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Q20498

- RRC1_CAEEL

UniProt

Q20498 - RRC1_CAEEL

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Protein
GTPase-activating protein rrc-1
Gene
rrc-1, F47A4.3
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Functions as a GTPase-activating protein (GAP) for ced-10/rac-1 and CDC42.1 Publication

GO - Molecular functioni

  1. GTPase activator activity Source: UniProtKB
  2. protein binding Source: IntAct

GO - Biological processi

  1. positive regulation of GTPase activity Source: UniProtKB
  2. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase-activating protein rrc-1
Alternative name(s):
RhoGAP for Rac-1 and Cdc-42
Gene namesi
Name:rrc-1
ORF Names:F47A4.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome X

Organism-specific databases

WormBaseiF47A4.3a; CE34188; WBGene00009800; rrc-1.
F47A4.3b; CE37375; WBGene00009800; rrc-1.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 759759GTPase-activating protein rrc-1
PRO_0000320116Add
BLAST

Proteomic databases

PaxDbiQ20498.
PRIDEiQ20498.

Expressioni

Tissue specificityi

Expressed in coelomocytes, excretory cells, uterine-seam cells and GLR cells.1 Publication

Developmental stagei

Expressed in all life stages with high expression in L1-L4 larvae stages.1 Publication

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CELE_F42G2.5O170995EBI-2316401,EBI-2316398

Protein-protein interaction databases

BioGridi46110. 2 interactions.
IntActiQ20498. 32 interactions.
STRINGi6239.F47A4.3a.

Structurei

3D structure databases

ProteinModelPortaliQ20498.
SMRiQ20498. Positions 169-242, 275-473.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini164 – 24380SH3
Add
BLAST
Domaini280 – 473194Rho-GAP
Add
BLAST

Sequence similaritiesi

Contains 1 Rho-GAP domain.
Contains 1 SH3 domain.

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiNOG311367.
GeneTreeiENSGT00720000108475.
HOGENOMiHOG000154194.
InParanoidiQ20498.
OMAiLEMSRYD.
OrthoDBiEOG7WMCHV.
PhylomeDBiQ20498.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
InterProiIPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform a (identifier: Q20498-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEGIEESFAP LSPKSPFARR NGRSLRIQRL VDCQHFHYSS VELGPVRVAI    50
IAINADENAT ERIKMRVESE SNSWLVERSR EDWAVFDRQL HRCVFERRHS 100
RLDELFPLIH LETAKFEEVL VKYTERLSEL TGSIITCYPV LKFLEIDSRG 150
GHFEPAEETS INVPAIAAAV VTKDFEPTES SQLRLRVGDI VSITEMSTAS 200
PSEQTFWKAK LTISNQKIVD PQNARLGFEI GYFPRDCVML IDDKRLPNPL 250
NNEQKASTRN ARRYMTTMFR NRRREPIFGL ELTDLYMRTG KKVPVIVEKC 300
CASIEDQGIV TGIYRQCGIQ SNIQRLRAKF DSGAEPDLHE FGQRDIYSVS 350
SLLKQYFRQL PNPLFTYQAY PKLIEAFEKE DSLSEKVESL RFSLETMPEA 400
HYRTAKFLME HLTRLCKSKS LTDMTSKNLA IVWSPNLFRP PPTLNGADTH 450
LLSGLNVHTA ICDFFIENSE SLFVNDIDEE QSKCTSVENS FTTISKSATM 500
SDMRSESESK WPRFFRGKSV EGFWKFNRKQ QTSTGELCGS PTSEVKWRSR 550
STRSHSTDAA FQSSRTDSFI QLMHTGMDQI REGMRIFRAR ARSMRPTSRP 600
PPSPRTRRAR FSNGSSNNVQ KLNESDIQHE IPLATTEPSI TPEPKNTVDP 650
HQIMTRTISV NDSDDQSFEE NGLREMRERK VMFKAATQEH VATFHERSSP 700
VEEWSSDSRE SLHLEMSRYD NVSPSGTITR NQREPITNLS PAAQMLFFES 750
SRASHLFSA 759

Note: No experimental confirmation available.

Length:759
Mass (Da):87,020
Last modified:October 1, 2003 - v3
Checksum:i45A9592D40D9D7F1
GO
Isoform b (identifier: Q20498-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: MEGIEESFAPLSPKSPFARRNGRS → MDPEIPG

Note: No experimental confirmation available.

Show »
Length:742
Mass (Da):85,114
Checksum:i8595677ADF1BE1B4
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2424MEGIE…RNGRS → MDPEIPG in isoform b.
VSP_031596Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49888 Genomic DNA. Translation: CAA90063.2.
Z49888 Genomic DNA. Translation: CAH60776.1.
PIRiT22329.
RefSeqiNP_001024683.1. NM_001029512.2. [Q20498-1]
NP_001024684.1. NM_001029513.2. [Q20498-2]
UniGeneiCel.6769.

Genome annotation databases

EnsemblMetazoaiF47A4.3a; F47A4.3a; WBGene00009800. [Q20498-1]
GeneIDi181195.
KEGGicel:CELE_F47A4.3.
UCSCiF47A4.3a. c. elegans. [Q20498-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49888 Genomic DNA. Translation: CAA90063.2 .
Z49888 Genomic DNA. Translation: CAH60776.1 .
PIRi T22329.
RefSeqi NP_001024683.1. NM_001029512.2. [Q20498-1 ]
NP_001024684.1. NM_001029513.2. [Q20498-2 ]
UniGenei Cel.6769.

3D structure databases

ProteinModelPortali Q20498.
SMRi Q20498. Positions 169-242, 275-473.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 46110. 2 interactions.
IntActi Q20498. 32 interactions.
STRINGi 6239.F47A4.3a.

Proteomic databases

PaxDbi Q20498.
PRIDEi Q20498.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F47A4.3a ; F47A4.3a ; WBGene00009800 . [Q20498-1 ]
GeneIDi 181195.
KEGGi cel:CELE_F47A4.3.
UCSCi F47A4.3a. c. elegans. [Q20498-1 ]

Organism-specific databases

CTDi 181195.
WormBasei F47A4.3a ; CE34188 ; WBGene00009800 ; rrc-1.
F47A4.3b ; CE37375 ; WBGene00009800 ; rrc-1.

Phylogenomic databases

eggNOGi NOG311367.
GeneTreei ENSGT00720000108475.
HOGENOMi HOG000154194.
InParanoidi Q20498.
OMAi LEMSRYD.
OrthoDBi EOG7WMCHV.
PhylomeDBi Q20498.

Miscellaneous databases

NextBioi 912852.

Family and domain databases

Gene3Di 1.10.555.10. 1 hit.
InterProi IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00620. RhoGAP. 1 hit.
[Graphical view ]
SMARTi SM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEi PS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORMS A AND B).
    Strain: Bristol N2.
  2. "Molecular characterization of a novel RhoGAP, RRC-1 of the nematode Caenorhabditis elegans."
    Delawary M., Nakazawa T., Tezuka T., Sawa M., Iino Y., Takenawa T., Yamamoto T.
    Biochem. Biophys. Res. Commun. 357:377-382(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.

Entry informationi

Entry nameiRRC1_CAEEL
AccessioniPrimary (citable) accession number: Q20498
Secondary accession number(s): Q5WRQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2003
Last modified: June 11, 2014
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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