Unreviewed, UniProtKB/TrEMBL Q206L0 (Q206L0_RAT)

Names and origin

Protein names	Submitted name:     SMAD3 EMBL ABD66605.1
Organism	Rattus norvegicus (Rat) EMBL ABD66605.1
Taxonomic identifier	10116 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	138 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

Ontologies

Gene Ontology (GO)
Biological process	SMAD protein complex assembly Inferred from physical interaction. Source: RGD T cell activation Inferred from electronic annotation. Source: Compara activation of pro-apoptotic gene products Inferred from mutant phenotype. Source: RGD mesoderm formation Inferred from electronic annotation. Source: Compara negative regulation of apoptosis Inferred from direct assay. Source: RGD negative regulation of cell proliferation Inferred from direct assay. Source: RGD negative regulation of gene-specific transcription from RNA polymerase II promoter Inferred from direct assay. Source: RGD negative regulation of osteoblast differentiation Inferred from electronic annotation. Source: Compara osteoblast development Inferred from electronic annotation. Source: Compara paraxial mesoderm morphogenesis Inferred from electronic annotation. Source: Compara positive regulation of alkaline phosphatase activity Inferred from direct assay. Source: RGD positive regulation of bone mineralization Inferred from direct assay. Source: RGD positive regulation of cell migration Inferred from mutant phenotype. Source: RGD positive regulation of focal adhesion formation Inferred from direct assay. Source: RGD positive regulation of gene-specific transcription from RNA polymerase II promoter Inferred from direct assay. Source: RGD positive regulation of interleukin-1 beta production Inferred from mutant phenotype. Source: RGD positive regulation of positive chemotaxis Inferred from direct assay. Source: RGD positive regulation of stress fiber formation Inferred from direct assay. Source: RGD positive regulation of transforming growth factor-beta3 production Inferred from mutant phenotype. Source: RGD regulation of binding Inferred from electronic annotation. Source: Compara regulation of epithelial cell proliferation Inferred from electronic annotation. Source: Compara regulation of immune response Inferred from electronic annotation. Source: Compara regulation of striated muscle tissue development Inferred from electronic annotation. Source: Compara regulation of transforming growth factor beta receptor signaling pathway Inferred from electronic annotation. Source: Compara release of cytochrome c from mitochondria Inferred from mutant phenotype. Source: RGD transdifferentiation Inferred from direct assay. Source: RGD transforming growth factor beta receptor signaling pathway Inferred from mutant phenotype. Source: RGD
Cellular component	cytoplasm Inferred from direct assay. Source: RGD plasma membrane Inferred from electronic annotation. Source: Compara transcription factor complex Inferred from mutant phenotype. Source: RGD
Molecular function	SMAD binding Inferred from physical interaction. Source: RGD collagen binding Inferred from electronic annotation. Source: Compara double-stranded DNA binding Inferred from electronic annotation. Source: Compara ligand-regulated transcription factor activity Inferred from mutant phenotype. Source: RGD sequence-specific DNA binding Inferred from direct assay. Source: RGD specific transcriptional repressor activity Inferred from direct assay. Source: RGD transcription activator activity Inferred from electronic annotation. Source: Compara transcription factor activity Inferred from direct assay. Source: RGD transcription factor binding Inferred from direct assay. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL ABD66605.1
	Non-terminal residue	138	1	EMBL ABD66605.1

Sequences

	Sequence		Length	Mass (Da)
	Q206L0-1 [UniParc]. Last modified April 18, 2006. Version 1. Checksum: 3B3B40379A8F0BC8	FASTA	138	15,247
	10 20 30 40 50 60 PGYLSEDGET SDHQMNHSMD AGSPNLSPNP MSPAHNNLDL QPVTYCEPAF WCSISYYELN 70 80 90 100 110 120 QRVGETFHAS QPSMTVDGFT DPSNSERFCL GLLSNVNRNA AVELTRRHIG RGVRLYYIGG 130 EVFAECLSDS AIFVQSPN

References

[1]

"The Expression and Possible Mechanism of C-ski, a Novel Tissue Repair-related Gene, during Normal and Radiation-impaired Wound Healing." Li P., Liu X., Xiong R.-P., Liu P., Chen X.-Y., Zhou Y.-G. Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: W EMBL ABD66605.1. Tissue: Skin EMBL ABD66605.1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ409172 mRNA. Translation: ABD66605.1.
IPI	IPI00209246.
UniGene	Rn.10636
3D structure databases
SMR	Q206L0. Positions 39-138.
ModBase	Search...
Protein-protein interaction databases
STRING	Q206L0.
Genome annotation databases
Ensembl	ENSRNOT00000039730; ENSRNOP00000037346; ENSRNOG00000008620; Rattus norvegicus. [Genome view]
Phylogenomic databases
HOVERGEN	Q206L0.
Gene expression databases
ArrayExpress	Q206L0.
Genevestigator	Q206L0.
Family and domain databases
InterPro	IPR013790. Dwarfin. IPR017855. SMAD_dom-like. IPR001132. SMAD_dom_Dwarfin-type. IPR008984. SMAD_FHA_domain. [Graphical view]
Gene3D	G3DSA:2.60.200.10. MH2_Dwarfin-type. 1 hit.
PANTHER	PTHR13703. Dwarfin. 1 hit.
Pfam	PF03166. MH2. 1 hit. [Graphical view]
SMART	SM00524. DWB. 1 hit. [Graphical view]
PROSITE	PS51076. MH2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q206L0_RAT

Accession

Primary (citable) accession number: Q206L0

Entry history

Integrated into UniProtKB/TrEMBL:	April 18, 2006
Last sequence update:	April 18, 2006
Last modified:	November 3, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)