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Q20498

- RRC1_CAEEL

UniProt

Q20498 - RRC1_CAEEL

Protein

GTPase-activating protein rrc-1

Gene

rrc-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 3 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Functions as a GTPase-activating protein (GAP) for ced-10/rac-1 and CDC42.1 Publication

    GO - Molecular functioni

    1. GTPase activator activity Source: UniProtKB
    2. protein binding Source: IntAct

    GO - Biological processi

    1. positive regulation of GTPase activity Source: UniProtKB
    2. signal transduction Source: InterPro

    Keywords - Molecular functioni

    GTPase activation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTPase-activating protein rrc-1
    Alternative name(s):
    RhoGAP for Rac-1 and Cdc-42
    Gene namesi
    Name:rrc-1
    ORF Names:F47A4.3
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome X

    Organism-specific databases

    WormBaseiF47A4.3a; CE34188; WBGene00009800; rrc-1.
    F47A4.3b; CE37375; WBGene00009800; rrc-1.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 759759GTPase-activating protein rrc-1PRO_0000320116Add
    BLAST

    Proteomic databases

    PaxDbiQ20498.
    PRIDEiQ20498.

    Expressioni

    Tissue specificityi

    Expressed in coelomocytes, excretory cells, uterine-seam cells and GLR cells.1 Publication

    Developmental stagei

    Expressed in all life stages with high expression in L1-L4 larvae stages.1 Publication

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CELE_F42G2.5O170995EBI-2316401,EBI-2316398

    Protein-protein interaction databases

    BioGridi46110. 2 interactions.
    IntActiQ20498. 32 interactions.
    STRINGi6239.F47A4.3a.

    Structurei

    3D structure databases

    ProteinModelPortaliQ20498.
    SMRiQ20498. Positions 169-242, 275-473.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini164 – 24380SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini280 – 473194Rho-GAPPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Rho-GAP domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3 domain

    Phylogenomic databases

    eggNOGiNOG311367.
    GeneTreeiENSGT00720000108475.
    HOGENOMiHOG000154194.
    InParanoidiQ20498.
    OMAiLEMSRYD.
    OrthoDBiEOG7WMCHV.
    PhylomeDBiQ20498.

    Family and domain databases

    Gene3Di1.10.555.10. 1 hit.
    InterProiIPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00620. RhoGAP. 1 hit.
    [Graphical view]
    SMARTiSM00324. RhoGAP. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF48350. SSF48350. 1 hit.
    SSF50044. SSF50044. 1 hit.
    PROSITEiPS50238. RHOGAP. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform a (identifier: Q20498-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEGIEESFAP LSPKSPFARR NGRSLRIQRL VDCQHFHYSS VELGPVRVAI    50
    IAINADENAT ERIKMRVESE SNSWLVERSR EDWAVFDRQL HRCVFERRHS 100
    RLDELFPLIH LETAKFEEVL VKYTERLSEL TGSIITCYPV LKFLEIDSRG 150
    GHFEPAEETS INVPAIAAAV VTKDFEPTES SQLRLRVGDI VSITEMSTAS 200
    PSEQTFWKAK LTISNQKIVD PQNARLGFEI GYFPRDCVML IDDKRLPNPL 250
    NNEQKASTRN ARRYMTTMFR NRRREPIFGL ELTDLYMRTG KKVPVIVEKC 300
    CASIEDQGIV TGIYRQCGIQ SNIQRLRAKF DSGAEPDLHE FGQRDIYSVS 350
    SLLKQYFRQL PNPLFTYQAY PKLIEAFEKE DSLSEKVESL RFSLETMPEA 400
    HYRTAKFLME HLTRLCKSKS LTDMTSKNLA IVWSPNLFRP PPTLNGADTH 450
    LLSGLNVHTA ICDFFIENSE SLFVNDIDEE QSKCTSVENS FTTISKSATM 500
    SDMRSESESK WPRFFRGKSV EGFWKFNRKQ QTSTGELCGS PTSEVKWRSR 550
    STRSHSTDAA FQSSRTDSFI QLMHTGMDQI REGMRIFRAR ARSMRPTSRP 600
    PPSPRTRRAR FSNGSSNNVQ KLNESDIQHE IPLATTEPSI TPEPKNTVDP 650
    HQIMTRTISV NDSDDQSFEE NGLREMRERK VMFKAATQEH VATFHERSSP 700
    VEEWSSDSRE SLHLEMSRYD NVSPSGTITR NQREPITNLS PAAQMLFFES 750
    SRASHLFSA 759

    Note: No experimental confirmation available.

    Length:759
    Mass (Da):87,020
    Last modified:October 1, 2003 - v3
    Checksum:i45A9592D40D9D7F1
    GO
    Isoform b (identifier: Q20498-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-24: MEGIEESFAPLSPKSPFARRNGRS → MDPEIPG

    Note: No experimental confirmation available.

    Show »
    Length:742
    Mass (Da):85,114
    Checksum:i8595677ADF1BE1B4
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2424MEGIE…RNGRS → MDPEIPG in isoform b. CuratedVSP_031596Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49888 Genomic DNA. Translation: CAA90063.2.
    Z49888 Genomic DNA. Translation: CAH60776.1.
    PIRiT22329.
    RefSeqiNP_001024683.1. NM_001029512.2. [Q20498-1]
    NP_001024684.1. NM_001029513.2. [Q20498-2]
    UniGeneiCel.6769.

    Genome annotation databases

    EnsemblMetazoaiF47A4.3a; F47A4.3a; WBGene00009800. [Q20498-1]
    GeneIDi181195.
    KEGGicel:CELE_F47A4.3.
    UCSCiF47A4.3a. c. elegans. [Q20498-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49888 Genomic DNA. Translation: CAA90063.2 .
    Z49888 Genomic DNA. Translation: CAH60776.1 .
    PIRi T22329.
    RefSeqi NP_001024683.1. NM_001029512.2. [Q20498-1 ]
    NP_001024684.1. NM_001029513.2. [Q20498-2 ]
    UniGenei Cel.6769.

    3D structure databases

    ProteinModelPortali Q20498.
    SMRi Q20498. Positions 169-242, 275-473.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 46110. 2 interactions.
    IntActi Q20498. 32 interactions.
    STRINGi 6239.F47A4.3a.

    Proteomic databases

    PaxDbi Q20498.
    PRIDEi Q20498.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai F47A4.3a ; F47A4.3a ; WBGene00009800 . [Q20498-1 ]
    GeneIDi 181195.
    KEGGi cel:CELE_F47A4.3.
    UCSCi F47A4.3a. c. elegans. [Q20498-1 ]

    Organism-specific databases

    CTDi 181195.
    WormBasei F47A4.3a ; CE34188 ; WBGene00009800 ; rrc-1.
    F47A4.3b ; CE37375 ; WBGene00009800 ; rrc-1.

    Phylogenomic databases

    eggNOGi NOG311367.
    GeneTreei ENSGT00720000108475.
    HOGENOMi HOG000154194.
    InParanoidi Q20498.
    OMAi LEMSRYD.
    OrthoDBi EOG7WMCHV.
    PhylomeDBi Q20498.

    Miscellaneous databases

    NextBioi 912852.

    Family and domain databases

    Gene3Di 1.10.555.10. 1 hit.
    InterProi IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00620. RhoGAP. 1 hit.
    [Graphical view ]
    SMARTi SM00324. RhoGAP. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48350. SSF48350. 1 hit.
    SSF50044. SSF50044. 1 hit.
    PROSITEi PS50238. RHOGAP. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORMS A AND B).
      Strain: Bristol N2.
    2. "Molecular characterization of a novel RhoGAP, RRC-1 of the nematode Caenorhabditis elegans."
      Delawary M., Nakazawa T., Tezuka T., Sawa M., Iino Y., Takenawa T., Yamamoto T.
      Biochem. Biophys. Res. Commun. 357:377-382(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiRRC1_CAEEL
    AccessioniPrimary (citable) accession number: Q20498
    Secondary accession number(s): Q5WRQ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 102 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3