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Q20498 (RRC1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTPase-activating protein rrc-1
Alternative name(s):
RhoGAP for Rac-1 and Cdc-42
Gene names
Name:rrc-1
ORF Names:F47A4.3
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length759 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Functions as a GTPase-activating protein (GAP) for ced-10/rac-1 and CDC42. Ref.2

Tissue specificity

Expressed in coelomocytes, excretory cells, uterine-seam cells and GLR cells. Ref.2

Developmental stage

Expressed in all life stages with high expression in L1-L4 larvae stages. Ref.2

Sequence similarities

Contains 1 Rho-GAP domain.

Contains 1 SH3 domain.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainSH3 domain
   Molecular functionGTPase activation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpositive regulation of GTPase activity

Inferred from direct assay Ref.2. Source: UniProtKB

signal transduction

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintracellular

Inferred from electronic annotation. Source: InterPro

   Molecular_functionGTPase activator activity

Inferred from direct assay Ref.2. Source: UniProtKB

protein binding

Inferred from physical interaction PubMed 19447967PubMed 23549480. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CELE_F42G2.5O170995EBI-2316401,EBI-2316398

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform a (identifier: Q20498-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform b (identifier: Q20498-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: MEGIEESFAPLSPKSPFARRNGRS → MDPEIPG
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 759759GTPase-activating protein rrc-1
PRO_0000320116

Regions

Domain164 – 24380SH3
Domain280 – 473194Rho-GAP

Natural variations

Alternative sequence1 – 2424MEGIE…RNGRS → MDPEIPG in isoform b.
VSP_031596

Sequences

Sequence LengthMass (Da)Tools
Isoform a [UniParc].

Last modified October 1, 2003. Version 3.
Checksum: 45A9592D40D9D7F1

FASTA75987,020
        10         20         30         40         50         60 
MEGIEESFAP LSPKSPFARR NGRSLRIQRL VDCQHFHYSS VELGPVRVAI IAINADENAT 

        70         80         90        100        110        120 
ERIKMRVESE SNSWLVERSR EDWAVFDRQL HRCVFERRHS RLDELFPLIH LETAKFEEVL 

       130        140        150        160        170        180 
VKYTERLSEL TGSIITCYPV LKFLEIDSRG GHFEPAEETS INVPAIAAAV VTKDFEPTES 

       190        200        210        220        230        240 
SQLRLRVGDI VSITEMSTAS PSEQTFWKAK LTISNQKIVD PQNARLGFEI GYFPRDCVML 

       250        260        270        280        290        300 
IDDKRLPNPL NNEQKASTRN ARRYMTTMFR NRRREPIFGL ELTDLYMRTG KKVPVIVEKC 

       310        320        330        340        350        360 
CASIEDQGIV TGIYRQCGIQ SNIQRLRAKF DSGAEPDLHE FGQRDIYSVS SLLKQYFRQL 

       370        380        390        400        410        420 
PNPLFTYQAY PKLIEAFEKE DSLSEKVESL RFSLETMPEA HYRTAKFLME HLTRLCKSKS 

       430        440        450        460        470        480 
LTDMTSKNLA IVWSPNLFRP PPTLNGADTH LLSGLNVHTA ICDFFIENSE SLFVNDIDEE 

       490        500        510        520        530        540 
QSKCTSVENS FTTISKSATM SDMRSESESK WPRFFRGKSV EGFWKFNRKQ QTSTGELCGS 

       550        560        570        580        590        600 
PTSEVKWRSR STRSHSTDAA FQSSRTDSFI QLMHTGMDQI REGMRIFRAR ARSMRPTSRP 

       610        620        630        640        650        660 
PPSPRTRRAR FSNGSSNNVQ KLNESDIQHE IPLATTEPSI TPEPKNTVDP HQIMTRTISV 

       670        680        690        700        710        720 
NDSDDQSFEE NGLREMRERK VMFKAATQEH VATFHERSSP VEEWSSDSRE SLHLEMSRYD 

       730        740        750 
NVSPSGTITR NQREPITNLS PAAQMLFFES SRASHLFSA 

« Hide

Isoform b [UniParc].

Checksum: 8595677ADF1BE1B4
Show »

FASTA74285,114

References

« Hide 'large scale' references
[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORMS A AND B).
Strain: Bristol N2.
[2]"Molecular characterization of a novel RhoGAP, RRC-1 of the nematode Caenorhabditis elegans."
Delawary M., Nakazawa T., Tezuka T., Sawa M., Iino Y., Takenawa T., Yamamoto T.
Biochem. Biophys. Res. Commun. 357:377-382(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z49888 Genomic DNA. Translation: CAA90063.2.
Z49888 Genomic DNA. Translation: CAH60776.1.
PIRT22329.
RefSeqNP_001024683.1. NM_001029512.2. [Q20498-1]
NP_001024684.1. NM_001029513.2. [Q20498-2]
UniGeneCel.6769.

3D structure databases

ProteinModelPortalQ20498.
SMRQ20498. Positions 169-242, 275-473.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid46110. 2 interactions.
IntActQ20498. 32 interactions.
STRING6239.F47A4.3a.

Proteomic databases

PaxDbQ20498.
PRIDEQ20498.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaF47A4.3a; F47A4.3a; WBGene00009800. [Q20498-1]
GeneID181195.
KEGGcel:CELE_F47A4.3.
UCSCF47A4.3a. c. elegans. [Q20498-1]

Organism-specific databases

CTD181195.
WormBaseF47A4.3a; CE34188; WBGene00009800; rrc-1.
F47A4.3b; CE37375; WBGene00009800; rrc-1.

Phylogenomic databases

eggNOGNOG311367.
GeneTreeENSGT00720000108475.
HOGENOMHOG000154194.
InParanoidQ20498.
OMALEMSRYD.
OrthoDBEOG7WMCHV.
PhylomeDBQ20498.

Family and domain databases

Gene3D1.10.555.10. 1 hit.
InterProIPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamPF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTSM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEPS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio912852.

Entry information

Entry nameRRC1_CAEEL
AccessionPrimary (citable) accession number: Q20498
Secondary accession number(s): Q5WRQ3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2003
Last modified: June 11, 2014
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase