Q20893 (CDO1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cysteine dioxygenase 1
Short name=CDO
EC=1.13.11.20

Gene names

Name:	cdo-1
ORF Names:	F56F10.3

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	190 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-cysteine + O2 = 3-sulfinoalanine.
Cofactor	Binds 1 iron ion per subunit By similarity.
Pathway	Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2.
Post-translational modification	The thioether cross-link between Cys-85 and Tyr-149 plays a structural role through stabilizing the Fe2+ ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen By similarity.
Sequence similarities	Belongs to the cysteine dioxygenase family.

Ontologies

Keywords
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
PTM	Thioether bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	L-cysteine metabolic process Inferred from electronic annotation. Source: InterPro taurine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	cysteine dioxygenase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 190	190	Cysteine dioxygenase 1		PRO_0000206612
Sites
	Metal binding	78	1	Iron; catalytic By similarity
	Metal binding	80	1	Iron; catalytic By similarity
	Metal binding	132	1	Iron; catalytic By similarity
Amino acid modifications
	Cross-link	85 ↔ 149		3'-(S-cysteinyl)-tyrosine (Cys-Tyr) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q20893 [UniParc]. Last modified October 1, 2001. Version 2. Checksum: 273A194DBFFA0C55	FASTA	190	21,879
	10 20 30 40 50 60 MISFVQLVVQ IREIFQQKLI DVDEVMKLMA SYKSNANEWR RFAIFDMNKY TRNLVDVGNG 70 80 90 100 110 120 KYNLMILCWG PGMASSVHDH TDAHCFVKIL DGELTETKYA WPRKRHVPLD ISENKTYGMN 130 140 150 160 170 180 GVSYMNDELG LHRMENLSHS NGAVSLHLYI PPYSTCNAFD ERTGKKTQCT VTFYSKYGKK 190 VDYRGSKNGN

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FO081336 Genomic DNA. Translation: CCD70867.1.
PIR	T16488.
RefSeq	NP_508168.1. NM_075767.3.
3D structure databases
ProteinModelPortal	Q20893.
SMR	Q20893. Positions 3-178.
ModBase	Search...
Protein-protein interaction databases
STRING	6239.F56F10.3.
Proteomic databases
PaxDb	Q20893.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	F56F10.3; F56F10.3; F56F10.3.
GeneID	180434.
KEGG	cel:CELE_F56F10.3.
UCSC	F56F10.3. c. elegans.
Organism-specific databases
CTD	180434.
WormBase	F56F10.3; CE28465; WBGene00018986; cdo-1.
Phylogenomic databases
eggNOG	NOG126313.
GeneTree	ENSGT00390000018226.
HOGENOM	HOG000177818.
InParanoid	Q20893.
KO	K00456.
OMA	KVAYIND.
Enzyme and pathway databases
UniPathway	UPA00012; UER00537.
Family and domain databases
Gene3D	2.60.120.10. 1 hit.
InterPro	IPR010300. Cys_dOase_I. IPR014710. RmlC-like_jellyroll. IPR011051. RmlC_Cupin. [Graphical view]
Pfam	PF05995. CDO_I. 1 hit. [Graphical view]
SUPFAM	SSF51182. RmlC_like_cupin. 1 hit.
ProtoNet	Search...
Other
NextBio	909356.

Entry information

Entry name

CDO1_CAEEL

Accession

Primary (citable) accession number: Q20893

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 16, 2004
Last sequence update:	October 1, 2001
Last modified:	May 1, 2013
This is version 86 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project