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Q20432 (CNEP1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CTD nuclear envelope phosphatase 1 homolog

EC=3.1.3.16
Alternative name(s):
Serine/threonine-protein phosphatase dullard homolog
Small C-terminal domain phosphatase-like phosphatase 2
Gene names
Name:scpl-2
ORF Names:F45E12.1
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length246 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Serine/threonine protein phosphatase that may dephosphorylate and activate lipin-like phosphatases. Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. Ref.3

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the dullard family.

Contains 1 FCP1 homology domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 246246CTD nuclear envelope phosphatase 1 homolog
PRO_0000297975

Regions

Transmembrane3 – 2321Helical; Potential
Domain53 – 220168FCP1 homology

Sequences

Sequence LengthMass (Da)Tools
Q20432 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 7D60A06A050EA3EA

FASTA24628,414
        10         20         30         40         50         60 
MTTIAQSVFC FLAGFFNFFL LYFRKTSRAY CKYQVVKYHS NIPMSPLTTH RLLTVKRKIL 

        70         80         90        100        110        120 
VLDLDETLIH SHHDGVLRQT VKPGTPSDFT IRVVIDRHPV KFSVHERPHV DYFLSVVSQW 

       130        140        150        160        170        180 
YELVVFTASM EVYGTSVADR LDRGRGILKR RYFRQHCTME VGGYTKDLSA IHPDLSSICI 

       190        200        210        220        230        240 
LDNSPGAYRK FPHNAIPIPS WFSDPNDTCL LNLLPFLDAL RFTSDVRSVL SRNMQALPET 


QSVQYY 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[2]"Molecular cloning and characterization of dullard: a novel gene required for neural development."
Satow R., Chan T.C., Asashima M.
Biochem. Biophys. Res. Commun. 295:85-91(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[3]"Nuclear envelope phosphatase-regulatory subunit 1 (formerly TMEM188) is the metazoan SPO7 ortholog and functions in the lipin activation pathway."
Han S., Bahmanyar S., Zhang P., Grishin N., Oegema K., Crooke R., Graham M., Reue K., Dixon J.E., Goodman J.M.
J. Biol. Chem. 287:3123-3137(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO080734 Genomic DNA. Translation: CCD66263.1.
PIRT16371.
RefSeqNP_001254124.1. NM_001267195.1.
UniGeneCel.15079.

3D structure databases

ProteinModelPortalQ20432.
SMRQ20432. Positions 58-232.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6239.F45E12.1.

Proteomic databases

PaxDbQ20432.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaF45E12.1a; F45E12.1a; F45E12.1.
GeneID185802.
KEGGcel:CELE_F45E12.1.
UCSCF45E12.1. c. elegans.

Organism-specific databases

CTD185802.
WormBaseF45E12.1a; CE02737; WBGene00018474; scpl-2.

Phylogenomic databases

eggNOGCOG5190.
InParanoidQ20432.
KOK17617.
PhylomeDBQ20432.

Family and domain databases

Gene3D3.40.50.1000. 1 hit.
InterProIPR011948. Dullard_phosphatase.
IPR023214. HAD-like_dom.
IPR004274. NIF.
[Graphical view]
PfamPF03031. NIF. 1 hit.
[Graphical view]
SMARTSM00577. CPDc. 1 hit.
[Graphical view]
SUPFAMSSF56784. SSF56784. 1 hit.
TIGRFAMsTIGR02251. HIF-SF_euk. 1 hit.
PROSITEPS50969. FCP1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio929562.
PROQ20432.

Entry information

Entry nameCNEP1_CAEEL
AccessionPrimary (citable) accession number: Q20432
Entry history
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase