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Protein

Stress-induced protein 1

Gene

sip-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • unfolded protein binding Source: WormBase

GO - Biological processi

  • determination of adult lifespan Source: WormBase
  • embryo development ending in birth or egg hatching Source: WormBase
  • protein metabolic process Source: WormBase
  • response to heat Source: WormBase

Enzyme and pathway databases

ReactomeiR-CEL-3371571 HSF1-dependent transactivation
R-CEL-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA

Names & Taxonomyi

Protein namesi
Recommended name:
Stress-induced protein 1
Gene namesi
Name:sip-1Imported
ORF Names:F43D9.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF43D9.4 ; CE00994 ; WBGene00004798 ; sip-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002399331 – 159Stress-induced protein 1Add BLAST159

Proteomic databases

EPDiQ20363
PaxDbiQ20363
PeptideAtlasiQ20363
PRIDEiQ20363

Expressioni

Gene expression databases

BgeeiWBGene00004798

Interactioni

GO - Molecular functioni

  • unfolded protein binding Source: WormBase

Protein-protein interaction databases

BioGridi41662, 1 interactor
IntActiQ20363, 4 interactors
MINTiQ20363
STRINGi6239.F43D9.4

Structurei

Secondary structure

1159
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi46 – 48Combined sources3
Beta strandi50 – 58Combined sources9
Helixi64 – 66Combined sources3
Beta strandi67 – 72Combined sources6
Beta strandi75 – 85Combined sources11
Beta strandi87 – 100Combined sources14
Helixi107 – 109Combined sources3
Beta strandi111 – 114Combined sources4
Beta strandi118 – 126Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4YDZX-ray3.60A/B/C/D1-159[»]
4YE0X-ray2.10A/B43-159[»]
ProteinModelPortaliQ20363
SMRiQ20363
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 141sHSPPROSITE-ProRule annotationAdd BLAST109

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3591 Eukaryota
ENOG410YERS LUCA
GeneTreeiENSGT00760000119238
HOGENOMiHOG000233954
InParanoidiQ20363
KOiK19769
OMAiDLAHIHT
OrthoDBiEOG091G0USC
PhylomeDBiQ20363

Family and domain databases

Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR002068 A-crystallin/Hsp20_dom
IPR001436 Alpha-crystallin/HSP
IPR031107 HSP20
IPR008978 HSP20-like_chaperone
PANTHERiPTHR11527 PTHR11527, 1 hit
PfamiView protein in Pfam
PF00011 HSP20, 1 hit
PIRSFiPIRSF036514 Sm_HSP_B1, 1 hit
PRINTSiPR00299 ACRYSTALLIN
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS01031 SHSP, 1 hit

Sequencei

Sequence statusi: Complete.

Q20363-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLCPYTGR PTGLFRDFED MMPYWAQRHS MLNNFNNIVP QQLNEVENTA
60 70 80 90 100
QKFCVKLDVA AFKPEELKVN LEGHVLTIEG HHEVKTEHGF SKRSFTRQFT
110 120 130 140 150
LPKDVDLAHI HTVINKEGQM TIDAPKTGSN TTVRALPIHT SAGHAVTQKP

SSTTTTGKH
Length:159
Mass (Da):17,839
Last modified:November 1, 1996 - v1
Checksum:i92B952775FFA9D53
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35640 Genomic DNA Translation: CAA84703.1
PIRiT22126
RefSeqiNP_499316.1, NM_066915.4
UniGeneiCel.16892

Genome annotation databases

EnsemblMetazoaiF43D9.4; F43D9.4; WBGene00004798
GeneIDi176471
KEGGicel:CELE_F43D9.4
UCSCiF43D9.4.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiSIP1_CAEEL
AccessioniPrimary (citable) accession number: Q20363
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health