Q20848 (P5CR_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative pyrroline-5-carboxylate reductase
Short name=P5C reductase
Short name=P5CR
EC=1.5.1.2

Gene names

ORF Names:

F55G1.9

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	299 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.
Sequence similarities	Belongs to the pyrroline-5-carboxylate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	proline biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	nucleotide binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro pyrroline-5-carboxylate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 299	299	Putative pyrroline-5-carboxylate reductase		PRO_0000187321

Sequences

	Sequence		Length	Mass (Da)
	Q20848 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 75D2D6D32E0A5670	FASTA	299	32,057
	10 20 30 40 50 60 MTIDTELTNG SSESVPFVFI GGGNMAAAII KGCQNKGFTP KSNIVIGVQT EKSAEKWRQL 70 80 90 100 110 120 GYKNVFTNTL EMLERYSTAI YVICVKPQVF EEVVSSWPVN SRPEFIISVM AGVPLKVLNA 130 140 150 160 170 180 KLPFVSGNTT IVRLMPNVAS SIGAGASTMC YEKNEKIMNQ DSHIELAREF AECVGTVELI 190 200 210 220 230 240 PERCFNPAMA IGGSSPAWTF MYIESLADGA VAQGLGRAEA KRLAAQAVLG AAQMVLNSNS 250 260 270 280 290 GFDIETQHFG SLKDMVCSPG GTTIEGVRAL EKNGFRYAVM EAVVAASTKA DEMAKSLAK

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FO081135 Genomic DNA. Translation: CCD69396.1.
PIR	T29226.
RefSeq	NP_501199.1. NM_068798.4.
UniGene	Cel.12859.
3D structure databases
ProteinModelPortal	Q20848.
SMR	Q20848. Positions 13-294.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q20848. 2 interactions.
STRING	Q20848.
Proteomic databases
PRIDE	Q20848.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	F55G1.9; F55G1.9; F55G1.9.
GeneID	177519.
KEGG	cel:F55G1.9.
NMPDR	fig|6239.3.peg.13938.
UCSC	F55G1.9. c. elegans.
Organism-specific databases
CTD	177519.
WormBase	F55G1.9; CE07286; WBGene00018904.
Phylogenomic databases
eggNOG	KOG3124.
GeneTree	EMGT00050000016432.
HOGENOM	HBG726602.
InParanoid	Q20848.
OMA	LATAKEC.
PhylomeDB	Q20848.
Gene expression databases
ArrayExpress	Q20848.
Family and domain databases
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR016040. NAD(P)-bd_dom. IPR004455. NADP_OxRdtase_F420. IPR000304. Pyrroline-COOH_reductase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00286.
PANTHER	PTHR11645. P5CR. 1 hit.
Pfam	PF03807. F420_oxidored. 1 hit. [Graphical view]
PIRSF	PIRSF000193. Pyrrol-5-carb_rd. 1 hit.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMs	TIGR00112. ProC. 1 hit.
PROSITE	PS00521. P5CR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	897180.

Entry information

Entry name

P5CR_CAEEL

Accession

Primary (citable) accession number: Q20848

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	December 14, 2011
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project