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Reviewed, UniProtKB/Swiss-Prot Q20893 (CDO_CAEEL)

Last modified November 25, 2008. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Cysteine dioxygenase
      Short name=CDO
    EC=1.13.11.20
Gene names
ORF Names: F56F10.3
OrganismCaenorhabditis elegans [Complete proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length190 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Catalytic activity

L-cysteine + O(2) = 3-sulfinoalanine.

Cofactor

Binds 1 iron ion per subunit By similarity.

Pathway

Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2.

Post-translational modification

The thioether cross-link between Cys-85 and Tyr-149 plays a structural role through stabilizing the ferrous ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen By similarity.

Sequence similarities

Belongs to the cysteine dioxygenase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 190190Cysteine dioxygenase
PRO_0000206612

Sites

Metal binding781Iron; catalytic By similarity
Metal binding801Iron; catalytic By similarity
Metal binding1321Iron; catalytic By similarity

Amino acid modifications

Cross-link85 ↔ 1493'-(S-cysteinyl)-tyrosine (Cys-Tyr) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q20893-1 [UniParc].

Last modified October 1, 2001. Version 2.
Checksum: 273A194DBFFA0C55

FASTA19021,879
        10         20         30         40         50         60 
MISFVQLVVQ IREIFQQKLI DVDEVMKLMA SYKSNANEWR RFAIFDMNKY TRNLVDVGNG 

        70         80         90        100        110        120 
KYNLMILCWG PGMASSVHDH TDAHCFVKIL DGELTETKYA WPRKRHVPLD ISENKTYGMN 

       130        140        150        160        170        180 
GVSYMNDELG LHRMENLSHS NGAVSLHLYI PPYSTCNAFD ERTGKKTQCT VTFYSKYGKK 

       190 
VDYRGSKNGN 

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References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.

Cross-references

Sequence databases

U51993 Genomic DNA. Translation: AAB36852.2.
PIRT16488.
RefSeqNP_508168.1.
UniGeneCel.5612

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblF56F10.3. Caenorhabditis elegans. [Contig view]
GeneID180434.
KEGGcel:F56F10.3.
NMPDRfig|6239.3.peg.22361.

Organism-specific databases

WormBaseWBGene00018986. F56F10.3.
WormPepF56F10.3. CE28465. [WorfDB]

Gene expression databases

ArrayExpressQ20893.

Family and domain databases

InterProIPR010300. Cys_dOase_I.
[Graphical view]
PfamPF05995. CDO_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio909356.

Entry information

Entry nameCDO_CAEEL
AccessionPrimary (citable) accession number: Q20893
Entry history
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: October 1, 2001
Last modified: November 25, 2008
This is version 51 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectCaenorhabditis annotation project

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents