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Q207Z6

- Q207Z6_9INFA

UniProt

Q207Z6 - Q207Z6_9INFA

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Protein
Submitted name: Hemagglutinin
Gene
HA
Organism
Influenza A virus (A/turkey/Turkey/1/2005(H5N1))
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore By similarity.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei104 – 1041Phosphate 1Imported
Binding sitei118 – 1181Phosphate 2; via carbonyl oxygen
Binding sitei178 – 1781Phosphate 3
Binding sitei226 – 2261Phosphate 6; via carbonyl oxygen
Binding sitei238 – 2381Phosphate 5Imported
Binding sitei243 – 2431Phosphate 6
Binding sitei475 – 4751Phosphate 8Imported

GO - Biological processi

  1. clathrin-mediated endocytosis of virus by host cell Source: UniProtKB-KW
  2. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  3. fusion of virus membrane with host plasma membrane Source: InterPro
  4. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

HemagglutininUniRule annotationSAAS annotations

Keywords - Biological processi

Clathrin- and caveolin-independent endocytosis of virus by hostSAAS annotations, Clathrin-mediated endocytosis of virus by hostSAAS annotations, Fusion of virus membrane with host endosomal membraneSAAS annotations, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cellSAAS annotations, Viral penetration into host cytoplasm, Virus endocytosis by host, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Submitted name:
HemagglutininImported
Gene namesi
Name:HAImported
OrganismiInfluenza A virus (A/turkey/Turkey/1/2005(H5N1))Imported
Taxonomic identifieri375457 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A

Subcellular locationi

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. viral envelope Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membraneSAAS annotations, Host membrane, Membrane, Viral envelope proteinUniRule annotationSAAS annotations, Virion

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi39 – 391N-linked (GlcNAc...)Imported
Glycosylationi181 – 1811N-linked (GlcNAc...)Imported

Keywords - PTMi

Disulfide bondSAAS annotations

Interactioni

Subunit structurei

Homotrimer of disulfide-linked HA1-HA2 By similarity.UniRule annotationSAAS annotations

Protein-protein interaction databases

DIPiDIP-60225N.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BGZX-ray2.68A/C/E17-338[»]
B/D/F347-512[»]
4BH0X-ray2.36A/C/E17-338[»]
B/D/F347-512[»]
4BH1X-ray2.15A/C/E17-338[»]
B/D/F347-512[»]
4CQVX-ray2.86A/C/E17-346[»]
B/D/F347-512[»]
4CQWX-ray2.30A/C/E17-346[»]
B/D/F347-512[»]
4CQXX-ray2.30A/C/E17-346[»]
B/D/F347-512[»]
4CQYX-ray2.05A/C/E17-346[»]
B/D/F347-512[»]

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni137 – 1415Phosphate 3 bindingImported
Regioni137 – 1415Phosphate 4 binding
Regioni148 – 1492Phosphate 5 bindingImported
Regioni237 – 2382Galactose binding
Regioni413 – 4153Phosphate 7 binding

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Family and domain databases

Gene3Di2.10.77.10. 1 hit.
3.90.20.10. 1 hit.
3.90.209.20. 1 hit.
InterProiIPR008980. Capsid_hemagglutn.
IPR013828. Hemagglutn_HA1_a/b_dom.
IPR013827. Hemagglutn_HA1_b-rbn_dom.
IPR000149. Hemagglutn_influenz_A.
IPR001364. Hemagglutn_influenz_A/B.
IPR013829. Hemagglutn_stalk.
[Graphical view]
PfamiPF00509. Hemagglutinin. 1 hit.
[Graphical view]
PRINTSiPR00330. HEMAGGLUTN1.
PR00329. HEMAGGLUTN12.
SUPFAMiSSF49818. SSF49818. 1 hit.

Sequencei

Sequence statusi: Complete.

Q207Z6-1 [UniParc]FASTAAdd to Basket

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MEKIVLLLAI VSLVKSDQIC IGYHANNSTE QVDTIMEKNV TVTHAQDILE    50
KTHNGKLCDL DGVKPLILRD CSVAGWLLGN PMCDEFLNVP EWSYIVEKIN 100
PANDLCYPGN FNDYEELKHL LSRINHFEKI QIIPKSSWSD HEASAGVSSA 150
CPYQGRSSFF RNVVWLIKKD NAYPTIKRSY NNTNQEDLLV LWGIHHPNDA 200
AEQTRLYQNP TTYISVGTST LNQRLVPKIA TRSKVNGQSG RMEFFWTILK 250
PNDAINFESN GNFIAPENAY KIVKKGDSTI MKSELEYGNC NTKCQTPIGA 300
INSSMPFHNI HPLTIGECPK YVKSSRLVLA TGLRNSPQGE RRRKKRGLFG 350
AIAGFIEGGW QGMVDGWYGY HHSNEQGSGY AADKESTQKA IDGVTNKVNS 400
IIDKMNTQFE AVGREFNNLE RRIENLNKKM EDGFLDVWTY NAELLVLMEN 450
ERTLDFHDSN VKNLYDKVRL QLRDNAKELG NGCFEFYHRC DNECMESVRN 500
GTYDYPQYSE EARLKREEIS GVKLESIGTY QILSIYSTVA SSLALAIMVA 550
GLSLWMCSNG SLQCRICI 568
Length:568
Mass (Da):64,248
Last modified:April 18, 2006 - v1
Checksum:i4763F22A2A73A57B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ407519 Genomic RNA. Translation: ABD73284.1.
EF619980 Viral cRNA. Translation: ABQ58921.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ407519 Genomic RNA. Translation: ABD73284.1 .
EF619980 Viral cRNA. Translation: ABQ58921.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4BGZ X-ray 2.68 A/C/E 17-338 [» ]
B/D/F 347-512 [» ]
4BH0 X-ray 2.36 A/C/E 17-338 [» ]
B/D/F 347-512 [» ]
4BH1 X-ray 2.15 A/C/E 17-338 [» ]
B/D/F 347-512 [» ]
4CQV X-ray 2.86 A/C/E 17-346 [» ]
B/D/F 347-512 [» ]
4CQW X-ray 2.30 A/C/E 17-346 [» ]
B/D/F 347-512 [» ]
4CQX X-ray 2.30 A/C/E 17-346 [» ]
B/D/F 347-512 [» ]
4CQY X-ray 2.05 A/C/E 17-346 [» ]
B/D/F 347-512 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-60225N.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.10.77.10. 1 hit.
3.90.20.10. 1 hit.
3.90.209.20. 1 hit.
InterProi IPR008980. Capsid_hemagglutn.
IPR013828. Hemagglutn_HA1_a/b_dom.
IPR013827. Hemagglutn_HA1_b-rbn_dom.
IPR000149. Hemagglutn_influenz_A.
IPR001364. Hemagglutn_influenz_A/B.
IPR013829. Hemagglutn_stalk.
[Graphical view ]
Pfami PF00509. Hemagglutinin. 1 hit.
[Graphical view ]
PRINTSi PR00330. HEMAGGLUTN1.
PR00329. HEMAGGLUTN12.
SUPFAMi SSF49818. SSF49818. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "First incursion of H5N1 highly pathogenic avian influenza viruses of the 'Asian' lineage into Europe."
    Londt B.Z., Brown I.H.
    Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A/turkey/Turkey/1/2005Imported.
  2. Lin Y.
    Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A/turkey/Turkey/1/2005Imported.
  3. "Receptor binding by a ferret-transmissible H5 avian influenza virus."
    Xiong X., Coombs P.J., Martin S.R., Liu J., Xiao H., McCauley J.W., Locher K., Walker P.A., Collins P.J., Kawaoka Y., Skehel J.J., Gamblin S.J.
    Nature 497:392-396(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 17-338 AND 347-512 IN COMPLEX WITH GALACTOSE AND PHOSPHATE, GLYCOSYLATION AT ASN-39 AND ASN-181.
  4. "Enhanced human receptor binding by H5 haemagglutinins."
    Xiong X., Xiao H., Martin S.R., Coombs P.J., Liu J., Collins P.J., Vachieri S.G., Walker P.A., Lin Y.P., McCauley J.W., Gamblin S.J., Skehel J.J.
    Virology 456-457:179-187(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 17-346 AND 347-512.

Entry informationi

Entry nameiQ207Z6_9INFA
AccessioniPrimary (citable) accession number: Q207Z6
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2006
Last sequence update: April 18, 2006
Last modified: September 3, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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