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Protein

Stress-induced protein 1

Gene

sip-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • unfolded protein binding Source: WormBase

GO - Biological processi

  • determination of adult lifespan Source: WormBase
  • embryo development ending in birth or egg hatching Source: WormBase
  • multicellular organismal protein metabolic process Source: WormBase
  • response to heat Source: WormBase
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-CEL-3371571. HSF1-dependent transactivation.

Names & Taxonomyi

Protein namesi
Recommended name:
Stress-induced protein 1
Gene namesi
Name:sip-1Imported
ORF Names:F43D9.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF43D9.4; CE00994; WBGene00004798; sip-1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: WormBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 159159Stress-induced protein 1PRO_0000239933Add
BLAST

Proteomic databases

EPDiQ20363.
PaxDbiQ20363.
PRIDEiQ20363.

Interactioni

GO - Molecular functioni

  • unfolded protein binding Source: WormBase

Protein-protein interaction databases

BioGridi41662. 1 interaction.
IntActiQ20363. 4 interactions.
MINTiMINT-115641.
STRINGi6239.F43D9.4.

Structurei

Secondary structure

1
159
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi46 – 483Combined sources
Beta strandi50 – 589Combined sources
Helixi64 – 663Combined sources
Beta strandi67 – 726Combined sources
Beta strandi75 – 8511Combined sources
Beta strandi87 – 10014Combined sources
Helixi107 – 1093Combined sources
Beta strandi111 – 1144Combined sources
Beta strandi118 – 1269Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4YDZX-ray3.60A/B/C/D1-159[»]
4YE0X-ray2.10A/B43-159[»]
ProteinModelPortaliQ20363.
SMRiQ20363. Positions 18-152.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
GeneTreeiENSGT00760000119238.
HOGENOMiHOG000233954.
InParanoidiQ20363.
KOiK19769.
OMAiDLAHIHT.
OrthoDBiEOG7WHHBK.
PhylomeDBiQ20363.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q20363-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLCPYTGR PTGLFRDFED MMPYWAQRHS MLNNFNNIVP QQLNEVENTA
60 70 80 90 100
QKFCVKLDVA AFKPEELKVN LEGHVLTIEG HHEVKTEHGF SKRSFTRQFT
110 120 130 140 150
LPKDVDLAHI HTVINKEGQM TIDAPKTGSN TTVRALPIHT SAGHAVTQKP

SSTTTTGKH
Length:159
Mass (Da):17,839
Last modified:November 1, 1996 - v1
Checksum:i92B952775FFA9D53
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35640 Genomic DNA. Translation: CAA84703.1.
PIRiT22126.
RefSeqiNP_499316.1. NM_066915.4.
UniGeneiCel.16892.

Genome annotation databases

EnsemblMetazoaiF43D9.4; F43D9.4; WBGene00004798.
GeneIDi176471.
KEGGicel:CELE_F43D9.4.
UCSCiF43D9.4.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35640 Genomic DNA. Translation: CAA84703.1.
PIRiT22126.
RefSeqiNP_499316.1. NM_066915.4.
UniGeneiCel.16892.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4YDZX-ray3.60A/B/C/D1-159[»]
4YE0X-ray2.10A/B43-159[»]
ProteinModelPortaliQ20363.
SMRiQ20363. Positions 18-152.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi41662. 1 interaction.
IntActiQ20363. 4 interactions.
MINTiMINT-115641.
STRINGi6239.F43D9.4.

Proteomic databases

EPDiQ20363.
PaxDbiQ20363.
PRIDEiQ20363.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF43D9.4; F43D9.4; WBGene00004798.
GeneIDi176471.
KEGGicel:CELE_F43D9.4.
UCSCiF43D9.4.1. c. elegans.

Organism-specific databases

CTDi176471.
WormBaseiF43D9.4; CE00994; WBGene00004798; sip-1.

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
GeneTreeiENSGT00760000119238.
HOGENOMiHOG000233954.
InParanoidiQ20363.
KOiK19769.
OMAiDLAHIHT.
OrthoDBiEOG7WHHBK.
PhylomeDBiQ20363.

Enzyme and pathway databases

ReactomeiR-CEL-3371571. HSF1-dependent transactivation.

Miscellaneous databases

NextBioi892714.
PROiQ20363.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. Bienvenut W.V.
    Submitted (MAR-2006) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 17-52; 57-68; 86-92 AND 98-134, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiSIP1_CAEEL
AccessioniPrimary (citable) accession number: Q20363
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: November 1, 1996
Last modified: March 16, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.