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Q20893

- CDO1_CAEEL

UniProt

Q20893 - CDO1_CAEEL

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Protein

Cysteine dioxygenase 1

Gene

cdo-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

L-cysteine + O2 = 3-sulfinoalanine.

Cofactori

Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi78 – 781Iron; catalyticBy similarity
Metal bindingi80 – 801Iron; catalyticBy similarity
Metal bindingi132 – 1321Iron; catalyticBy similarity

GO - Molecular functioni

  1. cysteine dioxygenase activity Source: UniProtKB-EC
  2. iron ion binding Source: InterPro

GO - Biological processi

  1. L-cysteine metabolic process Source: InterPro
  2. taurine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_197717. Degradation of cysteine and homocysteine.
UniPathwayiUPA00012; UER00537.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine dioxygenase 1 (EC:1.13.11.20)
Short name:
CDO
Gene namesi
Name:cdo-1
ORF Names:F56F10.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome X

Organism-specific databases

WormBaseiF56F10.3; CE28465; WBGene00018986; cdo-1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 190190Cysteine dioxygenase 1PRO_0000206612Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki85 ↔ 1493'-(S-cysteinyl)-tyrosine (Cys-Tyr)By similarity

Post-translational modificationi

The thioether cross-link between Cys-85 and Tyr-149 plays a structural role through stabilizing the Fe2+ ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen.By similarity

Keywords - PTMi

Thioether bond

Proteomic databases

PaxDbiQ20893.

Interactioni

Protein-protein interaction databases

STRINGi6239.F56F10.3.

Structurei

3D structure databases

ProteinModelPortaliQ20893.
SMRiQ20893. Positions 3-178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cysteine dioxygenase family.Curated

Phylogenomic databases

eggNOGiNOG126313.
GeneTreeiENSGT00390000018226.
HOGENOMiHOG000177818.
InParanoidiQ20893.
KOiK00456.
OMAiKMTFWSK.
OrthoDBiEOG77M8PK.
PhylomeDBiQ20893.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR010300. Cys_dOase_I.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF05995. CDO_I. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.

Sequencei

Sequence statusi: Complete.

Q20893-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MISFVQLVVQ IREIFQQKLI DVDEVMKLMA SYKSNANEWR RFAIFDMNKY
60 70 80 90 100
TRNLVDVGNG KYNLMILCWG PGMASSVHDH TDAHCFVKIL DGELTETKYA
110 120 130 140 150
WPRKRHVPLD ISENKTYGMN GVSYMNDELG LHRMENLSHS NGAVSLHLYI
160 170 180 190
PPYSTCNAFD ERTGKKTQCT VTFYSKYGKK VDYRGSKNGN
Length:190
Mass (Da):21,879
Last modified:October 1, 2001 - v2
Checksum:i273A194DBFFA0C55
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081336 Genomic DNA. Translation: CCD70867.1.
PIRiT16488.
RefSeqiNP_508168.1. NM_075767.3.
UniGeneiCel.5612.

Genome annotation databases

EnsemblMetazoaiF56F10.3; F56F10.3; WBGene00018986.
GeneIDi180434.
KEGGicel:CELE_F56F10.3.
UCSCiF56F10.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081336 Genomic DNA. Translation: CCD70867.1 .
PIRi T16488.
RefSeqi NP_508168.1. NM_075767.3.
UniGenei Cel.5612.

3D structure databases

ProteinModelPortali Q20893.
SMRi Q20893. Positions 3-178.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.F56F10.3.

Proteomic databases

PaxDbi Q20893.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F56F10.3 ; F56F10.3 ; WBGene00018986 .
GeneIDi 180434.
KEGGi cel:CELE_F56F10.3.
UCSCi F56F10.3. c. elegans.

Organism-specific databases

CTDi 180434.
WormBasei F56F10.3 ; CE28465 ; WBGene00018986 ; cdo-1.

Phylogenomic databases

eggNOGi NOG126313.
GeneTreei ENSGT00390000018226.
HOGENOMi HOG000177818.
InParanoidi Q20893.
KOi K00456.
OMAi KMTFWSK.
OrthoDBi EOG77M8PK.
PhylomeDBi Q20893.

Enzyme and pathway databases

UniPathwayi UPA00012 ; UER00537 .
Reactomei REACT_197717. Degradation of cysteine and homocysteine.

Miscellaneous databases

NextBioi 909356.
PROi Q20893.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
InterProi IPR010300. Cys_dOase_I.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
Pfami PF05995. CDO_I. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiCDO1_CAEEL
AccessioniPrimary (citable) accession number: Q20893
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: October 1, 2001
Last modified: November 26, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3