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Q20893 (CDO1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cysteine dioxygenase 1

Short name=CDO
EC=1.13.11.20
Gene names
Name:cdo-1
ORF Names:F56F10.3
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length190 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-cysteine + O2 = 3-sulfinoalanine.

Cofactor

Binds 1 iron ion per subunit By similarity.

Pathway

Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2.

Post-translational modification

The thioether cross-link between Cys-85 and Tyr-149 plays a structural role through stabilizing the Fe2+ ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen By similarity.

Sequence similarities

Belongs to the cysteine dioxygenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 190190Cysteine dioxygenase 1
PRO_0000206612

Sites

Metal binding781Iron; catalytic By similarity
Metal binding801Iron; catalytic By similarity
Metal binding1321Iron; catalytic By similarity

Amino acid modifications

Cross-link85 ↔ 1493'-(S-cysteinyl)-tyrosine (Cys-Tyr) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q20893 [UniParc].

Last modified October 1, 2001. Version 2.
Checksum: 273A194DBFFA0C55

FASTA19021,879
        10         20         30         40         50         60 
MISFVQLVVQ IREIFQQKLI DVDEVMKLMA SYKSNANEWR RFAIFDMNKY TRNLVDVGNG 

        70         80         90        100        110        120 
KYNLMILCWG PGMASSVHDH TDAHCFVKIL DGELTETKYA WPRKRHVPLD ISENKTYGMN 

       130        140        150        160        170        180 
GVSYMNDELG LHRMENLSHS NGAVSLHLYI PPYSTCNAFD ERTGKKTQCT VTFYSKYGKK 

       190 
VDYRGSKNGN 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO081336 Genomic DNA. Translation: CCD70867.1.
PIRT16488.
RefSeqNP_508168.1. NM_075767.3.
UniGeneCel.5612.

3D structure databases

ProteinModelPortalQ20893.
SMRQ20893. Positions 3-178.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6239.F56F10.3.

Proteomic databases

PaxDbQ20893.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaF56F10.3; F56F10.3; F56F10.3.
GeneID180434.
KEGGcel:CELE_F56F10.3.
UCSCF56F10.3. c. elegans.

Organism-specific databases

CTD180434.
WormBaseF56F10.3; CE28465; WBGene00018986; cdo-1.

Phylogenomic databases

eggNOGNOG126313.
HOGENOMHOG000177818.
InParanoidQ20893.
KOK00456.
OMAKMTFWSK.
OrthoDBEOG77M8PK.
PhylomeDBQ20893.

Enzyme and pathway databases

UniPathwayUPA00012; UER00537.

Family and domain databases

Gene3D2.60.120.10. 1 hit.
InterProIPR010300. Cys_dOase_I.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamPF05995. CDO_I. 1 hit.
[Graphical view]
SUPFAMSSF51182. SSF51182. 1 hit.
ProtoNetSearch...

Other

NextBio909356.
PROQ20893.

Entry information

Entry nameCDO1_CAEEL
AccessionPrimary (citable) accession number: Q20893
Entry history
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: October 1, 2001
Last modified: April 16, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase