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Protein

Guanine nucleotide-binding protein subunit beta-2

Gene

gpb-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

GO - Biological processi

  • dopamine receptor signaling pathway Source: WormBase
  • feeding behavior Source: WormBase
  • G-protein coupled acetylcholine receptor signaling pathway Source: WormBase
  • negative regulation of gene expression Source: UniProtKB
  • regulation of G-protein coupled receptor protein signaling pathway Source: WormBase
  • regulation of locomotion Source: WormBase
  • regulation of oviposition Source: WormBase
  • regulation of pharyngeal pumping Source: WormBase
  • response to food Source: WormBase

Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

ReactomeiR-CEL-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
SignaLinkiQ20636

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein subunit beta-2
Gene namesi
Name:gpb-2
ORF Names:F52A8.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF52A8.2a ; CE50400 ; WBGene00001680 ; gpb-2

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001277131 – 356Guanine nucleotide-binding protein subunit beta-2Add BLAST356

Proteomic databases

EPDiQ20636
PaxDbiQ20636
PeptideAtlasiQ20636
PRIDEiQ20636

Expressioni

Gene expression databases

BgeeiWBGene00001680

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma (By similarity). Interacts with G protein gamma subunits gpc-1 and gpc-2 and with egl-10 and eat-16 (PubMed:11333232).By similarity1 Publication

Protein-protein interaction databases

STRINGi6239.F52A8.2.2

Structurei

3D structure databases

ProteinModelPortaliQ20636
SMRiQ20636
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati66 – 96WD 1Add BLAST31
Repeati108 – 138WD 2Add BLAST31
Repeati154 – 184WD 3Add BLAST31
Repeati196 – 228WD 4Add BLAST33
Repeati240 – 270WD 5Add BLAST31
Repeati284 – 314WD 6Add BLAST31
Repeati326 – 356WD 7Add BLAST31

Sequence similaritiesi

Belongs to the WD repeat G protein beta family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IU55 Eukaryota
ENOG410YDDC LUCA
HOGENOMiHOG000176356
InParanoidiQ20636
KOiK04539
OrthoDBiEOG091G0A7T
PhylomeDBiQ20636

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR001632 Gprotein_B
IPR016346 Guanine_nucleotide-bd_bsu
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR19850 PTHR19850, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 6 hits
PRINTSiPR00319 GPROTEINB
PR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 3 hits
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q20636-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPENSQPTTT EKGSEYLEQL ANEAEELRKK LDQERHKLND IPIQQAAERL
60 70 80 90 100
DVMGALGVKQ RRILKGHVGK VLCMDWSLDK RHIVSSSQDG KVIVWDGFTT
110 120 130 140 150
NKEHALTMPT TWVMACAFSP SSQMIACGGL DNKCSVVPLS FEDDIIQKKR
160 170 180 190 200
QVATHTSYMS CCTFLRSDNL ILTGSGDSTC AIWDVESGQL IQNFHGHTGD
210 220 230 240 250
VFAIDVPKCD TGNTFISAGA DKHSLVWDIR SGQCVQSFEG HEADINTVRF
260 270 280 290 300
HPNGDAFATG SDDATCRLFD LRADRQVCVY EKESILFPVN GVDFSLSGRI
310 320 330 340 350
LFAGYGDYRV GVWDSLKCAR HSVLYGHENR ISCLRTSPDG TAVCSASWDC

TIRIWA
Length:356
Mass (Da):39,453
Last modified:July 15, 1998 - v2
Checksum:i293AA6DCF317D832
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF291847 mRNA Translation: AAK55964.1
Z71263 Genomic DNA Translation: CAA95824.1
PIRiT22478
RefSeqiNP_492072.2, NM_059671.6

Genome annotation databases

GeneIDi172483
KEGGicel:CELE_F52A8.2
UCSCiF52A8.2 c. elegans

Similar proteinsi

Entry informationi

Entry nameiGBB2_CAEEL
AccessioniPrimary (citable) accession number: Q20636
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: May 23, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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