Reviewed, UniProtKB/Swiss-Prot Q20772 (GCDH_CAEEL)

Names and origin

Protein names

Recommended name:
    Probable glutaryl-CoA dehydrogenase, mitochondrial
      Short name=GCD
    EC=1.3.99.7

Gene names

ORF Names:

F54D5.7

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	409 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	Glutaryl-CoA + acceptor = crotonoyl-CoA + CO(2) + reduced acceptor.
Cofactor	FAD By similarity.
Pathway	Amino-acid metabolism; lysine degradation. Amino-acid metabolism; tryptophan metabolism.
Subcellular location	Mitochondrion matrixPotential.
Sequence similarities	Belongs to the acyl-CoA dehydrogenase family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro glutaryl-CoA dehydrogenase activity Inferred from electronic annotation. Source: EC protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
mpk-1	P39745	1	EBI-313068,EBI-321013
pmk-1	Q17446	1	EBI-313068,EBI-312987

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 409		Probable glutaryl-CoA dehydrogenase, mitochondrial		PRO_0000000530
Sites
	Active site	388	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q20772-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 4D06241FB6768069	FASTA	409	44,964
	10 20 30 40 50 60 MLTRGFTSIG KIASRGLSST FYQDAFQLSD QLTEDERSLM LSAREYCQER LLPRVTEAYR 70 80 90 100 110 120 TEKFDPSLIP EMGSMGLLGA PYQGYGCAGT STVGYGLIAR EVERVDSGYR STMSVQTSLV 130 140 150 160 170 180 IGPIYNYGSE DQKQKYIPDL ASGKKIGCFG LTEPNHGSNP GGMETKATWD ETTKTYKLNG 190 200 210 220 230 240 SKTWISNSPV SDVMVVWARS ARHNNKIKGF ILERGMKGLT TPKIEGKLSL RASITGQIAM 250 260 270 280 290 300 DDVPVPEENL LPNAEGLQGP FGCLNNARLG IAWGALGAAE ECFHLARQYT LDRQQFGRPL 310 320 330 340 350 360 AQNQLMQLKM ADMLTEISLG LQGCLRVSRL KDEGKVQSEQ ISIIKRNSCG KALEVARKAR 370 380 390 400 DMLGGNGIVD EYHIMRHMVN LETVNTYEGT HDVHALILGR AITGLNGFC

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z66513 Genomic DNA. Translation: CAA91333.1.
PIR	T22647.
RefSeq	NP_496469.1.
UniGene	Cel.30446
3D structure databases
HSSP	HSSP built from PDB template 1BUC based on UniProtKB Q06319.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:25054N.
IntAct	Q20772.
Genome annotation databases
Ensembl	F54D5.7. Caenorhabditis elegans. [Contig view]
GeneID	174768.
KEGG	cel:F54D5.7.
Organism-specific databases
WormBase	WBGene00010052. F54D5.7.
WormPep	F54D5.7. CE03411. [WorfDB]
Gene expression databases
ArrayExpress	Q20772.
Family and domain databases
InterPro	IPR006091. Acyl-CoA_DHase/Oxase_M. IPR006089. Acyl-CoA_DHase_CS. IPR006092. Acyl-CoA_DHase_N. IPR006090. Acyl-CoA_Oxase/DHase_1. IPR013786. AcylCoA_DH/ox_N. IPR013764. AcylCoA_oxidase/DH_1/2_C. [Graphical view]
Gene3D	G3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit. G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit. G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 1 hit.
Pfam	PF00441. Acyl-CoA_dh_1. 1 hit. PF02770. Acyl-CoA_dh_M. 1 hit. PF02771. Acyl-CoA_dh_N. 1 hit. [Graphical view]
PROSITE	PS00072. ACYL_COA_DH_1. False negative. PS00073. ACYL_COA_DH_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	885416.

Entry information

Entry name

GCDH_CAEEL

Accession

Primary (citable) accession number: Q20772

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	November 25, 2008
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project