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Q20719

- NDUV2_CAEEL

UniProt

Q20719 - NDUV2_CAEEL

Protein

Probable NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

Gene

F53F4.10

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.By similarity

    Catalytic activityi

    NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
    NADH + acceptor = NAD+ + reduced acceptor.

    Cofactori

    Binds 1 2Fe-2S cluster.Curated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi124 – 1241Iron-sulfur (2Fe-2S)Sequence Analysis
    Metal bindingi129 – 1291Iron-sulfur (2Fe-2S)Sequence Analysis
    Metal bindingi165 – 1651Iron-sulfur (2Fe-2S)Sequence Analysis
    Metal bindingi169 – 1691Iron-sulfur (2Fe-2S)Sequence Analysis

    GO - Molecular functioni

    1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
    2. electron carrier activity Source: RefGenome
    3. metal ion binding Source: UniProtKB-KW
    4. NADH dehydrogenase (ubiquinone) activity Source: RefGenome

    GO - Biological processi

    1. mitochondrial electron transport, NADH to ubiquinone Source: RefGenome

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    2Fe-2S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
    Gene namesi
    ORF Names:F53F4.10
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome V

    Organism-specific databases

    WormBaseiF53F4.10; CE10972; WBGene00009992.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial respiratory chain complex I Source: RefGenome

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 239Probable NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrialPRO_0000020006
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Proteomic databases

    PaxDbiQ20719.

    2D gel databases

    World-2DPAGE0020:Q20719.

    Interactioni

    Subunit structurei

    Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme By similarity.By similarity

    Protein-protein interaction databases

    BioGridi44866. 1 interaction.
    DIPiDIP-26781N.
    IntActiQ20719. 1 interaction.
    MINTiMINT-1083480.
    STRINGi6239.F53F4.10.2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ20719.
    SMRiQ20719. Positions 44-202.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I 24 kDa subunit family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1905.
    GeneTreeiENSGT00390000017580.
    HOGENOMiHOG000257748.
    InParanoidiQ20719.
    KOiK03943.
    OMAiLGEMECM.
    PhylomeDBiQ20719.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR002023. NuoE-like.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PANTHERiPTHR10371. PTHR10371. 1 hit.
    PIRSFiPIRSF000216. NADH_DH_24kDa. 1 hit.
    SUPFAMiSSF52833. SSF52833. 1 hit.
    TIGRFAMsiTIGR01958. nuoE_fam. 1 hit.
    PROSITEiPS01099. COMPLEX1_24K. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q20719-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLASNVLLQ ASRLGEMVIK RGGATGLMVH RDTKENNLNV KFKFTSENQE    50
    RIKAIMDIYP EGHKAGALIP LLDLAQRQHG WLPISAMHEV AKILEVPRMR 100
    AYEVATFYTM FNRQPVGKYF LQVCATTPCM LRGAETITET IEKKLGIHAG 150
    ETTKDGLFTL AEVECLGACV NAPMIQINDD YFEDLTPKDV NEILDDLKAG 200
    RKPAAGPRSG RLAAEPFGEL TSLKETPPGP GFGLQAALK 239
    Length:239
    Mass (Da):26,241
    Last modified:November 1, 1996 - v1
    Checksum:i2A63223AFE663E91
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z77663 Genomic DNA. Translation: CAB01203.1.
    PIRiT22573.
    RefSeqiNP_506376.1. NM_073975.6.
    UniGeneiCel.23494.

    Genome annotation databases

    EnsemblMetazoaiF53F4.10; F53F4.10; WBGene00009992.
    GeneIDi179850.
    KEGGicel:CELE_F53F4.10.
    UCSCiF53F4.10.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z77663 Genomic DNA. Translation: CAB01203.1 .
    PIRi T22573.
    RefSeqi NP_506376.1. NM_073975.6.
    UniGenei Cel.23494.

    3D structure databases

    ProteinModelPortali Q20719.
    SMRi Q20719. Positions 44-202.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 44866. 1 interaction.
    DIPi DIP-26781N.
    IntActi Q20719. 1 interaction.
    MINTi MINT-1083480.
    STRINGi 6239.F53F4.10.2.

    2D gel databases

    World-2DPAGE 0020:Q20719.

    Proteomic databases

    PaxDbi Q20719.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai F53F4.10 ; F53F4.10 ; WBGene00009992 .
    GeneIDi 179850.
    KEGGi cel:CELE_F53F4.10.
    UCSCi F53F4.10.1. c. elegans.

    Organism-specific databases

    CTDi 179850.
    WormBasei F53F4.10 ; CE10972 ; WBGene00009992 .

    Phylogenomic databases

    eggNOGi COG1905.
    GeneTreei ENSGT00390000017580.
    HOGENOMi HOG000257748.
    InParanoidi Q20719.
    KOi K03943.
    OMAi LGEMECM.
    PhylomeDBi Q20719.

    Miscellaneous databases

    NextBioi 907116.
    PROi Q20719.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR002023. NuoE-like.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    PANTHERi PTHR10371. PTHR10371. 1 hit.
    PIRSFi PIRSF000216. NADH_DH_24kDa. 1 hit.
    SUPFAMi SSF52833. SSF52833. 1 hit.
    TIGRFAMsi TIGR01958. nuoE_fam. 1 hit.
    PROSITEi PS01099. COMPLEX1_24K. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiNDUV2_CAEEL
    AccessioniPrimary (citable) accession number: Q20719
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3