ID   CDO_CAEEL               Reviewed;         190 AA.
AC   Q20893;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 2.
DT   16-JUN-2009, entry version 55.
DE   RecName: Full=Cysteine dioxygenase;
DE            Short=CDO;
DE            EC=1.13.11.20;
GN   ORFNames=F56F10.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea;
OC   Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   MEDLINE=99069613; PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
CC   -!- CATALYTIC ACTIVITY: L-cysteine + O(2) = 3-sulfinoalanine.
CC   -!- COFACTOR: Binds 1 iron ion per subunit (By similarity).
CC   -!- PATHWAY: Organosulfur biosynthesis; taurine biosynthesis;
CC       hypotaurine from L-cysteine: step 1/2.
CC   -!- PTM: The thioether cross-link between Cys-85 and Tyr-149 plays a
CC       structural role through stabilizing the Fe(2+) ion, and prevents
CC       the production of highly damaging free hydroxyl radicals by
CC       holding the oxygen radical via hydroxyl hydrogen (By similarity).
CC   -!- SIMILARITY: Belongs to the cysteine dioxygenase family.
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DR   EMBL; U51993; AAB36852.2; -; Genomic_DNA.
DR   PIR; T16488; T16488.
DR   RefSeq; NP_508168.1; -.
DR   UniGene; Cel.5612; -.
DR   Ensembl; F56F10.3; Caenorhabditis elegans.
DR   GeneID; 180434; -.
DR   KEGG; cel:F56F10.3; -.
DR   NMPDR; fig|6239.3.peg.22361; -.
DR   WormBase; WBGene00018986; F56F10.3.
DR   WormPep; F56F10.3; CE28465.
DR   OMA; Q20893; EWAAYAK.
DR   BRENDA; 1.13.11.20; 672.
DR   NextBio; 909356; -.
DR   ArrayExpress; Q20893; -.
DR   GO; GO:0017172; F:cysteine dioxygenase activity; IEA:EC.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0046439; P:L-cysteine metabolic process; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR010300; Cys_dOase_I.
DR   Pfam; PF05995; CDO_I; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase;
KW   Thioether bond.
FT   CHAIN         1    190       Cysteine dioxygenase.
FT                                /FTId=PRO_0000206612.
FT   METAL        78     78       Iron; catalytic (By similarity).
FT   METAL        80     80       Iron; catalytic (By similarity).
FT   METAL       132    132       Iron; catalytic (By similarity).
FT   CROSSLNK     85    149       3'-(S-cysteinyl)-tyrosine (Cys-Tyr) (By
FT                                similarity).
SQ   SEQUENCE   190 AA;  21879 MW;  273A194DBFFA0C55 CRC64;
     MISFVQLVVQ IREIFQQKLI DVDEVMKLMA SYKSNANEWR RFAIFDMNKY TRNLVDVGNG
     KYNLMILCWG PGMASSVHDH TDAHCFVKIL DGELTETKYA WPRKRHVPLD ISENKTYGMN
     GVSYMNDELG LHRMENLSHS NGAVSLHLYI PPYSTCNAFD ERTGKKTQCT VTFYSKYGKK
     VDYRGSKNGN
//