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Protein

Probable rho GDP-dissociation inhibitor

Gene

rhi-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-CEL-194840. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable rho GDP-dissociation inhibitor
Short name:
Rho GDI
Gene namesi
Name:rhi-1
ORF Names:F46H6.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF46H6.1; CE04595; WBGene00004356; rhi-1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: WormBase
  • membrane Source: WormBase

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002190201 – 191Probable rho GDP-dissociation inhibitorAdd BLAST191

Proteomic databases

EPDiQ20496.
PaxDbiQ20496.
PeptideAtlasiQ20496.
PRIDEiQ20496.

PTM databases

iPTMnetiQ20496.

Expressioni

Gene expression databases

BgeeiWBGene00004356.
ExpressionAtlasiQ20496. baseline.

Interactioni

Protein-protein interaction databases

STRINGi6239.F46H6.1.3.

Structurei

3D structure databases

ProteinModelPortaliQ20496.
SMRiQ20496.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Rho GDI family.Curated

Phylogenomic databases

eggNOGiKOG3205. Eukaryota.
ENOG4111K44. LUCA.
GeneTreeiENSGT00390000006233.
HOGENOMiHOG000175765.
InParanoidiQ20496.
KOiK12462.
OMAiSYPPKKE.
OrthoDBiEOG091G0MBU.
PhylomeDBiQ20496.

Family and domain databases

Gene3Di2.70.50.30. 1 hit.
InterProiView protein in InterPro
IPR014756. Ig_E-set.
IPR000406. Rho_GDI.
IPR024792. RhoGDI_domain.
PANTHERiPTHR10980. PTHR10980. 1 hit.
PfamiView protein in Pfam
PF02115. Rho_GDI. 1 hit.
PRINTSiPR00492. RHOGDI.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Q20496-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDHENTGEN TSEYQYKQPP QKSIDELLNA DKEDESLKVY KAKLLGQGTV
60 70 80 90 100
IVDEKNPLRV IVRSVELLIN GKTAQSFDLS DPAKLVNSDL SVSIKEGSNY
110 120 130 140 150
RLSFAFHVQR EITSGLHYKH KVKRSGITVE NEKYMMGSYA PKLEIQEYKS
160 170 180 190
PNEEAPSGMM HRGKYKVYSK ITDDDNNVYL DWQWTLHITK E
Length:191
Mass (Da):21,919
Last modified:November 1, 1997 - v1
Checksum:i66A5B84ED0BCD450
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080405 Genomic DNA. Translation: CCD63475.1.
PIRiT16379.
RefSeqiNP_508774.1. NM_076373.5.
UniGeneiCel.19607.

Genome annotation databases

EnsemblMetazoaiF46H6.1; F46H6.1; WBGene00004356.
GeneIDi180721.
KEGGicel:CELE_F46H6.1.
UCSCiF46H6.1.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080405 Genomic DNA. Translation: CCD63475.1.
PIRiT16379.
RefSeqiNP_508774.1. NM_076373.5.
UniGeneiCel.19607.

3D structure databases

ProteinModelPortaliQ20496.
SMRiQ20496.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F46H6.1.3.

PTM databases

iPTMnetiQ20496.

Proteomic databases

EPDiQ20496.
PaxDbiQ20496.
PeptideAtlasiQ20496.
PRIDEiQ20496.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF46H6.1; F46H6.1; WBGene00004356.
GeneIDi180721.
KEGGicel:CELE_F46H6.1.
UCSCiF46H6.1.1. c. elegans.

Organism-specific databases

CTDi180721.
WormBaseiF46H6.1; CE04595; WBGene00004356; rhi-1.

Phylogenomic databases

eggNOGiKOG3205. Eukaryota.
ENOG4111K44. LUCA.
GeneTreeiENSGT00390000006233.
HOGENOMiHOG000175765.
InParanoidiQ20496.
KOiK12462.
OMAiSYPPKKE.
OrthoDBiEOG091G0MBU.
PhylomeDBiQ20496.

Enzyme and pathway databases

ReactomeiR-CEL-194840. Rho GTPase cycle.

Miscellaneous databases

PROiPR:Q20496.

Gene expression databases

BgeeiWBGene00004356.
ExpressionAtlasiQ20496. baseline.

Family and domain databases

Gene3Di2.70.50.30. 1 hit.
InterProiView protein in InterPro
IPR014756. Ig_E-set.
IPR000406. Rho_GDI.
IPR024792. RhoGDI_domain.
PANTHERiPTHR10980. PTHR10980. 1 hit.
PfamiView protein in Pfam
PF02115. Rho_GDI. 1 hit.
PRINTSiPR00492. RHOGDI.
SUPFAMiSSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGDIR_CAEEL
AccessioniPrimary (citable) accession number: Q20496
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 7, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.