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Q20751

- IF5A2_CAEEL

UniProt

Q20751 - IF5A2_CAEEL

Protein

Eukaryotic translation initiation factor 5A-2

Gene

iff-2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis By similarity. Acts in somatic tissues and its function in the soma is essential for normal growth and reproduction.By similarity1 Publication

    GO - Molecular functioni

    1. ribosome binding Source: InterPro
    2. translation elongation factor activity Source: UniProtKB-KW

    GO - Biological processi

    1. gamete generation Source: WormBase
    2. gonad morphogenesis Source: WormBase
    3. nematode larval development Source: WormBase
    4. nematode male tail tip morphogenesis Source: WormBase
    5. peptidyl-lysine modification to peptidyl-hypusine Source: InterPro
    6. positive regulation of translational elongation Source: InterPro
    7. positive regulation of translational termination Source: InterPro
    8. translational frameshifting Source: InterPro

    Keywords - Molecular functioni

    Elongation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_183782. Hypusine synthesis from eIF5A-lysine.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Eukaryotic translation initiation factor 5A-2
    Short name:
    eIF-5A-2
    Alternative name(s):
    Initiation factor five protein 2
    Gene namesi
    Name:iff-2
    ORF Names:F54C9.1
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome II

    Organism-specific databases

    WormBaseiF54C9.1; CE02249; WBGene00002065; iff-2.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 161161Eukaryotic translation initiation factor 5A-2PRO_0000142457Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei54 – 541HypusineBy similarity

    Post-translational modificationi

    eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).

    Keywords - PTMi

    Hypusine

    Proteomic databases

    PaxDbiQ20751.
    PRIDEiQ20751.

    Expressioni

    Tissue specificityi

    Expressed in the somatic tissues.1 Publication

    Developmental stagei

    Expressed throughout development.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.F54C9.1.3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ20751.
    SMRiQ20751. Positions 15-160.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the eIF-5A family.Curated

    Phylogenomic databases

    eggNOGiCOG0231.
    GeneTreeiENSGT00390000003738.
    HOGENOMiHOG000106270.
    InParanoidiQ20751.
    KOiK03263.
    OMAiICAVKEV.
    PhylomeDBiQ20751.

    Family and domain databases

    Gene3Di2.30.30.30. 1 hit.
    2.40.50.140. 1 hit.
    InterProiIPR005824. KOW.
    IPR012340. NA-bd_OB-fold.
    IPR014722. Rib_L2_dom2.
    IPR019769. Trans_elong_IF5A_hypusine_site.
    IPR001884. Transl_elong_IF5A.
    IPR020189. Transl_elong_IF5A_C.
    IPR008991. Translation_prot_SH3-like.
    [Graphical view]
    PANTHERiPTHR11673. PTHR11673. 1 hit.
    PfamiPF01287. eIF-5a. 1 hit.
    PF00467. KOW. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003025. eIF5A. 1 hit.
    SUPFAMiSSF50104. SSF50104. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00037. eIF_5A. 1 hit.
    PROSITEiPS00302. IF5A_HYPUSINE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q20751-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDDHHDDEH FHTGDSGAAA TFPKQCSALR KNEHVMIKGR PCKIVEMSTS    50
    KTGKHGHAKV HMVAIDIFTS KKLEDICPST HNMDVPVVKR REYLLMAIDD 100
    GYCSLMDPES CEQKDDLKLP DTELGQQIRD AYEKDEGSVL VQVVSAIGEE 150
    AILGWKVSTK E 161
    Length:161
    Mass (Da):17,953
    Last modified:November 1, 1997 - v1
    Checksum:iE497AFDE6580E53B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49967 Genomic DNA. Translation: CAA90247.1.
    PIRiT22628.
    RefSeqiNP_495807.1. NM_063406.6.
    UniGeneiCel.22474.

    Genome annotation databases

    EnsemblMetazoaiF54C9.1.1; F54C9.1.1; WBGene00002065.
    F54C9.1.2; F54C9.1.2; WBGene00002065.
    GeneIDi174367.
    KEGGicel:CELE_F54C9.1.
    UCSCiF54C9.1.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49967 Genomic DNA. Translation: CAA90247.1 .
    PIRi T22628.
    RefSeqi NP_495807.1. NM_063406.6.
    UniGenei Cel.22474.

    3D structure databases

    ProteinModelPortali Q20751.
    SMRi Q20751. Positions 15-160.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.F54C9.1.3.

    Proteomic databases

    PaxDbi Q20751.
    PRIDEi Q20751.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai F54C9.1.1 ; F54C9.1.1 ; WBGene00002065 .
    F54C9.1.2 ; F54C9.1.2 ; WBGene00002065 .
    GeneIDi 174367.
    KEGGi cel:CELE_F54C9.1.
    UCSCi F54C9.1.1. c. elegans.

    Organism-specific databases

    CTDi 174367.
    WormBasei F54C9.1 ; CE02249 ; WBGene00002065 ; iff-2.

    Phylogenomic databases

    eggNOGi COG0231.
    GeneTreei ENSGT00390000003738.
    HOGENOMi HOG000106270.
    InParanoidi Q20751.
    KOi K03263.
    OMAi ICAVKEV.
    PhylomeDBi Q20751.

    Enzyme and pathway databases

    Reactomei REACT_183782. Hypusine synthesis from eIF5A-lysine.

    Miscellaneous databases

    NextBioi 883730.

    Family and domain databases

    Gene3Di 2.30.30.30. 1 hit.
    2.40.50.140. 1 hit.
    InterProi IPR005824. KOW.
    IPR012340. NA-bd_OB-fold.
    IPR014722. Rib_L2_dom2.
    IPR019769. Trans_elong_IF5A_hypusine_site.
    IPR001884. Transl_elong_IF5A.
    IPR020189. Transl_elong_IF5A_C.
    IPR008991. Translation_prot_SH3-like.
    [Graphical view ]
    PANTHERi PTHR11673. PTHR11673. 1 hit.
    Pfami PF01287. eIF-5a. 1 hit.
    PF00467. KOW. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003025. eIF5A. 1 hit.
    SUPFAMi SSF50104. SSF50104. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00037. eIF_5A. 1 hit.
    PROSITEi PS00302. IF5A_HYPUSINE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. "The Caenorhabditis elegans eukaryotic initiation factor 5A homologue, IFF-1, is required for germ cell proliferation, gametogenesis and localization of the P-granule component PGL-1."
      Hanazawa M., Kawasaki I., Kunitomo H., Gengyo-Ando K., Bennett K.L., Mitani S., Iino Y.
      Mech. Dev. 121:213-224(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiIF5A2_CAEEL
    AccessioniPrimary (citable) accession number: Q20751
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. Translation initiation factors
      List of translation initiation factor entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3