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Protein

Palmitoyl-protein thioesterase 1

Gene

ppt-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides.1 Publication

Catalytic activityi

Palmitoyl-[protein] + H2O = palmitate + [protein].

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei107 – 1071NucleophileBy similarity
Active sitei224 – 2241By similarity
Active sitei280 – 2801By similarity

GO - Molecular functioni

  • palmitoyl-(protein) hydrolase activity Source: WormBase

GO - Biological processi

  • cellular protein catabolic process Source: WormBase
  • mitochondrion organization Source: WormBase
  • oviposition Source: WormBase
  • post-embryonic development Source: WormBase
  • protein depalmitoylation Source: GO_Central
  • receptor-mediated endocytosis Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiR-CEL-75876. Synthesis of very long-chain fatty acyl-CoAs.

Protein family/group databases

ESTHERicaeel-F44C4.5. Palmitoyl-protein_thioesterase.

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyl-protein thioesterase 1 (EC:3.1.2.22)
Short name:
PPT-1
Alternative name(s):
Palmitoyl-protein hydrolase 1
Gene namesi
Name:ppt-1
ORF Names:F44C4.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF44C4.5; CE47017; WBGene00004092; ppt-1.

Subcellular locationi

GO - Cellular componenti

  • lysosome Source: WormBase
Complete GO annotation...

Pathology & Biotechi

Disruption phenotypei

Worms exhibit a developmental delay and mild reproductive defects. They have abnormal mitochondria in muscle and neuronal cells.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Chaini17 – 298282Palmitoyl-protein thioesterase 1PRO_0000247504Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi20 – 201N-linked (GlcNAc...)Sequence analysis
Disulfide bondi37 ↔ 38By similarity
Disulfide bondi88 ↔ 120By similarity
Disulfide bondi144 ↔ 151By similarity
Glycosylationi250 – 2501N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ20390.
PaxDbiQ20390.
PRIDEiQ20390.

Expressioni

Gene expression databases

BgeeiWBGene00004092.

Interactioni

Protein-protein interaction databases

STRINGi6239.F44C4.5.

Structurei

3D structure databases

ProteinModelPortaliQ20390.
SMRiQ20390. Positions 25-293.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi197 – 2037Poly-Asn

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2541. Eukaryota.
COG1075. LUCA.
GeneTreeiENSGT00530000063368.
HOGENOMiHOG000199232.
InParanoidiQ20390.
KOiK01074.
OMAiLQETTLY.
OrthoDBiEOG091G0HJH.
PhylomeDBiQ20390.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002472. Palm_thioest.
IPR030294. PPT1.
[Graphical view]
PANTHERiPTHR11247:SF8. PTHR11247:SF8. 1 hit.
PfamiPF02089. Palm_thioest. 1 hit.
[Graphical view]
PRINTSiPR00414. PPTHIESTRASE.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q20390-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYFPLLLCL LAITTAEFRN ATKQVPVVMW HGMGDCCCNP LSMGSVKKLF
60 70 80 90 100
EEQIPGVYVH SLQLGSSITK DIEHGFYANT NELVYMACIK IKNDPELKNG
110 120 130 140 150
YNAIGFSQGA QFLRAVAQRC PNPPMKNLVS VGGQHQGVFG APYCIGDNIM
160 170 180 190 200
CNGVRRLIDL GAYLPFVQKR VVQAQYWHDP NQVEEYKKRS IFLADINNEN
210 220 230 240 250
NNNPTYKRNL LSLKNLVLVK FNQDHMVVPK DSSWFGFYKD GDIDTILPMN
260 270 280 290
ETDLYKEDRI GLKKLHESGR IHFMDVDGDH LQIPRSVLVN DIIKKYFM
Length:298
Mass (Da):33,984
Last modified:July 25, 2006 - v2
Checksum:i31DEFEFB164A6307
GO

Sequence cautioni

The sequence AAU01161 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081381 Genomic DNA. Translation: CCD71207.2.
AY691522 mRNA. Translation: AAU01161.1. Different initiation.
PIRiT30106.
RefSeqiNP_504684.2. NM_072283.5.
UniGeneiCel.2928.

Genome annotation databases

EnsemblMetazoaiF44C4.5; F44C4.5; WBGene00004092.
GeneIDi191744.
KEGGicel:CELE_F44C4.5.
UCSCiF44C4.5. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081381 Genomic DNA. Translation: CCD71207.2.
AY691522 mRNA. Translation: AAU01161.1. Different initiation.
PIRiT30106.
RefSeqiNP_504684.2. NM_072283.5.
UniGeneiCel.2928.

3D structure databases

ProteinModelPortaliQ20390.
SMRiQ20390. Positions 25-293.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F44C4.5.

Protein family/group databases

ESTHERicaeel-F44C4.5. Palmitoyl-protein_thioesterase.

Proteomic databases

EPDiQ20390.
PaxDbiQ20390.
PRIDEiQ20390.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF44C4.5; F44C4.5; WBGene00004092.
GeneIDi191744.
KEGGicel:CELE_F44C4.5.
UCSCiF44C4.5. c. elegans.

Organism-specific databases

CTDi191744.
WormBaseiF44C4.5; CE47017; WBGene00004092; ppt-1.

Phylogenomic databases

eggNOGiKOG2541. Eukaryota.
COG1075. LUCA.
GeneTreeiENSGT00530000063368.
HOGENOMiHOG000199232.
InParanoidiQ20390.
KOiK01074.
OMAiLQETTLY.
OrthoDBiEOG091G0HJH.
PhylomeDBiQ20390.

Enzyme and pathway databases

ReactomeiR-CEL-75876. Synthesis of very long-chain fatty acyl-CoAs.

Miscellaneous databases

PROiQ20390.

Gene expression databases

BgeeiWBGene00004092.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002472. Palm_thioest.
IPR030294. PPT1.
[Graphical view]
PANTHERiPTHR11247:SF8. PTHR11247:SF8. 1 hit.
PfamiPF02089. Palm_thioest. 1 hit.
[Graphical view]
PRINTSiPR00414. PPTHIESTRASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPPT1_CAEEL
AccessioniPrimary (citable) accession number: Q20390
Secondary accession number(s): Q68GX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: September 7, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.