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Protein

Guanine nucleotide-binding protein alpha-9 subunit

Gene

gpa-9

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi58 – 581MagnesiumBy similarity
Metal bindingi197 – 1971MagnesiumBy similarity
Binding sitei347 – 3471GTP; via amide nitrogenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi51 – 588GTPBy similarity
Nucleotide bindingi191 – 1977GTPBy similarity
Nucleotide bindingi218 – 2225GTPBy similarity
Nucleotide bindingi291 – 2944GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transducer

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein alpha-9 subunit
Gene namesi
Name:gpa-9
ORF Names:F56H9.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF56H9.4a; CE46507; WBGene00001671; gpa-9.
F56H9.4b; CE46135; WBGene00001671; gpa-9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 374374Guanine nucleotide-binding protein alpha-9 subunitPRO_0000203644Add
BLAST

Proteomic databases

PaxDbiQ20910.

Expressioni

Gene expression databases

BgeeiWBGene00001671.

Interactioni

Subunit structurei

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi6239.F56H9.4a.

Structurei

3D structure databases

ProteinModelPortaliQ20910.
SMRiQ20910. Positions 46-366.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-alpha family.Curated

Phylogenomic databases

eggNOGiKOG0082. Eukaryota.
ENOG410XNVQ. LUCA.
HOGENOMiHOG000038730.
InParanoidiQ20910.

Family and domain databases

Gene3Di1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10218. PTHR10218. 1 hit.
PfamiPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSiPR00318. GPROTEINA.
SMARTiSM00275. G_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: Q20910-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFSAESNLRN RWRLSKTLSE NIFLKIDENL KIETQILEER KKKALKLLII
60 70 80 90 100
GPGESGKSTI VKQVRILHCG GYSVEEKRAL KHGIYINILE GIDEIHWAIM
110 120 130 140 150
WRQLIYENPS SIECLNQIRI FTKQFNKTGE TENVLCKDII KSIQMYIKDE
160 170 180 190 200
TVAMMLRNKT VYNIEDSTIH FIENLARVIG KEYLPTGEDI LKTRVPTLGI
210 220 230 240 250
AQYEANIKHL TFKFIFFDIG GQRAQRRKIT HLSGHVLDDS HAILFITSLS
260 270 280 290 300
EYNQVLREDA FVSRIEESLH LFNEICNGMY FHSTAIILFL NKIDLFEIKI
310 320 330 340 350
THTNITVAFP DYEGPRERDC ALEYIRVQFI SLNNNKNRKI YQHVTSATDT
360 370
ARIQVVIDML FDIIISASLK MVGV
Note: No experimental confirmation available.
Length:374
Mass (Da):43,330
Last modified:October 3, 2012 - v3
Checksum:iF6CE5756AD460A89
GO
Isoform b (identifier: Q20910-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-278: Missing.

Note: No experimental confirmation available.
Show »
Length:96
Mass (Da):11,108
Checksum:i5A39915AE0934317
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 278278Missing in isoform b. CuratedVSP_044154Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74473 Genomic DNA. Translation: CCD31081.1.
Z74473 Genomic DNA. Translation: CCD31082.1.
PIRiT22810.
RefSeqiNP_001256444.1. NM_001269515.1. [Q20910-2]
UniGeneiCel.28724.

Genome annotation databases

GeneIDi191659.
KEGGicel:CELE_F56H9.4.
UCSCiF56H9.4. c. elegans. [Q20910-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74473 Genomic DNA. Translation: CCD31081.1.
Z74473 Genomic DNA. Translation: CCD31082.1.
PIRiT22810.
RefSeqiNP_001256444.1. NM_001269515.1. [Q20910-2]
UniGeneiCel.28724.

3D structure databases

ProteinModelPortaliQ20910.
SMRiQ20910. Positions 46-366.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F56H9.4a.

Proteomic databases

PaxDbiQ20910.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi191659.
KEGGicel:CELE_F56H9.4.
UCSCiF56H9.4. c. elegans. [Q20910-1]

Organism-specific databases

CTDi191659.
WormBaseiF56H9.4a; CE46507; WBGene00001671; gpa-9.
F56H9.4b; CE46135; WBGene00001671; gpa-9.

Phylogenomic databases

eggNOGiKOG0082. Eukaryota.
ENOG410XNVQ. LUCA.
HOGENOMiHOG000038730.
InParanoidiQ20910.

Miscellaneous databases

PROiQ20910.

Gene expression databases

BgeeiWBGene00001671.

Family and domain databases

Gene3Di1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10218. PTHR10218. 1 hit.
PfamiPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSiPR00318. GPROTEINA.
SMARTiSM00275. G_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiGPA9_CAEEL
AccessioniPrimary (citable) accession number: Q20910
Secondary accession number(s): G3MU18, G3MU19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: October 3, 2012
Last modified: September 7, 2016
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.