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Q20735

- SMS2_CAEEL

UniProt

Q20735 - SMS2_CAEEL

Protein

Phosphatidylcholine:ceramide cholinephosphotransferase 2

Gene

sms-2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide.1 Publication

    Catalytic activityi

    A ceramide + a phosphatidylcholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol.1 Publication

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei210 – 2101By similarity
    Active sitei253 – 2531By similarity
    Active sitei257 – 2571By similarity

    GO - Molecular functioni

    1. ceramide cholinephosphotransferase activity Source: UniProtKB
    2. sphingomyelin synthase activity Source: UniProtKB

    GO - Biological processi

    1. sphingomyelin biosynthetic process Source: UniProtKB

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Lipid metabolism, Sphingolipid metabolism

    Enzyme and pathway databases

    BRENDAi2.7.8.27. 1045.
    UniPathwayiUPA00222.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylcholine:ceramide cholinephosphotransferase 2 (EC:2.7.8.27)
    Alternative name(s):
    Sphingomyelin synthase 2
    Gene namesi
    Name:sms-2
    ORF Names:F53H8.4
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome X

    Organism-specific databases

    WormBaseiF53H8.4; CE04657; WBGene00004893; sms-2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 335335Phosphatidylcholine:ceramide cholinephosphotransferase 2PRO_0000221075Add
    BLAST

    Proteomic databases

    PaxDbiQ20735.
    PRIDEiQ20735.

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.F53H8.4.

    Structurei

    3D structure databases

    ProteinModelPortaliQ20735.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini279 – 33557CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei60 – 8021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei104 – 12421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei136 – 15621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei200 – 22021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei229 – 24921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei258 – 27821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the sphingomyelin synthase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG259509.
    GeneTreeiENSGT00390000001630.
    HOGENOMiHOG000018457.
    InParanoidiQ20735.
    KOiK04714.
    OMAiNRDEICQ.
    OrthoDBiEOG7KWSNC.
    PhylomeDBiQ20735.

    Family and domain databases

    InterProiIPR025749. Sphingomyelin_synth-like_dom.
    [Graphical view]
    PfamiPF14360. PAP2_C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q20735-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTNSSEFTDV LQSRDPCVSN GIVINIDPID PEPTPIRKEF TCEDTFHHEH    50
    HGNSEGFKTL TAFLCLMLSA FLNFFLLTVI HDVVPRQPLP DLTFMIIPQQ 100
    RWAWSVGDVL STVSSVVAFT IIFLHHQRWI VLRRTFLLGA IMYGLRAVIL 150
    GVTFLPPSFH NRDEICQPQV NRTAMYGMEI ATRFLTYVIT LGLTSGQDKI 200
    LCGDLMFSGH TVVLTIMYFV QLQYTPRGLV ILRYIAAPIT FLGIAALVVS 250
    GGHYTMDVLI AYWLTSHVFW SYHQIFEMRK DDRPQAPLSR LWWFWLCYWF 300
    ESDVADGKLV NKWNWPLEGP QRMHTIMNRI NYKLQ 335
    Length:335
    Mass (Da):38,737
    Last modified:November 1, 1996 - v1
    Checksum:i7FCA39B7B849A4A4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080855 Genomic DNA. Translation: CCD67244.1.
    PIRiT34296.
    RefSeqiNP_508182.1. NM_075781.3.
    UniGeneiCel.38936.

    Genome annotation databases

    EnsemblMetazoaiF53H8.4; F53H8.4; WBGene00004893.
    GeneIDi180445.
    KEGGicel:CELE_F53H8.4.
    UCSCiF53H8.4. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080855 Genomic DNA. Translation: CCD67244.1 .
    PIRi T34296.
    RefSeqi NP_508182.1. NM_075781.3.
    UniGenei Cel.38936.

    3D structure databases

    ProteinModelPortali Q20735.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.F53H8.4.

    Proteomic databases

    PaxDbi Q20735.
    PRIDEi Q20735.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai F53H8.4 ; F53H8.4 ; WBGene00004893 .
    GeneIDi 180445.
    KEGGi cel:CELE_F53H8.4.
    UCSCi F53H8.4. c. elegans.

    Organism-specific databases

    CTDi 180445.
    WormBasei F53H8.4 ; CE04657 ; WBGene00004893 ; sms-2.

    Phylogenomic databases

    eggNOGi NOG259509.
    GeneTreei ENSGT00390000001630.
    HOGENOMi HOG000018457.
    InParanoidi Q20735.
    KOi K04714.
    OMAi NRDEICQ.
    OrthoDBi EOG7KWSNC.
    PhylomeDBi Q20735.

    Enzyme and pathway databases

    UniPathwayi UPA00222 .
    BRENDAi 2.7.8.27. 1045.

    Miscellaneous databases

    NextBioi 909408.

    Family and domain databases

    InterProi IPR025749. Sphingomyelin_synth-like_dom.
    [Graphical view ]
    Pfami PF14360. PAP2_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. "Identification of a family of animal sphingomyelin synthases."
      Huitema K., Van Den Dikkenberg J., Brouwers J.F.H.M., Holthuis J.C.
      EMBO J. 23:33-44(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY, PATHWAY.

    Entry informationi

    Entry nameiSMS2_CAEEL
    AccessioniPrimary (citable) accession number: Q20735
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2004
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3