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Q20432

- CNEP1_CAEEL

UniProt

Q20432 - CNEP1_CAEEL

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Protein
CTD nuclear envelope phosphatase 1 homolog
Gene
scpl-2, F45E12.1
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Serine/threonine protein phosphatase that may dephosphorylate and activate lipin-like phosphatases. Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

  1. protein serine/threonine phosphatase activity Source: UniProtKB

GO - Biological processi

  1. nuclear envelope organization Source: UniProtKB
  2. positive regulation of triglyceride biosynthetic process Source: UniProtKB
  3. protein dephosphorylation Source: UniProtKB
  4. regulation of nuclear division Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
CTD nuclear envelope phosphatase 1 homolog (EC:3.1.3.16)
Alternative name(s):
Serine/threonine-protein phosphatase dullard homolog
Small C-terminal domain phosphatase-like phosphatase 2
Gene namesi
Name:scpl-2
ORF Names:F45E12.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome II

Organism-specific databases

WormBaseiF45E12.1a; CE02737; WBGene00018474; scpl-2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Nem1-Spo7 phosphatase complex Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. endoplasmic reticulum membrane Source: UniProtKB
  4. integral component of membrane Source: UniProtKB-KW
  5. nuclear envelope Source: UniProtKB
  6. nuclear membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 246246CTD nuclear envelope phosphatase 1 homolog
PRO_0000297975Add
BLAST

Proteomic databases

PaxDbiQ20432.

Interactioni

Protein-protein interaction databases

STRINGi6239.F45E12.1.

Structurei

3D structure databases

ProteinModelPortaliQ20432.
SMRiQ20432. Positions 58-232.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini53 – 220168FCP1 homology
Add
BLAST

Sequence similaritiesi

Belongs to the dullard family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5190.
GeneTreeiENSGT00550000075053.
InParanoidiQ20432.
KOiK17617.
PhylomeDBiQ20432.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR011948. Dullard_phosphatase.
IPR023214. HAD-like_dom.
IPR004274. NIF.
[Graphical view]
PfamiPF03031. NIF. 1 hit.
[Graphical view]
SMARTiSM00577. CPDc. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02251. HIF-SF_euk. 1 hit.
PROSITEiPS50969. FCP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q20432-1 [UniParc]FASTAAdd to Basket

« Hide

MTTIAQSVFC FLAGFFNFFL LYFRKTSRAY CKYQVVKYHS NIPMSPLTTH    50
RLLTVKRKIL VLDLDETLIH SHHDGVLRQT VKPGTPSDFT IRVVIDRHPV 100
KFSVHERPHV DYFLSVVSQW YELVVFTASM EVYGTSVADR LDRGRGILKR 150
RYFRQHCTME VGGYTKDLSA IHPDLSSICI LDNSPGAYRK FPHNAIPIPS 200
WFSDPNDTCL LNLLPFLDAL RFTSDVRSVL SRNMQALPET QSVQYY 246
Length:246
Mass (Da):28,414
Last modified:November 1, 1996 - v1
Checksum:i7D60A06A050EA3EA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080734 Genomic DNA. Translation: CCD66263.1.
PIRiT16371.
RefSeqiNP_001254124.1. NM_001267195.1.
UniGeneiCel.15079.

Genome annotation databases

EnsemblMetazoaiF45E12.1a; F45E12.1a; WBGene00018474.
GeneIDi185802.
KEGGicel:CELE_F45E12.1.
UCSCiF45E12.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080734 Genomic DNA. Translation: CCD66263.1 .
PIRi T16371.
RefSeqi NP_001254124.1. NM_001267195.1.
UniGenei Cel.15079.

3D structure databases

ProteinModelPortali Q20432.
SMRi Q20432. Positions 58-232.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.F45E12.1.

Proteomic databases

PaxDbi Q20432.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F45E12.1a ; F45E12.1a ; WBGene00018474 .
GeneIDi 185802.
KEGGi cel:CELE_F45E12.1.
UCSCi F45E12.1. c. elegans.

Organism-specific databases

CTDi 185802.
WormBasei F45E12.1a ; CE02737 ; WBGene00018474 ; scpl-2.

Phylogenomic databases

eggNOGi COG5190.
GeneTreei ENSGT00550000075053.
InParanoidi Q20432.
KOi K17617.
PhylomeDBi Q20432.

Miscellaneous databases

NextBioi 929562.
PROi Q20432.

Family and domain databases

Gene3Di 3.40.50.1000. 1 hit.
InterProi IPR011948. Dullard_phosphatase.
IPR023214. HAD-like_dom.
IPR004274. NIF.
[Graphical view ]
Pfami PF03031. NIF. 1 hit.
[Graphical view ]
SMARTi SM00577. CPDc. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
TIGRFAMsi TIGR02251. HIF-SF_euk. 1 hit.
PROSITEi PS50969. FCP1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Molecular cloning and characterization of dullard: a novel gene required for neural development."
    Satow R., Chan T.C., Asashima M.
    Biochem. Biophys. Res. Commun. 295:85-91(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  3. "Nuclear envelope phosphatase-regulatory subunit 1 (formerly TMEM188) is the metazoan SPO7 ortholog and functions in the lipin activation pathway."
    Han S., Bahmanyar S., Zhang P., Grishin N., Oegema K., Crooke R., Graham M., Reue K., Dixon J.E., Goodman J.M.
    J. Biol. Chem. 287:3123-3137(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiCNEP1_CAEEL
AccessioniPrimary (citable) accession number: Q20432
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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