Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q20856

- Q20856_CAEEL

UniProt

Q20856 - Q20856_CAEEL

Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

dot-1.4

Organism
Caenorhabditis elegans
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

    GO - Molecular functioni

    1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionineUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
    Alternative name(s):
    Histone H3-K79 methyltransferaseUniRule annotation
    Gene namesi
    Name:dot-1.4Imported
    ORF Names:CELE_F55G7.2Imported, F55G7.2Imported
    OrganismiCaenorhabditis elegansImported
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome X

    Organism-specific databases

    WormBaseiF55G7.2; CE03424; WBGene00010120; dot-1.4.

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    NucleusUniRule annotation

    PTM / Processingi

    Proteomic databases

    PRIDEiQ20856.

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.F55G7.2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ20856.
    SMRiQ20856. Positions 138-357.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation
    Contains 1 DOT1 domain.UniRule annotation

    Phylogenomic databases

    eggNOGiNOG294902.
    GeneTreeiENSGT00390000013515.
    HOGENOMiHOG000017265.
    InParanoidiQ20856.
    KOiK11427.
    OMAiWSITATK.
    OrthoDBiEOG7W6WJV.
    PhylomeDBiQ20856.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF08123. DOT1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51569. DOT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q20856-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLFQIQNHE ENNVDKIESK MLEDETDLLH ETLSTVFPNG KSIKFDSHKH    50
    HVPVILLNML KELFEPVLNQ LSIELIAANG KTTNTDNVLA ELAKFNEAVA 100
    LFRRDNPKKQ LLLPKHWDQS TCTQQVAQKI TEIAKDLSVP YPKKLNQHYK 150
    GFSSETYGET MLEQIGSIVD ELKLNSSDVF VDLGSGIGQL VCFVAAYSKV 200
    KKAVGIELSS VPAEYAVSQG MYFKNLMTFF DKQHGEIELI QGDFLHPQFH 250
    DLICKEATVI FINNYAFEDD LTRRIVFELL QNCADGTRIV SAKPLSLPRS 300
    VASRRHAMSD FGSMSNSRTL RATESNVSWT SNIVEFTLTT VDHLKLFKSF 350
    EMQKESKKSA NSKVKKVGKD FTKTSLKNKK ESK 383
    Length:383
    Mass (Da):43,332
    Last modified:November 1, 1996 - v1
    Checksum:i17B5C1A61BFC1252
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z50741 Genomic DNA. Translation: CAA90610.1.
    PIRiT22752.
    RefSeqiNP_509997.1. NM_077596.1.
    UniGeneiCel.856.

    Genome annotation databases

    EnsemblMetazoaiF55G7.2; F55G7.2; WBGene00010120.
    GeneIDi186332.
    KEGGicel:CELE_F55G7.2.
    UCSCiF55G7.2. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z50741 Genomic DNA. Translation: CAA90610.1 .
    PIRi T22752.
    RefSeqi NP_509997.1. NM_077596.1.
    UniGenei Cel.856.

    3D structure databases

    ProteinModelPortali Q20856.
    SMRi Q20856. Positions 138-357.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.F55G7.2.

    Proteomic databases

    PRIDEi Q20856.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai F55G7.2 ; F55G7.2 ; WBGene00010120 .
    GeneIDi 186332.
    KEGGi cel:CELE_F55G7.2.
    UCSCi F55G7.2. c. elegans.

    Organism-specific databases

    CTDi 186332.
    WormBasei F55G7.2 ; CE03424 ; WBGene00010120 ; dot-1.4.

    Phylogenomic databases

    eggNOGi NOG294902.
    GeneTreei ENSGT00390000013515.
    HOGENOMi HOG000017265.
    InParanoidi Q20856.
    KOi K11427.
    OMAi WSITATK.
    OrthoDBi EOG7W6WJV.
    PhylomeDBi Q20856.

    Miscellaneous databases

    NextBioi 931462.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF08123. DOT1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51569. DOT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2Imported.

    Entry informationi

    Entry nameiQ20856_CAEEL
    AccessioniPrimary (citable) accession number: Q20856
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1996
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Miscellaneous

    In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3