hide 'large scale' references
[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[2]"The astacin protein family in Caenorhabditis elegans."
Moehrlen F., Hutter H., Zwilling R.
Eur. J. Biochem. 270:4909-4920(2003) [PubMed: 14653817] [Abstract]
Cited for: IDENTIFICATION, NOMENCLATURE.

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Cross-references

Sequence databases

U41554 Genomic DNA. Translation: AAA83298.2.
PIRD89447.
RefSeqNP_508120.2.
UniGeneCel.19843

3D structure databases

HSSPHSSP built from PDB template 1IAE based on UniProtKB P07584.
ModBaseSearch...

Genome annotation databases

EnsemblF57C12.1. Caenorhabditis elegans. [Contig view]
GeneID180407.
KEGGcel:F57C12.1.

Organism-specific databases

WormBaseWBGene00003554. nas-38.
WormPepF57C12.1. CE31188. [WorfDB]

Phylogenomic databases

OMAQ20942. ERHIAIN.

Enzyme and pathway databases

BRENDA3.4.24.21. 672.

Gene expression databases

ArrayExpressQ20942.

Family and domain databases

InterProIPR000859. CUB.
IPR013032. EGF-like_reg_CS.
IPR006025. Pept_M_Zn_BS.
IPR006026. Peptidase_M.
IPR001506. Peptidase_M12A.
IPR000884. Thrombospondin_1_rpt.
[Graphical view]
Gene3DG3DSA:2.60.120.290. CUB. 1 hit.
PfamPF01400. Astacin. 1 hit.
PF00431. CUB. 1 hit.
[Graphical view]
PRINTSPR00480. ASTACIN.
SMARTSM00042. CUB. 1 hit.
SM00209. TSP1. 1 hit.
SM00235. ZnMc. 1 hit.
[Graphical view]
PROSITEPS01180. CUB. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. False negative.
PS50026. EGF_3. False negative.
PS50092. TSP1. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio909220.

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Entry information

Entry nameNAS38_CAEEL
AccessionPrimary (citable) accession number: Q20942
Entry history
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 1, 2002
Last modified: June 16, 2009
This is version 58 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectCaenorhabditis annotation project

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Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents