Reviewed, UniProtKB/Swiss-Prot Q20848 (P5CR_CAEEL)

Names and origin

Protein names

Recommended name:
    Putative pyrroline-5-carboxylate reductase
      Short name=P5C reductase
      Short name=P5CR
    EC=1.5.1.2

Gene names

ORF Names:

F55G1.9

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	299 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.
Sequence similarities	Belongs to the pyrroline-5-carboxylate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro pyrroline-5-carboxylate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 299	299	Putative pyrroline-5-carboxylate reductase		PRO_0000187321

Sequences

	Sequence		Length	Mass (Da)
	Q20848-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 75D2D6D32E0A5670	FASTA	299	32,057
	10 20 30 40 50 60 MTIDTELTNG SSESVPFVFI GGGNMAAAII KGCQNKGFTP KSNIVIGVQT EKSAEKWRQL 70 80 90 100 110 120 GYKNVFTNTL EMLERYSTAI YVICVKPQVF EEVVSSWPVN SRPEFIISVM AGVPLKVLNA 130 140 150 160 170 180 KLPFVSGNTT IVRLMPNVAS SIGAGASTMC YEKNEKIMNQ DSHIELAREF AECVGTVELI 190 200 210 220 230 240 PERCFNPAMA IGGSSPAWTF MYIESLADGA VAQGLGRAEA KRLAAQAVLG AAQMVLNSNS 250 260 270 280 290 GFDIETQHFG SLKDMVCSPG GTTIEGVRAL EKNGFRYAVM EAVVAASTKA DEMAKSLAK

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U58750 Genomic DNA. Translation: AAB00645.1.
PIR	T29226.
RefSeq	NP_501199.1.
UniGene	Cel.12859
3D structure databases
SMR	Q20848. Positions 14-298.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q20848. 2 interactions.
STRING	Q20848.
Genome annotation databases
Ensembl	F55G1.9; F55G1.9; F55G1.9; Caenorhabditis elegans. [Genome view]
GeneID	177519.
KEGG	cel:F55G1.9.
NMPDR	fig|6239.3.peg.13938.
UCSC	F55G1.9. c. elegans.
Organism-specific databases
CTD	177519.
WormBase	WBGene00018904. F55G1.9.
WormPep	F55G1.9. CE07286. [WorfDB]
Phylogenomic databases
eggNOG	KOG3124.
HOGENOM	HBG726602.
InParanoid	Q20848.
OMA	IVRLMPN.
PhylomeDB	Q20848.
Enzyme and pathway databases
BRENDA	1.5.1.2. 672.
Gene expression databases
ArrayExpress	Q20848.
Family and domain databases
InterPro	IPR016040. NAD(P)-bd_dom. IPR004455. NADP_OxRdtase_F420. IPR000304. P5CR. [Graphical view]
PANTHER	PTHR11645. P5CR. 1 hit.
Pfam	PF03807. F420_oxidored. 1 hit. [Graphical view]
PIRSF	PIRSF000193. Pyrrol-5-carb_rd. 1 hit.
TIGRFAMs	TIGR00112. proC. 1 hit.
PROSITE	PS00521. P5CR. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	897180.

Entry information

Entry name

P5CR_CAEEL

Accession

Primary (citable) accession number: Q20848

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	February 9, 2010
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project