Reviewed, UniProtKB/Swiss-Prot Q20893 (CDO_CAEEL)

Names and origin

Protein names

Recommended name:
    Cysteine dioxygenase
      Short name=CDO
    EC=1.13.11.20

Gene names

ORF Names:

F56F10.3

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	190 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	L-cysteine + O(2) = 3-sulfinoalanine.
Cofactor	Binds 1 iron ion per subunit By similarity.
Pathway	Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2.
Post-translational modification	The thioether cross-link between Cys-85 and Tyr-149 plays a structural role through stabilizing the ferrous ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen By similarity.
Sequence similarities	Belongs to the cysteine dioxygenase family.

Ontologies

Keywords
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
PTM	Thioether bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-cysteine metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	cysteine dioxygenase activity Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 190	190	Cysteine dioxygenase		PRO_0000206612
Sites
	Metal binding	78	1	Iron; catalytic By similarity
	Metal binding	80	1	Iron; catalytic By similarity
	Metal binding	132	1	Iron; catalytic By similarity
Amino acid modifications
	Cross-link	85 ↔ 149		3'-(S-cysteinyl)-tyrosine (Cys-Tyr) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q20893-1 [UniParc]. Last modified October 1, 2001. Version 2. Checksum: 273A194DBFFA0C55	FASTA	190	21,879
	10 20 30 40 50 60 MISFVQLVVQ IREIFQQKLI DVDEVMKLMA SYKSNANEWR RFAIFDMNKY TRNLVDVGNG 70 80 90 100 110 120 KYNLMILCWG PGMASSVHDH TDAHCFVKIL DGELTETKYA WPRKRHVPLD ISENKTYGMN 130 140 150 160 170 180 GVSYMNDELG LHRMENLSHS NGAVSLHLYI PPYSTCNAFD ERTGKKTQCT VTFYSKYGKK 190 VDYRGSKNGN

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U51993 Genomic DNA. Translation: AAB36852.2.
PIR	T16488.
RefSeq	NP_508168.1.
UniGene	Cel.5612
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	F56F10.3. Caenorhabditis elegans. [Contig view]
GeneID	180434.
KEGG	cel:F56F10.3.
NMPDR	fig|6239.3.peg.22361.
Organism-specific databases
WormBase	WBGene00018986. F56F10.3.
WormPep	F56F10.3. CE28465. [WorfDB]
Gene expression databases
ArrayExpress	Q20893.
Family and domain databases
InterPro	IPR010300. Cys_dOase_I. [Graphical view]
Pfam	PF05995. CDO_I. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	909356.

Entry information

Entry name

CDO_CAEEL

Accession

Primary (citable) accession number: Q20893

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 16, 2004
Last sequence update:	October 1, 2001
Last modified:	November 25, 2008
This is version 51 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project