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Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

dot-1.4

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
Histone H3-K79 methyltransferaseUniRule annotation
Gene namesi
Name:dot-1.4Imported
ORF Names:CELE_F55G7.2Imported, F55G7.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome X

Organism-specific databases

WormBaseiF55G7.2; CE03424; WBGene00010120; dot-1.4.

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

Proteomic databases

PRIDEiQ20856.

Interactioni

Protein-protein interaction databases

STRINGi6239.F55G7.2.

Structurei

3D structure databases

ProteinModelPortaliQ20856.
SMRiQ20856. Positions 138-357.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation
Contains 1 DOT1 domain.UniRule annotation

Phylogenomic databases

eggNOGiNOG294902.
GeneTreeiENSGT00390000013515.
HOGENOMiHOG000017265.
InParanoidiQ20856.
KOiK11427.
OMAiPFREAAT.
OrthoDBiEOG7W6WJV.
PhylomeDBiQ20856.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR025789. DOT1_dom.
IPR013110. DOT1_dom_Pfam.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q20856-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLFQIQNHE ENNVDKIESK MLEDETDLLH ETLSTVFPNG KSIKFDSHKH
60 70 80 90 100
HVPVILLNML KELFEPVLNQ LSIELIAANG KTTNTDNVLA ELAKFNEAVA
110 120 130 140 150
LFRRDNPKKQ LLLPKHWDQS TCTQQVAQKI TEIAKDLSVP YPKKLNQHYK
160 170 180 190 200
GFSSETYGET MLEQIGSIVD ELKLNSSDVF VDLGSGIGQL VCFVAAYSKV
210 220 230 240 250
KKAVGIELSS VPAEYAVSQG MYFKNLMTFF DKQHGEIELI QGDFLHPQFH
260 270 280 290 300
DLICKEATVI FINNYAFEDD LTRRIVFELL QNCADGTRIV SAKPLSLPRS
310 320 330 340 350
VASRRHAMSD FGSMSNSRTL RATESNVSWT SNIVEFTLTT VDHLKLFKSF
360 370 380
EMQKESKKSA NSKVKKVGKD FTKTSLKNKK ESK
Length:383
Mass (Da):43,332
Last modified:November 1, 1996 - v1
Checksum:i17B5C1A61BFC1252
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50741 Genomic DNA. Translation: CAA90610.1.
PIRiT22752.
RefSeqiNP_509997.1. NM_077596.1.
UniGeneiCel.856.

Genome annotation databases

EnsemblMetazoaiF55G7.2; F55G7.2; WBGene00010120.
GeneIDi186332.
KEGGicel:CELE_F55G7.2.
UCSCiF55G7.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50741 Genomic DNA. Translation: CAA90610.1.
PIRiT22752.
RefSeqiNP_509997.1. NM_077596.1.
UniGeneiCel.856.

3D structure databases

ProteinModelPortaliQ20856.
SMRiQ20856. Positions 138-357.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F55G7.2.

Proteomic databases

PRIDEiQ20856.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF55G7.2; F55G7.2; WBGene00010120.
GeneIDi186332.
KEGGicel:CELE_F55G7.2.
UCSCiF55G7.2. c. elegans.

Organism-specific databases

CTDi186332.
WormBaseiF55G7.2; CE03424; WBGene00010120; dot-1.4.

Phylogenomic databases

eggNOGiNOG294902.
GeneTreeiENSGT00390000013515.
HOGENOMiHOG000017265.
InParanoidiQ20856.
KOiK11427.
OMAiPFREAAT.
OrthoDBiEOG7W6WJV.
PhylomeDBiQ20856.

Miscellaneous databases

NextBioi931462.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR025789. DOT1_dom.
IPR013110. DOT1_dom_Pfam.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ20856_CAEEL
AccessioniPrimary (citable) accession number: Q20856
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: January 7, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.