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Q20856 (Q20856_CAEEL) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specific RuleBase RU271113

EC=2.1.1.43 RuleBase RU271113
Alternative name(s):
Histone H3-K79 methyltransferase RuleBase RU271113
Gene names
Name:dot-1.4 EMBL CAA90610.1 WormBase F55G7.2
ORF Names:CELE_F55G7.2 EMBL CAA90610.1, F55G7.2 WormBase F55G7.2
OrganismCaenorhabditis elegans [Reference proteome] EMBL CAA90610.1
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length383 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. RuleBase RU271113

Subcellular location

Nucleus By similarity RuleBase RU271113.

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones By similarity. RuleBase RU271113

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family. RuleBase RU271113

Contains 1 DOT1 domain. RuleBase RU271113

Ontologies

Sequences

Sequence LengthMass (Da)Tools
Q20856 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 17B5C1A61BFC1252

FASTA38343,332
        10         20         30         40         50         60 
MDLFQIQNHE ENNVDKIESK MLEDETDLLH ETLSTVFPNG KSIKFDSHKH HVPVILLNML 

        70         80         90        100        110        120 
KELFEPVLNQ LSIELIAANG KTTNTDNVLA ELAKFNEAVA LFRRDNPKKQ LLLPKHWDQS 

       130        140        150        160        170        180 
TCTQQVAQKI TEIAKDLSVP YPKKLNQHYK GFSSETYGET MLEQIGSIVD ELKLNSSDVF 

       190        200        210        220        230        240 
VDLGSGIGQL VCFVAAYSKV KKAVGIELSS VPAEYAVSQG MYFKNLMTFF DKQHGEIELI 

       250        260        270        280        290        300 
QGDFLHPQFH DLICKEATVI FINNYAFEDD LTRRIVFELL QNCADGTRIV SAKPLSLPRS 

       310        320        330        340        350        360 
VASRRHAMSD FGSMSNSRTL RATESNVSWT SNIVEFTLTT VDHLKLFKSF EMQKESKKSA 

       370        380 
NSKVKKVGKD FTKTSLKNKK ESK 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z50741 Genomic DNA. Translation: CAA90610.1.
PIRT22752.
RefSeqNP_509997.1. NM_077596.1.
UniGeneCel.856.

3D structure databases

ProteinModelPortalQ20856.
SMRQ20856. Positions 138-357.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6239.F55G7.2.

Proteomic databases

PRIDEQ20856.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaF55G7.2; F55G7.2; WBGene00010120.
GeneID186332.
KEGGcel:CELE_F55G7.2.
UCSCF55G7.2. c. elegans.

Organism-specific databases

CTD186332.
WormBaseF55G7.2; CE03424; WBGene00010120; dot-1.4.

Phylogenomic databases

eggNOGNOG294902.
GeneTreeENSGT00390000013515.
HOGENOMHOG000017265.
InParanoidQ20856.
KOK11427.
OMAWSITATK.
OrthoDBEOG7W6WJV.
PhylomeDBQ20856.

Family and domain databases

Gene3D3.40.50.150. 1 hit.
InterProIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamPF08123. DOT1. 1 hit.
[Graphical view]
SUPFAMSSF53335. SSF53335. 1 hit.
PROSITEPS51569. DOT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio931462.

Entry information

Entry nameQ20856_CAEEL
AccessionPrimary (citable) accession number: Q20856
Entry history
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)