Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q20751

- IF5A2_CAEEL

UniProt

Q20751 - IF5A2_CAEEL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Eukaryotic translation initiation factor 5A-2

Gene

iff-2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis (By similarity). Acts in somatic tissues and its function in the soma is essential for normal growth and reproduction.By similarity1 Publication

GO - Molecular functioni

  1. ribosome binding Source: InterPro
  2. translation elongation factor activity Source: UniProtKB-KW

GO - Biological processi

  1. gamete generation Source: WormBase
  2. gonad morphogenesis Source: WormBase
  3. nematode larval development Source: WormBase
  4. nematode male tail tip morphogenesis Source: WormBase
  5. peptidyl-lysine modification to peptidyl-hypusine Source: InterPro
  6. positive regulation of translational elongation Source: InterPro
  7. positive regulation of translational termination Source: InterPro
  8. translational frameshifting Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiREACT_183782. Hypusine synthesis from eIF5A-lysine.

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 5A-2
Short name:
eIF-5A-2
Alternative name(s):
Initiation factor five protein 2
Gene namesi
Name:iff-2
ORF Names:F54C9.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome II

Organism-specific databases

WormBaseiF54C9.1; CE02249; WBGene00002065; iff-2.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 161161Eukaryotic translation initiation factor 5A-2PRO_0000142457Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei54 – 541HypusineBy similarity

Post-translational modificationi

eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).

Keywords - PTMi

Hypusine

Proteomic databases

PaxDbiQ20751.
PRIDEiQ20751.

Expressioni

Tissue specificityi

Expressed in the somatic tissues.1 Publication

Developmental stagei

Expressed throughout development.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi6239.F54C9.1.3.

Structurei

3D structure databases

ProteinModelPortaliQ20751.
SMRiQ20751. Positions 15-160.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-5A family.Curated

Phylogenomic databases

eggNOGiCOG0231.
GeneTreeiENSGT00390000003738.
HOGENOMiHOG000106270.
InParanoidiQ20751.
KOiK03263.
OMAiICAVKEV.
PhylomeDBiQ20751.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR005824. KOW.
IPR012340. NA-bd_OB-fold.
IPR014722. Rib_L2_dom2.
IPR019769. Trans_elong_IF5A_hypusine_site.
IPR001884. Transl_elong_IF5A.
IPR020189. Transl_elong_IF5A_C.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR11673. PTHR11673. 1 hit.
PfamiPF01287. eIF-5a. 1 hit.
PF00467. KOW. 1 hit.
[Graphical view]
PIRSFiPIRSF003025. eIF5A. 1 hit.
SUPFAMiSSF50104. SSF50104. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00037. eIF_5A. 1 hit.
PROSITEiPS00302. IF5A_HYPUSINE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q20751-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDDHHDDEH FHTGDSGAAA TFPKQCSALR KNEHVMIKGR PCKIVEMSTS
60 70 80 90 100
KTGKHGHAKV HMVAIDIFTS KKLEDICPST HNMDVPVVKR REYLLMAIDD
110 120 130 140 150
GYCSLMDPES CEQKDDLKLP DTELGQQIRD AYEKDEGSVL VQVVSAIGEE
160
AILGWKVSTK E
Length:161
Mass (Da):17,953
Last modified:November 1, 1997 - v1
Checksum:iE497AFDE6580E53B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49967 Genomic DNA. Translation: CAA90247.1.
PIRiT22628.
RefSeqiNP_495807.1. NM_063406.6.
UniGeneiCel.22474.

Genome annotation databases

EnsemblMetazoaiF54C9.1.1; F54C9.1.1; WBGene00002065.
F54C9.1.2; F54C9.1.2; WBGene00002065.
GeneIDi174367.
KEGGicel:CELE_F54C9.1.
UCSCiF54C9.1.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49967 Genomic DNA. Translation: CAA90247.1 .
PIRi T22628.
RefSeqi NP_495807.1. NM_063406.6.
UniGenei Cel.22474.

3D structure databases

ProteinModelPortali Q20751.
SMRi Q20751. Positions 15-160.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.F54C9.1.3.

Proteomic databases

PaxDbi Q20751.
PRIDEi Q20751.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F54C9.1.1 ; F54C9.1.1 ; WBGene00002065 .
F54C9.1.2 ; F54C9.1.2 ; WBGene00002065 .
GeneIDi 174367.
KEGGi cel:CELE_F54C9.1.
UCSCi F54C9.1.1. c. elegans.

Organism-specific databases

CTDi 174367.
WormBasei F54C9.1 ; CE02249 ; WBGene00002065 ; iff-2.

Phylogenomic databases

eggNOGi COG0231.
GeneTreei ENSGT00390000003738.
HOGENOMi HOG000106270.
InParanoidi Q20751.
KOi K03263.
OMAi ICAVKEV.
PhylomeDBi Q20751.

Enzyme and pathway databases

Reactomei REACT_183782. Hypusine synthesis from eIF5A-lysine.

Miscellaneous databases

NextBioi 883730.

Family and domain databases

Gene3Di 2.30.30.30. 1 hit.
2.40.50.140. 1 hit.
InterProi IPR005824. KOW.
IPR012340. NA-bd_OB-fold.
IPR014722. Rib_L2_dom2.
IPR019769. Trans_elong_IF5A_hypusine_site.
IPR001884. Transl_elong_IF5A.
IPR020189. Transl_elong_IF5A_C.
IPR008991. Translation_prot_SH3-like.
[Graphical view ]
PANTHERi PTHR11673. PTHR11673. 1 hit.
Pfami PF01287. eIF-5a. 1 hit.
PF00467. KOW. 1 hit.
[Graphical view ]
PIRSFi PIRSF003025. eIF5A. 1 hit.
SUPFAMi SSF50104. SSF50104. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00037. eIF_5A. 1 hit.
PROSITEi PS00302. IF5A_HYPUSINE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "The Caenorhabditis elegans eukaryotic initiation factor 5A homologue, IFF-1, is required for germ cell proliferation, gametogenesis and localization of the P-granule component PGL-1."
    Hanazawa M., Kawasaki I., Kunitomo H., Gengyo-Ando K., Bennett K.L., Mitani S., Iino Y.
    Mech. Dev. 121:213-224(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiIF5A2_CAEEL
AccessioniPrimary (citable) accession number: Q20751
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Translation initiation factors
    List of translation initiation factor entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3