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Protein

Cysteine dioxygenase 1

Gene

cdo-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-cysteine + O2 = 3-sulfinoalanine.

Cofactori

Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi78 – 781Iron; catalyticBy similarity
Metal bindingi80 – 801Iron; catalyticBy similarity
Metal bindingi132 – 1321Iron; catalyticBy similarity

GO - Molecular functioni

  1. cysteine dioxygenase activity Source: UniProtKB-EC
  2. iron ion binding Source: InterPro

GO - Biological processi

  1. L-cysteine metabolic process Source: InterPro
  2. taurine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_304058. Degradation of cysteine and homocysteine.
UniPathwayiUPA00012; UER00537.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine dioxygenase 1 (EC:1.13.11.20)
Short name:
CDO
Gene namesi
Name:cdo-1
ORF Names:F56F10.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF56F10.3; CE28465; WBGene00018986; cdo-1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 190190Cysteine dioxygenase 1PRO_0000206612Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki85 ↔ 1493'-(S-cysteinyl)-tyrosine (Cys-Tyr)By similarity

Post-translational modificationi

The thioether cross-link between Cys-85 and Tyr-149 plays a structural role through stabilizing the Fe2+ ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen.By similarity

Keywords - PTMi

Thioether bond

Proteomic databases

PaxDbiQ20893.

Interactioni

Protein-protein interaction databases

STRINGi6239.F56F10.3.

Structurei

3D structure databases

ProteinModelPortaliQ20893.
SMRiQ20893. Positions 3-178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cysteine dioxygenase family.Curated

Phylogenomic databases

eggNOGiNOG126313.
GeneTreeiENSGT00390000018226.
HOGENOMiHOG000177818.
InParanoidiQ20893.
KOiK00456.
OMAiCFMKLLQ.
OrthoDBiEOG77M8PK.
PhylomeDBiQ20893.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR010300. Cys_dOase_I.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF05995. CDO_I. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.

Sequencei

Sequence statusi: Complete.

Q20893-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISFVQLVVQ IREIFQQKLI DVDEVMKLMA SYKSNANEWR RFAIFDMNKY
60 70 80 90 100
TRNLVDVGNG KYNLMILCWG PGMASSVHDH TDAHCFVKIL DGELTETKYA
110 120 130 140 150
WPRKRHVPLD ISENKTYGMN GVSYMNDELG LHRMENLSHS NGAVSLHLYI
160 170 180 190
PPYSTCNAFD ERTGKKTQCT VTFYSKYGKK VDYRGSKNGN
Length:190
Mass (Da):21,879
Last modified:October 1, 2001 - v2
Checksum:i273A194DBFFA0C55
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081336 Genomic DNA. Translation: CCD70867.1.
PIRiT16488.
RefSeqiNP_508168.1. NM_075767.3.
UniGeneiCel.5612.

Genome annotation databases

EnsemblMetazoaiF56F10.3; F56F10.3; WBGene00018986.
GeneIDi180434.
KEGGicel:CELE_F56F10.3.
UCSCiF56F10.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081336 Genomic DNA. Translation: CCD70867.1.
PIRiT16488.
RefSeqiNP_508168.1. NM_075767.3.
UniGeneiCel.5612.

3D structure databases

ProteinModelPortaliQ20893.
SMRiQ20893. Positions 3-178.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F56F10.3.

Proteomic databases

PaxDbiQ20893.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF56F10.3; F56F10.3; WBGene00018986.
GeneIDi180434.
KEGGicel:CELE_F56F10.3.
UCSCiF56F10.3. c. elegans.

Organism-specific databases

CTDi180434.
WormBaseiF56F10.3; CE28465; WBGene00018986; cdo-1.

Phylogenomic databases

eggNOGiNOG126313.
GeneTreeiENSGT00390000018226.
HOGENOMiHOG000177818.
InParanoidiQ20893.
KOiK00456.
OMAiCFMKLLQ.
OrthoDBiEOG77M8PK.
PhylomeDBiQ20893.

Enzyme and pathway databases

UniPathwayiUPA00012; UER00537.
ReactomeiREACT_304058. Degradation of cysteine and homocysteine.

Miscellaneous databases

NextBioi909356.
PROiQ20893.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR010300. Cys_dOase_I.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF05995. CDO_I. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiCDO1_CAEEL
AccessioniPrimary (citable) accession number: Q20893
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: October 1, 2001
Last modified: April 1, 2015
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.