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Protein

Guanine nucleotide-binding protein subunit beta-2

Gene

gpb-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

GO - Biological processi

  • dopamine receptor signaling pathway Source: WormBase
  • feeding behavior Source: WormBase
  • G-protein coupled acetylcholine receptor signaling pathway Source: WormBase
  • regulation of G-protein coupled receptor protein signaling pathway Source: WormBase
  • regulation of locomotion Source: WormBase
  • regulation of oviposition Source: WormBase
  • regulation of pharyngeal pumping Source: WormBase
  • response to food Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiR-CEL-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
SignaLinkiQ20636.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein subunit beta-2
Gene namesi
Name:gpb-2
ORF Names:F52A8.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF52A8.2a; CE50400; WBGene00001680; gpb-2.

Subcellular locationi

GO - Cellular componenti

  • neuronal cell body Source: WormBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 356356Guanine nucleotide-binding protein subunit beta-2PRO_0000127713Add
BLAST

Proteomic databases

EPDiQ20636.
PaxDbiQ20636.

Expressioni

Gene expression databases

BgeeiWBGene00001680.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma (By similarity). Interacts with G protein gamma subunits gpc-1 and gpc-2 and with egl-10 and eat-16 (PubMed:11333232).By similarity1 Publication

Protein-protein interaction databases

STRINGi6239.F52A8.2.2.

Structurei

3D structure databases

ProteinModelPortaliQ20636.
SMRiQ20636. Positions 14-356.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati66 – 9631WD 1Add
BLAST
Repeati108 – 13831WD 2Add
BLAST
Repeati154 – 18431WD 3Add
BLAST
Repeati196 – 22833WD 4Add
BLAST
Repeati240 – 27031WD 5Add
BLAST
Repeati284 – 31431WD 6Add
BLAST
Repeati326 – 35631WD 7Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat G protein beta family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IU55. Eukaryota.
ENOG410YDDC. LUCA.
HOGENOMiHOG000176356.
InParanoidiQ20636.
KOiK04539.
OMAiYCSTCAE.
OrthoDBiEOG091G0A7T.
PhylomeDBiQ20636.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR001632. Gprotein_B.
IPR016346. Guanine_nucleotide-bd_bsu.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR19850. PTHR19850. 1 hit.
PfamiPF00400. WD40. 6 hits.
[Graphical view]
PRINTSiPR00319. GPROTEINB.
PR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q20636-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPENSQPTTT EKGSEYLEQL ANEAEELRKK LDQERHKLND IPIQQAAERL
60 70 80 90 100
DVMGALGVKQ RRILKGHVGK VLCMDWSLDK RHIVSSSQDG KVIVWDGFTT
110 120 130 140 150
NKEHALTMPT TWVMACAFSP SSQMIACGGL DNKCSVVPLS FEDDIIQKKR
160 170 180 190 200
QVATHTSYMS CCTFLRSDNL ILTGSGDSTC AIWDVESGQL IQNFHGHTGD
210 220 230 240 250
VFAIDVPKCD TGNTFISAGA DKHSLVWDIR SGQCVQSFEG HEADINTVRF
260 270 280 290 300
HPNGDAFATG SDDATCRLFD LRADRQVCVY EKESILFPVN GVDFSLSGRI
310 320 330 340 350
LFAGYGDYRV GVWDSLKCAR HSVLYGHENR ISCLRTSPDG TAVCSASWDC

TIRIWA
Length:356
Mass (Da):39,453
Last modified:July 15, 1998 - v2
Checksum:i293AA6DCF317D832
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF291847 mRNA. Translation: AAK55964.1.
Z71263 Genomic DNA. Translation: CAA95824.1.
PIRiT22478.
RefSeqiNP_492072.2. NM_059671.6.

Genome annotation databases

GeneIDi172483.
KEGGicel:CELE_F52A8.2.
UCSCiF52A8.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF291847 mRNA. Translation: AAK55964.1.
Z71263 Genomic DNA. Translation: CAA95824.1.
PIRiT22478.
RefSeqiNP_492072.2. NM_059671.6.

3D structure databases

ProteinModelPortaliQ20636.
SMRiQ20636. Positions 14-356.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F52A8.2.2.

Proteomic databases

EPDiQ20636.
PaxDbiQ20636.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi172483.
KEGGicel:CELE_F52A8.2.
UCSCiF52A8.2. c. elegans.

Organism-specific databases

CTDi172483.
WormBaseiF52A8.2a; CE50400; WBGene00001680; gpb-2.

Phylogenomic databases

eggNOGiENOG410IU55. Eukaryota.
ENOG410YDDC. LUCA.
HOGENOMiHOG000176356.
InParanoidiQ20636.
KOiK04539.
OMAiYCSTCAE.
OrthoDBiEOG091G0A7T.
PhylomeDBiQ20636.

Enzyme and pathway databases

ReactomeiR-CEL-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
SignaLinkiQ20636.

Miscellaneous databases

PROiQ20636.

Gene expression databases

BgeeiWBGene00001680.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR001632. Gprotein_B.
IPR016346. Guanine_nucleotide-bd_bsu.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR19850. PTHR19850. 1 hit.
PfamiPF00400. WD40. 6 hits.
[Graphical view]
PRINTSiPR00319. GPROTEINB.
PR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGBB2_CAEEL
AccessioniPrimary (citable) accession number: Q20636
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: September 7, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.