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Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

dot-1.4

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotation, MethyltransferaseUniRule annotationImported, Transferase
LigandS-adenosyl-L-methionineUniRule annotation

Enzyme and pathway databases

ReactomeiR-CEL-3214841 PKMTs methylate histone lysines

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
Histone H3-K79 methyltransferaseUniRule annotation
Gene namesi
Name:dot-1.4Imported
ORF Names:CELE_F55G7.2Imported, F55G7.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF55G7.2 ; CE03424 ; WBGene00010120 ; dot-1.4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

Proteomic databases

EPDiQ20856
PaxDbiQ20856

Expressioni

Gene expression databases

BgeeiWBGene00010120

Interactioni

Protein-protein interaction databases

STRINGi6239.F55G7.2

Structurei

3D structure databases

ProteinModelPortaliQ20856
SMRiQ20856
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 354DOT1InterPro annotationAdd BLAST326

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3924 Eukaryota
ENOG410XSYC LUCA
GeneTreeiENSGT00390000013515
HOGENOMiHOG000017265
InParanoidiQ20856
KOiK11427
OMAiIDTIRWV
OrthoDBiEOG091G00FV
PhylomeDBiQ20856

Family and domain databases

InterProiView protein in InterPro
IPR025789 DOT1_dom
IPR030445 H3-K79_meTrfase
IPR029063 SAM-dependent_MTases
PANTHERiPTHR21451 PTHR21451, 1 hit
PfamiView protein in Pfam
PF08123 DOT1, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51569 DOT1, 1 hit

Sequencei

Sequence statusi: Complete.

Q20856-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLFQIQNHE ENNVDKIESK MLEDETDLLH ETLSTVFPNG KSIKFDSHKH
60 70 80 90 100
HVPVILLNML KELFEPVLNQ LSIELIAANG KTTNTDNVLA ELAKFNEAVA
110 120 130 140 150
LFRRDNPKKQ LLLPKHWDQS TCTQQVAQKI TEIAKDLSVP YPKKLNQHYK
160 170 180 190 200
GFSSETYGET MLEQIGSIVD ELKLNSSDVF VDLGSGIGQL VCFVAAYSKV
210 220 230 240 250
KKAVGIELSS VPAEYAVSQG MYFKNLMTFF DKQHGEIELI QGDFLHPQFH
260 270 280 290 300
DLICKEATVI FINNYAFEDD LTRRIVFELL QNCADGTRIV SAKPLSLPRS
310 320 330 340 350
VASRRHAMSD FGSMSNSRTL RATESNVSWT SNIVEFTLTT VDHLKLFKSF
360 370 380
EMQKESKKSA NSKVKKVGKD FTKTSLKNKK ESK
Length:383
Mass (Da):43,332
Last modified:November 1, 1996 - v1
Checksum:i17B5C1A61BFC1252
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA Translation: CAA90610.1
PIRiT22752
RefSeqiNP_509997.1, NM_077596.1
UniGeneiCel.856

Genome annotation databases

EnsemblMetazoaiF55G7.2; F55G7.2; WBGene00010120
GeneIDi186332
KEGGicel:CELE_F55G7.2
UCSCiF55G7.2 c. elegans

Entry informationi

Entry nameiQ20856_CAEEL
AccessioniPrimary (citable) accession number: Q20856
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: February 28, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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