Q20893 (CDO1_CAEEL) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 75.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Cysteine dioxygenase 1 Short name=CDO EC=1.13.11.20 | ||||
| Gene names |
| ||||
| Organism | Caenorhabditis elegans | ||||
| Taxonomic identifier | 6239 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Protein attributes
| Sequence length | 190 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Catalytic activity | L-cysteine + O2 = 3-sulfinoalanine. |
| Cofactor | Binds 1 iron ion per subunit By similarity. |
| Pathway | Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2. |
| Post-translational modification | The thioether cross-link between Cys-85 and Tyr-149 plays a structural role through stabilizing the Fe2+ ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen By similarity. |
| Sequence similarities | Belongs to the cysteine dioxygenase family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Iron Metal-binding |
| Molecular function | Dioxygenase Oxidoreductase |
| PTM | Thioether bond |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | L-cysteine metabolic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | cysteine dioxygenase activity Inferred from electronic annotation. Source: EC iron ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 190 | 190 | Cysteine dioxygenase 1 | PRO_0000206612 | |||||||
Sites | |||||||||||
| Metal binding | 78 | 1 | Iron; catalytic By similarity | ||||||||
| Metal binding | 80 | 1 | Iron; catalytic By similarity | ||||||||
| Metal binding | 132 | 1 | Iron; catalytic By similarity | ||||||||
Amino acid modifications | |||||||||||
| Cross-link | 85 ↔ 149 | 3'-(S-cysteinyl)-tyrosine (Cys-Tyr) By similarity | |||||||||
Sequences
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References
| [1] | "Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | FO081336 Genomic DNA. Translation: CCD70867.1. |
| PIR | T16488. |
| RefSeq | NP_508168.1. NM_075767.2. |
| UniGene | Cel.5612. |
3D structure databases | |
| ProteinModelPortal | Q20893. |
| SMR | Q20893. Positions 2-182. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q20893. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblMetazoa | F56F10.3; F56F10.3; F56F10.3. |
| GeneID | 180434. |
| KEGG | cel:F56F10.3. |
| NMPDR | fig|6239.3.peg.22361. |
| UCSC | F56F10.3. c. elegans. |
Organism-specific databases | |
| CTD | 180434. |
| WormBase | F56F10.3; CE28465; WBGene00018986; cdo-1. |
Phylogenomic databases | |
| eggNOG | meNOG11466. |
| GeneTree | EMGT00050000016834. |
| HOGENOM | HBG380588. |
| InParanoid | Q20893. |
| OMA | NDELGLH. |
| PhylomeDB | Q20893. |
Gene expression databases | |
| ArrayExpress | Q20893. |
Family and domain databases | |
| InterPro | IPR011051. Cupin_RmlC_type. IPR010300. Cys_dOase_I. IPR014710. RmlC-like_jellyroll. [Graphical view] |
| Gene3D | G3DSA:2.60.120.10. RmlC-like_jellyroll. 1 hit. |
| KO | K00456. |
| Pfam | PF05995. CDO_I. 1 hit. [Graphical view] |
| SUPFAM | SSF51182. RmlC_like_cupin. 1 hit. |
| ProtoNet | Search... |
Other | |
| NextBio | 909356. |
Entry information
| Entry name | CDO1_CAEEL | ||||||||
| Accession | Primary (citable) accession number: Q20893 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Caenorhabditis annotation project | ||||||||
Relevant documents
| Caenorhabditis elegans Caenorhabditis elegans: entries, gene names and cross-references to WormPep |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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