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Protein

26S proteasome non-ATPase regulatory subunit 6

Gene

rpn-7

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-CEL-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-CEL-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-CEL-382556. ABC-family proteins mediated transport.
R-CEL-4641258. Degradation of DVL.
R-CEL-5632684. Hedgehog 'on' state.
R-CEL-5689603. UCH proteinases.
R-CEL-5689880. Ub-specific processing proteases.
R-CEL-6798695. Neutrophil degranulation.
R-CEL-68949. Orc1 removal from chromatin.
R-CEL-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-CEL-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-CEL-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-CEL-8941858. Regulation of RUNX3 expression and activity.
R-CEL-8948751. Regulation of PTEN stability and activity.
R-CEL-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome non-ATPase regulatory subunit 6
Alternative name(s):
26S proteasome regulatory subunit rpn-7
Gene namesi
Name:rpn-7
ORF Names:F49C12.8
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiF49C12.8; CE03368; WBGene00004463; rpn-7.

Subcellular locationi

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001738401 – 41026S proteasome non-ATPase regulatory subunit 6Add BLAST410

Proteomic databases

EPDiQ20585.
PaxDbiQ20585.
PeptideAtlasiQ20585.
PRIDEiQ20585.

Expressioni

Tissue specificityi

Expressed in multiple tissues including the intestine, pharynx and hypodermis.1 Publication

Gene expression databases

BgeeiWBGene00004463.

Interactioni

Protein-protein interaction databases

BioGridi42859. 3 interactors.
DIPiDIP-26993N.
IntActiQ20585. 3 interactors.
MINTiMINT-211626.
STRINGi6239.F49C12.8.1.

Structurei

3D structure databases

ProteinModelPortaliQ20585.
SMRiQ20585.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini205 – 379PCIAdd BLAST175

Sequence similaritiesi

Belongs to the proteasome subunit S10 family.Curated

Phylogenomic databases

eggNOGiKOG0687. Eukaryota.
COG5187. LUCA.
GeneTreeiENSGT00510000046608.
HOGENOMiHOG000214998.
InParanoidiQ20585.
KOiK03037.
OMAiVDYIDQE.
OrthoDBiEOG091G03SE.
PhylomeDBiQ20585.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR000717. PCI_dom.
IPR035268. PSMD6.
IPR019585. Rpn7/CSN1.
IPR011991. WHTH_DNA-bd_dom.
PANTHERiPTHR14145:SF6. PTHR14145:SF6. 1 hit.
PfamiView protein in Pfam
PF01399. PCI. 1 hit.
PF10602. RPN7. 1 hit.
SMARTiView protein in SMART
SM00088. PINT. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.

Sequencei

Sequence statusi: Complete.

Q20585-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEAAKKSTK KPVDDGNFDK EIISRWPDLE LSQTRFMLNH PEVDSSVKEA
60 70 80 90 100
KLEKLQETIK EFDMAPFYEL VCADFKIVVD ATQLAAMKAA NQKKIDEITA
110 120 130 140 150
EVEDAEKNLG ESEVRQGLLR KFEYYCQIGD KDNALKAYTA TYEKTVGMGY
160 170 180 190 200
RIDVVFAMIR VGLFFLDHHL INKFITKAKE LMEQGGDWER KNRLRSYEAL
210 220 230 240 250
YRMSVRDFAG AADLFLEAVP TFGSYELMTY ENLILYTVIT TTFALDRPDL
260 270 280 290 300
RTKVIRCNEV QEQLTGGGLN GTLIPVREYL ESYYDCHYDR FFIQLAALES
310 320 330 340 350
ERFKFDRYLS PHFNYYSRGM RHRAYEQFLT PYKTVRIDMM AKDFGVSRAF
360 370 380 390 400
IDRELHRLIA TGQLQCRIDA VNGVIEVNHR DSKNHLYKAV IKDGDILLNR
410
IQKLARVINA
Length:410
Mass (Da):47,584
Last modified:November 1, 1996 - v1
Checksum:iF37390A3250109EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68227 Genomic DNA. Translation: CAA92512.1.
PIRiT22413.
RefSeqiNP_501632.1. NM_069231.6.
UniGeneiCel.12443.

Genome annotation databases

EnsemblMetazoaiF49C12.8; F49C12.8; WBGene00004463.
GeneIDi177753.
KEGGicel:CELE_F49C12.8.
UCSCiF49C12.8. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiPSMD6_CAEEL
AccessioniPrimary (citable) accession number: Q20585
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 27, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families