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Q20751 (IF5A2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Eukaryotic translation initiation factor 5A-2
Short name=eIF-5A-2
Alternative name(s):
Initiation factor five protein 2
Gene names
Name:iff-2
ORF Names:F54C9.1
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length161 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis By similarity. Acts in somatic tissues and its function in the soma is essential for normal growth and reproduction. Ref.2

Subcellular location

Cytoplasm By similarity.

Tissue specificity

Expressed in the somatic tissues. Ref.2

Developmental stage

Expressed throughout development. Ref.2

Post-translational modification

eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).

Sequence similarities

Belongs to the eIF-5A family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 161161Eukaryotic translation initiation factor 5A-2
PRO_0000142457

Amino acid modifications

Modified residue541Hypusine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q20751 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: E497AFDE6580E53B

FASTA16117,953
        10         20         30         40         50         60 
MSDDHHDDEH FHTGDSGAAA TFPKQCSALR KNEHVMIKGR PCKIVEMSTS KTGKHGHAKV 

        70         80         90        100        110        120 
HMVAIDIFTS KKLEDICPST HNMDVPVVKR REYLLMAIDD GYCSLMDPES CEQKDDLKLP 

       130        140        150        160 
DTELGQQIRD AYEKDEGSVL VQVVSAIGEE AILGWKVSTK E

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[2]"The Caenorhabditis elegans eukaryotic initiation factor 5A homologue, IFF-1, is required for germ cell proliferation, gametogenesis and localization of the P-granule component PGL-1."
Hanazawa M., Kawasaki I., Kunitomo H., Gengyo-Ando K., Bennett K.L., Mitani S., Iino Y.
Mech. Dev. 121:213-224(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z49967 Genomic DNA. Translation: CAA90247.1.
PIRT22628.
RefSeqNP_495807.1. NM_063406.6.

3D structure databases

ProteinModelPortalQ20751.
SMRQ20751. Positions 15-160.
ModBaseSearch...

Protein-protein interaction databases

STRING6239.F54C9.1.3.

Proteomic databases

PaxDbQ20751.
PRIDEQ20751.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaF54C9.1.1; F54C9.1.1; F54C9.1.
F54C9.1.2; F54C9.1.2; F54C9.1.
F54C9.1.3; F54C9.1.3; F54C9.1.
GeneID174367.
KEGGcel:CELE_F54C9.1.
UCSCF54C9.1.1. c. elegans.

Organism-specific databases

CTD174367.
WormBaseF54C9.1; CE02249; WBGene00002065; iff-2.

Phylogenomic databases

eggNOGCOG0231.
GeneTreeENSGT00390000003738.
HOGENOMHOG000106270.
InParanoidQ20751.
KOK03263.
OMAMAIDDGY.

Family and domain databases

Gene3D2.30.30.30. 1 hit.
2.40.50.140. 1 hit.
InterProIPR005824. KOW.
IPR012340. NA-bd_OB-fold.
IPR014722. Rib_L2_dom2.
IPR019769. Trans_elong_IF5A_hypusine_site.
IPR001884. Transl_elong_IF5A.
IPR020189. Transl_elong_IF5A_C.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERPTHR11673. PTHR11673. 1 hit.
PfamPF01287. eIF-5a. 1 hit.
PF00467. KOW. 1 hit.
[Graphical view]
PIRSFPIRSF003025. eIF5A. 1 hit.
SUPFAMSSF50249. Nucleic_acid_OB. 1 hit.
SSF50104. Transl_SH3_like. 1 hit.
TIGRFAMsTIGR00037. eIF_5A. 1 hit.
PROSITEPS00302. IF5A_HYPUSINE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio883730.

Entry information

Entry nameIF5A2_CAEEL
AccessionPrimary (citable) accession number: Q20751
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 1, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

Translation initiation factors

List of translation initiation factor entries

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase

SIMILARITY comments

Index of protein domains and families

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