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Protein

Pre-mRNA-splicing factor ATP-dependent RNA helicase ddx-15

Gene

ddx-15

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi99 – 106ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase
Biological processmRNA processing, mRNA splicing
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-splicing factor ATP-dependent RNA helicase ddx-15By similarity (EC:3.6.4.13By similarity)
Alternative name(s):
DEAH box protein 15By similarity
Gene namesi
Name:ddx-15Imported
ORF Names:F56D2.6Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF56D2.6a; CE01334; WBGene00018967; ddx-15.

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000551421 – 739Pre-mRNA-splicing factor ATP-dependent RNA helicase ddx-15CuratedAdd BLAST739

Proteomic databases

EPDiQ20875.
PaxDbiQ20875.
PeptideAtlasiQ20875.
PRIDEiQ20875.

PTM databases

iPTMnetiQ20875.

Expressioni

Gene expression databases

BgeeiWBGene00018967.
ExpressionAtlasiQ20875. baseline.

Interactioni

Protein-protein interaction databases

STRINGi6239.F56D2.6a.1.

Structurei

3D structure databases

ProteinModelPortaliQ20875.
SMRiQ20875.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 257Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST172
Domaini282 – 462Helicase C-terminalPROSITE-ProRule annotationAdd BLAST181

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi204 – 207DEAH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi119 – 124Poly-Gln6

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0925. Eukaryota.
COG1643. LUCA.
GeneTreeiENSGT00880000137867.
HOGENOMiHOG000175261.
InParanoidiQ20875.
KOiK12820.
OMAiQWCVDFA.
OrthoDBiEOG091G030Q.
PhylomeDBiQ20875.

Family and domain databases

InterProiView protein in InterPro
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00270. DEAD. 1 hit.
PF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.

Sequencei

Sequence statusi: Complete.

Q20875-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRHRLDLD GSGRGDRRRS PNRRSRSRSR SPHRRSSPDR KRQIGAVGNM
60 70 80 90 100
KIQINPYNNQ PFSNRYWAIW EKRSQLPVWE YKEKFMELLR NNQCITLVGE
110 120 130 140 150
TGSGKTTQIP QWAVEFMKQQ QQGQPPGQAR LVACTQPRRV AAMSVATRVA
160 170 180 190 200
EEMDVVLGQE VGYSIRFEDC ISERTVLKYC TDGMLLREAM NSPLLDKYKV
210 220 230 240 250
LILDEAHERT LATDILMGLI KEIVRNRADI KVVIMSATLD AGKFQRYFED
260 270 280 290 300
CPLLSVPGRT FPVEIFFTPN AEKDYLEAAI RTVIQIHMVE EVEGDILLFL
310 320 330 340 350
TGQEEIEEAC KRIDREIQAL GADAGALSCI PLYSTLPPAA QQRIFEPAPP
360 370 380 390 400
NRPNGAISRK CVISTNIAET SLTIDGVVFV IDPGFSKQKV YNPRIRVESL
410 420 430 440 450
LVCPISKASA MQRAGRAGRT KPGKCFRLYT ETAYGSEMQD QTYPEILRSN
460 470 480 490 500
LGSVVLQLKK LGTEDLVHFD FMDPPAPETL MRALELLNYL QAINDDGELT
510 520 530 540 550
ELGSLMAEFP LDPQLAKMLI TSTELNCSNE ILSITAMLSV PQCWVRPNEM
560 570 580 590 600
RTEADEAKAR FAHIDGDHLT LLNVYHSFKQ NQEDPQWCYD NFINYRTMKT
610 620 630 640 650
ADTVRTQLSR VMDKYNLRRV STDFKSRDYY LNIRKALVAG FFMQVAHLER
660 670 680 690 700
SGHYVTVKDN QLVNLHPSTV LDHKPEWALY NEFVLTTKNF IRTVTDVRPE
710 720 730
WLLQIAPQYY DLDNFPDGDT KRKLTTVMQT LQRNAGRGY
Length:739
Mass (Da):84,389
Last modified:November 1, 1996 - v1
Checksum:iA8E9FBDCFE22F40F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080358 Genomic DNA. Translation: CCD63138.1.
PIRiT16482.
RefSeqiNP_741147.1. NM_171130.4.
UniGeneiCel.5656.

Genome annotation databases

EnsemblMetazoaiF56D2.6a; F56D2.6a; WBGene00018967.
GeneIDi175771.
KEGGicel:CELE_F56D2.6.
UCSCiF56D2.6a. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiDHX15_CAEEL
AccessioniPrimary (citable) accession number: Q20875
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: July 5, 2017
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families