Q20351 (TPSTB_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative protein-tyrosine sulfotransferase
EC=2.8.2.20

Alternative name(s):
Tyrosylprotein sulfotransferase
Short name=TPST

Gene names

Name:	tpst-2
ORF Names:	F42G9.8

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	259 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides By similarity.
Catalytic activity	3'-phosphoadenylyl sulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate.
Sequence similarities	Belongs to the protein sulfotransferase family.

Ontologies

Keywords
Molecular function	Transferase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	apoptotic process Inferred from mutant phenotype. Source: WormBase embryo development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase reproduction Inferred from mutant phenotype. Source: WormBase
Molecular function	protein-tyrosine sulfotransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 259	259	Putative protein-tyrosine sulfotransferase		PRO_0000189832
Amino acid modifications
	Glycosylation	36	1	N-linked (GlcNAc...) Potential
	Glycosylation	115	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q20351 [UniParc]. Last modified February 2, 2004. Version 2. Checksum: 8773576C94130C4F	FASTA	259	29,922
	10 20 30 40 50 60 MRAILDAHPD VRCGGETMLL PSFLTWQAGW RNDWVNNSGI TQEVFDDAVS AFITEIVAKH 70 80 90 100 110 120 SELAPRLCNK DPYTALWLPT IRRLYPNAKF ILMIRDARAV VHSMIERKVP VAGYNTSDEI 130 140 150 160 170 180 SMFVQWNQEL RKMTFQCNNA PGQCIKVYYE RLIQKPAEEI LRITNFLDLP FSQQMLRHQD 190 200 210 220 230 240 LIGDEVDLND QEFSASQVKN SINTKALTSW FDCFSEETLR KLDDVAPFLG ILGYDTSISK 250 PDYSTFADDD FYQFKNFYS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[2]	"Existence of distinct tyrosylprotein sulfotransferase genes: molecular characterization of tyrosylprotein sulfotransferase-2." Beisswanger R., Corbeil D., Vannier C., Thiele C., Dohrmann U., Kellner R., Ashman K., Niehrs C., Huttner W.B. Proc. Natl. Acad. Sci. U.S.A. 95:11134-11139(1998) [PubMed: 9736702] [Abstract] Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FO080196 Genomic DNA. Translation: CCD61891.1.
PIR	T16350.
RefSeq	NP_497256.1. NM_064855.1.
UniGene	Cel.10493.
3D structure databases
ProteinModelPortal	Q20351.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q20351. 5 interactions.
MINT	MINT-6669461.
STRING	Q20351.
Proteomic databases
PRIDE	Q20351.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	F42G9.8; F42G9.8; F42G9.8.
GeneID	185681.
KEGG	cel:F42G9.8.
NMPDR	fig|6239.3.peg.8548.
Organism-specific databases
CTD	185681.
WormBase	F42G9.8; CE24966; WBGene00018365; tpst-2.
Phylogenomic databases
eggNOG	meNOG05430.
GeneTree	EMGT00050000006091.
HOGENOM	HBG382344.
InParanoid	Q20351.
OMA	VYYERLI.
PhylomeDB	Q20351.
Gene expression databases
ArrayExpress	Q20351.
Family and domain databases
InterPro	IPR000863. Sulfotransferase_dom. [Graphical view]
KO	K01021.
Pfam	PF00685. Sulfotransfer_1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	929122.

Entry information

Entry name

TPSTB_CAEEL

Accession

Primary (citable) accession number: Q20351
Secondary accession number(s): Q8T8N1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	February 2, 2004
Last modified:	January 25, 2012
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project