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Q20719 (NDUV2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

EC=1.6.5.3
EC=1.6.99.3
Gene names
ORF Names:F53F4.10
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length239 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

NADH + acceptor = NAD+ + reduced acceptor.

Cofactor

Binds 1 2Fe-2S cluster Potential.

Subunit structure

Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme By similarity.

Subcellular location

Mitochondrion inner membrane By similarity.

Sequence similarities

Belongs to the complex I 24 kDa subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 239Probable NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrialPRO_0000020006

Sites

Metal binding1241Iron-sulfur (2Fe-2S) Potential
Metal binding1291Iron-sulfur (2Fe-2S) Potential
Metal binding1651Iron-sulfur (2Fe-2S) Potential
Metal binding1691Iron-sulfur (2Fe-2S) Potential

Sequences

Sequence LengthMass (Da)Tools
Q20719 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 2A63223AFE663E91

FASTA23926,241
        10         20         30         40         50         60 
MSLASNVLLQ ASRLGEMVIK RGGATGLMVH RDTKENNLNV KFKFTSENQE RIKAIMDIYP 

        70         80         90        100        110        120 
EGHKAGALIP LLDLAQRQHG WLPISAMHEV AKILEVPRMR AYEVATFYTM FNRQPVGKYF 

       130        140        150        160        170        180 
LQVCATTPCM LRGAETITET IEKKLGIHAG ETTKDGLFTL AEVECLGACV NAPMIQINDD 

       190        200        210        220        230 
YFEDLTPKDV NEILDDLKAG RKPAAGPRSG RLAAEPFGEL TSLKETPPGP GFGLQAALK 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z77663 Genomic DNA. Translation: CAB01203.1.
PIRT22573.
RefSeqNP_506376.1. NM_073975.6.
UniGeneCel.23494.

3D structure databases

ProteinModelPortalQ20719.
SMRQ20719. Positions 44-202.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid44866. 1 interaction.
DIPDIP-26781N.
IntActQ20719. 1 interaction.
MINTMINT-1083480.
STRING6239.F53F4.10.2.

2D gel databases

World-2DPAGE0020:Q20719.

Proteomic databases

PaxDbQ20719.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaF53F4.10; F53F4.10; WBGene00009992.
GeneID179850.
KEGGcel:CELE_F53F4.10.
UCSCF53F4.10.1. c. elegans.

Organism-specific databases

CTD179850.
WormBaseF53F4.10; CE10972; WBGene00009992.

Phylogenomic databases

eggNOGCOG1905.
GeneTreeENSGT00390000017580.
HOGENOMHOG000257748.
InParanoidQ20719.
KOK03943.
OMALGEMECM.
PhylomeDBQ20719.

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR002023. NuoE-like.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERPTHR10371. PTHR10371. 1 hit.
PIRSFPIRSF000216. NADH_DH_24kDa. 1 hit.
SUPFAMSSF52833. SSF52833. 1 hit.
TIGRFAMsTIGR01958. nuoE_fam. 1 hit.
PROSITEPS01099. COMPLEX1_24K. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio907116.
PROQ20719.

Entry information

Entry nameNDUV2_CAEEL
AccessionPrimary (citable) accession number: Q20719
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase