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Protein

Serpentine receptor class alpha-13

Gene

sra-13

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Chemosensory receptor that negatively regulates RAS/MAPK signaling during vulva induction and the negative regulation of olfaction of volitile attractants. Required for the suppression of vulval induction in response to food starvation. Signaling acts through the GPA-5 G-alpha protein subunit.1 Publication

GO - Molecular functioni

  • G-protein coupled receptor activity Source: GO_Central
  • olfactory receptor activity Source: UniProtKB

GO - Biological processi

  • detection of chemical stimulus involved in sensory perception of smell Source: UniProtKB
  • negative regulation of Ras protein signal transduction Source: UniProtKB
  • negative regulation of response to food Source: UniProtKB
  • negative regulation of vulval development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

SignaLinkiQ20618.

Names & Taxonomyi

Protein namesi
Recommended name:
Serpentine receptor class alpha-13
Short name:
Protein sra-13
Gene namesi
Name:sra-13
ORF Names:F49E12.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiF49E12.5a; CE35552; WBGene00005039; sra-13.
F49E12.5b; CE35877; WBGene00005039; sra-13.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 61CytoplasmicSequence analysisAdd BLAST15
Transmembranei62 – 82Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini83 – 108ExtracellularSequence analysisAdd BLAST26
Transmembranei109 – 129Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini130 – 146CytoplasmicSequence analysisAdd BLAST17
Transmembranei147 – 167Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini168 – 192ExtracellularSequence analysisAdd BLAST25
Transmembranei193 – 213Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini214 – 243CytoplasmicSequence analysisAdd BLAST30
Transmembranei244 – 264Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini265 – 278ExtracellularSequence analysisAdd BLAST14
Transmembranei279 – 299Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini300 – 335CytoplasmicSequence analysisAdd BLAST36

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001044791 – 335Serpentine receptor class alpha-13Add BLAST335

Proteomic databases

PaxDbiQ20618.

Expressioni

Tissue specificityi

Expressed in the AWA and AWC chemosensory neurons.1 Publication

Gene expression databases

BgeeiWBGene00005039.

Interactioni

Protein-protein interaction databases

STRINGi6239.F49E12.5a.

Structurei

3D structure databases

ProteinModelPortaliQ20618.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410K7AK. Eukaryota.
ENOG41114YI. LUCA.
GeneTreeiENSGT00840000130179.
HOGENOMiHOG000016070.
InParanoidiQ20618.
OMAiNHCGFYP.
OrthoDBiEOG091G0I6L.
PhylomeDBiQ20618.

Family and domain databases

InterProiIPR000344. 7TM_GPCR_serpentine_rcpt_Sra.
[Graphical view]
PfamiPF02117. 7TM_GPCR_Sra. 1 hit.
[Graphical view]
PRINTSiPR00697. TMPROTEINSRA.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: Q20618-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAIISSVNRT CASESLLELY RSYKYILSTS FNIIIPIISL FFLVYAIKQL
60 70 80 90 100
CAQSIIQYST RVLLITTILF AVCHQIAYFC FKADLLYTML FKLDQPCNLQ
110 120 130 140 150
HSSYDCRFIT IATTTSNCGM ALVQLAMSID RVFALKFNRV YYKLKSIPGI
160 170 180 190 200
TLALITLSIS FSMFFILTID DPLSGYVNHC GFYPTYSQDK FHIFLDVTLY
210 220 230 240 250
LAVFNFVFDI GLMYYSYQEI LWKRSYSFVN RFQSRISLKC TQAIFIISIC
260 270 280 290 300
QCISNVLYSG LLSLLMKLGR YMSSADYNLS LSLAYTTPYS CLILPILICK
310 320 330
VLEYIKKQRT VGILSLRNQK QSMEGHMAMI NSAWK
Note: No experimental confirmation available.
Length:335
Mass (Da):38,522
Last modified:July 5, 2004 - v2
Checksum:iADC17A6015DC2A37
GO
Isoform b (identifier: Q20618-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MATPSSTNSDISTTQ
     157-159: LSI → AVI
     160-335: Missing.

Note: No experimental confirmation available.
Show »
Length:173
Mass (Da):19,449
Checksum:i49052D0ACD9A81C5
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0205271M → MATPSSTNSDISTTQ in isoform b. Curated1
Alternative sequenceiVSP_020528157 – 159LSI → AVI in isoform b. Curated3
Alternative sequenceiVSP_020529160 – 335Missing in isoform b. CuratedAdd BLAST176

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z66520 Genomic DNA. Translation: CAA91390.2.
Z66520 Genomic DNA. Translation: CAE48504.1.
PIRiT22450.
RefSeqiNP_001022186.1. NM_001027015.1. [Q20618-1]
NP_001022187.1. NM_001027016.2.
UniGeneiCel.15037.

Genome annotation databases

EnsemblMetazoaiF49E12.5a; F49E12.5a; WBGene00005039. [Q20618-1]
GeneIDi186058.
KEGGicel:CELE_F49E12.5.
UCSCiF49E12.5b. c. elegans. [Q20618-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z66520 Genomic DNA. Translation: CAA91390.2.
Z66520 Genomic DNA. Translation: CAE48504.1.
PIRiT22450.
RefSeqiNP_001022186.1. NM_001027015.1. [Q20618-1]
NP_001022187.1. NM_001027016.2.
UniGeneiCel.15037.

3D structure databases

ProteinModelPortaliQ20618.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F49E12.5a.

Proteomic databases

PaxDbiQ20618.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF49E12.5a; F49E12.5a; WBGene00005039. [Q20618-1]
GeneIDi186058.
KEGGicel:CELE_F49E12.5.
UCSCiF49E12.5b. c. elegans. [Q20618-1]

Organism-specific databases

CTDi186058.
WormBaseiF49E12.5a; CE35552; WBGene00005039; sra-13.
F49E12.5b; CE35877; WBGene00005039; sra-13.

Phylogenomic databases

eggNOGiENOG410K7AK. Eukaryota.
ENOG41114YI. LUCA.
GeneTreeiENSGT00840000130179.
HOGENOMiHOG000016070.
InParanoidiQ20618.
OMAiNHCGFYP.
OrthoDBiEOG091G0I6L.
PhylomeDBiQ20618.

Enzyme and pathway databases

SignaLinkiQ20618.

Miscellaneous databases

PROiQ20618.

Gene expression databases

BgeeiWBGene00005039.

Family and domain databases

InterProiIPR000344. 7TM_GPCR_serpentine_rcpt_Sra.
[Graphical view]
PfamiPF02117. 7TM_GPCR_Sra. 1 hit.
[Graphical view]
PRINTSiPR00697. TMPROTEINSRA.
ProtoNetiSearch...

Entry informationi

Entry nameiSRA13_CAEEL
AccessioniPrimary (citable) accession number: Q20618
Secondary accession number(s): Q7JM75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.