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Q20939

- PDXH_CAEEL

UniProt

Q20939 - PDXH_CAEEL

Protein

Putative pyridoxamine 5'-phosphate oxidase

Gene

F57B9.1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (19 Oct 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).By similarity

    Catalytic activityi

    Pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + H2O2.
    Pyridoxine 5'-phosphate + O2 = pyridoxal 5'-phosphate + H2O2.

    Cofactori

    Binds 1 FMN per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei72 – 721FMNBy similarity
    Binding sitei75 – 751FMN; via amide nitrogenBy similarity
    Binding sitei77 – 771SubstrateBy similarity
    Binding sitei94 – 941FMNBy similarity
    Binding sitei134 – 1341SubstrateBy similarity
    Binding sitei138 – 1381SubstrateBy similarity
    Binding sitei142 – 1421SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi87 – 882FMNBy similarity
    Nucleotide bindingi151 – 1522FMNBy similarity

    GO - Molecular functioni

    1. FMN binding Source: InterPro
    2. pyridoxamine-phosphate oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. pyridoxine biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pyridoxine biosynthesis

    Keywords - Ligandi

    Flavoprotein, FMN

    Enzyme and pathway databases

    ReactomeiREACT_183141. Vitamins B6 activation to pyridoxal phosphate.
    UniPathwayiUPA00190; UER00304.
    UPA00190; UER00305.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative pyridoxamine 5'-phosphate oxidase (EC:1.4.3.5)
    Alternative name(s):
    PNP/PMP oxidase
    Short name:
    PNPOx
    Gene namesi
    ORF Names:F57B9.1
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiF57B9.1; CE44186; WBGene00018996.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 226226Putative pyridoxamine 5'-phosphate oxidasePRO_0000167788Add
    BLAST

    Proteomic databases

    PaxDbiQ20939.
    PRIDEiQ20939.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    IntActiQ20939. 1 interaction.
    STRINGi6239.F57B9.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ20939.
    SMRiQ20939. Positions 25-226.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni205 – 2073Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0259.
    GeneTreeiENSGT00390000011219.
    HOGENOMiHOG000242755.
    InParanoidiQ20939.
    OMAiELDHRGF.
    OrthoDBiEOG7B8S4P.

    Family and domain databases

    Gene3Di2.30.110.10. 1 hit.
    InterProiIPR000659. Pyridox_Oxase.
    IPR019740. Pyridox_Oxase_CS.
    IPR011576. Pyridox_Oxase_FMN-bd.
    IPR019576. Pyridoxamine_oxidase_dimer_C.
    IPR012349. Split_barrel_FMN-bd.
    [Graphical view]
    PANTHERiPTHR10851. PTHR10851. 1 hit.
    PfamiPF10590. PNPOx_C. 1 hit.
    PF01243. Pyridox_oxidase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000190. Pyd_amn-ph_oxd. 1 hit.
    SUPFAMiSSF50475. SSF50475. 1 hit.
    TIGRFAMsiTIGR00558. pdxH. 1 hit.
    PROSITEiPS01064. PYRIDOX_OXIDASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q20939-1 [UniParc]FASTAAdd to Basket

    « Hide

    METPSIDIQN IRAKYLNSHD PYLLESKLPT TSPFELFDIW FRNVASQSDL    50
    TFEEINAVSL STVGKDLRPS SRMVLLKAYT PTGFSFYTNY TSRKGNQLEE 100
    NPNAAMLFYW PKVNRQIRVE GVVEKLPDEM AVAYWNSRPV ASRIGSKSSD 150
    QSKVVPDREF LESKKVALTE LSVREGAQAI TKPESWGGYH LIPRYFEFWQ 200
    GQSDRLHDRI VFERDVDVWL LKRLSP 226
    Length:226
    Mass (Da):26,101
    Last modified:October 19, 2011 - v2
    Checksum:i99E80C34C740AE2B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO081266 Genomic DNA. Translation: CCD70322.1.
    PIRiA88494.
    RefSeqiNP_498518.2. NM_066117.3.
    UniGeneiCel.10391.

    Genome annotation databases

    EnsemblMetazoaiF57B9.1; F57B9.1; WBGene00018996.
    GeneIDi175973.
    KEGGicel:CELE_F57B9.1.
    UCSCiF57B9.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO081266 Genomic DNA. Translation: CCD70322.1 .
    PIRi A88494.
    RefSeqi NP_498518.2. NM_066117.3.
    UniGenei Cel.10391.

    3D structure databases

    ProteinModelPortali Q20939.
    SMRi Q20939. Positions 25-226.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q20939. 1 interaction.
    STRINGi 6239.F57B9.1.

    Proteomic databases

    PaxDbi Q20939.
    PRIDEi Q20939.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai F57B9.1 ; F57B9.1 ; WBGene00018996 .
    GeneIDi 175973.
    KEGGi cel:CELE_F57B9.1.
    UCSCi F57B9.1. c. elegans.

    Organism-specific databases

    CTDi 175973.
    WormBasei F57B9.1 ; CE44186 ; WBGene00018996 .

    Phylogenomic databases

    eggNOGi COG0259.
    GeneTreei ENSGT00390000011219.
    HOGENOMi HOG000242755.
    InParanoidi Q20939.
    OMAi ELDHRGF.
    OrthoDBi EOG7B8S4P.

    Enzyme and pathway databases

    UniPathwayi UPA00190 ; UER00304 .
    UPA00190 ; UER00305 .
    Reactomei REACT_183141. Vitamins B6 activation to pyridoxal phosphate.

    Miscellaneous databases

    NextBioi 890562.
    PROi Q20939.

    Family and domain databases

    Gene3Di 2.30.110.10. 1 hit.
    InterProi IPR000659. Pyridox_Oxase.
    IPR019740. Pyridox_Oxase_CS.
    IPR011576. Pyridox_Oxase_FMN-bd.
    IPR019576. Pyridoxamine_oxidase_dimer_C.
    IPR012349. Split_barrel_FMN-bd.
    [Graphical view ]
    PANTHERi PTHR10851. PTHR10851. 1 hit.
    Pfami PF10590. PNPOx_C. 1 hit.
    PF01243. Pyridox_oxidase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000190. Pyd_amn-ph_oxd. 1 hit.
    SUPFAMi SSF50475. SSF50475. 1 hit.
    TIGRFAMsi TIGR00558. pdxH. 1 hit.
    PROSITEi PS01064. PYRIDOX_OXIDASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiPDXH_CAEEL
    AccessioniPrimary (citable) accession number: Q20939
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: October 19, 2011
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3