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Protein

Guanine nucleotide-binding protein alpha-5 subunit

Gene

gpa-5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47MagnesiumBy similarity1
Metal bindingi180MagnesiumBy similarity1
Binding sitei357GTP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi40 – 47GTPBy similarity8
Nucleotide bindingi174 – 180GTPBy similarity7
Nucleotide bindingi199 – 203GTPBy similarity5
Nucleotide bindingi298 – 301GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transducer

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ20701.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein alpha-5 subunit
Gene namesi
Name:gpa-5
ORF Names:F53B1.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF53B1.7; CE04647; WBGene00001667; gpa-5.

Subcellular locationi

GO - Cellular componenti

  • axon Source: WormBase
  • heterotrimeric G-protein complex Source: GO_Central
  • neuronal cell body Source: WormBase
  • synapse Source: WormBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00002036372 – 385Guanine nucleotide-binding protein alpha-5 subunitAdd BLAST384

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1
Lipidationi6S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Lipoprotein, Myristate, Palmitate

Proteomic databases

PaxDbiQ20701.

Expressioni

Gene expression databases

BgeeiWBGene00001667.

Interactioni

Subunit structurei

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi6239.F53B1.7.

Structurei

3D structure databases

ProteinModelPortaliQ20701.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-alpha family.Curated

Phylogenomic databases

eggNOGiKOG0082. Eukaryota.
ENOG410XNVQ. LUCA.
GeneTreeiENSGT00770000120503.
HOGENOMiHOG000038729.
InParanoidiQ20701.
KOiK04640.
OMAiWIHFFEG.
OrthoDBiEOG091G0BD1.
PhylomeDBiQ20701.

Family and domain databases

CDDicd00066. G-alpha. 1 hit.
Gene3Di1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10218. PTHR10218. 2 hits.
PfamiPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSiPR00318. GPROTEINA.
SMARTiSM00275. G_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q20701-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLVTCKQER EAELQNRQID TQIRIENQAN KRKIKMLLLG VTDSGKSTIV
60 70 80 90 100
KQMRVNYLDG FNETEVVNAI FVIRNNIIDA FKNICNIILH SDITVTQEEK
110 120 130 140 150
VLVKLFAYES GKIELMQEVD ELNVINAVSG YECIKQFFER FAFHPMVPDH
160 170 180 190 200
IHYFYPNLDR IASSNYVPTA EDLIHMRQTT LGVHEISFDY TKHIIRLIDV
210 220 230 240 250
GGQKTERRKW IHFFEGVTAV MFVCSLASFN QTTEEEPKAF VWESSLNKVQ
260 270 280 290 300
NKVLVRSAGK AKVEKPGLIN RLDESVDLFK SIRENSFLKM SNFMLFLNKK
310 320 330 340 350
DLLTKKLTKV VFSDYFPDYK KWITNDNSDV SVAEFIENMF REGLEPEKRM
360 370 380
YAHLTQATVT ANIEGTFALC CDVIFGKNYE DTNLE
Length:385
Mass (Da):44,538
Last modified:November 1, 1996 - v1
Checksum:i51801D3D05386E7D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY008128 mRNA. Translation: AAG32081.1.
FO081052 Genomic DNA. Translation: CCD68830.1.
PIRiT16447.
RefSeqiNP_508393.1. NM_075992.1.
UniGeneiCel.807.

Genome annotation databases

EnsemblMetazoaiF53B1.7; F53B1.7; WBGene00001667.
GeneIDi180527.
KEGGicel:CELE_F53B1.7.
UCSCiF53B1.7. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY008128 mRNA. Translation: AAG32081.1.
FO081052 Genomic DNA. Translation: CCD68830.1.
PIRiT16447.
RefSeqiNP_508393.1. NM_075992.1.
UniGeneiCel.807.

3D structure databases

ProteinModelPortaliQ20701.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F53B1.7.

Proteomic databases

PaxDbiQ20701.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF53B1.7; F53B1.7; WBGene00001667.
GeneIDi180527.
KEGGicel:CELE_F53B1.7.
UCSCiF53B1.7. c. elegans.

Organism-specific databases

CTDi180527.
WormBaseiF53B1.7; CE04647; WBGene00001667; gpa-5.

Phylogenomic databases

eggNOGiKOG0082. Eukaryota.
ENOG410XNVQ. LUCA.
GeneTreeiENSGT00770000120503.
HOGENOMiHOG000038729.
InParanoidiQ20701.
KOiK04640.
OMAiWIHFFEG.
OrthoDBiEOG091G0BD1.
PhylomeDBiQ20701.

Enzyme and pathway databases

SignaLinkiQ20701.

Miscellaneous databases

PROiQ20701.

Gene expression databases

BgeeiWBGene00001667.

Family and domain databases

CDDicd00066. G-alpha. 1 hit.
Gene3Di1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10218. PTHR10218. 2 hits.
PfamiPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSiPR00318. GPROTEINA.
SMARTiSM00275. G_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiGPA5_CAEEL
AccessioniPrimary (citable) accession number: Q20701
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.