ID   CDO1_CAEEL              Reviewed;         190 AA.
AC   Q20893;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 2.
DT   27-MAR-2024, entry version 133.
DE   RecName: Full=Cysteine dioxygenase 1;
DE            Short=CDO;
DE            EC=1.13.11.20;
GN   Name=cdo-1; ORFNames=F56F10.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-cysteine + O2 = 3-sulfino-L-alanine + H(+);
CC         Xref=Rhea:RHEA:20441, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:35235, ChEBI:CHEBI:61085; EC=1.13.11.20;
CC   -!- COFACTOR:
CC       Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000250};
CC       Note=Binds 1 Fe cation per subunit. {ECO:0000250};
CC   -!- PATHWAY: Organosulfur biosynthesis; taurine biosynthesis; hypotaurine
CC       from L-cysteine: step 1/2.
CC   -!- PTM: The thioether cross-link between Cys-85 and Tyr-149 plays a
CC       structural role through stabilizing the Fe(2+) ion, and prevents the
CC       production of highly damaging free hydroxyl radicals by holding the
CC       oxygen radical via hydroxyl hydrogen. {ECO:0000250|UniProtKB:Q16878}.
CC   -!- SIMILARITY: Belongs to the cysteine dioxygenase family. {ECO:0000305}.
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DR   EMBL; FO081336; CCD70867.1; -; Genomic_DNA.
DR   PIR; T16488; T16488.
DR   RefSeq; NP_508168.1; NM_075767.3.
DR   AlphaFoldDB; Q20893; -.
DR   SMR; Q20893; -.
DR   BioGRID; 45387; 5.
DR   STRING; 6239.F56F10.3.2; -.
DR   EPD; Q20893; -.
DR   PaxDb; 6239-F56F10-3; -.
DR   PeptideAtlas; Q20893; -.
DR   EnsemblMetazoa; F56F10.3.1; F56F10.3.1; WBGene00018986.
DR   GeneID; 180434; -.
DR   KEGG; cel:CELE_F56F10.3; -.
DR   UCSC; F56F10.3; c. elegans.
DR   AGR; WB:WBGene00018986; -.
DR   WormBase; F56F10.3; CE28465; WBGene00018986; cdo-1.
DR   eggNOG; KOG4064; Eukaryota.
DR   GeneTree; ENSGT00390000018226; -.
DR   HOGENOM; CLU_079443_4_1_1; -.
DR   InParanoid; Q20893; -.
DR   OMA; NQVAYMA; -.
DR   OrthoDB; 314969at2759; -.
DR   PhylomeDB; Q20893; -.
DR   Reactome; R-CEL-1614558; Degradation of cysteine and homocysteine.
DR   UniPathway; UPA00012; UER00537.
DR   PRO; PR:Q20893; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00018986; Expressed in larva and 4 other cell types or tissues.
DR   GO; GO:0017172; F:cysteine dioxygenase activity; IBA:GO_Central.
DR   GO; GO:0008198; F:ferrous iron binding; IBA:GO_Central.
DR   GO; GO:0019448; P:L-cysteine catabolic process; IBA:GO_Central.
DR   GO; GO:0042412; P:taurine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd10548; cupin_CDO; 1.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR   InterPro; IPR010300; CDO_1.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR011051; RmlC_Cupin_sf.
DR   PANTHER; PTHR12918; CYSTEINE DIOXYGENASE; 1.
DR   PANTHER; PTHR12918:SF1; CYSTEINE DIOXYGENASE TYPE 1; 1.
DR   Pfam; PF05995; CDO_I; 1.
DR   SUPFAM; SSF51182; RmlC-like cupins; 1.
PE   3: Inferred from homology;
KW   Dioxygenase; Iron; Metal-binding; Oxidoreductase; Reference proteome;
KW   Thioether bond.
FT   CHAIN           1..190
FT                   /note="Cysteine dioxygenase 1"
FT                   /id="PRO_0000206612"
FT   BINDING         78
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250|UniProtKB:Q16878"
FT   BINDING         80
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250|UniProtKB:Q16878"
FT   BINDING         132
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250|UniProtKB:Q16878"
FT   CROSSLNK        85..149
FT                   /note="3'-(S-cysteinyl)-tyrosine (Cys-Tyr)"
FT                   /evidence="ECO:0000250|UniProtKB:Q16878"
SQ   SEQUENCE   190 AA;  21879 MW;  273A194DBFFA0C55 CRC64;
     MISFVQLVVQ IREIFQQKLI DVDEVMKLMA SYKSNANEWR RFAIFDMNKY TRNLVDVGNG
     KYNLMILCWG PGMASSVHDH TDAHCFVKIL DGELTETKYA WPRKRHVPLD ISENKTYGMN
     GVSYMNDELG LHRMENLSHS NGAVSLHLYI PPYSTCNAFD ERTGKKTQCT VTFYSKYGKK
     VDYRGSKNGN
//