Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tyrosine-protein kinase

Gene

CELE_F57B9.8

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ20933.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
ORF Names:CELE_F57B9.8Imported, F57B9.8Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF57B9.8; CE29411; WBGene00018999.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ20933.

Expressioni

Gene expression databases

BgeeiWBGene00018999.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-25680N.
MINTiMINT-1104578.
STRINGi6239.F57B9.8.

Structurei

3D structure databases

ProteinModelPortaliQ20933.
SMRiQ20933. Positions 5-402.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 10396SH2InterPro annotationAdd
BLAST
Domaini115 – 369255Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotationSAAS annotation
Contains 1 SH2 domain.UniRule annotation
Contains 1 protein kinase domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG0194. Eukaryota.
ENOG410Y6RP. LUCA.
GeneTreeiENSGT00760000119011.
HOGENOMiHOG000233858.
InParanoidiQ20933.
OMAiLCWEVIE.
OrthoDBiEOG091G0922.
PhylomeDBiQ20933.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q20933-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEINEQPFFH GLLPREEVKL LLQKNGDYLM RTSEPQGQAR HLIISVMQNE
60 70 80 90 100
TSQEVAHYVI RTSDGAYSIT DKIKFGTLTE LVNHHKQAKI SEEVASSVLV
110 120 130 140 150
NPIGRQSWEL NHADITMTKV LGEGAFGEVK LGTLKMGSTT VDVAIKVAKL
160 170 180 190 200
EKVTKEQIKE IITEARLMRG FDHKNVVKCY GVAAIDEPLL VVMELVPGGA
210 220 230 240 250
LDKYLQKNSS VQWPEKLDII AQVAAGLAYI HSKNIIHRDI AARNILYGKG
260 270 280 290 300
VAKVSDFGLS RVGTEYQMDP SKRVPIRWLS PETIVSFLYT PQTDVFAFSI
310 320 330 340 350
LCWEVIENGA QPYPEMLVVQ VHQKVGRDDY RMPISQKAPA MLADVIKKCW
360 370 380 390 400
IRDPQQRPTM SQVVQMMYEI TGKKDKTSVN KSTGQLRAKM MSTGPMSDPM
410 420 430 440
RDKTAKKTGR RNKKKPSSAS NGPGGNSGPS SGPLSGKDSR LKKP
Length:444
Mass (Da):49,372
Last modified:December 1, 2001 - v2
Checksum:i63ADCF6F7E40508A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA. Translation: CCD70317.1.
PIRiC88493.
RefSeqiNP_498511.1. NM_066110.4.
UniGeneiCel.10386.

Genome annotation databases

EnsemblMetazoaiF57B9.8; F57B9.8; WBGene00018999.
GeneIDi175967.
KEGGicel:CELE_F57B9.8.
UCSCiF57B9.8. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA. Translation: CCD70317.1.
PIRiC88493.
RefSeqiNP_498511.1. NM_066110.4.
UniGeneiCel.10386.

3D structure databases

ProteinModelPortaliQ20933.
SMRiQ20933. Positions 5-402.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-25680N.
MINTiMINT-1104578.
STRINGi6239.F57B9.8.

Proteomic databases

PaxDbiQ20933.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF57B9.8; F57B9.8; WBGene00018999.
GeneIDi175967.
KEGGicel:CELE_F57B9.8.
UCSCiF57B9.8. c. elegans.

Organism-specific databases

CTDi175967.
WormBaseiF57B9.8; CE29411; WBGene00018999.

Phylogenomic databases

eggNOGiKOG0194. Eukaryota.
ENOG410Y6RP. LUCA.
GeneTreeiENSGT00760000119011.
HOGENOMiHOG000233858.
InParanoidiQ20933.
OMAiLCWEVIE.
OrthoDBiEOG091G0922.
PhylomeDBiQ20933.

Enzyme and pathway databases

SignaLinkiQ20933.

Gene expression databases

BgeeiWBGene00018999.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ20933_CAEEL
AccessioniPrimary (citable) accession number: Q20933
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.