SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q20735

- SMS2_CAEEL

UniProt

Q20735 - SMS2_CAEEL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Phosphatidylcholine:ceramide cholinephosphotransferase 2

Gene
sms-2, F53H8.4
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide.1 Publication

Catalytic activityi

A ceramide + a phosphatidylcholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol.1 Publication

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei210 – 2101 By similarity
Active sitei253 – 2531 By similarity
Active sitei257 – 2571 By similarity

GO - Molecular functioni

  1. ceramide cholinephosphotransferase activity Source: UniProtKB
  2. sphingomyelin synthase activity Source: UniProtKB

GO - Biological processi

  1. sphingomyelin biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid metabolism, Sphingolipid metabolism

Enzyme and pathway databases

BRENDAi2.7.8.27. 1045.
UniPathwayiUPA00222.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylcholine:ceramide cholinephosphotransferase 2 (EC:2.7.8.27)
Alternative name(s):
Sphingomyelin synthase 2
Gene namesi
Name:sms-2
ORF Names:F53H8.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome X

Organism-specific databases

WormBaseiF53H8.4; CE04657; WBGene00004893; sms-2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei60 – 8021Helical; Reviewed predictionAdd
BLAST
Transmembranei104 – 12421Helical; Reviewed predictionAdd
BLAST
Transmembranei136 – 15621Helical; Reviewed predictionAdd
BLAST
Transmembranei200 – 22021Helical; Reviewed predictionAdd
BLAST
Transmembranei229 – 24921Helical; Reviewed predictionAdd
BLAST
Transmembranei258 – 27821Helical; Reviewed predictionAdd
BLAST
Topological domaini279 – 33557Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 335335Phosphatidylcholine:ceramide cholinephosphotransferase 2PRO_0000221075Add
BLAST

Proteomic databases

PaxDbiQ20735.
PRIDEiQ20735.

Interactioni

Protein-protein interaction databases

STRINGi6239.F53H8.4.

Structurei

3D structure databases

ProteinModelPortaliQ20735.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG259509.
GeneTreeiENSGT00390000001630.
HOGENOMiHOG000018457.
InParanoidiQ20735.
KOiK04714.
OMAiNRDEICQ.
OrthoDBiEOG7KWSNC.
PhylomeDBiQ20735.

Family and domain databases

InterProiIPR025749. Sphingomyelin_synth-like_dom.
[Graphical view]
PfamiPF14360. PAP2_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q20735-1 [UniParc]FASTAAdd to Basket

« Hide

MTNSSEFTDV LQSRDPCVSN GIVINIDPID PEPTPIRKEF TCEDTFHHEH    50
HGNSEGFKTL TAFLCLMLSA FLNFFLLTVI HDVVPRQPLP DLTFMIIPQQ 100
RWAWSVGDVL STVSSVVAFT IIFLHHQRWI VLRRTFLLGA IMYGLRAVIL 150
GVTFLPPSFH NRDEICQPQV NRTAMYGMEI ATRFLTYVIT LGLTSGQDKI 200
LCGDLMFSGH TVVLTIMYFV QLQYTPRGLV ILRYIAAPIT FLGIAALVVS 250
GGHYTMDVLI AYWLTSHVFW SYHQIFEMRK DDRPQAPLSR LWWFWLCYWF 300
ESDVADGKLV NKWNWPLEGP QRMHTIMNRI NYKLQ 335
Length:335
Mass (Da):38,737
Last modified:November 1, 1996 - v1
Checksum:i7FCA39B7B849A4A4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080855 Genomic DNA. Translation: CCD67244.1.
PIRiT34296.
RefSeqiNP_508182.1. NM_075781.3.
UniGeneiCel.38936.

Genome annotation databases

EnsemblMetazoaiF53H8.4; F53H8.4; WBGene00004893.
GeneIDi180445.
KEGGicel:CELE_F53H8.4.
UCSCiF53H8.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080855 Genomic DNA. Translation: CCD67244.1 .
PIRi T34296.
RefSeqi NP_508182.1. NM_075781.3.
UniGenei Cel.38936.

3D structure databases

ProteinModelPortali Q20735.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.F53H8.4.

Proteomic databases

PaxDbi Q20735.
PRIDEi Q20735.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F53H8.4 ; F53H8.4 ; WBGene00004893 .
GeneIDi 180445.
KEGGi cel:CELE_F53H8.4.
UCSCi F53H8.4. c. elegans.

Organism-specific databases

CTDi 180445.
WormBasei F53H8.4 ; CE04657 ; WBGene00004893 ; sms-2.

Phylogenomic databases

eggNOGi NOG259509.
GeneTreei ENSGT00390000001630.
HOGENOMi HOG000018457.
InParanoidi Q20735.
KOi K04714.
OMAi NRDEICQ.
OrthoDBi EOG7KWSNC.
PhylomeDBi Q20735.

Enzyme and pathway databases

UniPathwayi UPA00222 .
BRENDAi 2.7.8.27. 1045.

Miscellaneous databases

NextBioi 909408.

Family and domain databases

InterProi IPR025749. Sphingomyelin_synth-like_dom.
[Graphical view ]
Pfami PF14360. PAP2_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Identification of a family of animal sphingomyelin synthases."
    Huitema K., Van Den Dikkenberg J., Brouwers J.F.H.M., Holthuis J.C.
    EMBO J. 23:33-44(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, PATHWAY.

Entry informationi

Entry nameiSMS2_CAEEL
AccessioniPrimary (citable) accession number: Q20735
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi