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Q20893

- CDO1_CAEEL

UniProt

Q20893 - CDO1_CAEEL

Protein

Cysteine dioxygenase 1

Gene

cdo-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (01 Oct 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-cysteine + O2 = 3-sulfinoalanine.

    Cofactori

    Binds 1 iron ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi78 – 781Iron; catalyticBy similarity
    Metal bindingi80 – 801Iron; catalyticBy similarity
    Metal bindingi132 – 1321Iron; catalyticBy similarity

    GO - Molecular functioni

    1. cysteine dioxygenase activity Source: UniProtKB-EC
    2. iron ion binding Source: InterPro

    GO - Biological processi

    1. L-cysteine metabolic process Source: InterPro
    2. taurine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_197717. Degradation of cysteine and homocysteine.
    UniPathwayiUPA00012; UER00537.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cysteine dioxygenase 1 (EC:1.13.11.20)
    Short name:
    CDO
    Gene namesi
    Name:cdo-1
    ORF Names:F56F10.3
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome X

    Organism-specific databases

    WormBaseiF56F10.3; CE28465; WBGene00018986; cdo-1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 190190Cysteine dioxygenase 1PRO_0000206612Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki85 ↔ 1493'-(S-cysteinyl)-tyrosine (Cys-Tyr)By similarity

    Post-translational modificationi

    The thioether cross-link between Cys-85 and Tyr-149 plays a structural role through stabilizing the Fe2+ ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen.By similarity

    Keywords - PTMi

    Thioether bond

    Proteomic databases

    PaxDbiQ20893.

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.F56F10.3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ20893.
    SMRiQ20893. Positions 3-178.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cysteine dioxygenase family.Curated

    Phylogenomic databases

    eggNOGiNOG126313.
    GeneTreeiENSGT00390000018226.
    HOGENOMiHOG000177818.
    InParanoidiQ20893.
    KOiK00456.
    OMAiKMTFWSK.
    OrthoDBiEOG77M8PK.
    PhylomeDBiQ20893.

    Family and domain databases

    Gene3Di2.60.120.10. 1 hit.
    InterProiIPR010300. Cys_dOase_I.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PfamiPF05995. CDO_I. 1 hit.
    [Graphical view]
    SUPFAMiSSF51182. SSF51182. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q20893-1 [UniParc]FASTAAdd to Basket

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    MISFVQLVVQ IREIFQQKLI DVDEVMKLMA SYKSNANEWR RFAIFDMNKY    50
    TRNLVDVGNG KYNLMILCWG PGMASSVHDH TDAHCFVKIL DGELTETKYA 100
    WPRKRHVPLD ISENKTYGMN GVSYMNDELG LHRMENLSHS NGAVSLHLYI 150
    PPYSTCNAFD ERTGKKTQCT VTFYSKYGKK VDYRGSKNGN 190
    Length:190
    Mass (Da):21,879
    Last modified:October 1, 2001 - v2
    Checksum:i273A194DBFFA0C55
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO081336 Genomic DNA. Translation: CCD70867.1.
    PIRiT16488.
    RefSeqiNP_508168.1. NM_075767.3.
    UniGeneiCel.5612.

    Genome annotation databases

    EnsemblMetazoaiF56F10.3; F56F10.3; WBGene00018986.
    GeneIDi180434.
    KEGGicel:CELE_F56F10.3.
    UCSCiF56F10.3. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO081336 Genomic DNA. Translation: CCD70867.1 .
    PIRi T16488.
    RefSeqi NP_508168.1. NM_075767.3.
    UniGenei Cel.5612.

    3D structure databases

    ProteinModelPortali Q20893.
    SMRi Q20893. Positions 3-178.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.F56F10.3.

    Proteomic databases

    PaxDbi Q20893.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai F56F10.3 ; F56F10.3 ; WBGene00018986 .
    GeneIDi 180434.
    KEGGi cel:CELE_F56F10.3.
    UCSCi F56F10.3. c. elegans.

    Organism-specific databases

    CTDi 180434.
    WormBasei F56F10.3 ; CE28465 ; WBGene00018986 ; cdo-1.

    Phylogenomic databases

    eggNOGi NOG126313.
    GeneTreei ENSGT00390000018226.
    HOGENOMi HOG000177818.
    InParanoidi Q20893.
    KOi K00456.
    OMAi KMTFWSK.
    OrthoDBi EOG77M8PK.
    PhylomeDBi Q20893.

    Enzyme and pathway databases

    UniPathwayi UPA00012 ; UER00537 .
    Reactomei REACT_197717. Degradation of cysteine and homocysteine.

    Miscellaneous databases

    NextBioi 909356.
    PROi Q20893.

    Family and domain databases

    Gene3Di 2.60.120.10. 1 hit.
    InterProi IPR010300. Cys_dOase_I.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    Pfami PF05995. CDO_I. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51182. SSF51182. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiCDO1_CAEEL
    AccessioniPrimary (citable) accession number: Q20893
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 16, 2004
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3