Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc metalloproteinase nas-38

Gene

nas-38

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Probable metalloprotease.By similarity

Catalytic activityi

Hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi207 – 2071Zinc; catalyticPROSITE-ProRule annotation
Active sitei208 – 2081PROSITE-ProRule annotation
Metal bindingi211 – 2111Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi217 – 2171Zinc; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM12.A28.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc metalloproteinase nas-38 (EC:3.4.24.21)
Alternative name(s):
Nematode astacin 38
Gene namesi
Name:nas-38
ORF Names:F57C12.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF57C12.1; CE31188; WBGene00003554; nas-38.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 745720Zinc metalloproteinase nas-38PRO_0000028942Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi311 ↔ 320By similarity
Disulfide bondi315 ↔ 331By similarity
Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence analysis
Disulfide bondi336 ↔ 345By similarity
Disulfide bondi371 ↔ 401By similarity
Disulfide bondi429 ↔ 450By similarity
Disulfide bondi641 ↔ 670By similarity
Disulfide bondi645 ↔ 675By similarity
Disulfide bondi657 ↔ 662By similarity
Glycosylationi671 – 6711N-linked (GlcNAc...)Sequence analysis
Glycosylationi732 – 7321N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ20942.
PRIDEiQ20942.

Expressioni

Gene expression databases

BgeeiWBGene00003554.

Interactioni

Protein-protein interaction databases

STRINGi6239.F57C12.1.

Structurei

3D structure databases

ProteinModelPortaliQ20942.
SMRiQ20942. Positions 84-314.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini306 – 34540EGF-likeAdd
BLAST
Domaini371 – 487117CUBPROSITE-ProRule annotationAdd
BLAST
Domaini628 – 67649TSP type-1PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi496 – 595100Thr-richAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase M12A family.Curated
Contains 1 CUB domain.PROSITE-ProRule annotation
Contains 1 EGF-like domain.Curated
Contains 1 TSP type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Signal

Phylogenomic databases

eggNOGiKOG3714. Eukaryota.
ENOG410ZPX7. LUCA.
GeneTreeiENSGT00760000119227.
HOGENOMiHOG000018489.
InParanoidiQ20942.
KOiK08076.
OMAiLDYQAIN.
OrthoDBiEOG091G0N5F.
PhylomeDBiQ20942.

Family and domain databases

Gene3Di2.60.120.290. 1 hit.
3.40.390.10. 1 hit.
InterProiIPR000859. CUB_dom.
IPR024079. MetalloPept_cat_dom.
IPR017050. Metallopeptidase_nem.
IPR001506. Peptidase_M12A.
IPR006026. Peptidase_Metallo.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF01400. Astacin. 1 hit.
PF00431. CUB. 1 hit.
[Graphical view]
PIRSFiPIRSF036365. Astacin_nematoda. 1 hit.
PRINTSiPR00480. ASTACIN.
SMARTiSM00042. CUB. 1 hit.
SM00209. TSP1. 1 hit.
SM00235. ZnMc. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
PROSITEiPS01180. CUB. 1 hit.
PS00022. EGF_1. 1 hit.
PS50092. TSP1. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q20942-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSPSYNRHI IIASCFCCLL IFSSAARVPK ASKKHLARVK QLLNDEAERH
60 70 80 90 100
NTLIQSDSVT VFDDIQRNPN TGVHHDELAV NNADEYFQGD VDLSEQQVKI
110 120 130 140 150
IEDQFTQGKR EKRKIGRNPL YKKWDTRGPI SFDYAESIPF QTRQKIRSAM
160 170 180 190 200
LLWQQHTCLR FEEGGPNVDR LEFFDGGGCS SFVGRVGGTQ GISISTPGCD
210 220 230 240 250
VVGIISHEIG HALGIFHEQA RPDQERHIAI NYNNIPLSRW NNFQAVGENH
260 270 280 290 300
AETYNLPYDT GSVMHYGPYG FASDPYTPTI RTLERVQQST IGQRAGPSFL
310 320 330 340 350
DYQAINMAYG CTESCADLPC LRNGYTHPNN CSMCACPEGL SGRYCEQVYP
360 370 380 390 400
SNAQCARGKL TRERHINERE CYQSAIWTAT KEVKYITSPN YPDKFPIDTE
410 420 430 440 450
CNWIIAAPIE GRVFMEFEGD FDFLCEDTCD KAYVEVKYHS DKRLTGARYC
460 470 480 490 500
CSLLPKNRFI SFKNEMIIIM RGYRSSGAGF KAKFWSNLGE PEGVSTPLPP
510 520 530 540 550
TTAPLPEISE TTQKPEPTTV QSTTTYTTAI PRRTAKKQFF TRKPITIPLT
560 570 580 590 600
PLTSSSTTTE STTVSSTTQS TTWLPTEPSF ATGETEITTA SPTITLFPSL
610 620 630 640 650
STILPPINSL AGVLPSTQAP DIINSVLECG CGAWSEWQGE CSQQCGGCGH
660 670 680 690 700
RLRKRECKKE ACRKEEKRPC NFSACPDGTN FLINNAEFHI LWRGCCVGLF
710 720 730 740
RSGDQCSALE TESNPFFKII NSLLNIQDAK NNDTLIAKRM MRGEH
Length:745
Mass (Da):83,350
Last modified:October 1, 2002 - v2
Checksum:iB94630CE86366D95
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081141 Genomic DNA. Translation: CCD69445.1.
PIRiD89447.
RefSeqiNP_508120.2. NM_075719.4.
UniGeneiCel.19843.

Genome annotation databases

EnsemblMetazoaiF57C12.1; F57C12.1; WBGene00003554.
GeneIDi180407.
KEGGicel:CELE_F57C12.1.
UCSCiF57C12.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081141 Genomic DNA. Translation: CCD69445.1.
PIRiD89447.
RefSeqiNP_508120.2. NM_075719.4.
UniGeneiCel.19843.

3D structure databases

ProteinModelPortaliQ20942.
SMRiQ20942. Positions 84-314.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F57C12.1.

Protein family/group databases

MEROPSiM12.A28.

Proteomic databases

PaxDbiQ20942.
PRIDEiQ20942.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF57C12.1; F57C12.1; WBGene00003554.
GeneIDi180407.
KEGGicel:CELE_F57C12.1.
UCSCiF57C12.1. c. elegans.

Organism-specific databases

CTDi180407.
WormBaseiF57C12.1; CE31188; WBGene00003554; nas-38.

Phylogenomic databases

eggNOGiKOG3714. Eukaryota.
ENOG410ZPX7. LUCA.
GeneTreeiENSGT00760000119227.
HOGENOMiHOG000018489.
InParanoidiQ20942.
KOiK08076.
OMAiLDYQAIN.
OrthoDBiEOG091G0N5F.
PhylomeDBiQ20942.

Miscellaneous databases

PROiQ20942.

Gene expression databases

BgeeiWBGene00003554.

Family and domain databases

Gene3Di2.60.120.290. 1 hit.
3.40.390.10. 1 hit.
InterProiIPR000859. CUB_dom.
IPR024079. MetalloPept_cat_dom.
IPR017050. Metallopeptidase_nem.
IPR001506. Peptidase_M12A.
IPR006026. Peptidase_Metallo.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF01400. Astacin. 1 hit.
PF00431. CUB. 1 hit.
[Graphical view]
PIRSFiPIRSF036365. Astacin_nematoda. 1 hit.
PRINTSiPR00480. ASTACIN.
SMARTiSM00042. CUB. 1 hit.
SM00209. TSP1. 1 hit.
SM00235. ZnMc. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
PROSITEiPS01180. CUB. 1 hit.
PS00022. EGF_1. 1 hit.
PS50092. TSP1. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNAS38_CAEEL
AccessioniPrimary (citable) accession number: Q20942
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.