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Q20939

- PDXH_CAEEL

UniProt

Q20939 - PDXH_CAEEL

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Protein

Putative pyridoxamine 5'-phosphate oxidase

Gene

F57B9.1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).By similarity

Catalytic activityi

Pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + H2O2.
Pyridoxine 5'-phosphate + O2 = pyridoxal 5'-phosphate + H2O2.

Cofactori

FMNBy similarityNote: Binds 1 FMN per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei72 – 721FMNBy similarity
Binding sitei75 – 751FMN; via amide nitrogenBy similarity
Binding sitei77 – 771SubstrateBy similarity
Binding sitei94 – 941FMNBy similarity
Binding sitei134 – 1341SubstrateBy similarity
Binding sitei138 – 1381SubstrateBy similarity
Binding sitei142 – 1421SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi87 – 882FMNBy similarity
Nucleotide bindingi151 – 1522FMNBy similarity

GO - Molecular functioni

  1. FMN binding Source: InterPro
  2. pyridoxamine-phosphate oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. pyridoxine biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridoxine biosynthesis

Keywords - Ligandi

Flavoprotein, FMN

Enzyme and pathway databases

ReactomeiREACT_183141. Vitamins B6 activation to pyridoxal phosphate.
UniPathwayiUPA00190; UER00304.
UPA00190; UER00305.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative pyridoxamine 5'-phosphate oxidase (EC:1.4.3.5)
Alternative name(s):
PNP/PMP oxidase
Short name:
PNPOx
Gene namesi
ORF Names:F57B9.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiF57B9.1; CE44186; WBGene00018996.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 226226Putative pyridoxamine 5'-phosphate oxidasePRO_0000167788Add
BLAST

Proteomic databases

PaxDbiQ20939.
PRIDEiQ20939.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiQ20939. 1 interaction.
STRINGi6239.F57B9.1.

Structurei

3D structure databases

ProteinModelPortaliQ20939.
SMRiQ20939. Positions 25-226.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni205 – 2073Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0259.
GeneTreeiENSGT00390000011219.
HOGENOMiHOG000242755.
InParanoidiQ20939.
OMAiELDHRGF.
OrthoDBiEOG7B8S4P.

Family and domain databases

Gene3Di2.30.110.10. 1 hit.
InterProiIPR000659. Pyridox_Oxase.
IPR019740. Pyridox_Oxase_CS.
IPR011576. Pyridox_Oxase_FMN-bd.
IPR019576. Pyridoxamine_oxidase_dimer_C.
IPR012349. Split_barrel_FMN-bd.
[Graphical view]
PANTHERiPTHR10851. PTHR10851. 1 hit.
PfamiPF10590. PNPOx_C. 1 hit.
PF01243. Pyridox_oxidase. 1 hit.
[Graphical view]
PIRSFiPIRSF000190. Pyd_amn-ph_oxd. 1 hit.
SUPFAMiSSF50475. SSF50475. 1 hit.
TIGRFAMsiTIGR00558. pdxH. 1 hit.
PROSITEiPS01064. PYRIDOX_OXIDASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q20939-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
METPSIDIQN IRAKYLNSHD PYLLESKLPT TSPFELFDIW FRNVASQSDL
60 70 80 90 100
TFEEINAVSL STVGKDLRPS SRMVLLKAYT PTGFSFYTNY TSRKGNQLEE
110 120 130 140 150
NPNAAMLFYW PKVNRQIRVE GVVEKLPDEM AVAYWNSRPV ASRIGSKSSD
160 170 180 190 200
QSKVVPDREF LESKKVALTE LSVREGAQAI TKPESWGGYH LIPRYFEFWQ
210 220
GQSDRLHDRI VFERDVDVWL LKRLSP
Length:226
Mass (Da):26,101
Last modified:October 19, 2011 - v2
Checksum:i99E80C34C740AE2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081266 Genomic DNA. Translation: CCD70322.1.
PIRiA88494.
RefSeqiNP_498518.2. NM_066117.3.
UniGeneiCel.10391.

Genome annotation databases

EnsemblMetazoaiF57B9.1; F57B9.1; WBGene00018996.
GeneIDi175973.
KEGGicel:CELE_F57B9.1.
UCSCiF57B9.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081266 Genomic DNA. Translation: CCD70322.1 .
PIRi A88494.
RefSeqi NP_498518.2. NM_066117.3.
UniGenei Cel.10391.

3D structure databases

ProteinModelPortali Q20939.
SMRi Q20939. Positions 25-226.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q20939. 1 interaction.
STRINGi 6239.F57B9.1.

Proteomic databases

PaxDbi Q20939.
PRIDEi Q20939.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F57B9.1 ; F57B9.1 ; WBGene00018996 .
GeneIDi 175973.
KEGGi cel:CELE_F57B9.1.
UCSCi F57B9.1. c. elegans.

Organism-specific databases

CTDi 175973.
WormBasei F57B9.1 ; CE44186 ; WBGene00018996 .

Phylogenomic databases

eggNOGi COG0259.
GeneTreei ENSGT00390000011219.
HOGENOMi HOG000242755.
InParanoidi Q20939.
OMAi ELDHRGF.
OrthoDBi EOG7B8S4P.

Enzyme and pathway databases

UniPathwayi UPA00190 ; UER00304 .
UPA00190 ; UER00305 .
Reactomei REACT_183141. Vitamins B6 activation to pyridoxal phosphate.

Miscellaneous databases

NextBioi 890562.
PROi Q20939.

Family and domain databases

Gene3Di 2.30.110.10. 1 hit.
InterProi IPR000659. Pyridox_Oxase.
IPR019740. Pyridox_Oxase_CS.
IPR011576. Pyridox_Oxase_FMN-bd.
IPR019576. Pyridoxamine_oxidase_dimer_C.
IPR012349. Split_barrel_FMN-bd.
[Graphical view ]
PANTHERi PTHR10851. PTHR10851. 1 hit.
Pfami PF10590. PNPOx_C. 1 hit.
PF01243. Pyridox_oxidase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000190. Pyd_amn-ph_oxd. 1 hit.
SUPFAMi SSF50475. SSF50475. 1 hit.
TIGRFAMsi TIGR00558. pdxH. 1 hit.
PROSITEi PS01064. PYRIDOX_OXIDASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiPDXH_CAEEL
AccessioniPrimary (citable) accession number: Q20939
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 19, 2011
Last modified: November 26, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3