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Protein

Putative ammonium transporter 2

Gene

amt-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the uptake of ammonia (Probable). Implicated in aging.Curated1 Publication

GO - Molecular functioni

GO - Biological processi

  • aging Source: UniProtKB
  • ammonium transmembrane transport Source: GO_Central
  • organic cation transport Source: GO_Central

Keywordsi

Biological processAmmonia transport, Transport

Protein family/group databases

TCDBi1.A.11.2.10. the ammonium transporter channel (amt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ammonium transporter 2
Gene namesi
Name:amt-2
ORF Names:F49E11.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiF49E11.3; CE45919; WBGene00000134; amt-2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei34 – 54HelicalSequence analysisAdd BLAST21
Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Transmembranei266 – 286HelicalSequence analysisAdd BLAST21
Transmembranei291 – 311HelicalSequence analysisAdd BLAST21
Transmembranei321 – 337HelicalSequence analysisAdd BLAST17
Transmembranei346 – 366HelicalSequence analysisAdd BLAST21
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
Transmembranei404 – 424HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001397521 – 515Putative ammonium transporter 2Add BLAST515

Proteomic databases

PaxDbiQ20605.

Expressioni

Gene expression databases

BgeeiWBGene00000134.

Interactioni

Protein-protein interaction databases

STRINGi6239.F49E11.3.

Structurei

3D structure databases

ProteinModelPortaliQ20605.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0682. Eukaryota.
COG0004. LUCA.
GeneTreeiENSGT00530000064546.
HOGENOMiHOG000017735.
InParanoidiQ20605.
OMAiHCFISFF.
OrthoDBiEOG091G05F5.

Family and domain databases

InterProiView protein in InterPro
IPR001905. Ammonium_transpt.
IPR018047. Ammonium_transpt_CS.
IPR024041. NH4_transpt_AmtB-like_dom.
PfamiView protein in Pfam
PF00909. Ammonium_transp. 1 hit.
SUPFAMiSSF111352. SSF111352. 1 hit.
TIGRFAMsiTIGR00836. amt. 1 hit.
PROSITEiView protein in PROSITE
PS01219. AMMONIUM_TRANSP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q20605-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTLQNLTLK MDRQPTIRMK PDKQLDCSLS QDDGVWMMAS SFIIFTMTAG
60 70 80 90 100
FGLLESGRVS SKDEVNCMVK NVFDVIFGGL AYWMFGYGLT FGDSKHQLGR
110 120 130 140 150
YVGFGDFFFD PERVSDDDST DEKGISYSLF IFQMSFATTT STIVSAGMSE
160 170 180 190 200
RIHLKSHCFI SFFITLVHSV AGHWVWDQEG VFRMMGVVDS AGCSAVHLVG
210 220 230 240 250
GVSGLVATLY LKPRRNRFAK NGIRTVSDPT KAILGFLMIW WGWLAFNTSS
260 270 280 290 300
NYAVTHGQWT EGMRSAVGTI LASAGGGVVT VIITRLSTKK IQMDMLIDGM
310 320 330 340 350
LASLVASTGG CLYFTPWQAT LVGAIGSSLA LAAYPVTEWL KIDDPVGVFP
360 370 380 390 400
VHVVGSIWGM IAPAIFVYRR PMNFGPPECD FQTSDEINGL LYGGGFYLLF
410 420 430 440 450
LQSFVILVIG TYSAICAFII LFLIHHSPVG LRVDKYTEEL GADLIEHGLA
460 470 480 490 500
GFNVMTYTIE KKLDTKTLSA VLMIIVRWRA KAKLGAQRRK KIHDSGSVAP
510
QQAESVEMNV IHRRH
Length:515
Mass (Da):56,840
Last modified:May 16, 2012 - v3
Checksum:iDE105498817E087B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70308 Genomic DNA. Translation: CAA94345.3.
PIRiT22433.
RefSeqiNP_502496.3. NM_070095.3.
UniGeneiCel.2458.

Genome annotation databases

EnsemblMetazoaiF49E11.3; F49E11.3; WBGene00000134.
GeneIDi186047.
KEGGicel:CELE_F49E11.3.
UCSCiF49E11.3. c. elegans.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiAMT2_CAEEL
AccessioniPrimary (citable) accession number: Q20605
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 16, 2012
Last modified: May 10, 2017
This is version 103 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families