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Protein

Putative syntaxin-5

Gene

syx-5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Potentially involved in docking of synaptic vesicles at presynaptic active zones.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-CEL-5694530. Cargo concentration in the ER.
R-CEL-6807878. COPI-mediated anterograde transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative syntaxin-5
Gene namesi
Name:syx-5
Synonyms:syn-3
ORF Names:F55A11.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF55A11.2; CE05944; WBGene00006373; syx-5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 391391CytoplasmicSequence analysisAdd
BLAST
Transmembranei392 – 41221Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST
Topological domaini413 – 4131ExtracellularSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 413413Putative syntaxin-5PRO_0000210241Add
BLAST

Proteomic databases

EPDiQ20797.
PaxDbiQ20797.
PRIDEiQ20797.

PTM databases

iPTMnetiQ20797.

Interactioni

Protein-protein interaction databases

BioGridi44636. 5 interactions.
IntActiQ20797. 4 interactions.
STRINGi6239.F55A11.2.

Structurei

3D structure databases

ProteinModelPortaliQ20797.
SMRiQ20797. Positions 330-367.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini321 – 38363t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0812. Eukaryota.
ENOG410Y2MB. LUCA.
GeneTreeiENSGT00390000000652.
HOGENOMiHOG000194860.
InParanoidiQ20797.
KOiK08490.
OMAiSHNDERN.
OrthoDBiEOG7NCV41.
PhylomeDBiQ20797.

Family and domain databases

InterProiIPR021538. Syntaxin-5_N.
IPR006012. Syntaxin/epimorphin_CS.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
PF11416. Syntaxin-5_N. 1 hit.
[Graphical view]
SMARTiSM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q20797-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDFHNIRSR RRIPEASSYS TVDFDYDPDQ KNHTSAVAPT SFAYSSLTTV
60 70 80 90 100
FNASASQLWN SAQEALVSSY DTAEGTESID ADRSKVVETL ESLSIFGNPL
110 120 130 140 150
DHIIITMPSR DRTSEFRATA KSYEMKAAAN GIRPQPKHEM LSESVQFNQL
160 170 180 190 200
AKRIGKELSQ TCAKMEKLAE YAKKKSCYEE RSQIDHLSSI VKSDITGLNK
210 220 230 240 250
QIGQLQEFSK RRAGNMKNQN SGHIQLVVVG LQSKLANVGK DYQSVLEIST
260 270 280 290 300
ETMKAEKNRR DKFSSGAAVP MGLPSSSSGA NVRSKLLQDD EQHGSSSIAL
310 320 330 340 350
DMGALSNMQS QQTMQQRDSS LEYAQARSNT MATIEGSISE LGQIFSQLAS
360 370 380 390 400
LVSEQGEMIT RIDSNVEDTA LNIDMAHSEL VRYLQNISKN RWLMIQVFGV
410
LMVFFVVFVL FLT
Length:413
Mass (Da):45,853
Last modified:November 1, 1996 - v1
Checksum:i41DB9C1634BC493A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72511 Genomic DNA. Translation: CAA96656.1.
PIRiT22686.
RefSeqiNP_505968.1. NM_073567.6.
UniGeneiCel.3408.

Genome annotation databases

EnsemblMetazoaiF55A11.2; F55A11.2; WBGene00006373.
GeneIDi179611.
KEGGicel:CELE_F55A11.2.
UCSCiF55A11.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72511 Genomic DNA. Translation: CAA96656.1.
PIRiT22686.
RefSeqiNP_505968.1. NM_073567.6.
UniGeneiCel.3408.

3D structure databases

ProteinModelPortaliQ20797.
SMRiQ20797. Positions 330-367.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi44636. 5 interactions.
IntActiQ20797. 4 interactions.
STRINGi6239.F55A11.2.

PTM databases

iPTMnetiQ20797.

Proteomic databases

EPDiQ20797.
PaxDbiQ20797.
PRIDEiQ20797.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF55A11.2; F55A11.2; WBGene00006373.
GeneIDi179611.
KEGGicel:CELE_F55A11.2.
UCSCiF55A11.2. c. elegans.

Organism-specific databases

CTDi179611.
WormBaseiF55A11.2; CE05944; WBGene00006373; syx-5.

Phylogenomic databases

eggNOGiKOG0812. Eukaryota.
ENOG410Y2MB. LUCA.
GeneTreeiENSGT00390000000652.
HOGENOMiHOG000194860.
InParanoidiQ20797.
KOiK08490.
OMAiSHNDERN.
OrthoDBiEOG7NCV41.
PhylomeDBiQ20797.

Enzyme and pathway databases

ReactomeiR-CEL-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-CEL-5694530. Cargo concentration in the ER.
R-CEL-6807878. COPI-mediated anterograde transport.

Miscellaneous databases

NextBioi906146.
PROiQ20797.

Family and domain databases

InterProiIPR021538. Syntaxin-5_N.
IPR006012. Syntaxin/epimorphin_CS.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
PF11416. Syntaxin-5_N. 1 hit.
[Graphical view]
SMARTiSM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiSTX5_CAEEL
AccessioniPrimary (citable) accession number: Q20797
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.