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Protein

GTPase-activating protein rrc-1

Gene

rrc-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a GTPase-activating protein (GAP) for ced-10/rac-1 and CDC42.1 Publication

GO - Molecular functioni

  1. GTPase activator activity Source: UniProtKB

GO - Biological processi

  1. positive regulation of GTPase activity Source: UniProtKB
  2. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiREACT_305147. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase-activating protein rrc-1
Alternative name(s):
RhoGAP for Rac-1 and Cdc-42
Gene namesi
Name:rrc-1
ORF Names:F47A4.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF47A4.3a; CE34188; WBGene00009800; rrc-1.
F47A4.3b; CE37375; WBGene00009800; rrc-1.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 759759GTPase-activating protein rrc-1PRO_0000320116Add
BLAST

Proteomic databases

PaxDbiQ20498.
PRIDEiQ20498.

Expressioni

Tissue specificityi

Expressed in coelomocytes, excretory cells, uterine-seam cells and GLR cells.1 Publication

Developmental stagei

Expressed in all life stages with high expression in L1-L4 larvae stages.1 Publication

Gene expression databases

ExpressionAtlasiQ20498. baseline and differential.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CELE_F42G2.5O170995EBI-2316401,EBI-2316398

Protein-protein interaction databases

BioGridi46110. 2 interactions.
IntActiQ20498. 32 interactions.
STRINGi6239.F47A4.3a.

Structurei

3D structure databases

ProteinModelPortaliQ20498.
SMRiQ20498. Positions 275-473.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini164 – 24380SH3PROSITE-ProRule annotationAdd
BLAST
Domaini280 – 473194Rho-GAPPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Rho-GAP domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiNOG311367.
GeneTreeiENSGT00720000108475.
HOGENOMiHOG000154194.
InParanoidiQ20498.
OMAiLEMSRYD.
OrthoDBiEOG7WMCHV.
PhylomeDBiQ20498.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
InterProiIPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: Q20498-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGIEESFAP LSPKSPFARR NGRSLRIQRL VDCQHFHYSS VELGPVRVAI
60 70 80 90 100
IAINADENAT ERIKMRVESE SNSWLVERSR EDWAVFDRQL HRCVFERRHS
110 120 130 140 150
RLDELFPLIH LETAKFEEVL VKYTERLSEL TGSIITCYPV LKFLEIDSRG
160 170 180 190 200
GHFEPAEETS INVPAIAAAV VTKDFEPTES SQLRLRVGDI VSITEMSTAS
210 220 230 240 250
PSEQTFWKAK LTISNQKIVD PQNARLGFEI GYFPRDCVML IDDKRLPNPL
260 270 280 290 300
NNEQKASTRN ARRYMTTMFR NRRREPIFGL ELTDLYMRTG KKVPVIVEKC
310 320 330 340 350
CASIEDQGIV TGIYRQCGIQ SNIQRLRAKF DSGAEPDLHE FGQRDIYSVS
360 370 380 390 400
SLLKQYFRQL PNPLFTYQAY PKLIEAFEKE DSLSEKVESL RFSLETMPEA
410 420 430 440 450
HYRTAKFLME HLTRLCKSKS LTDMTSKNLA IVWSPNLFRP PPTLNGADTH
460 470 480 490 500
LLSGLNVHTA ICDFFIENSE SLFVNDIDEE QSKCTSVENS FTTISKSATM
510 520 530 540 550
SDMRSESESK WPRFFRGKSV EGFWKFNRKQ QTSTGELCGS PTSEVKWRSR
560 570 580 590 600
STRSHSTDAA FQSSRTDSFI QLMHTGMDQI REGMRIFRAR ARSMRPTSRP
610 620 630 640 650
PPSPRTRRAR FSNGSSNNVQ KLNESDIQHE IPLATTEPSI TPEPKNTVDP
660 670 680 690 700
HQIMTRTISV NDSDDQSFEE NGLREMRERK VMFKAATQEH VATFHERSSP
710 720 730 740 750
VEEWSSDSRE SLHLEMSRYD NVSPSGTITR NQREPITNLS PAAQMLFFES

SRASHLFSA

Note: No experimental confirmation available.

Length:759
Mass (Da):87,020
Last modified:September 30, 2003 - v3
Checksum:i45A9592D40D9D7F1
GO
Isoform b (identifier: Q20498-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: MEGIEESFAPLSPKSPFARRNGRS → MDPEIPG

Note: No experimental confirmation available.

Show »
Length:742
Mass (Da):85,114
Checksum:i8595677ADF1BE1B4
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2424MEGIE…RNGRS → MDPEIPG in isoform b. CuratedVSP_031596Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49888 Genomic DNA. Translation: CAA90063.2.
Z49888 Genomic DNA. Translation: CAH60776.1.
PIRiT22329.
RefSeqiNP_001024683.1. NM_001029512.2. [Q20498-1]
NP_001024684.1. NM_001029513.2. [Q20498-2]
UniGeneiCel.6769.

Genome annotation databases

EnsemblMetazoaiF47A4.3a; F47A4.3a; WBGene00009800. [Q20498-1]
GeneIDi181195.
KEGGicel:CELE_F47A4.3.
UCSCiF47A4.3a. c. elegans. [Q20498-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49888 Genomic DNA. Translation: CAA90063.2.
Z49888 Genomic DNA. Translation: CAH60776.1.
PIRiT22329.
RefSeqiNP_001024683.1. NM_001029512.2. [Q20498-1]
NP_001024684.1. NM_001029513.2. [Q20498-2]
UniGeneiCel.6769.

3D structure databases

ProteinModelPortaliQ20498.
SMRiQ20498. Positions 275-473.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi46110. 2 interactions.
IntActiQ20498. 32 interactions.
STRINGi6239.F47A4.3a.

Proteomic databases

PaxDbiQ20498.
PRIDEiQ20498.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF47A4.3a; F47A4.3a; WBGene00009800. [Q20498-1]
GeneIDi181195.
KEGGicel:CELE_F47A4.3.
UCSCiF47A4.3a. c. elegans. [Q20498-1]

Organism-specific databases

CTDi181195.
WormBaseiF47A4.3a; CE34188; WBGene00009800; rrc-1.
F47A4.3b; CE37375; WBGene00009800; rrc-1.

Phylogenomic databases

eggNOGiNOG311367.
GeneTreeiENSGT00720000108475.
HOGENOMiHOG000154194.
InParanoidiQ20498.
OMAiLEMSRYD.
OrthoDBiEOG7WMCHV.
PhylomeDBiQ20498.

Enzyme and pathway databases

ReactomeiREACT_305147. Rho GTPase cycle.

Miscellaneous databases

NextBioi912852.

Gene expression databases

ExpressionAtlasiQ20498. baseline and differential.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
InterProiIPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORMS A AND B).
    Strain: Bristol N2.
  2. "Molecular characterization of a novel RhoGAP, RRC-1 of the nematode Caenorhabditis elegans."
    Delawary M., Nakazawa T., Tezuka T., Sawa M., Iino Y., Takenawa T., Yamamoto T.
    Biochem. Biophys. Res. Commun. 357:377-382(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.

Entry informationi

Entry nameiRRC1_CAEEL
AccessioniPrimary (citable) accession number: Q20498
Secondary accession number(s): Q5WRQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 25, 2008
Last sequence update: September 30, 2003
Last modified: March 31, 2015
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.