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Q20939

- PDXH_CAEEL

UniProt

Q20939 - PDXH_CAEEL

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Protein

Putative pyridoxamine 5'-phosphate oxidase

Gene
F57B9.1
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) By similarity.

Catalytic activityi

Pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + H2O2.
Pyridoxine 5'-phosphate + O2 = pyridoxal 5'-phosphate + H2O2.

Cofactori

Binds 1 FMN per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei72 – 721FMN By similarity
Binding sitei75 – 751FMN; via amide nitrogen By similarity
Binding sitei77 – 771Substrate By similarity
Binding sitei94 – 941FMN By similarity
Binding sitei134 – 1341Substrate By similarity
Binding sitei138 – 1381Substrate By similarity
Binding sitei142 – 1421Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi87 – 882FMN By similarity
Nucleotide bindingi151 – 1522FMN By similarity

GO - Molecular functioni

  1. FMN binding Source: InterPro
  2. pyridoxamine-phosphate oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. pyridoxine biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridoxine biosynthesis

Keywords - Ligandi

Flavoprotein, FMN

Enzyme and pathway databases

ReactomeiREACT_183141. Vitamins B6 activation to pyridoxal phosphate.
UniPathwayiUPA00190; UER00304.
UPA00190; UER00305.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative pyridoxamine 5'-phosphate oxidase (EC:1.4.3.5)
Alternative name(s):
PNP/PMP oxidase
Short name:
PNPOx
Gene namesi
ORF Names:F57B9.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiF57B9.1; CE44186; WBGene00018996.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 226226Putative pyridoxamine 5'-phosphate oxidasePRO_0000167788Add
BLAST

Proteomic databases

PaxDbiQ20939.
PRIDEiQ20939.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

IntActiQ20939. 1 interaction.
STRINGi6239.F57B9.1.

Structurei

3D structure databases

ProteinModelPortaliQ20939.
SMRiQ20939. Positions 25-226.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni205 – 2073Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0259.
GeneTreeiENSGT00390000011219.
HOGENOMiHOG000242755.
InParanoidiQ20939.
OMAiELDHRGF.
OrthoDBiEOG7B8S4P.

Family and domain databases

Gene3Di2.30.110.10. 1 hit.
InterProiIPR000659. Pyridox_Oxase.
IPR019740. Pyridox_Oxase_CS.
IPR011576. Pyridox_Oxase_FMN-bd.
IPR019576. Pyridoxamine_oxidase_dimer_C.
IPR012349. Split_barrel_FMN-bd.
[Graphical view]
PANTHERiPTHR10851. PTHR10851. 1 hit.
PfamiPF10590. PNPOx_C. 1 hit.
PF01243. Pyridox_oxidase. 1 hit.
[Graphical view]
PIRSFiPIRSF000190. Pyd_amn-ph_oxd. 1 hit.
SUPFAMiSSF50475. SSF50475. 1 hit.
TIGRFAMsiTIGR00558. pdxH. 1 hit.
PROSITEiPS01064. PYRIDOX_OXIDASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q20939-1 [UniParc]FASTAAdd to Basket

« Hide

METPSIDIQN IRAKYLNSHD PYLLESKLPT TSPFELFDIW FRNVASQSDL    50
TFEEINAVSL STVGKDLRPS SRMVLLKAYT PTGFSFYTNY TSRKGNQLEE 100
NPNAAMLFYW PKVNRQIRVE GVVEKLPDEM AVAYWNSRPV ASRIGSKSSD 150
QSKVVPDREF LESKKVALTE LSVREGAQAI TKPESWGGYH LIPRYFEFWQ 200
GQSDRLHDRI VFERDVDVWL LKRLSP 226
Length:226
Mass (Da):26,101
Last modified:October 19, 2011 - v2
Checksum:i99E80C34C740AE2B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO081266 Genomic DNA. Translation: CCD70322.1.
PIRiA88494.
RefSeqiNP_498518.2. NM_066117.3.
UniGeneiCel.10391.

Genome annotation databases

EnsemblMetazoaiF57B9.1; F57B9.1; WBGene00018996.
GeneIDi175973.
KEGGicel:CELE_F57B9.1.
UCSCiF57B9.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO081266 Genomic DNA. Translation: CCD70322.1 .
PIRi A88494.
RefSeqi NP_498518.2. NM_066117.3.
UniGenei Cel.10391.

3D structure databases

ProteinModelPortali Q20939.
SMRi Q20939. Positions 25-226.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q20939. 1 interaction.
STRINGi 6239.F57B9.1.

Proteomic databases

PaxDbi Q20939.
PRIDEi Q20939.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F57B9.1 ; F57B9.1 ; WBGene00018996 .
GeneIDi 175973.
KEGGi cel:CELE_F57B9.1.
UCSCi F57B9.1. c. elegans.

Organism-specific databases

CTDi 175973.
WormBasei F57B9.1 ; CE44186 ; WBGene00018996 .

Phylogenomic databases

eggNOGi COG0259.
GeneTreei ENSGT00390000011219.
HOGENOMi HOG000242755.
InParanoidi Q20939.
OMAi ELDHRGF.
OrthoDBi EOG7B8S4P.

Enzyme and pathway databases

UniPathwayi UPA00190 ; UER00304 .
UPA00190 ; UER00305 .
Reactomei REACT_183141. Vitamins B6 activation to pyridoxal phosphate.

Miscellaneous databases

NextBioi 890562.
PROi Q20939.

Family and domain databases

Gene3Di 2.30.110.10. 1 hit.
InterProi IPR000659. Pyridox_Oxase.
IPR019740. Pyridox_Oxase_CS.
IPR011576. Pyridox_Oxase_FMN-bd.
IPR019576. Pyridoxamine_oxidase_dimer_C.
IPR012349. Split_barrel_FMN-bd.
[Graphical view ]
PANTHERi PTHR10851. PTHR10851. 1 hit.
Pfami PF10590. PNPOx_C. 1 hit.
PF01243. Pyridox_oxidase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000190. Pyd_amn-ph_oxd. 1 hit.
SUPFAMi SSF50475. SSF50475. 1 hit.
TIGRFAMsi TIGR00558. pdxH. 1 hit.
PROSITEi PS01064. PYRIDOX_OXIDASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiPDXH_CAEEL
AccessioniPrimary (citable) accession number: Q20939
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 19, 2011
Last modified: September 3, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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