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Protein

Putative ammonium transporter 2

Gene

amt-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the uptake of ammonia (Probable). Implicated in aging.Curated1 Publication

GO - Molecular functioni

GO - Biological processi

  • aging Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ammonia transport, Transport

Protein family/group databases

TCDBi1.A.11.2.10. the ammonia transporter channel (amt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ammonium transporter 2
Gene namesi
Name:amt-2
ORF Names:F49E11.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiF49E11.3; CE45919; WBGene00000134; amt-2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei34 – 5421HelicalSequence analysisAdd
BLAST
Transmembranei72 – 9221HelicalSequence analysisAdd
BLAST
Transmembranei124 – 14421HelicalSequence analysisAdd
BLAST
Transmembranei156 – 17621HelicalSequence analysisAdd
BLAST
Transmembranei191 – 21121HelicalSequence analysisAdd
BLAST
Transmembranei226 – 24621HelicalSequence analysisAdd
BLAST
Transmembranei266 – 28621HelicalSequence analysisAdd
BLAST
Transmembranei291 – 31121HelicalSequence analysisAdd
BLAST
Transmembranei321 – 33717HelicalSequence analysisAdd
BLAST
Transmembranei346 – 36621HelicalSequence analysisAdd
BLAST
Transmembranei381 – 40121HelicalSequence analysisAdd
BLAST
Transmembranei404 – 42421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 515515Putative ammonium transporter 2PRO_0000139752Add
BLAST

Proteomic databases

PaxDbiQ20605.

Interactioni

Protein-protein interaction databases

STRINGi6239.F49E11.3.

Structurei

3D structure databases

ProteinModelPortaliQ20605.
SMRiQ20605. Positions 32-453.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0682. Eukaryota.
COG0004. LUCA.
GeneTreeiENSGT00530000064546.
HOGENOMiHOG000017735.
InParanoidiQ20605.
OMAiHCFISFF.
OrthoDBiEOG7FBRHH.

Family and domain databases

Gene3Di1.10.3430.10. 1 hit.
InterProiIPR029020. Ammonium/urea_transptr.
IPR001905. Ammonium_transpt.
IPR018047. Ammonium_transpt_CS.
IPR024041. NH4_transpt_AmtB-like_dom.
[Graphical view]
PANTHERiPTHR11730. PTHR11730. 1 hit.
PfamiPF00909. Ammonium_transp. 1 hit.
[Graphical view]
SUPFAMiSSF111352. SSF111352. 1 hit.
TIGRFAMsiTIGR00836. amt. 1 hit.
PROSITEiPS01219. AMMONIUM_TRANSP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q20605-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTLQNLTLK MDRQPTIRMK PDKQLDCSLS QDDGVWMMAS SFIIFTMTAG
60 70 80 90 100
FGLLESGRVS SKDEVNCMVK NVFDVIFGGL AYWMFGYGLT FGDSKHQLGR
110 120 130 140 150
YVGFGDFFFD PERVSDDDST DEKGISYSLF IFQMSFATTT STIVSAGMSE
160 170 180 190 200
RIHLKSHCFI SFFITLVHSV AGHWVWDQEG VFRMMGVVDS AGCSAVHLVG
210 220 230 240 250
GVSGLVATLY LKPRRNRFAK NGIRTVSDPT KAILGFLMIW WGWLAFNTSS
260 270 280 290 300
NYAVTHGQWT EGMRSAVGTI LASAGGGVVT VIITRLSTKK IQMDMLIDGM
310 320 330 340 350
LASLVASTGG CLYFTPWQAT LVGAIGSSLA LAAYPVTEWL KIDDPVGVFP
360 370 380 390 400
VHVVGSIWGM IAPAIFVYRR PMNFGPPECD FQTSDEINGL LYGGGFYLLF
410 420 430 440 450
LQSFVILVIG TYSAICAFII LFLIHHSPVG LRVDKYTEEL GADLIEHGLA
460 470 480 490 500
GFNVMTYTIE KKLDTKTLSA VLMIIVRWRA KAKLGAQRRK KIHDSGSVAP
510
QQAESVEMNV IHRRH
Length:515
Mass (Da):56,840
Last modified:May 16, 2012 - v3
Checksum:iDE105498817E087B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70308 Genomic DNA. Translation: CAA94345.3.
PIRiT22433.
RefSeqiNP_502496.3. NM_070095.3.
UniGeneiCel.2458.

Genome annotation databases

EnsemblMetazoaiF49E11.3; F49E11.3; WBGene00000134.
GeneIDi186047.
KEGGicel:CELE_F49E11.3.
UCSCiF49E11.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70308 Genomic DNA. Translation: CAA94345.3.
PIRiT22433.
RefSeqiNP_502496.3. NM_070095.3.
UniGeneiCel.2458.

3D structure databases

ProteinModelPortaliQ20605.
SMRiQ20605. Positions 32-453.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F49E11.3.

Protein family/group databases

TCDBi1.A.11.2.10. the ammonia transporter channel (amt) family.

Proteomic databases

PaxDbiQ20605.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF49E11.3; F49E11.3; WBGene00000134.
GeneIDi186047.
KEGGicel:CELE_F49E11.3.
UCSCiF49E11.3. c. elegans.

Organism-specific databases

CTDi186047.
WormBaseiF49E11.3; CE45919; WBGene00000134; amt-2.

Phylogenomic databases

eggNOGiKOG0682. Eukaryota.
COG0004. LUCA.
GeneTreeiENSGT00530000064546.
HOGENOMiHOG000017735.
InParanoidiQ20605.
OMAiHCFISFF.
OrthoDBiEOG7FBRHH.

Miscellaneous databases

PROiQ20605.

Family and domain databases

Gene3Di1.10.3430.10. 1 hit.
InterProiIPR029020. Ammonium/urea_transptr.
IPR001905. Ammonium_transpt.
IPR018047. Ammonium_transpt_CS.
IPR024041. NH4_transpt_AmtB-like_dom.
[Graphical view]
PANTHERiPTHR11730. PTHR11730. 1 hit.
PfamiPF00909. Ammonium_transp. 1 hit.
[Graphical view]
SUPFAMiSSF111352. SSF111352. 1 hit.
TIGRFAMsiTIGR00836. amt. 1 hit.
PROSITEiPS01219. AMMONIUM_TRANSP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Functional genomic approach to identify novel genes involved in the regulation of oxidative stress resistance and animal lifespan."
    Kim Y., Sun H.
    Aging Cell 6:489-503(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiAMT2_CAEEL
AccessioniPrimary (citable) accession number: Q20605
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 16, 2012
Last modified: June 8, 2016
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.