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Protein

Probable 26S proteasome regulatory subunit rpn-6.1

Gene

rpn-6.1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, rpn-6.1 is required for proteasome assembly. Plays a key role in increased proteasome activity in response to proteotoxic stress: induced by daf-16, promoting enhanced assembly of the 26S proteasome and higher proteasome activity, leading to extended lifespan.1 Publication

GO - Molecular functioni

GO - Biological processi

  • determination of adult lifespan Source: UniProtKB
  • proteasome assembly Source: UniProtKB
  • ubiquitin-dependent protein catabolic process Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-CEL-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-CEL-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-CEL-382556. ABC-family proteins mediated transport.
R-CEL-4641258. Degradation of DVL.
R-CEL-5632684. Hedgehog 'on' state.
R-CEL-5689603. UCH proteinases.
R-CEL-5689880. Ub-specific processing proteases.
R-CEL-6798695. Neutrophil degranulation.
R-CEL-68949. Orc1 removal from chromatin.
R-CEL-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-CEL-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-CEL-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-CEL-8941858. Regulation of RUNX3 expression and activity.
R-CEL-8948751. Regulation of PTEN stability and activity.
R-CEL-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 26S proteasome regulatory subunit rpn-6.1By similarity
Gene namesi
Name:rpn-6.1Imported
ORF Names:F57B9.10
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF57B9.10a; CE25011; WBGene00004462; rpn-6.1.
F57B9.10b; CE38077; WBGene00004462; rpn-6.1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Proteasome

Pathology & Biotechi

Disruption phenotypei

Embryonic lethal, larval arrest.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003990341 – 438Probable 26S proteasome regulatory subunit rpn-6.1Add BLAST438

Proteomic databases

EPDiQ20938.
PaxDbiQ20938.
PeptideAtlasiQ20938.
PRIDEiQ20938.

Expressioni

Inductioni

By daf-16.1 Publication

Gene expression databases

BgeeiWBGene00004462.

Interactioni

Subunit structurei

Component of the lid subcomplex of the 19S proteasome regulatory particle complex (also named PA700 complex). The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits (By similarity).By similarity

Protein-protein interaction databases

BioGridi41186. 1 interactor.
STRINGi6239.F57B9.10a.

Structurei

3D structure databases

ProteinModelPortaliQ20938.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini302 – 403PCISequence analysisAdd BLAST102

Sequence similaritiesi

Belongs to the proteasome subunit S9 family.Sequence analysis

Phylogenomic databases

eggNOGiKOG1463. Eukaryota.
COG5159. LUCA.
GeneTreeiENSGT00530000063301.
HOGENOMiHOG000210093.
InParanoidiQ20938.
KOiK03036.
OMAiCKIMLGQ.
OrthoDBiEOG091G0B4C.
PhylomeDBiQ20938.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.25.40.10. 1 hit.
InterProiView protein in InterPro
IPR000717. PCI_dom.
IPR011990. TPR-like_helical_dom.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF01399. PCI. 1 hit.
SMARTiView protein in SMART
SM00088. PINT. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a1 Publication (identifier: Q20938-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRETSSREDT NNIGKAPEMS GGTIMDTMTS LPHQNDQNVI RHLTNLVKSP
60 70 80 90 100
ASGDDDIKKK EDSIMELGNI LAQNKQTEEL RNMIEQTRPF LVSLGKAKAA
110 120 130 140 150
KLVRDLVDLC LKIDDQDGDI KVGLVKECIQ WATEQNRTFL RQTLTARLVR
160 170 180 190 200
LYNDLQRYTQ ALPLAADLIR ELKKVDDKDV LVEVELEESK AYYNLSNIGR
210 220 230 240 250
ARASLTGART TANAIYVNPR MQAALDLQSG ILHAADEKDF KTAFSYFYEA
260 270 280 290 300
FEGYDSVDEK VSALTALKYM LLCKVMLDLP DEVNSLLSAK LALKYNGSDL
310 320 330 340 350
DAMKAIAAAA QKRSLKDFQV AFGSFPQELQ MDPVVRKHFH SLSERMLEKD
360 370 380 390 400
LCRIIEPYSF VQIEHVAQQI GIDRSKVEKK LSQMILDQKL SGSLDQGEGM
410 420 430
LIVFEIAVPD EAYQTALDTI HAMGEVVDAL YSNASKIN
Note: No experimental confirmation available.Curated
Length:438
Mass (Da):49,091
Last modified:October 1, 2001 - v2
Checksum:i4F6B245626C4098F
GO
Isoform b1 Publication (identifier: Q20938-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:420
Mass (Da):47,074
Checksum:iAD9DD4CF099A083B
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0398251 – 18Missing in isoform b. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081266 Genomic DNA. Translation: CCD70319.1.
FO081266 Genomic DNA. Translation: CCD70320.1.
PIRiH88493.
RefSeqiNP_001022621.1. NM_001027450.2. [Q20938-1]
NP_001022622.1. NM_001027451.2. [Q20938-2]
UniGeneiCel.17066.

Genome annotation databases

EnsemblMetazoaiF57B9.10a; F57B9.10a; WBGene00004462. [Q20938-1]
GeneIDi175972.
KEGGicel:CELE_F57B9.10.
UCSCiF57B9.10a. c. elegans.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPS11A_CAEEL
AccessioniPrimary (citable) accession number: Q20938
Secondary accession number(s): Q5DX45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: October 1, 2001
Last modified: September 27, 2017
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families